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George F. Murphy, MD

Publications

  • Hodi FS, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, Zeng W, Giobbie-Hurder A, Atkins MB, Ibrahim N, Friedlander P, Flaherty KT, Murphy GF, Rodig S, Velazquez EF, Mihm MC, Russell S, DiPiro PJ, Yap JT, Ramaiya N, Van den Abbeele AD, Gargano M, McDermott D.Bevacizumab plus ipilimumab in patients with metastatic melanoma.Cancer Immunol Res. 2014 Jul(7):632-42.
    24838938
  • Larson AR, Dresser KA, Zhan Q, Lezcano C, Woda BA, Yosufi B, Thompson JF, Scolyer RA, Mihm MC, Shi YG, Murphy GF, Lian CG.Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors.Mod Pathol. 2014 Jul(7):936-44.
    24390216
  • Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL.A Small-Molecule c-Rel Inhibitor Reduces Alloactivation of T Cells without Compromising Antitumor Activity.Cancer Discovery. 2014 Apr 11.
    24550032
  • Luke JJ, Lezcano C, Hodi FS, Murphy GF.Antitumor Granuloma Formation by CD4+ T Cells in a Patient With Rapidly Progressive Melanoma Experiencing Spiking Fevers, Neuropathy, and Other Immune-Related Toxicity After Treatment With Ipilimumab.J Clin Oncol. 2014 Mar 10.
    24616309
  • Karia PS, Jambusaria-Pahlajani A, Harrington DP, Murphy GF, Qureshi AA, Schmults CD.Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma.J Clin Oncol. 2014 Feb 1;32(4):327-34.
    24366933
  • Lezcano C, Lee CW, Larson AR, Menzies AM, Kefford RF, Thompson JF, Mihm MC, Ogino S, Long GV, Scolyer RA, Murphy GF.Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors.Mod Pathol. 2014 Jan 17.
    24434899
  • Larson AR, Lee CW, Lezcano C, Zhan Q, Huang J, Fischer AH, Murphy GF.Melanoma spheroid formation involves laminin-associated vasculogenic mimicry.Am J Pathol. 2014 Jan;184(1):71-8.
    24332013
  • Volpicelli ER, Lezcano C, Zhan Q, Girouard SD, Kindelberger DW, Frank MH, Frank NY, Crum CP, Murphy GF.The multidrug-resistance transporter ABCB5 is expressed in human placenta.Int J Gynecol Pathol. 2014 Jan;33(1):45-51.
    24300535
  • Murphy GF, Wilson BJ, Girouard SD, Frank NY, Frank MH.Stem cells and targeted approaches to melanoma cure.Mol Aspects Med. 2013 Oct 19.
    24145241
  • Ghosh A, Holland AM, Dogan Y, Yim NL, Rao UK, Young LF, West ML, Singer NV, Lee H, Na IK, Tsai JJ, Jenq RR, Penack O, Hanash AM, Lezcano C, Murphy GF, Liu C, Sadelain M, Sauer MG, Sant'angelo D, van den Brink MR.PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD.Cancer Res. 2013 Aug 1;73(15):4687-96.
    23733752
  • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA.BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.Clin Cancer Res. 2013 Mar 1;19(5):1225-31.
    23307859
  • Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM.Erratum to: Progression of cutaneous melanoma: implications for treatment.Clin Exp Metastasis. 2012 Oct;29(7):797-9.
    23053741
  • Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM.Progression of cutaneous melanoma: implications for treatment.Clin Exp Metastasis. 2012 Oct;29(7):775-96.
    22892755
  • Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG.Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.Cell. 2012 Sep 14;150(6):1135-46.
    22980977
  • Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA.Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma.J Clin Oncol. 2012 Sep 1;30(25):e233-6.
    22826278
  • Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR.Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.Immunity. 2012 Aug 24;37(2):339-50.
    22921121
  • Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, Schulz S, Schanche R, Murphy GF, Waldman SA.Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of sonazoid in a melanoma tumor animal model.J Ultrasound Med. 2011 Apr;30(4):441-53.
    21460143
  • Girouard SD, Murphy GF.Melanoma stem cells: not rare, but well done.Lab Invest. 2011 Mar 28.
    21445060
  • Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF.SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study.Exp Dermatol. 2011 Apr;20(4):339-45.
    21410764
  • Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH.VEGFR-1 expressed by malignant melanoma initiating cells is required for tumor growth.Cancer Res. 2011 Jan 11.
    21212411
  • Erba P, Ogawa R, Ackermann M, Adini A, Miele LF, Dastouri P, Helm D, Mentzer SJ, D'Amato RJ, Murphy GF, Konerding MA, Orgill DP.Angiogenesis in Wounds Treated by Microdeformational Wound Therapy.Ann Surg. 2011 Jan 6.
    21217515
  • Laga AC, Murphy GF.Cellular heterogeneity in vertical growth phase melanoma.Arch Pathol Lab Med. 2010 Dec;134(12):1750-7. Review.
    21128771
  • Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Hodi FS, Frank NY, Frank MH.Isolation of tumorigenic circulating melanoma cells.Biochem Biophys Res Commun. 2010 Nov 26;402(4):711-7.
    20977885
  • Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP.Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.PLoS ONE. 2010;5(11):e13973.
    21085595
  • Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Lu TT, May C, Scheinberg DA, Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR.Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth.Journal of the National Cancer Institute. 2010 Jun 16;102(12):894-908.
    20463307
  • Murphy GF.A Festschrift for Martin C. Mihm, Jr.J Cutan Pathol. 2010 Apr;37 Suppl 1:1-5.
    20482668
  • McAllister JC, Zhan Q, Weishaupt C, Hsu MY, Murphy GF.The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts.J Cutan Pathol. 2010 Apr;37 Suppl 1:19-25.
    20482672
  • Laga AC, Lai CY, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu MY, Murphy GF.Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology.Am J Pathol. 2010 Feb;176(2):903-13.
    20042675
  • Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH.Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells.Cancer Res. 2010 Jan 15;70(2):697-708.
    20068175
  • Martin JE, Wagner AJ, Murphy GF, Pinkus GS, Wang LC.Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma.J Clin Oncol. 2009 Nov 1;27(31):e168-71.
    19770367
  • Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R.Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.Blood. 2009 Oct 22;114(17):3693-706.
    19666872
  • Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA.Imiquimod Enhances IFN-gamma Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin.J Invest Dermatol. 2009 Nov;129(11):2676-85.
    19516264
  • Penack O, Smith OM, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Brandl K, van den Brink MR.NOD2 regulates hematopoietic cell function during graft-versus-host disease.J Exp Med. 2009 Sep 28;206(10):2101-10.
    19737867
  • Clark RA,Huang SJ,Murphy GF,Mollet IG,Hijnen D,Muthukuru M,Schanbacher CF,Edwards V,Miller DM,Kim JE,Lambert J,Kupper TS.Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.J Exp Med. 2008 Sep 29;205(10):2221-34.
    18794336
  • Rothberg BE, Moeder CB, Kluger H, Halaban R, Elder DE, Murphy GF, Lazar A, Prieto V, Duncan LM, Rimm DL.Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions.Mod Pathol. 2008 Sep;21(9):1121-9.
    18552823
  • Gleason BC, Crum CP, Murphy GF.Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts.J Cutan Pathol. 2008 Jul;35(7):615-22.
    18312434
  • Hsu MY,Rovinsky SA,Lai CY,Qasem S,Liu X,How J,Engelhardt JF,Murphy GF.Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation.Lab Invest. 2008 Aug;88(8):842-55.
    18560367
  • Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9.
    18202660
  • Kim TD, Terwey TH, Zakrzewski JL, Suh D, Kochman AA, Chen ME, King CG, Borsotti C, Grubin J, Smith OM, Heller G, Liu C, Murphy GF, Alpdogan O, van den Brink MR.Organ-derived dendritic cells have differential effects on alloreactive T cells.Blood. 2008 Mar 1;111(5):2929-40.
    18178870
  • Murphy GF.Target cells in graft-versus-host disease: implications for cancer therapy.Clin Rev Allergy Immunol. 2007 Oct;33(1-2):113-23. Review.
    18094950
  • Alison MR, Murphy G, Leedham S.Stem cells and cancer: a deadly mix.Cell Tissue Res. 2008 Jan;331(1):109-124. Review.
    17938965
  • Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N, Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR.IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease.J Immunol. 2007 Aug 1;179(3):1669-80.
    17641033
  • DiRienzo CG, Murphy GF, Friedman TM, Korngold R.T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.Biol Blood Marrow Transplant. 2007 Mar;13(3):265-76.
    17317580
  • Zhan Q, Signoretti S, Whitaker-Menezes D, Friedman TM, Korngold R, Murphy GF.Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype.J Invest Dermatol. 2007 Jan;127(1):106-15.
    17039241
  • Durakovic N, Bezak KB, Skarica M, Radojcic V, Fuchs EJ, Murphy GF, Luznik L.Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions.J Immunol. 2006 Oct 1;177(7):4414-25.
    16982876
  • DiRienzo CG, Murphy GF, Jones SC, Korngold R, Friedman TM.T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease.Biol Blood Marrow Transplant. 2006 Aug;12(8):818-27.
    16864052
  • Deguchi M, Whitaker-Menezes D, Jones SC, Aiba S, Nakagawa S, Tagami H, Korngold R, Murphy GF.12E2: a cloned murine dermal cell with features of dermal dendrocytes and capacity to produce pathologic changes resembling early Kaposi's sarcoma.Am J Pathol. 2003 Nov;163(5):1817-25.
    14578182
  • Whitaker-Menezes D, Jones SC, Friedman TM, Korngold R, Murphy GF.An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression.Biol Blood Marrow Transplant. 2003 Sep;9(9):559-70.
    14506658
  • Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon JJ, van den Brink MR.T cells require TRAIL for optimal graft-versus-tumor activity.Nat Med. 2002 Dec;8(12):1433-7.
    12426560
  • Kim JC, Whitaker-Menezes D, Deguchi M, Adair BS, Korngold R, Murphy GF.Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease.Am J Pathol. 2002 Sep;161(3):763-70.
    12213703
  • van den Brink MR, Moore E, Horndasch KJ, Crawford JM, Murphy GF, Burakoff SJ.Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.Transplantation. 2000 Jul 15;70(1):184-91.
    10919598