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Myles Brown, MD


  • Yoo S, Pettersson A, Jordahl KM, Lis RT, Lindstrom S, Meisner A, Nuttall EJ, Stack EC, Stampfer MJ, Kraft P, Brown M, Loda M, Giovannucci EL, Kantoff PW, Mucci LA.Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG positive prostate cancer.Cancer Epidemiol Biomarkers Prev. 2014 Jun 12.
  • Lim E, Ni M, Cao S, Hazra A, Tamimi RM, Brown M.Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy.Curr Breast Cancer Rep. 2014 Jun 1;6(2):71-78.
  • Sun T, Wang X, He HH, Sweeney CJ, Liu SX, Brown M, Balk S, Lee GS, Kantoff PW.MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.Oncogene. 2014 May 22(21):2790-800.
  • Hsieh CL, Fei T, Chen Y, Li T, Gao Y, Wang X, Sun T, Sweeney CJ, Lee GS, Chen S, Balk SP, Liu XS, Brown M, Kantoff PW.Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation.Proc Natl Acad Sci U S A. 2014 May 20(20):7319-24.
  • Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH.XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.Nature. 2014 Apr 3;508(7494):103-7.
  • Jeselsohn R, Yelensky R, Buchwalter G, Frampton G, Meric-Bernstam F, Gonzalez-Angulo AM, Ferrer-Lozano J, Perez-Fidalgo JA, Cristofanilli M, Gómez H, Arteaga CL, Giltnane J, Balko JM, Cronin MT, Jarosz M, Sun J, Hawryluk M, Lipson D, Otto G, Ross JS, Dvir A, Soussan-Gutman L, Wolf I, Rubinek T, Gilmore L, Schnitt S, Come SE, Pusztai L, Stephens P, Brown M, Miller VA.Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.Clin Cancer Res. 2014 Apr 1;20(7):1757-67.
  • Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carbó LR, Estébanez-Perpiñá E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Bräse S, Brown M, Cato AC.Coregulator Control of Androgen Receptor Action by a Novel Nuclear Receptor-binding Motif.J Biol Chem. 2014 Mar 28;289(13):8839-51.
  • Bailey ST, Miron PL, Choi YJ, Kochupurakkal B, Maulik G, Rodig SJ, Tian R, Foley KM, Bowman T, Miron A, Brown M, Iglehart JD, Biswas DK.NF-κB activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth.Mol Cancer Res. 2014 Mar;12(3):408-20.
  • He HH, Meyer CA, Hu SS, Chen MW, Zang C, Liu Y, Rao PK, Fei T, Xu H, Long H, Liu XS, Brown M.Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification.Nat Methods. 2014 Jan;11(1):73-8.
  • Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM.Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.Genome Biol. 2013 Nov 12;14(11):R125.
  • Merenbakh-Lamin K, Ben-Baruch N, Yeheskel A, Dvir A, Soussan-Gutman L, Jeselsohn R, Yelensky R, Brown M, Miller VA, Sarid D, Rizel S, Klein B, Rubinek T, Wolf I.D538G mutation in estrogen receptor-α: A novel mechanism for acquired endocrine resistance in breast cancer.Cancer Res. 2013 Dec 1;73(23):6856-64.
  • van Kruchten M, de Vries EG, Brown M, de Vries EF, Glaudemans AW, Dierckx RA, Schröder CP, Hospers GA.PET imaging of oestrogen receptors in patients with breast cancer.Lancet Oncol. 2013 Oct;14(11):e465-75. Review.
  • McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K.The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.Cancer Cell. 2013 Sep 9;24(3):365-78.
  • Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA.Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.Cancer Cell. 2013 Sep 9;24(3):347-64.
  • Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y, Liu XS.Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.Nat Struct Mol Biol. 2013 Jul;20(7):908-13.
  • Bhat-Nakshatri P, Song EK, Collins NR, Uversky VN, Dunker AK, O'Malley BW, Geistlinger TR, Carroll JS, Brown M, Nakshatri H.Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.BMC Med Genomics. 2013;6:21.
  • Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.Cancer Cell. 2013 Jun 10;23(6):753-67.
  • Jeselsohn RM, Werner L, Regan MM, Fatima A, Gilmore L, Collins LC, Beck AH, Bailey ST, He HH, Buchwalter G, Brown M, Iglehart JD, Richardson A, Come SE.Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response.PLoS ONE. 2013;8(5):e64225.
  • Sun H, Qin B, Liu T, Wang Q, Liu J, Wang J, Lin X, Yang Y, Taing L, Rao PK, Brown M, Zhang Y, Long HW, Liu XS.CistromeFinder for ChIP-seq and DNase-seq data reuse.Bioinformatics. 2013 Apr 17.
  • Ni M, Chen Y, Fei T, Li D, Lim E, Liu XS, Brown M.Amplitude modulation of androgen signaling by c-MYC.Genes Dev. 2013 Apr 1;27(7):734-48.
  • Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X.ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.J Clin Invest. 2013 Mar 1;123(3):1109-22.
  • Li Q, Seo JH, Stranger B, McKenna A, Pe'er I, Laframboise T, Brown M, Tyekucheva S, Freedman ML.Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.Cell. 2013 Jan 31;152(3):633-41. Review.
  • Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M.EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.Science. 2012 Dec 14;338(6113):1465-9.
  • Bailey ST, Shin H, Westerling T, Liu XS, Brown M.Estrogen receptor prevents p53-dependent apoptosis in breast cancer.Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18060-5.
  • Villa A, Della Torre S, Stell A, Cook J, Brown M, Maggi A.Tetradian oscillation of estrogen receptor α is necessary to prevent liver lipid deposition.Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11806-11.
  • He HH, Meyer CA, Chen MW, Jordan VC, Brown M, Liu XS.Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics.Genome Res. 2012 Jun;22(6):1015-25.
  • Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S.GlcNAcylation of histone H2B facilitates its monoubiquitination.Nature. 2011 Dec 22;480(7378):557-60.
  • Sun T, Yang M, Chen S, Balk S, Pomerantz M, Hsieh CL, Brown M, Lee GS, Kantoff PW.The altered expression of MiR-221/-222 and MiR-23b/-27b is associated with the development of human castration resistant prostate cancer.Prostate. 2011 Nov 29.
  • Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z, Chen S, Nelson PS, Liu XS, Brown M, Balk SP.Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.Cancer Cell. 2011 Oct 18;20(4):457-71.
  • Zhang C, Wang L, Wu D, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W, Wang Q.Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer.Cancer Res. 2011 Oct 18.
  • Tang Q, Chen Y, Meyer C, Geistlinger T, Lupien M, Wang Q, Liu T, Zhang Y, Brown M, Liu XS.A Comprehensive View of Nuclear Receptor Cancer Cistromes.Cancer Res. 2011 Oct 12.
  • Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Pape UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS.Cistrome: an integrative platform for transcriptional regulation studies.Genome Biol. 2011 Aug 22;12(8):R83.
  • Wang C, Mayer JA, Mazumdar A, Fertuck K, Kim H, Brown M, Brown PH.Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor.Mol Endocrinol. 2011 Sep;25(9):1527-38.
  • Scott SM, Brown M, Come SE.Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer.Expert Opin Drug Saf. 2011 Sep;10(5):819-26.
  • Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M.Targeting androgen receptor in estrogen receptor-negative breast cancer.Cancer Cell. 2011 Jul 12;20(1):119-31.
  • Meyer CA, He HH, Brown M, Liu XS.BINOCh: binding inference from nucleosome occupancy changes.Bioinformatics. 2011 Jul 1;27(13):1867-8.
  • Yang M, Xie W, Mostaghel E, Nakabayashi M, Werner L, Sun T, Pomerantz M, Freedman M, Ross R, Regan M, Sharifi N, Figg WD, Balk S, Brown M, Taplin ME, Oh WK, Lee GS, Kantoff PW.SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.J Clin Oncol. 2011 Jun 20;29(18):2565-73.
  • Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S.PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.Nat Cell Biol. 2011 Jun;13(6):668-75.
  • Sérandour AA, Avner S, Percevault F, Demay F, Bizot M, Lucchetti-Miganeh C, Barloy-Hubler F, Brown M, Lupien M, Métivier R, Salbert G, Eeckhoute J.Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.Genome Res. 2011 Apr;21(4):555-65.
  • Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP.CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.Cancer Res. 2011 Jan 15;71(2):528-37.
  • Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS.Genomic Collaboration of Estrogen Receptor-{alpha} and ERK2 in Regulating Gene and Proliferation Programs.Mol Cell Biol. 2011 Jan;31(1):226-36.
  • Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA.Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2.Dev Cell. 2010 Nov 16;19(5):713-26.
  • Lupien M, Meyer CA, Bailey ST, Eeckhoute J, Cook J, Westerling T, Zhang X, Carroll JS, Rhodes DR, Liu XS, Brown M.Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.Genes Dev. 2010 Oct 1;24(19):2219-27.
  • Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA.TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15157-62.
  • Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L, Almendro V, He HH, Brown M, Liu XS, Davis M, Caswell JL, Beckwith CA, Hills A, Macconaill L, Coetzee GA, Regan MM, Freedman ML.8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.Proc Natl Acad Sci U S A. 2010 May 25;107(21):9742-6.
  • Torres-Arzayus MI, Zhao J, Bronson R, Brown M.Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.Cancer Res. 2010 May 15;70(10):4102-11.
  • Badve S, Collins NR, Bhat-Nakshatri P, Turbin D, Leung S, Thorat M, Dunn SE, Geistlinger TR, Carroll JS, Brown M, Bose S, Teitell MA, Nakshatri H.Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers. Potential Clinical Implications.Am J Pathol. 2010 May;176(5):2139-49.
  • He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS.Nucleosome dynamics define transcriptional enhancers.Nat Genet. 2010 Apr;42(4):343-7.
  • Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP.Multimodal regulation of E2F1 gene expression by progestins.Mol Cell Biol. 2010 Apr;30(8):1866-77.
  • Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S.MYC regulation of a "poor-prognosis" metastatic cancer cell state.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3698-703.
  • Boros J, Donaldson IJ, O'Donnell A, Odrowaz ZA, Zeef L, Lupien M, Meyer CA, Liu XS, Brown M, Sharrocks AD.Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery.Genome Res. 2009 Nov;19(11):1963-73.
  • Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A.Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.Cancer Cell. 2009 Nov 6;16(5):413-24.
  • Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP.Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.Mol Endocrinol. 2009 Sep;23(9):1385-96.
  • Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, Nakshatri H.Estradiol-regulated microRNAs control estradiol response in breast cancer cells.Nucleic Acids Res. 2009 Aug;37(14):4850-61.
  • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M.Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.Cell. 2009 Jul 23;138(2):245-56.
  • Eeckhoute J, Lupien M, Brown M.Combining Chromatin Immunoprecipitation and Oligonucleotide Tiling Arrays (ChIP-Chip) for Functional Genomic Studies.Methods Mol Biol. 2009;556:155-64.
  • Lupien M, Brown M.Cistromics of hormone-dependent cancer.Endocr. Relat. Cancer. 2009 Jun;16(2):381-9. Review.
  • Nucera C,Eeckhoute J,Finn S,Carroll JS,Ligon AH,Priolo C,Fadda G,Toner M,Sheils O,Attard M,Pontecorvi A,Nose V,Loda M,Brown M.FOXA1 Is a Potential Oncogene in Anaplastic Thyroid Carcinoma.Clin Cancer Res. 2009 Jun 1;15(11):3680-9.
  • Lupien M, Eeckhoute J, Meyer CA, Krum SA, Rhodes DR, Liu XS, Brown M.Coactivator function defines the active estrogen receptor alpha cistrome.Mol Cell Biol. 2009 Jun;29(12):3413-23.
  • Sun T, Wang Q, Balk S, Brown M, Lee GS, Kantoff P.The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.Cancer Res. 2009 Apr 15;69(8):3356-63.
  • Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ, Logan SK.Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells.Cancer Res. 2009 Apr 1;69(7):3140-7.
  • Xia X,Lemieux ME,Li W,Carroll JS,Brown M,Liu XS,Kung AL.Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4260-5.
  • Eeckhoute J,Lupien M,Meyer CA,Verzi MP,Shivdasani RA,Liu XS,Brown M.Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.Genome Res. 2009 Mar;19(3):372-80.
  • Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS.Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.Nature. 2008 Dec 4;456(7222):663-6.
  • Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nussbaum C, Myers RM, Brown M, Li W, Liu XS.Model-based analysis of ChIP-Seq (MACS).Genome Biol. 2008;9(9):R137.
  • Bhat-Nakshatri P, Wang G, Appaiah H, Luktuke N, Carroll JS, Geistlinger TR, Brown M, Badve S, Liu Y, Nakshatri H.AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer.Mol Cell Biol. 2008 Dec;28(24):7487-503.
  • Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M.Unique ERalpha cistromes control cell type-specific gene regulation.Mol Endocrinol. 2008 Nov;22(11):2393-406.
  • Agoulnik IU, Bingman WE, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL.Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase.Mol Endocrinol. 2008 Nov;22(11):2420-32.
  • Holmes KA,Song JS,Liu XS,Brown M,Carroll JS.Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity.Cancer Res. 2008 Sep 15;68(18):7380-5.
  • Setlur SR,Mertz KD,Hoshida Y,Demichelis F,Lupien M,Perner S,Sboner A,Pawitan Y,Andren O,Johnson LA,Tang J,Adami HO,Calza S,Chinnaiyan AM,Rhodes D,Tomlins S,Fall K,Mucci LA,Kantoff PW,Stampfer MJ,Andersson SO,Varenhorst E,Johansson JE,Brown M,Golub TR,Rubin MA.Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.Journal of the National Cancer Institute. 2008 Jun 4;100(11):815-25.
  • Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melham MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM.Targeting NF-{kappa}B in Waldenstrom macroglobulinemia.Blood. 2008 May 15;111(10):5068-77.
  • Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME.CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.Cancer Res. 2008 May 1;68(9):3204-13.
  • Li W, Carroll JS, Brown M, Liu S.xMAN: extreme MApping of OligoNucleotides.BMC Genomics. 2008;9 Suppl 1:S20.
  • Tan-Wong SM, French JD, Proudfoot NJ, Brown MA.Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene.Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5160-5.
  • Spurdle AB, Lakhani SR, Healey S, Parry S, Da Silva LM, Brinkworth R, Hopper JL, Brown MA, Babikyan D, Chenevix-Trench G, Tavtigian SV, Goldgar DE.Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators.J Clin Oncol. 2008 Apr 1;26(10):1657-63.
  • Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M.FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.Cell. 2008 Mar 21;132(6):958-70.
  • Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ, Monteith GR.Localization of plasma membrane and secretory calcium pumps in the mammary gland.Biochem Biophys Res Commun. 2008 May 9;369(3):977-81.
  • Bao BY,Chuang BF,Wang Q,Sartor O,Balk SP,Brown M,Kantoff PW,Lee GS.Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.Prostate. 2008 Jun 1;68(8):839-48.
  • Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS.Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.Genome Res. 2008 Mar;18(3):393-403.
  • Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M.Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.EMBO J. 2008 Feb 6;27(3):535-45.
  • Frietze S, Lupien M, Silver PA, Brown M.CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.Cancer Res. 2008 Jan 1;68(1):301-6.
  • Wang Q, Li W, Liu XS, Carroll JS, Jnne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M.A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.Mol Cell. 2007 Aug 3;27(3):380-92.
  • Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M.Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.Cancer Res. 2007 Jul 1;67(13):6477-83.
  • Harvey TJ, Henderson A, Gazi E, Clarke NW, Brown M, Faria EC, Snook RD, Gardner P.Discrimination of prostate cancer cells by reflection mode FTIR photoacoustic spectroscopy.Analyst. 2007 Apr;132(4):292-5.
  • Brown MW, Brooks JP, Albert PS, Poggi MM.An analysis of erectile function after intensity modulated radiation therapy for localized prostate carcinoma.Prostate Cancer Prostatic Dis. 2007;10(2):189-93.
  • Kaplan L, Brown MA.The transition of nurse practitioners to changes in prescriptive authority.J Nurs Scholarsh. 2007;39(2):184-90.
  • Clarke NW, Brown MD.The Influence of Lipid Metabolism on Prostate Cancer Development and Progression: Is it Time for a Closer Look?.Eur Urol. 2007 Jul;52(1):3-4.
  • O'Mahony D, Morris JC, Quinn C, Gao W, Wilson WH, Gause B, Pittaluga S, Neelapu S, Brown M, Fleisher TA, Gulley JL, Schlom J, Nussenblatt R, Albert P, Davis TA, Lowy I, Petrus M, Waldmann TA, Janik JE.A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.Clin Cancer Res. 2007 Feb 1;13(3):958-64.
  • Gazi E, Dwyer J, Lockyer NP, Gardner P, Shanks JH, Roulson J, Hart CA, Clarke NW, Brown MD.Biomolecular profiling of metastatic prostate cancer cells in bone marrow tissue using FTIR microspectroscopy: a pilot study.Anal Bioanal Chem. 2007 Mar;387(5):1621-31.
  • Yabroff KR, Davis WW, Lamont EB, Fahey A, Topor M, Brown ML, Warren JL.Patient time costs associated with cancer care.Journal of the National Cancer Institute. 2007 Jan 3;99(1):14-23.
  • Torres-Arzayus MI, Yuan J, DellaGatta JL, Lane H, Kung AL, Brown M.Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland.Cancer Res. 2006 Dec 1;66(23):11381-8.
  • Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M.Genome-wide analysis of estrogen receptor binding sites.Nat Genet. 2006 Nov;38(11):1289-97.
  • Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M.A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer.Genes Dev. 2006 Sep 15;20(18):2513-26.
  • Johnson WE, Li W, Meyer CA, Gottardo R, Carroll JS, Brown M, Liu XS.Model-based analysis of tiling-arrays for ChIP-chip.Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12457-62.
  • Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW.p63 regulates an adhesion programme and cell survival in epithelial cells.Nat Cell Biol. 2006 Jun;8(6):551-61.
  • De Roos AJ, Rothman N, Brown M, Bell DA, Pittman GS, Shapiro WR, Selker RG, Fine HA, Black PM, Inskip PD.Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.Neuro-oncol. 2006 Apr;8(2):145-55.
  • Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.X chromosomal abnormalities in basal-like human breast cancer.Cancer Cell. 2006 Feb;9(2):121-32.
  • Come SE, Buzdar AU, Ingle JN, Arteaga CL, Brown M, Dowsett M, Hilsenbeck SG, Kumar R, Johnston SR, Lee AV, Paik S, Pritchard KI, Winer EP, Hart C.Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statement.Clin Cancer Res. 2006 Feb 1;12(3 Pt 2):997s-1000s.
  • Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M, Jacks T.The differential effects of mutant p53 alleles on advanced murine lung cancer.Cancer Res. 2005 Nov 15;65(22):10280-8.
  • Lewis AG, Flanagan J, Marsh A, Pupo GM, Mann G, Spurdle AB, Lindeman GJ, Visvader JE, Brown MA, Chenevix-Trench G,.Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer.Breast Cancer Res. 2005;7(6):R1005-16.
  • Colilla S, Kantoff PW, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Garber JE, Lynch HT, Brown M, Weber BL, Rebbeck TR.The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers.Carcinogenesis. 2006 Mar;27(3):599-605.
  • Tesoriero AA, Wong EM, Jenkins MA, Hopper JL, Brown MA, Chenevix-Trench G, Spurdle AB, Southey MC,.Molecular characterization and cancer risk associated with BRCA1 and BRCA2 splice site variants identified in multiple-case breast cancer families.Hum Mutat. 2005 Nov;26(5):495.
  • Wang Q, Carroll JS, Brown M.Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.Mol Cell. 2005 Sep 2;19(5):631-42.
  • Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M.Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.Cell. 2005 Jul 15;122(1):33-43.
  • Febbo PG, Lowenberg M, Thorner AR, Brown M, Loda M, Golub TR.Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.J Urol. 2005 May;173(5):1772-7.
  • Torres-Arzayus MI, De Mora JF, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR, Brown M.High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.Cancer Cell. 2004 Sep;6(3):263-74.
  • Shao W, Keeton EK, McDonnell DP, Brown M.Coactivator AIB1 links estrogen receptor transcriptional activity and stability.Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11599-604.
  • Hestermann EV, Brown M.Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor.Mol Cell Biol. 2003 Nov;23(21):7920-5.
  • Carroll PR, Kantoff PW, Balk SP, Brown MA, D'amico AV, George DJ, Grossfeld GD, Johnson CS, Kelly WK, Klotz L, Lee WR, Lubeck DP, Mcleod DG, Oh WK, Pollack A, Sartor O, Smith MR, Hart C,.Overview consensus statement. Newer approaches to androgen deprivation therapy in prostate cancer.Urology. 2002 Sep;60(3 Suppl 1):1-6.
  • Shang Y, Myers M, Brown M.Formation of the androgen receptor transcription complex.Mol Cell. 2002 Mar;9(3):601-10.
  • Shang Y, Brown M.Molecular determinants for the tissue specificity of SERMs.Science. 2002 Mar 29;295(5564):2465-8.
  • Haiman CA, Hankinson SE, Spiegelman D, Brown M, Hunter DJ.No association between a single nucleotide polymorphism in CYP19 and breast cancer risk.Cancer Epidemiol Biomarkers Prev. 2002 Feb;11(2):215-6.
  • Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ.The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.Cancer Res. 2002 Feb 15;62(4):1045-9.
  • DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M.Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.Cancer Res. 2002 Jan 1;62(1):89-98.
  • Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T.Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.Genes Dev. 2001 Oct 1;15(19):2598-612.
  • Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Brunet JS, Vesprini D, Garber JE, Lynch HT, Weber BL, Brown M.Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history.Cancer Res. 2001 Jul 15;61(14):5420-4.
  • Jones GB, Hynd G, Wright JM, Purohit A, Plourde GW, Huber RS, Mathews JE, Li A, Kilgore MW, Bubley GJ, Yancisin M, Brown MA.Target-directed enediynes: designed estramycins.J Org Chem. 2001 Jun 1;66(11):3688-95.
  • Planas-Silva MD, Shang Y, Donaher JL, Brown M, Weinberg RA.AIB1 enhances estrogen-dependent induction of cyclin D1 expression.Cancer Res. 2001 May 15;61(10):3858-62.
  • Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M.Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.Cell. 2000 Dec 8;103(6):843-52.
  • Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Brown M, Hunter DJ.Polymorphic repeat in AIB1 does not alter breast cancer risk.Breast Cancer Res. 2000;2(5):378-85.
  • Krithivas K, Yurgalevitch SM, Mohr BA, Wilcox CJ, Batter SJ, Brown M, Longcope C, McKinlay JB, Kantoff PW.Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men.J Endocrinol. 1999 Jul;162(1):137-42.
  • Hanstein B, Liu H, Yancisin MC, Brown M.Functional analysis of a novel estrogen receptor-beta isoform.Mol Endocrinol. 1999 Jan;13(1):129-37.
  • Shim WS, DiRenzo J, DeCaprio JA, Santen RJ, Brown M, Jeng MH.Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium.Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):208-13.
  • Febbo PG, Kantoff PW, Giovannucci E, Brown M, Chang G, Hennekens CH, Stampfer M.Debrisoquine hydroxylase (CYP2D6) and prostate cancer.Cancer Epidemiol Biomarkers Prev. 1998 Dec;7(12):1075-8.
  • Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH, Kantoff PW.The CAG repeat within the androgen receptor gene and its relationship to prostate cancer.Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3320-3.
  • Kantoff PW, Febbo PG, Giovannucci E, Krithivas K, Dahl DM, Chang G, Hennekens CH, Brown M, Stampfer MJ.A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis.Cancer Epidemiol Biomarkers Prev. 1997 Mar;6(3):189-92.
  • Hanstein B, Eckner R, DiRenzo J, Halachmi S, Liu H, Searcy B, Kurokawa R, Brown M.p300 is a component of an estrogen receptor coactivator complex.Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11540-5.
  • Halachmi S, Marden E, Martin G, MacKay H, Abbondanza C, Brown M.Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription.Science. 1994 Jun 3;264(5164):1455-8.
  • Cherington V, Brown M, Paucha E, St Louis J, Spiegelman BM, Roberts TM.Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.Mol Cell Biol. 1988 Mar;8(3):1380-4.
  • Bikel I, Montano X, Agha ME, Brown M, McCormack M, Boltax J, Livingston DM.SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen.Cell. 1987 Jan 30;48(2):321-30.