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A. T. Look, MD


  • Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, Joung JK, Rao A, Look AT.
    A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
    Mol Cell Biol. 2015 Mar;35(5):789-804.
  • McGee SF, Kornblau SM, Qiu Y, Look AT, Zhang N, Yoo SY, Coombes KR, Kentsis A.
    Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia.
    Leukemia. 2014 Dec 26.
  • Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman LB, Sallan SE, Bradner JE, Neuberg DS, Look AT, Walensky LD, Kelliher MA, Gutierrez A.
    Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
    Leukemia. 2014 Sep(9):1819-27.
  • Lobry C, Oh P, Mansour MR, Look AT, Aifantis I.
    Notch signaling: switching an oncogene to a tumor suppressor.
    Blood. 2014 Apr 17;123(16):2451-9.
  • Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT.
    Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.
    British Journal of Haematology. 2014 Apr 2.
  • Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT, Qi J, Bradner JE, Kelliher MA.
    c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
    Blood. 2014 Feb 13;123(7):1040-50.
  • Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.
    Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.
    J Clin Invest. 2014 Feb 3;124(2):644-55.
  • Zuurbier L, Gutierrez A, Mullighan CG, Canté-Barrett K, Gevaert AO, de Rooi J, Li Y, Smits WK, Buijs-Gladdines JG, Sonneveld E, Look AT, Horstmann M, Pieters R, Meijerink JP.
    Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.
    Haematologica. 2014 Jan;99(1):94-102.
  • Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H.
    BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines.
    Leukemia. 2013 Dec 17.
  • Wang LL, Suganuma R, Ikegaki N, Tang X, Naranjo A, McGrady P, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Shimada H.
    Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group.
    Cancer. 2013 Oct 15;119(20):3718-26.
  • Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT.
    The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
    J Exp Med. 2013 Jul 29;210(8):1545-57.
  • Heinrichs S, Conover LF, Bueso-Ramos CE, Kilpivaara O, Stevenson K, Neuberg D, Loh ML, Wu WS, Rodig SJ, Garcia-Manero G, Kantarjian HM, Look AT.
    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.
    Elife. 2013;2:e00825.
  • Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT.
    TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.
    Cancer Discovery. 2013 May;3(5):564-77.
  • Liu F, Zhang X, Weisberg E, Chen S, Hur W, Wu H, Zhao Z, Wang W, Mao M, Cai C, Simon NI, Sanda T, Wang J, Look AT, Griffin JD, Balk SP, Liu Q, Gray NS.
    Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer.
    ACS Chem Biol. 2013 Apr 17.
  • Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A.
    KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
    British Journal of Haematology. 2013 Apr;161(1):117-27.
  • Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT.
    Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
    Leukemia. 2013 Jan;27(1):66-74.
  • Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL.
    Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
    Blood. 2012 Nov 1;120(18):3764-73.
  • Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT.
    Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
    Dis Model Mech. 2012 Nov;5(6):881-94.
  • Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P.
    The requirement for cyclin D function in tumor maintenance.
    Cancer Cell. 2012 Oct 16;22(4):438-51.
  • Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S.
    PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
    Mol Cell. 2012 Sep 14;47(5):681-93.
  • Payne EM, Virgilio M, Narla A, Sun H, Levine M, Paw BH, Berliner N, Look AT, Ebert BL, Khanna-Gupta A.
    L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.
    Blood. 2012 Sep 13;120(11):2214-24.
  • Kentsis A, Look AT.
    Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis.
    Cell Stem Cell. 2012 Sep 7;11(3):281-2.
  • Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, Vande Woude G, Licht JD, Kung AL, Staudt LM, Look AT.
    Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
    Nat Med. 2012 Jul;18(7):1118-22.
  • Sorrells S, Carbonneau S, Harrington E, Chen AT, Hast B, Milash B, Pyati U, Major MB, Zhou Y, Zon LI, Stewart RA, Look AT, Jette C.
    Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.
    PLoS Genet. 2012 Aug;8(8):e1002922.
  • Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM.
    Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
    Leukemia. 2012 Sep;26(9):2069-78.
  • Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT.
    Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
    Cancer Cell. 2012 Aug 14;22(2):209-21.
  • Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH.
    NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
    PLoS ONE. 2012;7(6):e39725.
  • Suganuma R, Wang LL, Sano H, Naranjo A, London WB, Seeger RC, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Jarzembowski JA, Joshi VV, Navarro S, Peuchmaur M, Shimada H.
    Peripheral neuroblastic tumors with genotype-phenotype discordance: A report from the Children's Oncology Group and the international neuroblastoma pathology committee.
    Pediatr Blood Cancer. 2012 Jun 28.
  • Li X, Sanda T, Look AT, Novina CD, von Boehmer H.
    Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
    J Exp Med. 2011 Apr 4.
  • Grabher C, Payne EM, Johnston AB, Bolli N, Lechman E, Dick JE, Kanki JP, Look AT.
    Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
    Leukemia. 2011 Mar;25(3):506-14.
  • Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
    SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
    Nature. 2011 Mar 3;471(7336):104-9.
  • Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT.
    cpsf1 is required for definitive hematopoietic stem cell survival in zebrafish.
    Blood. 2011 Feb 17.
  • Robinson BW, Germano G, Song Y, Abrams J, Scott M, Guariento I, Tiso N, Argenton F, Basso G, Rhodes J, Kanki JP, Look AT, Balice-Gordon RJ, Felix CA.
    mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
    British Journal of Haematology. 2011 Feb;152(3):307-21.
  • Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT.
    Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.
    Hum Mol Genet. 2010 Dec 1;19(23):4643-53.
  • Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.
    T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
    Cancer Cell. 2010 Oct 19;18(4):353-66.
  • Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK, .
    Outcome after reduced chemotherapy for intermediate-risk neuroblastoma.
    N Engl J Med. 2010 Sep 30;363(14):1313-23.
  • Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT.
    Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
    J Clin Oncol. 2010 Aug 20;28(24):3816-23.
  • Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K.
    Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
    Blood. 2010 Aug 12;116(6):962-70.
  • Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.
    ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
    J Exp Med. 2010 Jul 5;207(7):1369-80.
  • Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, Wang ZZ, Look AT, Wu WS.
    Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.
    Blood. 2010 Jun 10;115(23):4707-14.
  • Heinrichs S, Li C, Look AT.
    SNP array analysis in hematological malignancies: avoiding false discoveries.
    Blood. 2010 May 27;115(21):4157-61. Review.
  • Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG.
    Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
    Dev Cell. 2010 May 18;18(5):750-62.
  • Hubmann R, Düchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Hölbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jäger U, Shehata M.
    NOTCH2 links protein kinase C delta to the expression of CD23 in chronic lymphocytic leukaemia (CLL) cells.
    British Journal of Haematology. 2010 Mar;148(6):868-78.
  • Bolli N, Payne EM, Grabher C, Lee JS, Johnston AB, Falini B, Kanki JP, Look AT.
    Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.
    Blood. 2010 Apr 22;115(16):3329-40.
  • Akahane K, Inukai T, Inaba T, Kurosawa H, Look AT, Kiyokawa N, Fujimoto J, Goto H, Endo M, Zhang X, Hirose K, Kuroda I, Honna H, Kagami K, Goi K, Nakazawa S, Sugita K.
    Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
    Leukemia. 2010 Apr;24(4):865-9.
  • Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT.
    Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
    Blood. 2010 Apr 8;115(14):2845-51.
  • Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.
    Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
    Blood. 2010 Mar 4;115(9):1735-45.
  • Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA.
    Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
    Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22305-10.
  • Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T.
    Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.
    J Biol Chem. 2010 Jan 15;285(3):1850-60.
  • Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW.
    Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
    J Exp Med. 2009 Dec 21;206(13):2977-86.
  • Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK.
    Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.
    Br J Pharmacol. 2009 Nov;158(5):1183-95.
  • Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.
    Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
    Mol Cell Biol. 2009 Nov;29(21):5911-22.
  • Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, Neuberg D, Kornblau SM, Issa JP, Gilliland DG, Garcia-Manero G, Kantarjian HM, Estey EH, Look AT.
    Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.
    Leukemia. 2009 Sep;23(9):1605-13.
  • Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H.
    Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
    Pediatr Blood Cancer. 2009 Oct;53(4):563-9.
  • Payne E, Look T.
    Zebrafish modelling of leukaemias.
    British Journal of Haematology. 2009 Aug;146(3):247-56. Review.
  • Gutierrez A,Sanda T,Grebliunaite R,Carracedo A,Salmena L,Ahn Y,Dahlberg S,Neuberg D,Moreau LA,Winter SS,Larson R,Zhang J,Protopopov A,Chin L,Pandolfi PP,Silverman LB,Hunger SP,Sallan SE,Look AT.
    High frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia.
    Blood. 2009 Jul 16;114(3):647-50.
  • Dodd ME, Hatzold J, Mathias JR, Walters KB, Bennin DA, Rhodes J, Kanki JP, Look AT, Hammerschmidt M, Huttenlocher A.
    The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
    Development. 2009 Aug;136(15):2591-600.
  • Niethammer P, Grabher C, Look AT, Mitchison TJ.
    A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
    Nature. 2009 Jun 18;459(7249):996-9.
  • Volchenboum SL,Li C,Li S,Attiyeh EF,Reynolds CP,Maris JM,Look AT,George RE.
    Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis.
    Cancer Res. 2009 May 15;69(10):4143-9.
  • Chen CC,Kennedy RD,Sidi S,Look AT,D'Andrea A.
    CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors.
    Mol Cancer. 2009;8:24.
  • Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.
    Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
    Cancer Res. 2009 Apr 1;69(7):3060-8.
  • Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW.
    Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.
    Expert Rev Anticancer Ther. 2009 Mar;9(3):331-56. Review.
  • Walters KB, Dodd ME, Mathias JR, Gallagher AJ, Bennin DA, Rhodes J, Kanki JP, Look AT, Grinblat Y, Huttenlocher A.
    Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.
    Dev Dyn. 2009 Jan;238(1):86-99.
  • Freeman JL,Ceol C,Feng H,Langenau DM,Belair C,Stern HM,Song A,Paw BH,Look AT,Zhou Y,Zon LI,Lee C.
    Construction and application of a zebrafish array comparative genomic hybridization platform.
    Genes Chromosomes Cancer. 2009 Feb;48(2):155-70.
  • George RE,Sanda T,Hanna M,Frohling S,Luther W 2nd,Zhang J,Ahn Y,Zhou W,London WB,McGrady P,Xue L,Zozulya S,Gregor VE,Webb TR,Gray NS,Gilliland DG,Diller L,Greulich H,Morris SW,Meyerson M,Look AT.
    Activating mutations in ALK provide a therapeutic target in neuroblastoma.
    Nature. 2008 Oct 16;455(7215):975-8.
  • Zhang Y, Bai XT, Zhu KY, Jin Y, Deng M, Le HY, Fu YF, Chen Y, Zhu J, Look AT, Kanki J, Chen Z, Chen SJ, Liu TX.
    In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury.
    J Immunol. 2008 Aug 1;181(3):2155-64.
  • Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI.
    Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.
    Oncogene. 2008 Jul 10;27(30):4242-8.
  • Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT.
    Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
    Cell. 2008 May 30;133(5):864-77.
  • Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, Stewart RA, Langenau DM, Look AT, Letai A.
    BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals.
    Cell Death Differ. 2008 Jun;15(6):1063-72.
  • Pui CH, Robison LL, Look AT.
    Acute lymphoblastic leukaemia.
    Lancet. 2008 Mar 22;371(9617):1030-43. Review.
  • Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr.
    The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
    Genes Dev. 2008 Apr 1;22(7):884-93.
  • Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.
    Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
    Blood. 2008 May 1;111(9):4716-22.
  • Schneiderman J, London WB, Brodeur GM, Castleberry RP, Look AT, Cohn SL.
    Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.
    J Clin Oncol. 2008 Feb 20;26(6):913-8.
  • O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.
    Alu elements mediate MYB gene tandem duplication in human T-ALL.
    J Exp Med. 2007 Dec 24;204(13):3059-66.
  • Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG.
    SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients.
    Genes Chromosomes Cancer. 2007 Dec 6;47(3):253-259.
  • Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR.
    Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.
    Cancer Res. 2007 Dec 1;67(23):11234-43.
  • Gutierrez A, Look AT.
    NOTCH and PI3K-AKT pathways intertwined.
    Cancer Cell. 2007 Nov;12(5):411-3.
  • Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT.
    Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.
    British Journal of Haematology. 2007 Jul;138(2):169-75.
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    Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
    Nature. 2007 Jun 21;447(7147):966-71.
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    {beta}-Catenin stabilization stalls the transition from Double-Positive to Single Positive stage and predisposes thymocytes to malignant transformation.
    Blood. 2007 Jun 15;109(12):5463-72.
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    Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays.
    PLoS ONE. 2007;2:e255.
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    Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
    Chem Biol. 2007 Feb;14(2):209-19.
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    NOTCH1-induced T-cell leukemia in transgenic zebrafish.
    Leukemia. 2007 Mar;21(3):462-71.
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    Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.
    Semin Cancer Biol. 2007 Apr;17(2):154-65. Review.
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    NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
    Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6.
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    Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study.
    Clin Cancer Res. 2006 Oct 1;12(19):5693-7.
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    A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.
    Leukemia. 2006 Jul;20(7):1245-53.
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    Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.
    Blood. 2006 Aug 1;108(3):986-92.
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    Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
    Nat Rev Cancer. 2006 May;6(5):347-59. Review.
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    Activating Notch1 mutations in mouse models of T-ALL.
    Blood. 2006 Jan 15;107(2):781-5.
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    Molecular genetics of acute lymphoblastic leukemia.
    J Clin Oncol. 2005 Sep 10;23(26):6306-15.
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    Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.
    J Clin Oncol. 2005 Sep 20;23(27):6466-73.
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    The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
    Blood. 2005 Nov 15;106(10):3377-9.
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    Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.
    Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6068-73.
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    The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
    J Exp Med. 2005 Feb 21;201(4):603-14.
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    BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
    Curr Biol. 2005 Feb 8;15(3):249-54.
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    tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
    Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):407-12.
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    Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.
    Dev Cell. 2005 Jan;8(1):97-108.
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    Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.
    Blood. 2005 Apr 15;105(8):3278-85.
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    Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
    Science. 2004 Oct 8;306(5694):269-71.
  • Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, Vermeesch JR, Stul M, Dutta B, Boeckx N, Bosly A, Heimann P, Uyttebroeck A, Mentens N, Somers R, MacLeod RA, Drexler HG, Look AT, Gilliland DG, Michaux L, Vandenberghe P, Wlodarska I, Marynen P, Hagemeijer A.
    Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
    Nat Genet. 2004 Oct;36(10):1084-9.
  • Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, Kutok JL, Look AT, Zon LI.
    Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.
    Blood. 2004 Sep 1;104(5):1298-305.
  • Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS.
    In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.
    Proc Natl Acad Sci U S A. 2004 May 11;101(19):7369-74.
  • Paietta E, Ferrando AA, Neuberg D, Bennett JM, Racevskis J, Lazarus H, Dewald G, Rowe JM, Wiernik PH, Tallman MS, Look AT.
    Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
    Blood. 2004 Jul 15;104(2):558-60.
  • Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, Paw BH, Rhodes J, Berman JN, Zon LI, Kanki JP, Look AT.
    The pu.1 promoter drives myeloid gene expression in zebrafish.
    Blood. 2004 Sep 1;104(5):1291-7.
  • Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH, Rowe JM, Caligiuri MA, Bloomfield CD, Look AT.
    Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
    Lancet. 2004 Feb 14;363(9408):535-6.
  • Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT.
    Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.
    Dev Cell. 2003 Dec;5(6):903-14.
  • Morris JP, Berghmans S, Zahrieh D, Neuberg DS, Kanki JP, Look AT.
    Zebrafish sperm cryopreservation with N,N-dimethylacetamide.
    Biotechniques. 2003 Nov;35(5):956-8, 960, 962 passim.
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    IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
    Blood. 2004 Mar 1;103(5):1891-900.
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    Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
    Blood. 2004 Mar 1;103(5):1909-11.
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    Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
    Blood. 2003 Jul 1;102(1):262-8.
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    Myc-induced T cell leukemia in transgenic zebrafish.
    Science. 2003 Feb 7;299(5608):887-90.
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    Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.
    Cancer Cell. 2002 Oct;2(4):279-88.
  • Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT.
    Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).
    Mech Dev. 2002 Sep;117(1-2):243-8.
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    Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
    Cancer Cell. 2002 Feb;1(1):75-87.
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    Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
    Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6136-41.
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    The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.
    Mol Cell Biol. 2001 Sep;21(17):5935-45.
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    The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Leukemia. 2001 Jul;15(7):1081-8.
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    Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors.
    Mol Cell Biol. 2001 Feb;21(3):854-64.
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    Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.
    Nat Med. 2000 May;6(5):529-35.
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    SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
    Mol Cell. 1999 Sep;4(3):343-52.
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    Oncogenic transcription factors in the human acute leukemias.
    Science. 1997 Nov 7;278(5340):1059-64.
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    Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
    Nature. 1996 Aug 8;382(6591):541-4.
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    Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
    Mol Cell Biol. 1994 Dec;14(12):8085-95.
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    The retinoblastoma protein binds to a family of E2F transcription factors.
    Mol Cell Biol. 1993 Dec;13(12):7813-25.