Jean J. Zhao, PhD

Publications

• Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J.Therapeutic implication
  21209904
• Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE,
  21107320
• Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK.PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.Cell Metab. 2010 Jul 4
  20620998
• Sopasakis VR, Liu P, Suzuki R, Kondo T, Winnay J, Tran TT, Asano T, Smyth G, Sajan MP, Farese RV, Kahn CR, Zhao JJ.Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.Cell Metab.
  20197055
• Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis
  19819947
• Zhao JJ, Silver DP.Estrogen Receptor-Negative Breast Cancer: New Insights into Subclassification and Targeting.Clin Cancer Res. 2009 Oct 15;15(20):6309-10.
  19825953
• Liu P, Cheng H, Roberts TM, Zhao JJ.Targeting the phosphoinositide 3-kinase pathway in cancer.Nat Rev Drug Discov. 2009 Aug;8(8):627-44. Review.
  19644473
• Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ
  19602588
• Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ.SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.Sci Signal. 2009;2(80):ra35.
  19622832
• Jia S,Roberts TM,Zhao JJ.Should individual PI3 kinase isoforms be targeted in cancer?.Curr Opin Cell Biol. 2009 Apr;21(2):199-208. Review.
  19200708
• Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.Nature.;454:776-9.
• Jia S,Liu Z,Zhang S,Liu P,Zhang L,Lee SH,Zhang J,Signoretti S,Loda M,Roberts TM,Zhao JJ.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.Nature. 2008 Aug 7;454(7205):776-9.
  18594509
• Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Rober
  17574021
• Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ.The p110{alpha} isoform of PI3K is essential for polyoma middle T antigen mediated transformation.J Virol. 2007 Jul;81(13):7069-76.
  17442716
• Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM.Surveillance mechanism linking Bub1 loss to the p53 pathway.Proc Natl Acad Sci U S A. 2007 May 15;104(20):8334-9.
  17488820
• He Q, Zhu X, Shi M, Zhao B, Zhao J, Zhang S, Miao J.Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells.Bioorg Med Chem. 2007 Jun 1;15(11):3889-95.
  17395471
• Zhao JJ, Roberts TM.PI3 kinases in cancer: from oncogene artifact to leading cancer target.Sci STKE. 2006 Dec 12;2006(365):pe52.
  17164467
• Zhao JJ, Cheng H, Jia S, Wang L, Gjoerup OV, Mikami A, Roberts TM.The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300.
  17060635
• Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM.The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18443-8.
  16339315
• Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.A genetic screen for candidate tumor suppressors identifies REST.Cell. 2005 Jun 17;121(6):837-48.
  15960972
• Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Cancer Res. 2004 Dec 15;64(24):8867-
  15604246
• Zhao JJ, Roberts TM, Hahn WC.Functional genetics and experimental models of human cancer.Trends Mol Med. 2004 Jul;10(7):344-50.
  15242683
• Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA.A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.Cancer Ce
  14706338
• Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC.Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.Cancer Cell. 2003 May;3(5):483-95.
  12781366