DF/HCC Program Affiliation

Cancer Cell Biology

Research Abstract

We are interested in the biological function and mechanism of action of a number of transcriptional regulators that are targets of viral oncoproteins. These proteins include p300/CBP, CtBP and YY1. We are using both genetic (C. elegans and mouse) and biochemical approaches to address relevant questions.

Publications

• Horwitz AA, Affar el B, Heine GF, Shi Y, Parvin JD.A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase.Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6614-9.
  17420471
• Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y.The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.Cell 2007 Mar 23;128(6):1077-88.
  17320160
• Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT.Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch.Mol Cell 2007 Jan 12;25(1):43-56.
  17218270
• Sui GC, Affar EB, Shi YJ, Wall N, Brignone C, Yin P, Dohonoe M, Calvo D, Grossman S, Shi Y.Yin Yang 1 is a negative regulator of p53.Cell 2004 June 25;117:859-872.
• Shi YJ, Sawada JI, Su GC, Affar EB, Whetstine J, Lan F, Ogawa H, Luke M, Nakatani Y, Shi, Y.Coordinated histone modifications mediated by a CtBP co-repressor complex.Nature 2003 Apr 17;422:735-738.
• Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC, Shi Y.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5515-20.
  11960009
• Lan F, Nottke AC, Shi Y.Mechanisms involved in the regulation of histone lysine demethylases.Curr Opin Cell Biol 2008 Apr 25.
  18440794
• Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.Nature 2008 Mar 20;452(7185):370-4.
  18354483
• Shi Y, Liu YW, Gao PJ, Gao YH, Tan Y.[Identification of the beta(2)GPI-binding receptor on hepatocyte membrane].Zhonghua Yi Xue Za Zhi 2007 Sep 11;87(34):2429-31.
  18036325
• Matthews AG, Kuo AJ, Ramon-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA.RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J
  18033247
• Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C, Shi Y.A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.Nat Struct Mol Biol 2007 Dec;14(12):1165-72.
  18026119
• Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons DM.Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.In
  17534895
• Lan M, Shi Y, Sun L, Liu L, Guo X, Lu Y, Wang J, Liang J, Fan D.KCl Depolarization Increases HIF-1 Transcriptional Activity via the Calcium-Independent Pathway in SGC7901 Gastric Cancer Cells.Tumour Biol 2007 May 21;28(3):173-180.
  17519536
• Liu L, Ning X, Sun L, Shi Y, Han S, Guo C, Chen Y, Sun S, Yin F, Wu K, Fan D.Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells.Mol Cell Biochem 2007 May 3.
  17476462
• Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons DM.Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth.Hum Gene Ther 2007 Apr;18(4):379-86.
  17472570
• Niu Y, Yu Q, Yu Y, Ding XM, Shi YR.[Clonality of the peripheral papilloma and cancerous cells of breast].Zhonghua Yi Xue Za Zhi 2007 Feb 27;87(8):542-5.
  17459204
• Lin M, Xie HL, Su Q, Zhou JG, Tan H, Yi L, Tang HL, Huang Y, Shi Y.[Effects of Diallyl Disulfide on Differential Expression of Apoptosis-associated Genes in Leukemia Cell Line HL-60.].Ai Zheng 2007 Apr;26(4):351-6.
  17430650
• Han Y, Shi Y, Han Z, Sun L, Fan D.Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells.Cell Biol Int 2007 Jul;31(7):741-7.
  17428690
• Liang J, Pan Y, Zhang D, Guo C, Shi Y, Wang J, Chen Y, Wang X, Liu J, Guo X, Chen Z, Qiao T, Fan D.Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS.FASEB J 2007 Apr 4.
  17409275
• Bai F, Guo X, Yang L, Wang J, Shi Y, Zhang F, Zhai H, Lu Y, Xie H, Wu K, Fan D.Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation.Dig Dis Sci 2007 Jun;52(6):15
  17404872
• Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson DA, Jin S, White E.Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.Cancer Cell 2006 Jul;10(1):51-64
  16843265
• Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G.Structural insights into histone demethylation by JMJD2 family members.Cell 2006 May 19;125(4):691-702.
  16677698
• Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y.Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.Cell 2006 May 5;125(3):467-81.
  16603238
• Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G.NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.Proc Natl Acad Sci U S A 2006 Apr 4;103(14):5308-13.
  16567619
• Chen J, Wall NR, Kocher K, Duclos N, Fabbro D, Neuberg D, Griffin JD, Shi Y, Gilliland DG.Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.J Clin Invest 2004 Jun;113(12):1784-91.
  15199413
• Gay F, Calvo D, Lo MC, Ceron J, Maduro M, Lin R, Shi Y.Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.Genes Dev 2003 Mar 15;17(6):717-22.
  12651889