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David N. Louis, MD

Publications

  • Chi AS, Batchelor TT, Yang D, Dias-Santagata D, Borger DR, Ellisen LW, Iafrate AJ, Louis DN.BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.J Clin Oncol. 2013 May 10;31(14):e233-6.
    23547069
  • Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, Yu M, Chen PI, Morgan B, Trautwein J, Kimura A, Sengupta S, Stott SL, Karabacak NM, Barber TA, Walsh JR, Smith K, Spuhler PS, Sullivan JP, Lee RJ, Ting DT, Luo X, Shaw AT, Bardia A, Sequist LV, Louis DN, Maheswaran S, Kapur R, Haber DA, Toner M.Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.Sci Transl Med. 2013 Apr 3;5(179):179ra47.
    23552373
  • Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Nat Genet. 2013 Mar;45(3):285-9.
    23334667
  • Tanaka S, Louis DN, Curry WT, Batchelor TT, Dietrich J.Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?.Nat Rev Clin Oncol. 2013 Jan;10(1):14-26.
    23183634
  • Louis DN.The next step in brain tumor classification: "Let us now praise famous men"… or molecules?.Acta Neuropathol. 2012 Nov 15.
    23151844
  • Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ.Prospective, high-throughput molecular profiling of human gliomas.J. Neurooncol. 2012 Oct;110(1):89-98.
    22821383
  • Panageas KS, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Cairncross JG, Roldán Urgoiti GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM, Kamar FG, Abrey LE, Deangelis LM, Jhanwar SC, Rosenblum MK, Lassman AB.Initial treatment patterns over time for anaplastic oligodendroglial tumors.Neuro Oncology. 2012 Jun;14(6):761-7.
    22661585
  • Mohapatra G, Engler DA, Starbuck KD, Kim JC, Bernay DC, Scangas GA, Rousseau A, Batchelor TT, Betensky RA, Louis DN.Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas.Acta Neuropathol. 2011 Apr;121(4):529-43.
    21080181
  • Horbinski C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M.Isocitrate Dehydrogenase 1 Analysis Differentiates Gangliogliomas from Infiltrative Gliomas.Brain Pathol. 2011 Feb 14.
    21314850
  • Camelo-Piragua S, Jansen M, Ganguly A, Kim JC, Cosper AK, Dias-Santagata D, Nutt CL, Iafrate AJ, Louis DN.A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53.J Neuropathol Exp Neurol. 2011 Feb;70(2):110-5.
    21343879
  • Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A.Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.Acta Neuropathol. 2011 Mar;121(3):397-405.
    21274720
  • Jansen M, Yip S, Louis DN.Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers.Lancet Neurol. 2010 Jul;9(7):717-26. Review.
    20610347
  • Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK.Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.J Clin Oncol. 2010 Jun 10;28(17):2817-23.
    20458050
  • van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K.Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.Oncogene. 2010 Jun 3;29(22):3185-95.
    20305695
  • Dias-Santagata D, Akhavanfard S, David SS, Vernovsky K, Kuhlmann G, Boisvert SL, Stubbs H, McDermott U, Settleman J, Kwak EL, Clark JW, Isakoff SJ, Sequist LV, Engelman JA, Lynch TJ, Haber DA, Louis DN, Ellisen LW, Borger DR, Iafrate AJ.Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.EMBO Mol Med. 2010 May;2(5):146-58.
    20432502
  • Camelo-Piragua S, Jansen M, Ganguly A, Kim JC, Louis DN, Nutt CL.Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis.Acta Neuropathol. 2010 Apr;119(4):509-11.
    20044756
  • Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN, Klibanski A.Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression.Cancer Res. 2010 Mar 15;70(6):2350-8.
    20179190
  • Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA.A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.Cancer Res. 2010 Mar 15;70(6):2158-64.
    20215515
  • Colman H, Zhang L, Sulman EP, McDonald JM, Shooshtari NL, Rivera A, Popoff S, Nutt CL, Louis DN, Cairncross JG, Gilbert MR, Phillips HS, Mehta MP, Chakravarti A, Pelloski CE, Bhat K, Feuerstein BG, Jenkins RB, Aldape K.A multigene predictor of outcome in glioblastoma.Neuro Oncology. 2010 Jan;12(1):49-57.
    20150367
  • Desantis SM,Houseman EA,Coull BA,Louis DN,Mohapatra G,Betensky RA.A Latent Class Model with Hidden Markov Dependence for Array CGH Data.Biometrics. 2009 Dec;65(4):1296-305.
    19397578
  • Stamoulis C, Betensky RA, Mohapatra G, Louis DN.Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA.Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6973-6.
    19964720
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W.Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.Arch Pathol Lab Med. 2009 Dec;133(12):1949-53.
    19961250
  • Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG, Loeffler JS, Louis DN, Mohapatra G.Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome.J Neuropathol Exp Neurol. 2009 Oct;68(10):1155-65.
    19918127
  • Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ.Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.Clin Cancer Res. 2009 Oct 15;15(20):6430-7.
    19808867
  • Gabeau-Lacet D,Aghi M,Betensky RA,Barker FG,Loeffler JS,Louis DN.Bone involvement predicts poor outcome in atypical meningioma.J Neurosurg. 2009 Sep;111(3):464-71.
    19267533
  • Koga T,Morita A,Maruyama K,Tanaka M,Ino Y,Shibahara J,Louis DN,Reifenberger G,Itami J,Hara R,Saito N,Todo T.Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.Neuro-oncol. 2009 Aug;11(4):446-51.
    19164434
  • Yip S, Miao J, Cahill DP, Iafrate AJ, Aldape K, Nutt CL, Louis DN.MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.Clin Cancer Res. 2009 Jul 15;15(14):4622-9.
    19584161
  • Aghi MK,Batchelor TT,Louis DN,Barker FG 2nd,Curry WT Jr.Decreased rate of infection in glioblastoma patients with allelic loss of chromosome 10q.J Neurooncol. 2009 May;93(1):115-20.
    19430887
  • Du J,Bernasconi P,Clauser KR,Mani DR,Finn SP,Beroukhim R,Burns M,Julian B,Peng XP,Hieronymus H,Maglathlin RL,Lewis TA,Liau LM,Nghiemphu P,Mellinghoff IK,Louis DN,Loda M,Carr SA,Kung AL,Golub TR.Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.Nat Biotechnol. 2009 Jan;27(1):77-83.
    19098899
  • Lawlor MW, Nielsen GP, Louis DN.Malignant solitary fibrous tumour of the meninges with marked amianthoid fibre deposition.Neuropathol Appl Neurobiol. 2008 Oct;34(5):569-72.
    18298634
  • Stegh AH,Chin L,Louis DN,DePinho RA.What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator.Cell Cycle. 2008 Sep 15;7(18):2833-9.
    18769159
  • Stegh AH,Kesari S,Mahoney JE,Jenq HT,Forloney KL,Protopopov A,Louis DN,Chin L,DePinho RA.Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10703-8.
    18669646
  • Mohile NA, Forsyth P, Stewart D, Raizer JJ, Paleologos N, Kewalramani T, Louis DN, Cairncross JG, Abrey LE.A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.J Neurooncol. 2008 Sep;89(2):187-93.
    18458821
  • Iafrate AJ,Louis DN."MGMT for pt mgmt": is methylguanine-DNA methyltransferase testing ready for patient management?.J Mol Diagn. 2008 Jul;10(4):308-10.
    18556768
  • de la Iglesia N,Konopka G,Lim KL,Nutt CL,Bromberg JF,Frank DA,Mischel PS,Louis DN,Bonni A.Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.J Neurosci. 2008 Jun 4;28(23):5870-8.
    18524891
  • Yip S, Iafrate AJ, Louis DN.Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers.J Neuropathol Exp Neurol. 2008 Jan;67(1):1-15. Review.
    18091559
  • Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.Malignant astrocytic glioma: genetics, biology, and paths to treatment.Genes Dev. 2007 Nov 1;21(21):2683-710. Review.
    17974913
  • Betensky RA, Louis DN, Cairncross JG.Tests of association under misclassification: Application to histological sampling in oncology.Stat Med. 2007 Nov 20;26(26):4808-16.
    17476651
  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P.The 2007 WHO classification of tumours of the central nervous system.Acta Neuropathol. 2007 Aug;114(2):97-109. Review.
    17618441
  • Abrey LE, Louis DN, Paleologos N, Lassman AB, Raizer JJ, Mason W, Finlay J, Macdonald DR, Deangelis LM, Cairncross JG.Survey of treatment recommendations for anaplastic oligodendroglioma.Neuro-oncol. 2007 Jul;9(3):314-8.
    17435180
  • Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN.Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Clin Cancer Res. 2007 Apr 1;13(7):2038-45.
    17404084
  • Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR.Patterns of somatic mutation in human cancer genomes.Nature. 2007 Mar 8;446(7132):153-8.
    17344846
  • Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.Neuron. 2007 Feb 15;53(4):503-17.
    17296553
  • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.Cancer Cell. 2007 Jan;11(1):83-95.
    17222792
  • Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L.Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.Genes Dev. 2007 Jan 1;21(1):98-111.
    17210792
  • Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN.Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56.
    17146289
  • Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL.Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.J Neuropathol Exp Neurol. 2006 Dec;65(12):1181-8.
    17146292
  • Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.Cancer Res. 2006 Dec 1;66(23):11502-13.
    17114236
  • Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA.Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses.Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12873-8.
    16908838
  • Mueller W, Nutt CL, Ehrich M, Riemenschneider MJ, von Deimling A, van den Boom D, Louis DN.Downregulation of RUNX3 and TES by hypermethylation in glioblastoma.Oncogene. 2007 Jan 25;26(4):583-93.
    16909125
  • Iliopoulos O, Chan-Smutko G, Gonzalez RG, Louis DN, Stone JR.Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the right hand and hypertension.N Engl J Med. 2006 Jul 27;355(4):394-402.
    16870919
  • Sequist LV, Joshi VA, Jnne PA, Bell DW, Fidias P, Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ.Epidermal growth factor receptor mutation testing in the care of lung cancer patients.Clin Cancer Res. 2006 Jul 15;12(14):4403s-8s. Review.
    16857818
  • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN.AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.Cancer Res. 2006 Jun 1;66(11):5618-23.
    16740698
  • Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN.Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization.J Mol Diagn. 2006 May;8(2):268-76.
    16645215
  • Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Richardson D, Shepherd R, Small A, Solomon H, Tofts C, Varian J, West S, Widaa S, Yates A, Easton DF, Riggins G, Roy JE, Levine KK, Mueller W, Batchelor TT, Louis DN, Stratton MR, Futreal PA, Wooster R.A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.Cancer Res. 2006 Apr 15;66(8):3987-91.
    16618716
  • Engler DA, Mohapatra G, Louis DN, Betensky RA.A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations.Biostatistics. 2006 Jul;7(3):399-421.
    16401686
  • Aghi M, Gaviani P, Henson JW, Batchelor TT, Louis DN, Barker FG.Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma.Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8600-5.
    16361543
  • Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN.Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma.J Neuropathol Exp Neurol. 2005 Nov;64(11):948-955.
    16254489
  • Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN.In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.Am J Pathol. 2005 Nov;167(5):1379-87.
    16251422
  • Henson JW, Hobbs W, Chakravarti A, Louis DN.Alterations in p53, p21, and MIB-1 labeling index in primary human astrocytomas following radiation therapy.J Neurooncol. 2005 Sep;74(2):151-4.
    16193385
  • McDonald JM, See SJ, Tremont IW, Colman H, Gilbert MR, Groves M, Burger PC, Louis DN, Giannini C, Fuller G, Passe S, Blair H, Jenkins RB, Yang H, Ledoux A, Aaron J, Tipnis U, Zhang W, Hess K, Aldape K.The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors.Cancer. 2005 Oct 1;104(7):1468-77.
    16088966
  • Ma D, Nutt CL, Shanehsaz P, Peng X, Louis DN, Kaetzel DM.Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival i.Cancer Res. 2005 Jul 1;65(13):5523-34.
    15994924
  • Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT.Genetic analyses for predictors of radiation response in glioblastoma.Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):704-10.
    15978739
  • Dahiya S, Sarkar C, Hedley-Whyte ET, Sharma MC, Zervas NT, Sridhar E, Louis DN.Spindle cell oncocytoma of the adenohypophysis: report of two cases.Acta Neuropathol. 2005 Jul;110(1):97-9.
    15973544
  • Mueller W, Mizoguchi M, Silen E, D'Amore K, Nutt CL, Louis DN.Mutations of the PIK3CA gene are rare in human glioblastoma.Acta Neuropathol. 2005 Jun;109(6):654-5.
    15924252
  • Betensky RA, Nutt CL, Batchelor TT, Louis DN.Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers.J Mol Diagn. 2005 May;7(2):276-82.
    15858152
  • Nutt CL, Betensky RA, Brower MA, Batchelor TT, Louis DN, Stemmer-Rachamimov AO.YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas.Clin Cancer Res. 2005 Mar 15;11(6):2258-64.
    15788675
  • Kreiger PA, Okada Y, Simon S, Rorke LB, Louis DN, Golden JA.Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas.Acta Neuropathol. 2005 Apr;109(4):387-92.
    15739101
  • Voloschin AD, Louis DN, Cosgrove GR, Batchelor TT.Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study.Neuro-oncol. 2005 Jan;7(1):97-100.
    15701287
  • Chiocca EA, Abbed KM, Tatter S, Louis DN, Hochberg FH, Barker F, Kracher J, Grossman SA, Fisher JD, Carson K, Rosenblum M, Mikkelsen T, Olson J, Markert J, Rosenfeld S, Nabors LB, Brem S, Phuphanich S, Freeman S, Kaplan R, Zwiebel J.A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.Mol Ther. 2004 Nov;10(5):958-66.
    15509513
  • Borowsky AD, Munn RJ, Galvez JJ, Cardiff RD, Ward JM, Morse HC, Kogan SC, Aldape KD, Louis DN, Bosenberg MW.Mouse models of human cancers (part 3).Comp Med. 2004 Jun;54(3):258-70.
    15253271
  • Megyesi JF, Kachur E, Lee DH, Zlatescu MC, Betensky RA, Forsyth PA, Okada Y, Sasaki H, Mizoguchi M, Louis DN, Cairncross JG.Imaging correlates of molecular signatures in oligodendrogliomas.Clin Cancer Res. 2004 Jul 1;10(13):4303-6.
    15240515
  • Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH.The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.J Neuropathol Exp Neurol. 2004 May;63(5):499-509.
    15198128
  • Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M.Comparative pathology of nerve sheath tumors in mouse models and humans.Cancer Res. 2004 May 15;64(10):3718-24.
    15150133
  • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA.Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.N Engl J Med. 2004 May 20;350(21):2129-39.
    15118073
  • Kiehl TR, Kalkanis SN, Louis DN.Pigmented central neurocytoma.Acta Neuropathol. 2004 Jun;107(6):571-4.
    14991386
  • Mizoguchi M, Nutt CL, Louis DN.Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma.Neurogenetics. 2004 Feb;5(1):81-2.
    14618415
  • Yang C, Ionescu-Tiba V, Burns K, Gadd M, Zukerberg L, Louis DN, Sgroi D, Schmidt EV.The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer.Am J Pathol. 2004 Mar;164(3):1031-8.
    14982856
  • Batchelor TT, Betensky RA, Esposito JM, Pham LD, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN.Age-dependent prognostic effects of genetic alterations in glioblastoma.Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):228-33.
    14734474
  • Gutmann DH, James CD, Poyhonen M, Louis DN, Ferner R, Guha A, Hariharan S, Viskochil D, Perry A.Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.Neurology. 2003 Nov 25;61(10):1397-400.
    14638962
  • Betensky RA, Louis DN, Cairncross JG.Analysis of a molecular genetic neuro-oncology study with partially biased selection.Biostatistics. 2003 Apr;4(2):167-78.
    12925514
  • Deisboeck TS, Wakimoto H, Nestler U, Louis DN, Sehgal PK, Simon M, Chiocca EA, Hochberg FH.Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study.Gene Ther. 2003 Aug;10(15):1225-33.
    12858187
  • MacCollin M, Willett C, Heinrich B, Jacoby LB, Acierno JS, Perry A, Louis DN.Familial schwannomatosis: Exclusion of the NF2 locus as the germline event.Neurology. 2003 Jun 24;60(12):1968-74.
    12821741
  • Hampl JA, Camp SM, Mydlarz WK, Hampl M, Ichikawa T, Chiocca EA, Louis DN, Sena-Esteves M, Breakefield XO.Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors.Hum Gene Ther. 2003 May 1;14(7):611-26.
    12804144
  • Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN.Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.Cancer Res. 2003 Apr 1;63(7):1602-7.
    12670911
  • Braaten KM, Betensky RA, de Leval L, Okada Y, Hochberg FH, Louis DN, Harris NL, Batchelor TT.BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma.Clin Cancer Res. 2003 Mar;9(3):1063-9.
    12631608
  • Reifenberger G, Louis DN.Oligodendroglioma: toward molecular definitions in diagnostic neuro-oncology.J Neuropathol Exp Neurol. 2003 Feb;62(2):111-26.
    12578221
  • Lam P, Hui KM, Wang Y, Allen PD, Louis DN, Yuan CJ, Breakefield XO.Dynamics of transgene expression in human glioblastoma cells mediated by herpes simplex virus/adeno-associated virus amplicon vectors.Hum Gene Ther. 2002 Dec 10;13(18):2147-59.
    12542846
  • Okada Y, Hurwitz EE, Esposito JM, Brower MA, Nutt CL, Louis DN.Selection pressures of TP53 mutation and microenvironmental location influence epidermal growth factor receptor gene amplification in human glioblastomas.Cancer Res. 2003 Jan 15;63(2):413-6.
    12543796
  • Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh GR, Cosgrove GR, Chiocca EA, Thornton AF, Loeffler JS, Henson JW, Gonzalez RG.In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience.Radiology. 2002 Dec;225(3):871-9.
    12461273
  • Hartmann C, Johnk L, Kitange G, Wu Y, Ashworth LK, Jenkins RB, Louis DN.Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19.Cancer Res. 2002 Jul 15;62(14):4100-8.
    12124348
  • Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J, Veelken J, Schramm J, Weller M, Wiestler OD, Louis DN, von Deimling A.Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets.Am J Pathol. 2002 Jul;161(1):313-9.
    12107116
  • Louis DN, Pomeroy SL, Cairncross JG.Focus on central nervous system neoplasia.Cancer Cell. 2002 Mar;1(2):125-8.
    12086870
  • Xiao A, Wu H, Pandolfi PP, Louis DN, Van Dyke T.Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.Cancer Cell. 2002 Mar;1(2):157-68.
    12086874
  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA.Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.Cancer Cell. 2002 Apr;1(3):269-77.
    12086863
  • Okada Y, Nishikawa R, Matsutani M, Louis DN.Hypomethylated X chromosome gain and rare isochromosome 12p in diverse intracranial germ cell tumors.J Neuropathol Exp Neurol. 2002 Jun;61(6):531-8.
    12071636
  • Betensky RA, Louis DN, Cairncross JG.Influence of unrecognized molecular heterogeneity on randomized clinical trials.J Clin Oncol. 2002 May 15;20(10):2495-9.
    12011127
  • Hartmann C, Johnk L, Sasaki H, Jenkins RB, Louis DN.Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas.Brain Pathol. 2002 Apr;12(2):178-82.
    11958371
  • Schmidt MC, Antweiler S, Urban N, Mueller W, Kuklik A, Meyer-Puttlitz B, Wiestler OD, Louis DN, Fimmers R, von Deimling A.Impact of genotype and morphology on the prognosis of glioblastoma.J Neuropathol Exp Neurol. 2002 Apr;61(4):321-8.
    11939587
  • Sasaki H, Betensky RA, Cairncross JG, Louis DN.DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.Cancer Res. 2002 Mar 15;62(6):1790-6.
    11912156
  • Li Y, Betensky RA, Louis DN, Cairncross JG.The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power.Biometrics. 2002 Mar;58(1):232-6.
    11890320
  • Sasaki H, Zlatescu MC, Betensky RA, Johnk LB, Cutone AN, Cairncross JG, Louis DN.Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma".J Neuropathol Exp Neurol. 2002 Jan;61(1):58-63.
    11829344
  • Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR.Prediction of central nervous system embryonal tumour outcome based on gene expression.Nature. 2002 Jan 24;415(6870):436-42.
    11807556
  • Smith ER, Ott M, Wain J, Louis DN, Chiocca EA.Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature.J Neurosurg. 2002 Jan;96(1 Suppl):107-11.
    11795697
  • Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM.Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10851-6.
    11526205
  • Niida Y, Stemmer-Rachamimov AO, Logrip M, Tapon D, Perez R, Kwiatkowski DJ, Sims K, MacCollin M, Louis DN, Ramesh V.Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions.Am J Hum Genet. 2001 Sep;69(3):493-503.
    11468687
  • Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA.Malignant glioma: genetics and biology of a grave matter.Genes Dev. 2001 Jun 1;15(11):1311-33.
    11390353
  • Murthy V, Stemmer-Rachamimov AO, Haddad LA, Roy JE, Cutone AN, Beauchamp RL, Smith N, Louis DN, Ramesh V.Developmental expression of the tuberous sclerosis proteins tuberin and hamartin.Acta Neuropathol. 2001 Mar;101(3):202-10.
    11307618
  • Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Ramsay DA, Cairncross JG, Louis DN.Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.Clin Cancer Res. 2001 Apr;7(4):839-45.
    11309331
  • Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN.NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas.Am J Pathol. 2001 Jan;158(1):57-62.
    11141479
  • Chan AW, Tarbell NJ, Black PM, Louis DN, Frosch MP, Ancukiewicz M, Chapman P, Loeffler JS.Adult medulloblastoma: prognostic factors and patterns of relapse.Neurosurgery. 2000 Sep;47(3):623-31; discussion 631-2.
    10981749
  • Harsh GR, Deisboeck TS, Louis DN, Hilton J, Colvin M, Silver JS, Qureshi NH, Kracher J, Finkelstein D, Chiocca EA, Hochberg FH.Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.J Neurosurg. 2000 May;92(5):804-11.
    10794295
  • Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN.ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3.Neurogenetics. 1997 May;1(1):31-6.
    10735272
  • Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG.Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Mol Cell Biol. 2000 Feb;20(4):1436-47.
    10648628
  • Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK.Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.Gastroenterology. 1999 Oct;117(4):831-7.
    10500065
  • Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA.Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses.Nat Med. 1999 Aug;5(8):881-7.
    10426310
  • Stemmer-Rachamimov AO, Nielsen GP, Rosenberg AE, Louis DN, Jones D, Ramesh V, Gusella JF, Jacoby LB.The NF2 gene and merlin protein in human osteosarcomas.Neurogenetics. 1998 Dec;2(1):73-4.
    9933303
  • Stemmer-Rachamimov AO, Ino Y, Lim ZY, Jacoby LB, MacCollin M, Gusella JF, Ramesh V, Louis DN.Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2.J Neuropathol Exp Neurol. 1998 Dec;57(12):1164-7.
    9862639
  • Cairncross JG, Ueki K, Zlatescu MC, Lisle DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC, Macdonald DR, Ino Y, Ramsay DA, Louis DN.Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.J Natl Cancer Inst. 1998 Oct 7;90(19):1473-9.
    9776413
  • Burns KL, Ueki K, Jhung SL, Koh J, Louis DN.Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas.J Neuropathol Exp Neurol. 1998 Feb;57(2):122-30.
    9600204
  • Cheng LL, Chang IW, Louis DN, Gonzalez RG.Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens.Cancer Res. 1998 May 1;58(9):1825-32.
    9581820
  • Chung DC, Smith AP, Louis DN, Graeme-Cook F, Warshaw AL, Arnold A.Analysis of the retinoblastoma tumour suppressor gene in pancreatic endocrine tumours.Clin Endocrinol (Oxf). 1997 Nov;47(5):523-8.
    9425391
  • Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, Burwick JA, Pinney D, Beauchamp R, Jacoby LB, Gusella JF, Ramesh V, Louis DN.Universal absence of merlin, but not other ERM family members, in schwannomas.Am J Pathol. 1997 Dec;151(6):1649-54.
    9403715
  • Mason W, Louis DN, Cairncross JG.Chemosensitive gliomas in adults: which ones and why?.J Clin Oncol. 1997 Dec;15(12):3423-6.
    9396392
  • Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN.Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene.Somat Cell Mol Genet. 1997 May;23(3):229-31.
    9330635
  • Stemmer-Rachamimov AO, Horgan MA, Taratuto AL, Munoz DG, Smith TW, Frosch MP, Louis DN.Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene.J Neuropathol Exp Neurol. 1997 May;56(5):485-9.
    9143261
  • Rosenberg JE, Lisle DK, Burwick JA, Ueki K, von Deimling A, Mohrenweiser HW, Louis DN.Refined deletion mapping of the chromosome 19q glioma tumor suppressor gene to the D19S412-STD interval.Oncogene. 1996 Dec 5;13(11):2483-5.
    8957092
  • Ono Y, Tamiya T, Ichikawa T, Kunishio K, Matsumoto K, Furuta T, Ohmoto T, Ueki K, Louis DN.Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices.J Neuropathol Exp Neurol. 1996 Oct;55(10):1026-31.
    8857999
  • Platten M, Giordano MJ, Dirven CM, Gutmann DH, Louis DN.Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.Am J Pathol. 1996 Aug;149(2):621-7.
    8702000
  • Chou D, Miyashita T, Mohrenweiser HW, Ueki K, Kastury K, Druck T, von Deimling A, Huebner K, Reed JC, Louis DN.The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas.Cancer Genet Cytogenet. 1996 Jun;88(2):136-40.
    8640722
  • Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN.CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.Cancer Res. 1996 Jan 1;56(1):150-3.
    8548755
  • Paulus W, Lisle DK, Tonn JC, Wolf HK, Roggendorf W, Reeves SA, Louis DN.Molecular genetic alterations in pleomorphic xanthoastrocytoma.Acta Neuropathol. 1996;91(3):293-7.
    8834542
  • Alderson L, Fetell MR, Sisti M, Hochberg F, Cohen M, Louis DN.Sentinel lesions of primary CNS lymphoma.J Neurol Neurosurg Psychiatry. 1996 Jan;60(1):102-5.
    8558135
  • Joseph JT, Lisle DK, Jacoby LB, Paulus W, Barone R, Cohen ML, Roggendorf WH, Bruner JM, Gusella JF, Louis DN.NF2 gene analysis distinguishes hemangiopericytoma from meningioma.Am J Pathol. 1995 Nov;147(5):1450-5.
    7485407
  • Louis DN, Gusella JF.A tiger behind many doors: multiple genetic pathways to malignant glioma.Trends Genet. 1995 Oct;11(10):412-5.
    7482768
  • Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN.Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3.Genomics. 1995 Sep 20;29(2):533-6.
    8666404
  • Yong WH, Chou D, Ueki K, Harsh GR, von Deimling A, Gusella JF, Mohrenweiser HW, Louis DN.Chromosome 19q deletions in human gliomas overlap telomeric to D19S219 and may target a 425 kb region centromeric to D19S112.J Neuropathol Exp Neurol. 1995 Sep;54(5):622-6.
    7666049
  • Henson JW, Schnitker BL, Correa KM, von Deimling A, Fassbender F, Xu HJ, Benedict WF, Yandell DW, Louis DN.The retinoblastoma gene is involved in malignant progression of astrocytomas.Ann Neurol. 1994 Nov;36(5):714-21.
    7979217
  • Ueki K, Rubio MP, Ramesh V, Correa KM, Rutter JL, von Deimling A, Buckler AJ, Gusella JF, Louis DN.MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p.Hum Mol Genet. 1994 Oct;3(10):1841-5.
    7849711
  • Rubio MP, Correa KM, Ramesh V, MacCollin MM, Jacoby LB, von Deimling A, Gusella JF, Louis DN.Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.Cancer Res. 1994 Jan 1;54(1):45-7.
    8261460