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Peter Sicinski, MD, PhD

Publications

  • Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.Nature. 2014 May 25.
    24870244
  • Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM.PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length.Mol Cell. 2014 May 21.
    24857551
  • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.Nature. 2014 Apr 24;508(7497):541-5.
    24670654
  • Martinerie L, Manterola M, Chung SS, Panigrahi SK, Weisbach M, Vasileva A, Geng Y, Sicinski P, Wolgemuth DJ.Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.PLoS Genet. 2014 Feb;10(2):e1004165.
    24586195
  • Nakaya T, Ishiguro KI, Belzil C, Rietsch AM, Yu Q, Mizuno SI, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y.p600 Plays Essential Roles in Fetal Development.PLoS ONE. 2013;8(6):e66269.
    23824717
  • Geng Y, Sicinski P.Differences in regulation and function of E-cyclins in human cancer cells.Cell Cycle. 2013 Apr 15;12(8):1165.
    23549169
  • Cho KH, Sicinski P.Unexpected outcomes of CDK4/6 inhibition.Oncotarget. 2013 Feb;4(2):176-7.
    23563596
  • Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H.β-Selection-Induced Proliferation Is Required for αβ T Cell Differentiation.Immunity. 2012 Nov 16;37(5):840-53.
    23159226
  • Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G.Canonical and atypical E2Fs regulate the mammalian endocycle.Nat Cell Biol. 2012 Nov;14(11):1192-202.
    23064266
  • Choi YJ, Li X, Hydbring P, Sanda T, Stefano J, Christie AL, Signoretti S, Look AT, Kung AL, von Boehmer H, Sicinski P.The requirement for cyclin D function in tumor maintenance.Cancer Cell. 2012 Oct 16;22(4):438-51.
    23079655
  • Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF.Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.Genes Dev. 2012 Sep 15;26(18):2075-87.
    22929040
  • Jirawatnotai S, Hu Y, Livingston DM, Sicinski P.Proteomic identification of a direct role for cyclin d1 in DNA damage repair.Cancer Res. 2012 Sep 1;72(17):4289-93.
    22915759
  • Odajima J, Kalaszczynska I, Sicinski P.Cyclins A and E trigger DNA damage.Cell Cycle. 2010 Dec 17;9(7):1231-2.
    20404525
  • Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ.Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.Cancer Res. 2010 Oct 15;70(20):8149-58.
    20736363
  • Peled JU, Yu JJ, Venkatesh J, Bi E, Ding BB, Krupski-Downs M, Shaknovich R, Sicinski P, Diamond B, Scharff MD, Ye BH.Requirement for cyclin D3 in germinal center formation and function.Cell Res. 2010 Jun;20(6):631-46.
    20404856
  • Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P.Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.Nature. 2010 Jan 21;463(7279):374-8.
    20090754
  • Nevzorova YA,Tschaharganeh D,Gassler N,Geng Y,Weiskirchen R,Sicinski P,Trautwein C,Liedtke C.Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin.Gastroenterology. 2009 Aug;137(2):691-703, 703.e1-6.
    19445941
  • Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.Cell. 2009 Jul 23;138(2):352-65.
    19592082
  • Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW.FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.Int J Oncol. 2009 Jul;35(1):57-68.
    19513552
  • Joshi I,Minter LM,Telfer J,Demarest RM,Capobianco AJ,Aster JC,Sicinski P,Fauq A,Golde TE,Osborne BA.Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.Blood. 2009 Feb 19;113(8):1689-98.
    19001083
  • Zeng L,Geng Y,Tretiakova M,Yu X,Sicinski P,Kroll TG.Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors.Cancer Res. 2008 Aug 15;68(16):6578-86.
    18701481
  • Landis MW, Brown NE, Baker GL, Shifrin A, Das M, Geng Y, Sicinski P, Hinds PW.The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.Cancer Res. 2007 Aug 15;67(16):7613-20.
    17699765
  • Sicinski P, Zacharek S, Kim C.Duality of p27Kip1 function in tumorigenesis.Genes Dev. 2007 Jul 15;21(14):1703-6. Review.
    17639075
  • Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P.Kinase-independent function of cyclin E.Mol Cell. 2007 Jan 12;25(1):127-39.
    17218276
  • Lee YM, Sicinski P.Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human.Cell Cycle. 2006 Sep;5(18):2110-4. Review.
    16969111
  • Sicinska E, Lee YM, Gits J, Shigematsu H, Yu Q, Rebel VI, Geng Y, Marshall CJ, Akashi K, Dorfman DM, Touw IP, Sicinski P.Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.Mol Cell Biol. 2006 Nov;26(21):8052-60.
    16954383
  • Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binn UK, Harrington L, Sicinski P, Brub NG, Dyson NJ, Dick FA.The retinoblastoma protein regulates pericentric heterochromatin.Mol Cell Biol. 2006 May;26(9):3659-71.
    16612004
  • Cooper AB, Sawai CM, Sicinska E, Powers SE, Sicinski P, Clark MR, Aifantis I.A unique function for cyclin D3 in early B cell development.Nat Immunol. 2006 May;7(5):489-97.
    16582912
  • Yu Q, Sicinska E, Geng Y, Ahnstrm M, Zagozdzon A, Kong Y, Gardner H, Kiyokawa H, Harris LN, Stl O, Sicinski P.Requirement for CDK4 kinase function in breast cancer.Cancer Cell. 2006 Jan;9(1):23-32.
    16413469
  • Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW.Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.Cancer Cell. 2006 Jan;9(1):13-22.
    16413468
  • Yu Q, Ciemerych MA, Sicinski P.Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins.Oncogene. 2005 Oct 27;24(47):7114-9.
    16103884
  • Deshpande A, Sicinski P, Hinds PW.Cyclins and cdks in development and cancer: a perspective.Oncogene. 2005 Apr 18;24(17):2909-15.
    15838524
  • Ciemerych MA, Sicinski P.Cell cycle in mouse development.Oncogene. 2005 Apr 18;24(17):2877-98.
    15838522
  • Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF.Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.Mol Cell Biol. 2005 May;25(9):3752-62.
    15831479
  • Kozar K, Sicinski P.Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.Cell Cycle. 2005 Mar;4(3):388-91.
    15738651
  • Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P.Genetic replacement of cyclin D1 function in mouse development by cyclin D2.Mol Cell Biol. 2005 Feb;25(3):1081-8.
    15657434
  • Kowalczyk A, Filipkowski RK, Rylski M, Wilczynski GM, Konopacki FA, Jaworski J, Ciemerych MA, Sicinski P, Kaczmarek L.The critical role of cyclin D2 in adult neurogenesis.J Cell Biol. 2004 Oct 25;167(2):209-13.
    15504908
  • Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P.Mouse development and cell proliferation in the absence of D-cyclins.Cell. 2004 Aug 20;118(4):477-91.
    15315760
  • Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H, Sicinski P.Cyclin E ablation in the mouse.Cell. 2003 Aug 22;114(4):431-43.
    12941272
  • Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H, Sicinski P.Development of mice expressing a single D-type cyclin.Genes Dev. 2002 Dec 15;16(24):3277-89.
    12502747
  • Jena N, Deng M, Sicinska E, Sicinski P, Daley GQ.Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.Cancer Res. 2002 Jan 15;62(2):535-41.
    11809706
  • Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P.Expression of cyclins E1 and E2 during mouse development and in neoplasia.Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13138-43.
    11687642
  • Yu Q, Geng Y, Sicinski P.Specific protection against breast cancers by cyclin D1 ablation.Nature. 2001 Jun 28;411(6841):1017-21.
    11429595
  • Geng Y, Yu Q, Sicinska E, Das M, Bronson RT, Sicinski P.Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):194-9.
    11134518
  • Sicinski P, Weinberg RA.A specific role for cyclin D1 in mammary gland development.J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):335-42.
    10935021
  • Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM.A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1.Neuron. 2000 May;26(2):405-16.
    10839359
  • Geng Y, Whoriskey W, Park MY, Bronson RT, Medema RH, Li T, Weinberg RA, Sicinski P.Rescue of cyclin D1 deficiency by knockin cyclin E.Cell. 1999 Jun 11;97(6):767-77.
    10380928
  • Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ.Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.Genes Dev. 1998 Aug 15;12(16):2469-74.
    9716400
  • Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA.Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.Nature. 1996 Dec 5;384(6608):470-4.
    8945475
  • Wang Z, Sicinski P, Weinberg RA, Zhang Y, Ravid K.Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity.Genomics. 1996 Jul 1;35(1):156-63.
    8661116
  • Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA.Cyclin D1 provides a link between development and oncogenesis in the retina and breast.Cell. 1995 Aug 25;82(4):621-30.
    7664341
  • Geng Y, Sicinski P, Gorecki D, Barnard PJ.Developmental and tissue-specific regulation of mouse dystrophin: the embryonic isoform in muscular dystrophy.Neuromuscul Disord. 1991;1(2):125-33.
    1822783
  • Sicinski P, Rowinski J, Warchol JB, Jarzabek Z, Gut W, Szczygiel B, Bielecki K, Koch G.Poliovirus type 1 enters the human host through intestinal M cells.Gastroenterology. 1990 Jan;98(1):56-8.
    2152776
  • Sicinski P, Geng Y, Ryder-Cook AS, Barnard EA, Darlison MG, Barnard PJ.The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.Science. 1989 Jun 30;244(4912):1578-80.
    2662404
  • Ryder-Cook AS, Sicinski P, Thomas K, Davies KE, Worton RG, Barnard EA, Darlison MG, Barnard PJ.Localization of the mdx mutation within the mouse dystrophin gene.EMBO J. 1988 Oct;7(10):3017-21.
    2903046
  • Rell KW, Lamprecht J, Sicinski P, Bem W, Rowinski J.Frequency of occurrence and distribution of the intra-epithelial lymphoid cells in the follicle-associated epithelium in phenotypically normal and athymic nude mice.J Anat. 1987 Jun;152:121-31.
    3654364
  • Sicinski P, Rowinski J, Warchol JB, Bem W.Morphometric evidence against lymphocyte-induced differentiation of M cells from absorptive cells in mouse Peyer's patches.Gastroenterology. 1986 Mar;90(3):609-16.
    2935444
  • Rowinski J, Lamprecht J, Sicinski P.Non-random distribution of intraepithelial lymphoid cells in follicle-associated epithelium of Peyer's patches in mice.J Anat. 1984 Aug;139 ( Pt 1):21-32.
    6469854
  • Sicinski P, Rowinski J, Warchol J.Intracisternal granules in the intestinal absorptive cells in mice.Cell Biol Int Rep. 1984 Jun;8(6):499-506.
    6744427