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Karl Munger, Ph.D.

Publications

  • Xylas J, Varone A, Quinn KP, Pouli D, McLaughlin-Drubin ME, Thieu HT, Garcia-Moliner ML, House M, Hunter M, Munger K, Georgakoudi I.Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development.Int J Cancer. 2014 May 26.
    24862444
  • Varone A, Xylas J, Quinn KP, Pouli D, Sridharan G, McLaughlin-Drubin ME, Alonzo C, Lee K, Münger K, Georgakoudi I.Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues.Cancer Res. 2014 Apr 24.
    24686167
  • Mesri EA, Feitelson MA, Munger K.Human viral oncogenesis: a cancer hallmarks analysis.Cell Host Microbe. 2014 Mar 12;15(3):266-82.
    24629334
  • Munger K.Are selective estrogen receptor modulators (SERMs) a therapeutic option for HPV-associated cervical lesions and cancers?.Am J Pathol. 2014 Feb;184(2):358-61.
    24345353
  • Munger K, Gwin TK, McLaughlin-Drubin ME.p16 in HPV-associated cancers.Oncotarget. 2013 Nov;4(11):1864-5.
    24192550
  • McLaughlin-Drubin ME, Park D, Munger K.Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16175-80.
    24046371
  • Yu Y, Munger K.Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.Virology. 2013 Nov;446(1-2):251-9.
    24074588
  • Mack HI, Munger K.The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines.Virology. 2013 Nov;446(1-2):9-16.
    24074562
  • Meyers JM, Spangle JM, Munger K.The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte Differentiation.J Virol. 2013 Apr;87(8):4762-7.
    23365452
  • Spangle JM, Munger K.The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species.PLoS Pathog. 2013 Mar;9(3):e1003237.
    23516367
  • McLaughlin-Drubin ME, Meyers J, Munger K.Cancer associated human papillomaviruses.Curr Opin Virol. 2012 Aug;2(4):459-66.
    22658985
  • Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M.Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.Nature. 2012 Jul 26;487(7408):491-5.
    22810586
  • Yu Y, Munger K.Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint.Virology. 2012 Oct 10;432(1):120-6.
    22748180
  • Gulbahce N, Yan H, Dricot A, Padi M, Byrdsong D, Franchi R, Lee DS, Rozenblatt-Rosen O, Mar JC, Calderwood MA, Baldwin A, Zhao B, Santhanam B, Braun P, Simonis N, Huh KW, Hellner K, Grace M, Chen A, Rubio R, Marto JA, Christakis NA, Kieff E, Roth FP, Roecklein-Canfield J, Decaprio JA, Cusick ME, Quackenbush J, Hill DE, Münger K, Vidal M, Barabási AL.Viral perturbations of host networks reflect disease etiology.PLoS Comput. Biol. 2012;8(6):e1002531.
    22761553
  • Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W, Crum CP.A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10516-21.
    22689991
  • Spangle JM, Ghosh-Choudhury N, Munger K.Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.J Virol. 2012 Jul;86(14):7466-72.
    22553330
  • McLaughlin-Drubin ME, Crum CP, Münger K.Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2130-5.
    21245294
  • Hellner K, Münger K.Human Papillomaviruses As Therapeutic Targets in Human Cancer.J Clin Oncol. 2011 Jan 10.
    21220591
  • Zhou X, Münger K.Clld7, a candidate tumor suppressor on chromosome 13q14, regulates pathways of DNA damage/repair and apoptosis.Cancer Res. 2010 Nov 15;70(22):9434-43.
    20926398
  • Spangle JM, Münger K.The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis.J Virol. 2010 Sep;84(18):9398-407.
    20631133
  • Baldwin A, Grueneberg DA, Hellner K, Sawyer J, Grace M, Li W, Harlow E, Munger K.Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12463-8.
    20616055
  • Lowy DR, Munger K.Prognostic implications of HPV in oropharyngeal cancer.N Engl J Med. 2010 Jul 1;363(1):82-4.
    20530315
  • Kamil JP, Hume AJ, Jurak I, Münger K, Kalejta RF, Coen DM.Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16823-8.
    19805380
  • McLaughlin-Drubin ME, Münger K.Oncogenic activities of human papillomaviruses.Virus Res. 2009 Aug;143(2):195-208. Review.
    19540281
  • Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.Cancer Res. 2009 Aug 15;69(16):6668-75.
    19679553
  • Hellner K, Mar J, Fang F, Quackenbush J, Münger K.HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition.Virology. 2009 Aug 15;391(1):57-63.
    19552933
  • Zhou X,Spangle JM,Munger K.Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: is autophagy an "Achilles' heel" of human cancers?.Autophagy. 2009 May;5(4):578-9.
    19333004
  • Zhou X,Munger K.Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation.Virology. 2009 Mar 1;385(1):192-7.
    19135224
  • Nguyen CL,Munger K.Human papillomavirus E7 protein deregulates mitosis via an association with nuclear mitotic apparatus protein 1.J Virol. 2009 Feb;83(4):1700-7.
    19052088
  • McLaughlin-Drubin ME,Munger K.The human papillomavirus E7 oncoprotein.Virology. 2009 Feb 20;384(2):335-44. Review.
    19007963
  • Nguyen CL,McLaughlin-Drubin ME,Munger K.Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses.Cancer Res. 2008 Nov 1;68(21):8715-22.
    18974113
  • Grueneberg DA,Degot S,Pearlberg J,Li W,Davies JE,Baldwin A,Endege W,Doench J,Sawyer J,Hu Y,Boyce F,Xian J,Munger K,Harlow E.Kinase requirements in human cells: I. Comparing kinase requirements across various cell types.Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16472-7.
    18948591
  • Baldwin A,Li W,Grace M,Pearlberg J,Harlow E,Munger K,Grueneberg DA.Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells.Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16478-83.
    18948598
  • Nguyen CL,Munger K.Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes.Virology. 2008 Oct 10;380(1):21-5.
    18718623
  • McLaughlin-Drubin M,Munger K.The human papillomavirus type 8 E2 gene encodes a transforming activity sufficient for skin tumor formation in transgenic mice.J Invest Dermatol. 2008 Sep;128(9):2142-4.
    18695686
  • McLaughlin-Drubin ME,Huh KW,Munger K.Human papillomavirus type 16 E7 oncoprotein associates with E2F6.J Virol. 2008 Sep;82(17):8695-705.
    18579589
  • Ruiz M, Singh P, Thomson SC, Munger K, Blantz RC, Gabbai FB.L-arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG II.Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1744-51.
    18353876
  • De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A.Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.Neurology. 2008 Mar 25;70(13 Pt 2):1113-8.
    18272866
  • Mangold U, Hayakawa H, Coughlin M, Münger K, Zetter BR.Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification.Oncogene.;27(5):604-13.
  • McLaughlin-Drubin ME, Munger K.Viruses associated with human cancer.Biochim Biophys Acta. 2008 Mar;1782(3):127-50. Review.
    18201576
  • Mujat C, Greiner C, Baldwin A, Levitt JM, Tian F, Stucenski LA, Hunter M, Kim YL, Backman V, Feld M, Munger K, Georgakoudi I.Endogenous optical biomarkers of normal and human papillomavirus immortalized epithelial cells.Int J Cancer. 2008 Jan 15;122(2):363-71.
    17935126
  • Nguyen CL, Eichwald C, Nibert ML, Mnger K.Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin.J Virol. 2007 Dec;81(24):13533-43.
    17913829
  • Simon K, Yang X, Munger K, Ascherio A.Variation in the Epstein-Barr virus receptor, CR2, and risk of multiple sclerosis.Mult Scler. 2007 Aug;13(7):947-8.
    17881405
  • Mangold U, Hayakawa H, Coughlin M, Mnger K, Zetter BR.Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification.Oncogene. 2008 Jan 24;27(5):604-13.
    17667942
  • Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Wade Harper J, Munger K.Human papillomavirus type 16 e7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.J Virol. 2007 Sep;81(18):9737-47.
    17609271
  • Levitt JM, Baldwin A, Papadakis A, Puri S, Xylas J, Mnger K, Georgakoudi I.Intrinsic fluorescence and redox changes associated with apoptosis of primary human epithelial cells.J Biomed Opt. 2006 Nov-Dec;11(6):064012.
    17212535
  • Baldwin A, Huh KW, Mnger K.Human papillomavirus E7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function.J Virol. 2006 Jul;80(13):6669-77.
    16775354
  • Georgakoudi I, Levitt J, Baldwin A, Papadakis A, Mnger K.Intrinsic fluorescence changes associated with apoptosis of human epithelial keratinocytes.Gynecol Oncol. 2005 Dec;99(3 Suppl 1):S54-7.
    16419185
  • Mnger K, Hayakawa H, Nguyen CL, Melquiot NV, Duensing A, Duensing S.Viral carcinogenesis and genomic instability.EXS. 2006(96):179-99.
    16383019
  • DeMasi J, Huh KW, Nakatani Y, Mnger K, Howley PM.Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11486-91.
    16081543
  • Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Mnger K.Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11492-7.
    16061792
  • Hasskarl J, Velupillai P, Piboonniyom SO, Grace M, Mnger K.Long-term maintenance of human keratinocytes in vitro.J Invest Dermatol. 2005 Feb;124(2):475-8.
    15675970
  • Tarunina M, Alger L, Chu G, Munger K, Gudkov A, Jat PS.Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival.Mol Cell Biol. 2004 Dec;24(24):10792-801.
    15572682
  • Mnger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M, Huh K.Mechanisms of human papillomavirus-induced oncogenesis.J Virol. 2004 Nov;78(21):11451-60.
    15479788
  • Duensing S, Duensing A, Lee DC, Edwards KM, Piboonniyom SO, Manuel E, Skaltsounis L, Meijer L, Mnger K.Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies.Oncogene. 2004 Oct 28;23(50):8206-15.
    15378001
  • Edwards KM, Mnger K.Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli.Oncogene. 2004 Nov 4;23(52):8419-31.
    15156195
  • Edwards KM, Mnger K.Make WARTS, not cancer!.Oncogene. 2004 Jul 8;23(31):5263-5.
    15122320
  • Badizadegan K, Backman V, Boone CW, Crum CP, Dasari RR, Georgakoudi I, Keefe K, Munger K, Shapshay SM, Sheetse EE, Feld MS.Spectroscopic diagnosis and imaging of invisible pre-cancer.Faraday Discuss. 2004;126:265-79; discussion 303-11.
    14992412
  • Eichten A, Rud DS, Grace M, Piboonniyom SO, Zacny V, Mnger K.Molecular pathways executing the "trophic sentinel" response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation.Virology. 2004 Feb 5;319(1):81-93.
    14967490
  • Hasskarl J, Duensing S, Manuel E, Mnger K.The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers.Oncogene. 2004 Mar 11;23(10):1930-8.
    14755252
  • Duensing S, Mnger K.Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.Int J Cancer. 2004 Mar 20;109(2):157-62.
    14750163
  • Balsitis SJ, Sage J, Duensing S, Mnger K, Jacks T, Lambert PF.Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo.Mol Cell Biol. 2003 Dec;23(24):9094-103.
    14645521
  • Duensing S, Mnger K.Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins.Prog Cell Cycle Res. 2003;5:383-91.
    14593733
  • Duensing S, Mnger K.Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members.J Virol. 2003 Nov;77(22):12331-5.
    14581569
  • Kleine-Lowinski K, Rheinwald JG, Fichorova RN, Anderson DJ, Basile J, Mnger K, Daly CM, Rsl F, Rollins BJ.Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells.Int J Cancer. 2003 Nov 10;107(3):407-15.
    14506741
  • Duensing S, Lee BH, Dal Cin P, Mnger K.Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma.Mol Cancer. 2003 Sep 8;2(1):30.
    14498992
  • Riley RR, Duensing S, Brake T, Mnger K, Lambert PF, Arbeit JM.Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.Cancer Res. 2003 Aug 15;63(16):4862-71.
    12941807
  • Syken J, Macian F, Agarwal S, Rao A, Mnger K.TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells.Oncogene. 2003 Jul 24;22(30):4636-41.
    12879007
  • Duensing S, Mnger K.Centrosomes, genomic instability, and cervical carcinogenesis.Crit Rev Eukaryot Gene Expr. 2003;13(1):9-23.
    12839094
  • Basile JR, Eichten A, Zacny V, Mnger K.NF-kappaB-Mediated Induction of p21(Cip1/Waf1) by Tumor Necrosis Factor alpha Induces Growth Arrest and Cytoprotection in Normal Human Keratinocytes.Mol Cancer Res. 2003 Feb;1(4):262-70.
    12612054
  • Genther SM, Sterling S, Duensing S, Mnger K, Sattler C, Lambert PF.Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle.J Virol. 2003 Mar;77(5):2832-42.
    12584306
  • Piboonniyom SO, Duensing S, Swilling NW, Hasskarl J, Hinds PW, Mnger K.Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability.Cancer Res. 2003 Jan 15;63(2):476-83.
    12543805
  • Duensing S, Mnger K.The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.Cancer Res. 2002 Dec 1;62(23):7075-82.
    12460929
  • Eichten A, Westfall M, Pietenpol JA, Mnger K.Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein.Virology. 2002 Mar 30;295(1):74-85.
    12033767
  • Piboonniyom SO, Timmermann S, Hinds P, Mnger K.Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity.Oral Oncol. 2002 Feb;38(2):179-86.
    11854066
  • Mnger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, Zacny VL.Biological activities and molecular targets of the human papillomavirus E7 oncoprotein.Oncogene. 2001 Nov 26;20(54):7888-98.
    11753671
  • Jiang X, Wilford C, Duensing S, Munger K, Jones G, Jones D.Participation of Survivin in mitotic and apoptotic activities of normal and tumor-derived cells.J Cell Biochem. 2001 Aug 1-9;83(2):342-54.
    11573250
  • Gonzalez SL, Stremlau M, He X, Basile JR, Mnger K.Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.J Virol. 2001 Aug;75(16):7583-91.
    11462030
  • Duensing S, Duensing A, Flores ER, Do A, Lambert PF, Mnger K.Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes.J Virol. 2001 Aug;75(16):7712-6.
    11462043
  • Thompson DA, Zacny V, Belinsky GS, Classon M, Jones DL, Schlegel R, Mnger K.The HPV E7 oncoprotein inhibits tumor necrosis factor alpha-mediated apoptosis in normal human fibroblasts.Oncogene. 2001 Jun 21;20(28):3629-40.
    11439326
  • Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Munger K, Crum CP.Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia.Am J Surg Pathol. 2001 Jul;25(7):884-91.
    11420459
  • Duensing S, Mnger K.Centrosome abnormalities, genomic instability and carcinogenic progression.Biochim Biophys Acta. 2001;1471(2):M81-8.
    11342187
  • Basile JR, Zacny V, Mnger K.The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein.J Biol Chem. 2001 Jun 22;276(25):22522-8.
    11306566
  • Duensing S, Duensing A, Crum CP, Mnger K.Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.Cancer Res. 2001 Mar 15;61(6):2356-60.
    11289095
  • Mnger K.Learning old tricks from new viruses.Nat Med. 2000 Oct;6(10):1091-2.
    11017130
  • Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom S, Gonzalez S, Crum CP, Munger K.The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle.Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10002-7.
    10944189
  • Wong DT, Mnger K.Association of human papillomaviruses with a subgroup of head and neck squamous cell carcinomas.J Natl Cancer Inst. 2000 May 3;92(9):675-7.
    10793095
  • Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA.Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.J Biol Chem. 1999 Oct 8;274(41):29439-52.
    10506207
  • Alani RM, Hasskarl J, Grace M, Hernandez MC, Israel MA, Mnger K.Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1.Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9637-41.
    10449746
  • Timmermann S, Hinds PW, Mnger K.Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2'-deoxycytidine treatment induces a senescence-like state.Oncogene. 1998 Dec 31;17(26):3445-53.
    10030668
  • Alani RM, Hasskarl J, Mnger K.Alterations in cyclin-dependent kinase 2 function during differentiation of primary human keratinocytes.Mol Carcinog. 1998 Dec;23(4):226-33.
    9869451
  • Schilling B, De-Medina T, Syken J, Vidal M, Mnger K.A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein.Virology. 1998 Jul 20;247(1):74-85.
    9683573
  • Mavromatis KO, Jones DL, Mukherjee R, Yee C, Grace M, Mnger K.The carboxyl-terminal zinc-binding domain of the human papillomavirus E7 protein can be functionally replaced by the homologous sequences of the E6 protein.Virus Res. 1997 Nov;52(1):109-18.
    9453149
  • Thompson DA, Belinsky G, Chang TH, Jones DL, Schlegel R, Mnger K.The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.Oncogene. 1997 Dec 18;15(25):3025-35.
    9444951
  • Jones DL, Thompson DA, Mnger K.Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis.Virology. 1997 Dec 8;239(1):97-107.
    9426450
  • Jones DL, Alani RM, Mnger K.The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.Genes Dev. 1997 Aug 15;11(16):2101-11.
    9284049
  • Jones DL, Mnger K.Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein.J Virol. 1997 Apr;71(4):2905-12.
    9060648
  • Timmermann S, Hinds PW, Mnger K.Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines.Cell Growth Differ. 1997 Apr;8(4):361-70.
    9101082
  • Clemens KE, Brent R, Gyuris J, Mnger K.Dimerization of the human papillomavirus E7 oncoprotein in vivo.Virology. 1995 Dec 1;214(1):289-93.
    8525630
  • Brokaw JL, Yee CL, Mnger K.A mutational analysis of the amino terminal domain of the human papillomavirus type 16 E7 oncoprotein.Virology. 1994 Dec;205(2):603-7.
    7975265
  • Arbeit JM, Mnger K, Howley PM, Hanahan D.Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice.J Virol. 1994 Jul;68(7):4358-68.
    7515971
  • Mnger K, Phelps WC.The human papillomavirus E7 protein as a transforming and transactivating factor.Biochim Biophys Acta. 1993 May 25;1155(1):111-23.
    8389201
  • Arbeit JM, Mnger K, Howley PM, Hanahan D.Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs.Am J Pathol. 1993 Apr;142(4):1187-97.
    8386443