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A. T. Look, MD
Publications
- Li X, Sanda T, Look AT, Novina CD, von Boehmer H.Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.J Exp Med. 2011 Apr 4.
21464222 - Grabher C, Payne EM, Johnston AB, Bolli N, Lechman E, Dick JE, Kanki JP, Look AT.Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.Leukemia. 2011 Mar;25(3):506-14.
21079614 - Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for u
21368833 - Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT.cpsf1 is required for definitive hematopoietic stem cell survival in zebrafish.Blood. 2011 Feb 17.
21330472 - Robinson BW, Germano G, Song Y, Abrams J, Scott M, Guariento I, Tiso N, Argenton F, Basso G, Rhodes J, Kanki JP, Look AT, Balice-Gordon RJ, Felix CA.mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and
21155757 - Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT.Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.Hum Mol Genet. 2010 Dec 1;19(23):4643-53.
20858602 - Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a
20951945 - Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK, .Outcome after reduced chemotherapy for intermediate-risk neuroblastoma.N Engl J Med.
20879880 - Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT.Absence of biallelic TCRgam
20644084 - Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K.Aberrant induction of LMO2 by t
20519628 - Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.J Exp Med. 2010 Jul 5;207(7):1369-80.
20566716 - Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS.Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.Blood. 2010 Jun 10;115(23):4707-14.
20360471 - Heinrichs S, Li C, Look AT.SNP array analysis in hematological malignancies: avoiding false discoveries.Blood. 2010 May 27;115(21):4157-61. Review.
20304806 - Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG.Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.Dev Cell. 2010
20493809 - Hubmann R, Düchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Hölbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jäger U, Shehata M.NOTCH2 links protein kinase C delta to the expression of CD23 in chronic lymphocytic leukaemia (CLL)
19995395 - Bolli N, Payne EM, Grabher C, Lee JS, Johnston AB, Falini B, Kanki JP, Look AT.Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Blood. 2010 Apr 22;115(16):3329-40.
20197555 - Akahane K, Inukai T, Inaba T, Kurosawa H, Look AT, Kiyokawa N, Fujimoto J, Goto H, Endo M, Zhang X, Hirose K, Kuroda I, Honna H, Kagami K, Goi K, Nakazawa S, Sugita K.Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloi
20147975 - Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT.Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.Blood.
20124220 - Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.Blood. 2010
20007543 - Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA.Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22305-10.
19966217 - Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T.Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia c
19887369 - Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW.Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.J Exp Med. 2009 Dec 21;206(13):2977-86.
19995955 - Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strac
19775282 - Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM
19704007 - Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, Neuberg D, Kornblau SM, Issa JP, Gilliland DG, Garcia-Manero G, Kantarjian HM, Estey EH, Look AT.Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelod
19387468 - Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H.Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and CO
19530234 - Payne E, Look T.Zebrafish modelling of leukaemias.British Journal of Haematology. 2009 Aug;146(3):247-56. Review.
19466976 - Gutierrez A,Sanda T,Grebliunaite R,Carracedo A,Salmena L,Ahn Y,Dahlberg S,Neuberg D,Moreau LA,Winter SS,Larson R,Zhang J,Protopopov A,Chin L,Pandolfi PP,Silverman LB,Hunger SP,Sallan SE,Look AT.High frequency of PTEN, PI3K and AKT abnormalities in T cell
19458356 - Dodd ME, Hatzold J, Mathias JR, Walters KB, Bennin DA, Rhodes J, Kanki JP, Look AT, Hammerschmidt M, Huttenlocher A.The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.Development. 2009 Aug;136(15):2591-600.
19570844 - Niethammer P, Grabher C, Look AT, Mitchison TJ.A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.Nature. 2009 Jun 18;459(7249):996-9.
19494811 - Volchenboum SL,Li C,Li S,Attiyeh EF,Reynolds CP,Maris JM,Look AT,George RE.Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis.Cancer Res. 2009 May 15;69(10):41
19435921 - Chen CC,Kennedy RD,Sidi S,Look AT,D'Andrea A.CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors.Mol Cancer. 2009;8:24.
19371427 - Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pat
19318552 - Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW.Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.Expert Rev Anticancer Ther. 2009 Mar;9(3):331-56. Review.
19275511 - Walters KB, Dodd ME, Mathias JR, Gallagher AJ, Bennin DA, Rhodes J, Kanki JP, Look AT, Grinblat Y, Huttenlocher A.Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.Dev Dyn. 2009 Jan;238(1):86-99.
19097072 - Freeman JL,Ceol C,Feng H,Langenau DM,Belair C,Stern HM,Song A,Paw BH,Look AT,Zhou Y,Zon LI,Lee C.Construction and application of a zebrafish array comparative genomic hybridization platform.Genes Chromosomes Cancer. 2009 Feb;48(2):155-70.
18973135 - George RE,Sanda T,Hanna M,Frohling S,Luther W 2nd,Zhang J,Ahn Y,Zhou W,London WB,McGrady P,Xue L,Zozulya S,Gregor VE,Webb TR,Gray NS,Gilliland DG,Diller L,Greulich H,Morris SW,Meyerson M,Look AT.Activating mutations in ALK provide a therapeutic target in
18923525 - Zhang Y, Bai XT, Zhu KY, Jin Y, Deng M, Le HY, Fu YF, Chen Y, Zhu J, Look AT, Kanki J, Chen Z, Chen SJ, Liu TX.In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury.J Immu
18641354 - Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI.Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.Oncogene. 2008 Jul 10;27(30):4242-8.
18345029 - Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.Cel
18510930 - Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A.BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.Cell Death Differ. 2008 Jun;15(6):1063-72.
18404156 - Pui CH, Robison LL, Look AT.Acute lymphoblastic leukaemia.Lancet. 2008 Mar 22;371(9617):1030-43. Review.
18358930 - Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr.The kinesin KIF1Bbeta acts downstream from EglN3 to induce a
18334619 - Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Blood.
18299447 - Schneiderman J, London WB, Brodeur GM, Castleberry RP, Look AT, Cohn SL.Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.J Clin Oncol. 2008 Feb 20;26(6):913-8.
18281664 - O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.Alu elements mediate MYB gene tandem duplication in human T
18070937 - Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG.SOS1 mutations are rare in h
18064648 - Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR.Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.Cancer Res
18056449 - Gutierrez A, Look AT.NOTCH and PI3K-AKT pathways intertwined.Cancer Cell. 2007 Nov;12(5):411-3.
17996644 - Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT.Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.British Journal of Haematology. 2007 Jul;138(2):169-75.
17593023 - Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, As
17515920 - Guo Z, Dose M, Kovalovsky D, Chang R, O'neil J, Look AT, von Boehmer H, Khazaie K, Gounari F.{beta}-Catenin stabilization stalls the transition from Double-Positive to Single Positive stage and predisposes thymocytes to malignant transformation.Blood
17317856 - George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM.Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays.PLoS ONE. 2007;2:e255.
17327916 - Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D.Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmac
17317574 - Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD.NOTCH1-induced T-cell leukemia in transgenic zebrafish.Leukemia. 2007 Mar;21(3):462-71.
17252014 - Pyati UJ, Look AT, Hammerschmidt M.Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.Semin Cancer Biol. 2007 Apr;17(2):154-65. Review.
17210257 - Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcrip
17114293 - Moreau LA, McGrady P, London WB, Shimada H, Cohn SL, Maris JM, Diller L, Look AT, George RE.Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncolog
17020972 - van Vlierberghe P, Meijerink JP, Lee C, Ferrando AA, Look AT, van Wering ER, Beverloo HB, Aster JC, Pieters R.A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.Leukemia. 2006 Jul;20(7):1245-53.
16673019 - Palomero T, Odom DT, O'neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT.Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.Blood. 2006 Aug 1;108(3):986-9
16621969 - Grabher C, von Boehmer H, Look AT.Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.Nat Rev Cancer. 2006 May;6(5):347-59. Review.
16612405 - O'neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.Activating Notch1 mutations in mouse models of T-ALL.Blood. 2006 Jan 15;107(2):781-5.
16166587 - Armstrong SA, Look AT.Molecular genetics of acute lymphoblastic leukemia.J Clin Oncol. 2005 Sep 10;23(26):6306-15.
16155013 - George RE, London WB, Cohn SL, Maris JM, Kretschmar C, Diller L, Brodeur GM, Castleberry RP, Look AT.Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology G
16116152 - Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW.The JAK2V617F activ
16081687 - Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT.Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6068-73.
15827121 - Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I.The BCL2A1 gene as a pre-T cell receptor-induced regulator of thym
15728238 - Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI.BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in
15694309 - Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT.tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.Proc Natl Acad Sci U S A. 2005 Jan 11
15630097 - Rhodes J, Hagen A, Hsu K, Deng M, Liu TX, Look AT, Kanki JP.Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.Dev Cell. 2005 Jan;8(1):97-108.
15621533 - Langenau DM, Jette C, Berghmans S, Palomero T, Kanki JP, Kutok JL, Look AT.Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.Blood. 2005 Apr 15;105(8):3278-85.
15618471 - Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.Science. 2004 Oct 8;306(5694):269-71.
15472075 - Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, Vermeesch JR, Stul M, Dutta B, Boeckx N, Bosly A, Heimann P, Uyttebroeck A, Mentens N, Somers R, MacLeod RA, Drexler HG, Look AT, Gilliland DG, Michaux L, Vandenberghe P, Wlodarska I, Maryne
15361874 - Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI.Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.Blood. 2004 Sep 1;104(5):1298-305.
15142873 - Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS.In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7369-74.
15123839 - Paietta E, Ferrando AA, Neuberg D, Bennett JM, Racevskis J, Lazarus H, Dewald G, Rowe JM, Wiernik PH, Tallman MS, Look AT.Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.Blood. 2004 Jul 15;104(2):558-60.
15044257 - Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT.The pu.1 promoter drives myeloid gene expression in zebrafish.Blood. 2004 Sep 1;104(5):1291-7.
14996705 - Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH, Rowe JM, Caligiuri MA, Bloomfield CD, Look AT.Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.Lancet. 2004 Feb 14;363(9408):
14975618 - Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT.Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.Dev Cell. 2003 Dec;5(6):903-14.
14667412 - Morris JP, Berghmans S, Zahrieh D, Neuberg DS, Kanki JP, Look AT.Zebrafish sperm cryopreservation with N,N-dimethylacetamide.Biotechniques. 2003 Nov;35(5):956-8, 960, 962 passim.
14628669 - Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA.IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.Blood. 2004 Mar 1;103(5):1891-900.
14615384 - Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA, Look AT.Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.Blood. 2004 Mar 1;103(5):1909-11.
14604958 - Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT.Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.Blood. 2003 Jul 1;102(1):262-8.
12637319 - Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.Myc-induced T cell leukemia in transgenic zebrafish.Science. 2003 Feb 7;299(5608):887-90.
12574629 - Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT.Slug, a highly conserved zinc finger transcriptional repres
12398892 - Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT.Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).Mech Dev. 2002 Sep;117(1-2):243-8.
12204264 - Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT.Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.Cancer Cell. 2002
12086890 - Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT.Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.Proc Natl Acad Sci U S A. 2002 Apr 30;99(9
11983906 - Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT.The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.Mol Cell Biol. 2001 Sep;21(17):5935-45.
11486032 - Whitehead VM, Payment C, Cooley L, Lauer SJ, Mahoney DH, Shuster JJ, Vuchich MJ, Bernstein ML, Look AT, Pullen DJ, Camitta B.The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and
11455977 - Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T.Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenito
11154272 - Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ.Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.Nat Med. 2000 May;6(5):529-35.
10802708 - Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT.SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.Mol Cell. 1999 Sep;4(3):343-52.
10518215 - Look AT.Oncogenic transcription factors in the human acute leukemias.Science. 1997 Nov 7;278(5340):1059-64.
9353180 - Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB, Look AT.Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.Nature. 1996 Aug 8;382(6591):541-4.
8700228 - Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG.Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (A
7969146 - Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.The retinoblastoma protein binds to a family of E2F transcription factors.Mol Cell Biol. 1993 Dec;13(12):7813-25.
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