• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Toshihiro Shioda, MD, PhD


  • Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA.The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.Genes Dev. 2013 Dec 1;27(23):2543-8.
  • Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, Singh A, Settleman J, Benes CH, Mino-Kenudson M, Wong KK, Engelman JA.Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.Cancer Cell. 2013 Jan 14;23(1):121-8.
  • Taylor JA, Richter CA, Suzuki A, Watanabe H, Iguchi T, Coser KR, Shioda T, Vom Saal FS.Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells.PLoS ONE. 2012;7(10):e48311.
  • Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-Ghiso JA, Shioda T, Waxman S, Germain D.Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a pro-apoptotic unfolded protein response.Clin Cancer Res. 2011 Feb 3.
  • Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner A.TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.J Cell Sci. 2011 Jan 15;124(Pt 2):252-60.
  • Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K.Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.Nat Biotechnol. 2010 Aug;28(8):848-55.
  • Chen L, Shioda T, Coser KR, Lynch MC, Yang C, Schmidt EV.Genome-wide analysis of YY2 versus YY1 target genes.Nucleic Acids Res. 2010 Jul 1;38(12):4011-26.
  • Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.Genes Dev. 2010 Jul 1;24(13):1403-17.
  • Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM.MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.Science. 2010 Jun 18;328(5985):1566-9.
  • Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K.Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.Nature. 2010 May 13;465(7295):175-81.
  • Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S.MYC regulation of a "poor-prognosis" metastatic cancer cell state.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3698-703.
  • Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco MM, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran S.HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1100-5.
  • Coser KR, Wittner BS, Rosenthal NF, Collins SC, Melas A, Smith SL, Mahoney CJ, Shioda K, Isselbacher KJ, Ramaswamy S, Shioda T.Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor.Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14536-41.
  • Montagut C,Sharma SV,Shioda T,McDermott U,Ulman M,Ulkus LE,Dias-Santagata D,Stubbs H,Lee DY,Singh A,Drew L,Haber DA,Settleman J.Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.Cancer Res. 2008 Jun 15;68(12):4853-61.
  • McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J.Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.Cancer Res. 2008 May 1;68(9):3389-95.
  • Sakuragi J, Sakuragi S, Ohishi M, Shioda T.A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker.Microbes Infect. 2008 Apr;10(4):396-404.
  • Yang D, Guo J, Divieti P, Shioda T, Bringhurst FR.CBP/P300-Interacting Protein CITED1 Modulates PTH Regulation of Osteoblastic Differentiation.Endocrinology. 2008 Apr;149(4):1728-35.
  • Louisirirotchanakul S, Sutthent R, Wasi C, Chuenchitra T, Nitayaphan S, Brown AE, Polonis VR, Nakayama EE, Shioda T, Liu H, Takebe Y.Host genetic analysis of HIV type 1 subtype CRF01_AE (E)-infected Thai patients with different rates of disease progression.AIDS Res Hum Retroviruses. 2007 Dec;23(12):1605-8.
  • Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK.Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.Neoplasia. 2007 Dec;9(12):1038-45.
  • Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DC.The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.Clin Cancer Res. 2007 Nov 1;13(21):6327-34.
  • Dillon RL, Brown ST, Ling C, Shioda T, Muller WJ.An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.Mol Cell Biol. 2007 Dec;27(24):8648-57.
  • McBryan J, Howlin J, Kenny PA, Shioda T, Martin F.ERalpha-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis.Oncogene. 2007 Sep 27;26(44):6406-19.
  • Boyle S, Shioda T, Perantoni AO, de Caestecker M.Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis.Dev Dyn. 2007 Aug;236(8):2321-30.
  • Kashiwagi A, DiGirolamo CM, Kanda Y, Niikura Y, Esmon CT, Hansen TR, Shioda T, Pru JK.The postimplantation embryo differentially regulates endometrial gene expression and decidualization.Endocrinology. 2007 Sep;148(9):4173-84.
  • Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA.Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.Am J Physiol Renal Physiol. 2007 May;292(5):F1303-13.
  • Yang C, Trent S, Ionescu-Tiba V, Lan L, Shioda T, Sgroi D, Schmidt EV.Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression.Cancer Res. 2006 Dec 15;66(24):11649-58.
  • Hur J, Bell DW, Dean KL, Coser KR, Hilario PC, Okimoto RA, Tobey EM, Smith SL, Isselbacher KJ, Shioda T.Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.Cancer Res. 2006 Oct 15;66(20):10153-61.
  • Shioda T, Chesnes J, Coser KR, Zou L, Hur J, Dean KL, Sonnenschein C, Soto AM, Isselbacher KJ.Importance of dosage standardization for interpreting transcriptomal signature profiles: evidence from studies of xenoestrogens.Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12033-8.
  • Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP.Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.J Am Soc Nephrol. 2005 Jun;16(6):1632-44.
  • Shioda T.Application of DNA microarray to toxicological research.J Environ Pathol Toxicol Oncol. 2004;23(1):13-31.
  • Hur J, Chesnes J, Coser KR, Lee RS, Geck P, Isselbacher KJ, Shioda T.The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis.Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2351-6.
  • Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL.Cited1 is required in trophoblasts for placental development and for embryo growth and survival.Mol Cell Biol. 2004 Jan;24(1):228-44.
  • Coser KR, Chesnes J, Hur J, Ray S, Isselbacher KJ, Shioda T.Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray.Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13994-9.
  • Yahata T, Takedatsu H, Dunwoodie SL, Bragana J, Swingler T, Withington SL, Hur J, Coser KR, Isselbacher KJ, Bhattacharya S, Shioda T.Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.Genomics. 2002 Dec;80(6):601-13.
  • Bragana J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S.Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.J Biol Chem. 2002 Mar 8;277(10):8559-65.
  • Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T.Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.Genes Dev. 2001 Oct 1;15(19):2598-612.
  • Nair SS, Chaubal VA, Shioda T, Coser KR, Mojamdar M.Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis.Pigment Cell Res. 2001 Jun;14(3):206-9.
  • Sado T, Fenner MH, Tan SS, Tam P, Shioda T, Li E.X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.Dev Biol. 2000 Sep 15;225(2):294-303.
  • Yahata T, Andriole S, Isselbacher KJ, Shioda T.Estimation of baculovirus titer by beta-galactosidase activity assay of virus preparations.Biotechniques. 2000 Aug;29(2):214-5.
  • Andrews JE, O'Neill MJ, Binder M, Shioda T, Sinclair AH.Isolation and expression of a novel member of the CITED family.Mech Dev. 2000 Jul;95(1-2):305-8.
  • Shioda T, Andriole S, Yahata T, Isselbacher KJ.A green fluorescent protein-reporter mammalian two-hybrid system with extrachromosomal maintenance of a prey expression plasmid: application to interaction screening.Proc Natl Acad Sci U S A. 2000 May 9;97(10):5220-4.
  • Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T.The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.J Biol Chem. 2000 Mar 24;275(12):8825-34.
  • de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ.The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.J Biol Chem. 2000 Jan 21;275(3):2115-22.
  • Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T.MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.Genomics. 1998 Aug 1;51(3):401-7.
  • Shioda T, Lechleider RJ, Dunwoodie SL, Li H, Yahata T, de Caestecker MP, Fenner MH, Roberts AB, Isselbacher KJ.Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9785-90.
  • Li H, Ahmed NU, Fenner MH, Ueda M, Isselbacher KJ, Shioda T.Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells.Exp Cell Res. 1998 Aug 1;242(2):478-86.
  • Shioda T, Fenner MH, Isselbacher KJ.MSG1 and its related protein MRG1 share a transcription activating domain.Gene. 1997 Dec 19;204(1-2):235-41.
  • Shiraki K, Tsuji N, Shioda T, Isselbacher KJ, Takahashi H.Expression of Fas ligand in liver metastases of human colonic adenocarcinomas.Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6420-5.
  • Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ.Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.Am J Pathol. 1997 Jun;150(6):2099-112.
  • Shioda T, Fenner MH, Isselbacher KJ.Experimental animal model of hematogenous cardiac metastasis and neoplastic cardiac tamponade.J Surg Oncol. 1997 Feb;64(2):122-6.
  • Shioda T, Fenner MH, Isselbacher KJ.msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation.Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12298-303.
  • Shioda T, Ohta T, Isselbacher KJ, Rhoads DB.Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11919-23.
  • Itoh H, Shioda T, Matsura T, Koyama S, Nakanishi T, Kajiyama G, Kawasaki T.Iron ion induces mitochondrial DNA damage in HTC rat hepatoma cell culture--role of antioxidants in mitochondrial DNA protection from oxidative stresses.Arch Biochem Biophys. 1994 Aug 15;313(1):120-5.
  • Egi Y, Koyama S, Shioda T, Yamada K, Kawasaki T.Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells.Biochim Biophys Acta. 1992 Nov 20;1160(2):171-8.
  • Shioda T, Kawasaki T.Thiamin triphosphate does not affect contraction of skinned fibers.J Nutr Sci Vitaminol (Tokyo). 1992 Oct;38(5):529-33.
  • Shioda T, Egi Y, Yamada K, Kawasaki T.Properties of thiamin triphosphate-synthesizing activity of chicken cytosolic adenylate kinase and the effect of adenine nucleotides.Biochim Biophys Acta. 1991 Nov 14;1115(1):30-5.
  • Shioda T, Egi Y, Yamada K, Yamada M, Nakazawa A, Kawasaki T.Synthesis and accumulation of thiamin triphosphate in Escherichia coli cells expressing chicken cytosolic adenylate kinase.Biochim Biophys Acta. 1991 Nov 14;1115(1):36-41.
  • Miyoshi K, Egi Y, Shioda T, Kawasaki T.Evidence for in vivo synthesis of thiamin triphosphate by cytosolic adenylate kinase in chicken skeletal muscle.J Biochem (Tokyo). 1990 Aug;108(2):267-70.