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Hensin Tsao, MD, PhD

Publications

  • Yonekawa Y, Kim IK, Gragoudas ES, Njauw CN, Tsao H, Jakobiec FA, Stacy RC.Aggressive skull base metastasis from uveal melanoma: a clinicopathologic study.Eur J Ophthalmol. 2014 May 12:0.
    24729140
  • Miller DM, Flaherty KT, Tsao H.Commentary: Molecular testing in melanoma.J Am Acad Dermatol. 2014 May;70(5):863-70.
    24534656
  • Redmond RW, Rajadurai A, Udayakumar D, Sviderskaya EV, Tsao H.Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling.J Invest Dermatol. 2014 Apr;134(4):1083-90.
    24335898
  • Marzuka-Alcalá A, Gabree MJ, Tsao H.Melanoma susceptibility genes and risk assessment.Methods Mol Biol. 2014;1102:381-93.
    24258989
  • Ji Z, Kumar R, Taylor M, Rajadurai A, Marzuka-Alcalá A, Chen YE, Njauw CN, Flaherty K, Jönsson G, Tsao H.Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.Clin Cancer Res. 2013 Aug 15;19(16):4383-91.
    23812671
  • Salas Fragomeni RA, Chung HW, Landesman Y, Senapedis W, Saint-Martin JR, Tsao H, Flaherty KT, Shacham S, Kauffman M, Cusack JC.CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma.Mol Cancer Ther. 2013 Apr 24.
    23615632
  • Chen ST, Geller AC, Tsao H.Update on the Epidemiology of Melanoma.Curr Dermatol Rep. 2013 Mar 1;2(1):24-34.
    23580930
  • Puntervoll HE, Yang XR, Vetti HH, Bachmann IM, Avril MF, Benfodda M, Catricalà C, Dalle S, Duval-Modeste AB, Ghiorzo P, Grammatico P, Harland M, Hayward NK, Hu HH, Jouary T, Martin-Denavit T, Ozola A, Palmer JM, Pastorino L, Pjanova D, Soufir N, Steine SJ, Stratigos AJ, Thomas L, Tinat J, Tsao H, Veinalde R, Tucker MA, Bressac-de Paillerets B, Newton-Bishop JA, Goldstein AM, Akslen LA, Molven A.Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants.J Med Genet. 2013 Apr;50(4):264-70.
    23384855
  • Bis S, Tsao H.Melanoma genetics: the other side.Clin Dermatol.;31(2):148-55.
    23438378
  • Lobo AZ, Tanabe KK, Luo S, Muzikansky A, Sober AJ, Tsao H, Cosimi AB, Duncan LM.The distribution of microscopic melanoma metastases in sentinel lymph nodes: implications for pathology protocols.Am J Surg Pathol. 2012 Dec;36(12):1841-8.
    23154770
  • Hawryluk EB, Sober AJ, Piris A, Nazarian RM, Hoang MP, Tsao H, Mihm MC, Duncan LM.Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic.J Am Acad Dermatol. 2012 Oct;67(4):727-35.
    22521204
  • Hung T, Piris A, Lobo A, Mihm MC, Sober AJ, Tsao H, Tanabe KK, Duncan LM.Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors.Hum Pathol. 2012 Aug 30.
    22939951
  • Harbst K, Staaf J, Lauss M, Karlsson A, Måsbäck A, Johansson I, Bendahl PO, Vallon-Christersson J, Törngren T, Ekedahl H, Geisler J, Höglund M, Ringnér M, Lundgren L, Jirström K, Olsson H, Ingvar C, Borg Å, Tsao H, Jönsson G.Molecular profiling reveals low- and high-grade forms of primary melanoma.Clin Cancer Res. 2012 Aug 1;18(15):4026-36.
    22675174
  • Tsao H, Chin L, Garraway LA, Fisher DE.Melanoma: from mutations to medicine.Genes Dev. 2012 Jun 1;26(11):1131-55.
    22661227
  • Lipworth AD, Park JM, Trefrey BL, Rubin KM, Geller AC, Sober AJ, Tsao H.Urgent access to a specialty care melanoma clinic is associated with a higher rate of melanoma detection.J Am Acad Dermatol. 2011 Mar 29.
    21453985
  • Luo S, Chaplin AC, Langley RG, Njauw CN, Duncan LM, Miller RA, Tsao H.Agminated segmental nevi demonstrating intranevic concordance of BRAF status.J Invest Dermatol. 2011 Mar;131(3):788-90.
    21160499
  • Ko JM, Velez NF, Tsao H.Pathways to melanoma.Seminars In Cutaneous Medicine And Surgery. 2010 Dec;29(4):210-7.
    21277534
  • Lang JM, Shennan M, Njauw JC, Luo S, Bishop JN, Harland M, Hayward NK, Tucker MA, Goldstein AM, Landi MT, Puig S, Gruis NA, Bergman W, Bianchi-Scarra G, Ghiorzo P, Hogg D, Tsao H.A flexible multiplex bead-based assay for detecting germline CDKN2A and CDK4 variants in melanoma-prone kindreds.J Invest Dermatol. 2011 Feb;131(2):480-6.
    21085193
  • Udayakumar D, Mahato B, Gabree M, Tsao H.Genetic determinants of cutaneous melanoma predisposition.Seminars In Cutaneous Medicine And Surgery. 2010 Sep;29(3):190-5.
    21051013
  • Tsao H, Tanabe KK, Lawrence DP, Piris A.Case records of the Massachusetts General Hospital. Case 30-2010. A 15-year-old boy with a recurrent skin lesion.N Engl J Med. 2010 Sep 30;363(14):1352-60.
    20879885
  • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA.Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.Cancer Res. 2010 Jul 1;70(13):5213-9.
    20551059
  • Feramisco JD, Tsao H, Siegel DH.Genetics for the Practicing Dermatologist.Seminars In Cutaneous Medicine And Surgery. 2010 Jun;29(2):127-136. Review.
    20579602
  • Sober AJ, Tsao H.Martin C. Mihm, Jr and the history of the Pigmented Lesion Clinic at the Massachusetts General Hospital.J Cutan Pathol. 2010 Apr;37 Suppl 1:8-11.
    20482670
  • Ji Z, Flaherty KT, Tsao H.Molecular therapeutic approaches to melanoma.Mol Aspects Med. 2010 Apr;31(2):194-204. Review.
    20176049
  • Wang W, Niendorf KB, Patel D, Blackford A, Marroni F, Sober AJ, Parmigiani G, Tsao H.Estimating CDKN2A carrier probability and personalizing cancer risk assessments in hereditary melanoma using MelaPRO.Cancer Res. 2010 Jan 15;70(2):552-9.
    20068151
  • Yang G, Thieu K, Tsai KY, Piris A, Udayakumar D, Njauw CN, Ramoni MF, Tsao H.Dynamic gene expression analysis links melanocyte growth arrest with nevogenesis.Cancer Res. 2009 Dec 1;69(23):9029-37.
    19903842
  • Udayakumar D, Tsao H.Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies.Genome Med. 2009;1(10):95.
    19863770
  • Sadreyev RI, Feramisco JD, Tsao H, Grishin NV.Phenotypic categorization of genetic skin diseases reveals new relations between phenotypes, genes and pathways.Bioinformatics. 2009 Nov 15;25(22):2891-6.
    19744994
  • Feramisco JD, Sadreyev RI, Murray ML, Grishin NV, Tsao H.Phenotypic and genotypic analyses of genetic skin disease through the Online Mendelian Inheritance in Man (OMIM) database.J Invest Dermatol. 2009 Nov;129(11):2628-36.
    19536140
  • Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie RM, Mann GJ, Mueller K, Newton-Bishop J, Olsson H, Petersen GM, Puig S, Rigel D, Swetter SM, Tucker MA, Yakobson E, Zitelli JA, Tsao H.Selection criteria for genetic assessment of patients with familial melanoma.J Am Acad Dermatol. 2009 Oct;61(4):677.e1-14. Review.
    19751883
  • Park JM, Tsao H, Tsao S.Acquired bilateral nevus of Ota-like macules (Hori nevus): etiologic and therapeutic considerations.J Am Acad Dermatol. 2009 Jul;61(1):88-93. Review.
    19539841
  • Udayakumar D,Tsao H.Melanoma genetics: an update on risk-associated genes.Hematol Oncol Clin North Am. 2009 Jun;23(3):415-29, vii. Review.
    19464594
  • Sun BK,Tsao H.Small RNAs in development and disease.J Am Acad Dermatol. 2008 Nov;59(5):725-37; quiz 738-40. Review.
    19119093
  • Nelson AA,Tsao H.Melanoma and genetics.Clin Dermatol. 2009 Jan-Feb;27(1):46-52. Review.
    19095153
  • Hocker TL,Singh MK,Tsao H.Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside.J Invest Dermatol. 2008 Nov;128(11):2575-95. Review.
    18927540
  • Harland M, Goldstein AM, Kukalizch K, Taylor C, Hogg D, Puig S, Badenas C, Gruis N, Ter Huurne J, Bergman W, Hayward NK, Stark M, Tsao H, Tucker MA, Landi MT, Scarra GB, Ghiorzo P, Kanetsky PA, Elder D, Mann GJ, Holland EA, Bishop DT, Newton Bishop J.A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL).Eur J Cancer. 2008 Jun;44(9):1269-74.
    18394881
  • Sun BK,Tsao H.X-chromosome inactivation and skin disease.J Invest Dermatol. 2008 Dec;128(12):2753-9. Review.
    18509358
  • Friedman RJ, Gutkowicz-Krusin D, Farber MJ, Warycha M, Schneider-Kels L, Papastathis N, Mihm MC Jr, Googe P, King R, Prieto VG, Kopf AW, Polsky D, Rabinovitz H, Oliviero M, Cognetta A, Rigel DS, Marghoob A, Rivers J, Johr R, Grant-Kels JM, Tsao H.The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas.Arch Dermatol. 2008 Apr;144(4):476-82.
    18427041
  • Zhang G, Njauw CN, Park JM, Naruse C, Asano M, Tsao H.EphA2 is an essential mediator of UV radiation-induced apoptosis.Cancer Res. 2008 Mar 15;68(6):1691-6.
    18339848
  • Park JM, Tsao H, Tsao S.Combined use of intense pulsed light and Q-switched ruby laser for complex dyspigmentation among Asian patients.Lasers Surg Med. 2008 Feb;40(2):128-33.
    18306166
  • Feramisco JD, Casey RL, Tsao H.Recent updates on genetics: teaching old dogmas new tricks.Pediatr Dermatol. 2008 Jan-Feb;25(1):99-108. Review.
    18304166
  • McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA, Settleman J.Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
    18077425
  • Somoano B, Tsao H.Genodermatoses with cutaneous tumors and internal malignancies.Dermatol Clin. 2008 Jan;26(1):69-87, viii. Review.
    18023772
  • Tsao H, Florez JC.Introduction to genetic association studies.J Invest Dermatol. 2007 Oct;127(10):2283-7.
    17853910
  • Yang G, Curley D, Bosenberg MW, Tsao H.Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice.Cancer Res. 2007 Jun 15;67(12):5649-57.
    17575131
  • Tsai KY, Tsao H.Primer on the human genome.J Am Acad Dermatol. 2007 May;56(5):719-35.
    17437886
  • Hocker T, Tsao H.Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants.Hum Mutat. 2007 Jun;28(6):578-88. Review.
    17295241
  • Lang J, Hayward N, Goldgar D, Tsao H, Hogg D, Palmer J, Stark M, Tobias ES, MacKie R.The M53I mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry.Genes Chromosomes Cancer. 2007 Mar;46(3):277-87.
    17171691
  • Goldstein AM, Chan M, Harland M, Gillanders EM, Hayward NK, Avril MF, Azizi E, Bianchi-Scarra G, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon Albright LA, Demenais F, Elder DE, Ghiorzo P, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Niendorf K, Newton Bishop J, Palmer JM, Puig S, Puig-Butille JA, de Snoo FA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E.High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL.Cancer Res. 2006 Oct 15;66(20):9818-28.
    17047042
  • Yang G, Zhang G, Pittelkow MR, Ramoni M, Tsao H.Expression Profiling of UVB Response in Melanocytes Identifies a Set of p53-Target Genes.J Invest Dermatol. 2006 Nov;126(11):2490-506.
    16888633
  • Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-Scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, MacKie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-Butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E.Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.J Med Genet. 2007 Feb;44(2):99-106.
    16905682
  • Haluska FG, Tsao H, Wu H, Haluska FS, Lazar A, Goel V.Genetic alterations in signaling pathways in melanoma.Clin Cancer Res. 2006 Apr 1;12(7 Pt 2):2301s-2307s. Review.
    16609049
  • Niendorf KB, Tsao H.Cutaneous melanoma: family screening and genetic testing.Dermatol Ther. 2006 Jan-Feb;19(1):1-8. Review.
    16405564
  • Stratigos AJ, Yang G, Dimisianos R, Nicolaou V, Stefanaki I, Katsambas AD, Tsao H.Germline CDKN2A mutations among Greek patients with early-onset and multiple primary cutaneous melanoma.J Invest Dermatol. 2006 Feb;126(2):399-401.
    16374456
  • Yang G, Rajadurai A, Tsao H.Recurrent patterns of dual RB and p53 pathway inactivation in melanoma.J Invest Dermatol. 2005 Dec;125(6):1242-51.
    16354195
  • Tsao H.The SNPs of RAF.J Invest Dermatol. 2005 Dec;125(6):xiv-xv.
    16354174
  • Niendorf KB, Goggins W, Yang G, Tsai KY, Shennan M, Bell DW, Sober AJ, Hogg D, Tsao H.MELPREDICT: a logistic regression model to estimate CDKN2A carrier probability.J Med Genet. 2006 Jun;43(6):501-6.
    16169933
  • Goggins W, Daniels GH, Tsao H.Elevation of thyroid cancer risk among cutaneous melanoma survivors.Int J Cancer. 2006 Jan 1;118(1):185-8.
    16049985
  • Tsao H, Goel V, Wu H, Yang G, Haluska FG.Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.J Invest Dermatol. 2004 Feb;122(2):337-41.
    15009714
  • Tsao H, Sober AJ, Niendorf KB, Zembowicz A.Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2004. A 48-year-old woman with multiple pigmented lesions and a personal and family history of melanoma.N Engl J Med. 2004 Feb 26;350(9):924-32.
    14985491
  • Tsao H, Feldman M, Fullerton JE, Sober AJ, Rosenthal D, Goggins W.Early detection of asymptomatic pulmonary melanoma metastases by routine chest radiographs is not associated with improved survival.Arch Dermatol. 2004 Jan;140(1):67-70.
    14732662
  • Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H.Cutaneous melanomas associated with nevi.Arch Dermatol. 2003 Dec;139(12):1620-4; discussion 1624.
    14676081
  • Tsao H, Mihm MC, Sheehan C.PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma.J Am Acad Dermatol. 2003 Nov;49(5):865-72.
    14576666
  • Bevona C, Tannous Z, Tsao H.Dermal melanocytic proliferation with features of a plaque-type blue nevus and neurocristic hamartoma.J Am Acad Dermatol. 2003 Nov;49(5):924-9.
    14576682
  • Tsao H, Bevona C, Goggins W, Quinn T.The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate.Arch Dermatol. 2003 Mar;139(3):282-8.
    12622618
  • Goggins WB, Tsao H.A population-based analysis of risk factors for a second primary cutaneous melanoma among melanoma survivors.Cancer. 2003 Feb 1;97(3):639-43.
    12548605
  • Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catrical C, O'Toole KM.A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Mol Cell Biol. 2002 Jul;22(14):5157-72.
    12077343
  • Tsao H, Millman P, Linette GP, Hodi FS, Sober AJ, Goldberg MA, Haluska FG.Hypopigmentation associated with an adenovirus-mediated gp100/MART-1-transduced dendritic cell vaccine for metastatic melanoma.Arch Dermatol. 2002 Jun;138(6):799-802.
    12056962
  • Tsao H, Kwitkiwski K, Sober AJ.A single-institution case series of patients with cutaneous melanoma and non-Hodgkin's lymphoma.J Am Acad Dermatol. 2002 Jan;46(1):55-61.
    11756946
  • Tsao H.Genetics of nonmelanoma skin cancer.Arch Dermatol. 2001 Nov;137(11):1486-92.
    11708952
  • Tsao H, Nadiminti U, Sober AJ, Bigby M.A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.Arch Dermatol. 2001 Mar;137(3):325-30.
    11255333
  • Goggins WB, Finkelstein DM, Tsao H.Evidence for an association between cutaneous melanoma and non-Hodgkin lymphoma.Cancer. 2001 Feb 15;91(4):874-80.
    11241258
  • Tsao H, Zhang X, Kwitkiwski K, Finkelstein DM, Sober AJ, Haluska FG.Low prevalence of germline CDKN2A and CDK4 mutations in patients with early-onset melanoma.Arch Dermatol. 2000 Sep;136(9):1118-22.
    10987867
  • Tsao H, Lerner LH.Pigmented purpuric eruption associated with injection medroxyprogesterone acetate.J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):308-10.
    10906656
  • Jonasch E, Kumar UN, Linette GP, Hodi FS, Soiffer RJ, Ryan BF, Sober AJ, Mihm MC, Tsao H, Langley RG, Cosimi BA, Gadd MA, Tanabe KK, Souba W, Haynes HA, Barnhill R, Osteen R, Haluska FG.Adjuvant high-dose interferon alfa-2b in patients with high-risk melanoma.Cancer J. 2000 May-Jun;6(3):139-45.
    10882328
  • Tsao H.Update on familial cancer syndromes and the skin.J Am Acad Dermatol. 2000 Jun;42(6):939-69; quiz 970-2.
    10827397
  • Tsao H, Zhang X, Fowlkes K, Haluska FG.Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.Cancer Res. 2000 Apr 1;60(7):1800-4.
    10766161
  • Tsao H.American Academy of Dermatology 1999 Awards for Young Investigators in Dermatology. Targets of genetic injury in cutaneous melanoma.J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):459-61.
    10507912
  • Tsao H, Sober AJ, Rogers GS.Reply.J Am Acad Dermatol. 1999 Aug;41(2 Pt 1):282-3.
    10426907
  • Tsao H, Tahan SR.Images in clinical medicine. Keratoacanthoma.N Engl J Med. 1999 Mar 4;340(9):708.
    10053180
  • Tsao H, Zhang X, Majewski P, Haluska FG.Mutational and expression analysis of the p73 gene in melanoma cell lines.Cancer Res. 1999 Jan 1;59(1):172-4.
    9892203
  • Tsao H, Benoit E, Sober AJ, Thiele C, Haluska FG.Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene.Cancer Res. 1998 Jan 1;58(1):109-13.
    9426066