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George Q. Daley, MD, PhD

Publications

  • Arora N, Wenzel PL, McKinney-Freeman SL, Ross SJ, Kim PG, Chou SS, Yoshimoto M, Yoder MC, Daley GQ.Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes.Dev Cell. 2014 Jun 9;29(5):621-8.
    24914562
  • Lu Y, Loh YH, Li H, Cesana M, Ficarro SB, Parikh JR, Salomonis N, Toh CX, Andreadis ST, Luckey CJ, Collins JJ, Daley GQ, Marto JA.Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells.Cell Stem Cell. 2014 May 7.
    24813856
  • Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ.Lin28 sustains early renal progenitors and induces Wilms tumor.Genes Dev. 2014 Apr 14.
    24732380
  • Kelley JM, Daley GQ.Hematopoietic defects and iPSC disease modeling: lessons learned.Immunol Lett.;155(1-2):18-20.
    24076116
  • Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ.Lin28 enhances tissue repair by reprogramming cellular metabolism.Cell. 2013 Nov 7;155(4):778-92.
    24209617
  • Doulatov S, Daley GQ.Development. A stem cell perspective on cellular engineering.Science. 2013 Nov 8;342(6159):700-2.
    24202165
  • De Los Angeles A, Daley GQ.Stem cells: Reprogramming in situ.Nature. 2013 Oct 17;502(7471):309-10.
    24025771
  • Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ.Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.Cell Stem Cell. 2013 Oct 3;13(4):459-70.
    24094326
  • Lee JB, Werbowetski-Ogilvie TE, Lee JH, McIntyre BA, Schnerch A, Hong SH, Park IH, Daley GQ, Bernstein ID, Bhatia M.Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells.Blood. 2013 Aug 15;122(7):1162-73.
    23733337
  • Trounson A, Daley GQ, Pasque V, Plath K.A new route to human embryonic stem cells.Nat Med. 2013 Jul;19(7):820-1.
    23836223
  • Shinoda G, Shyh-Chang N, de Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ.Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism.Stem Cells. 2013 May 10.
    23666760
  • Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A.Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.EMBO J. 2013 May 3.
    23644381
  • Cesana M, Daley GQ.Deciphering the rules of ceRNA networks.Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7112-3.
    23620514
  • Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ.Lin28a regulates germ cell pool size and fertility.Stem Cells. 2013 May;31(5):1001-9.
    23378032
  • Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ.Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction.Cell Stem Cell. 2013 Apr 17.
    23602541
  • Gustafsson K, Heffner G, Wenzel PL, Curran M, Grawé J, McKinney-Freeman SL, Daley GQ, Welsh M.The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity.Exp Cell Res. 2013 Mar 23.
    23528453
  • Shyh-Chang N, Daley GQ.Lin28: primal regulator of growth and metabolism in stem cells.Cell Stem Cell. 2013 Apr 4;12(4):395-406.
    23561442
  • Cherry AB, Gagne KE, McLoughlin EM, Baccei A, Gorman B, Hartung O, Miller JD, Zhang J, Zon RL, Ince TA, Neufeld EJ, Lerou PH, Fleming MD, Daley GQ, Agarwal S.Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion.Stem Cells. 2013 Feb 8.
    23400930
  • Cherry AB, Daley GQ.Reprogrammed cells for disease modeling and regenerative medicine.Annu Rev Med. 2013;64:277-90.
    23327523
  • Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC.Influence of threonine metabolism on S-adenosylmethionine and histone methylation.Science. 2013 Jan 11;339(6116):222-6.
    23118012
  • Kim PG, Albacker CE, Lu YF, Jang IH, Lim Y, Heffner GC, Arora N, Bowman TV, Lin MI, Lensch MW, De Los Angeles A, Zon LI, Loewer S, Daley GQ.Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E141-50.
    23236128
  • Morris SA, Daley GQ.A blueprint for engineering cell fate: current technologies to reprogram cell identity.Cell Res. 2013 Jan;23(1):33-48.
    23277278
  • Daley GQ.Cellular alchemy and the golden age of reprogramming.Cell. 2012 Dec 7;151(6):1151-4.
    23217698
  • Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP.Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.PLoS Genet. 2012;8(11):e1003105.
    23209448
  • Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD.Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.Nature. 2012 Oct 28.
    23103873
  • Bajpai VK, Mistriotis P, Loh YH, Daley GQ, Andreadis ST.Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.Cardiovasc Res. 2012 Dec 1;96(3):391-400.
    22941255
  • Onder TT, Daley GQ.New lessons learned from disease modeling with induced pluripotent stem cells.Curr Opin Genet Dev. 2012 Oct;22(5):500-8.
    22749051
  • McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Langdon EM, Lengerke C, Zon LI, Collins JJ, Daley GQ.The transcriptional landscape of hematopoietic stem cell ontogeny.Cell Stem Cell. 2012 Nov 2;11(5):701-14.
    23122293
  • Zhang J, Nuebel E, Daley GQ, Koehler CM, Teitell MA.Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal.Cell Stem Cell. 2012 Nov 2;11(5):589-95.
    23122286
  • Wen B, Wu H, Loh YH, Briem E, Daley GQ, Feinberg AP.Euchromatin islands in large heterochromatin domains are enriched for ctcf binding and differentially dna-methylated regions.BMC Genomics. 2012 Oct 26;13(1):566.
    23102236
  • Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH.Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17567-72.
    23045682
  • Chang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Do JT, Lee DR, Lee H, Moon H, Hong KS, Daley GQ, Song J.Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke.Cell Transplant. 2012 Oct 3.
    23044029
  • Chae JI, Kim DW, Lee N, Jeon YJ, Jeon I, Kwon J, Kim J, Soh Y, Lee DS, Seo KS, Choi NJ, Park BC, Kang SH, Ryu J, Oh SH, Shin DA, Lee DR, Do JT, Park IH, Daley GQ, Song J.Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient.Biochem J. 2012 Sep 15;446(3):359-71.
    22694310
  • Jeon I, Lee N, Li JY, Park IH, Park KS, Moon J, Shim SH, Choi C, Chang DJ, Kwon J, Oh SH, Shin DA, Kim HS, Do JT, Lee DR, Kim M, Kang KS, Daley GQ, Brundin P, Song J.Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells.Stem Cells. 2012 Sep;30(9):2054-62.
    22628015
  • Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S.Stem cells assessed.Nat Rev Mol Cell Biol. 2012 Jul;13(7):471-6.
    22678486
  • Lengerke C, Wingert R, Beeretz M, Grauer M, Schmidt AG, Konantz M, Daley GQ, Davidson AJ.Interactions between Cdx genes and retinoic acid modulate early cardiogenesis.Dev Biol. 2011 Apr 2.
    21466798
  • Zhu H, Lensch MW, Cahan P, Daley GQ.Investigating monogenic and complex diseases with pluripotent stem cells.Nat Rev Genet. 2011 Apr;12(4):266-75.
    21386866
  • Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.Somatic coding mutations in human induced pluripotent stem cells.Nature. 2011 Mar 3;471(7336):63-7.
    21368825
  • Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G.Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.Development. 2011 Mar;138(5):861-71.
    21270052
  • Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A.Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Cell Stem Cell. 2011 Feb 4;8(2):200-13.
    21295276
  • Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, McElmurry RT, Eide CR, Orchard PJ, Kyba M, Osborn MJ, Lund TC, Wagner JE, Daley GQ, Blazar BR.Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).Blood. 2011 Jan 20;117(3):839-47.
    21037085
  • MacMillan ML, Hughes MR, Agarwal S, Daley GQ.Cellular therapy for fanconi anemia: the past, present, and future.Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S109-14.
    21195298
  • Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD.Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies.J Allergy Clin Immunol. 2010 Dec 23.
    21185069
  • Cherry A, Daley GQ.Another horse in the meta-stable state of pluripotency.Cell Stem Cell. 2010 Dec 3;7(6):641-2.
    21112555
  • Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS.MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.Cell Stem Cell. 2010 Dec 3;7(6):671-81.
    21112562
  • Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.Nat Genet. 2010 Dec;42(12):1113-7.
    21057500
  • Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ.Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA.Cell Stem Cell. 2010 Nov 5;7(5):618-30.
    20888316
  • Ooi SK, Wolf D, Hartung O, Agarwal S, Daley GQ, Goff SP, Bestor TH.Dynamic instability of genomic methylation patterns in pluripotent stem cells.Epigenetics Chromatin. 2010;3(1):17.
    20868487
  • Koo S, Huntly B, Wang Y, Chen J, Brumme K, Ball B, McKinney-Freeman S, Yabuuchi A, Scholl C, Bansal D, Zon L, Froehling S, Daley G, Gilliland G, Mercher T.Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis.Haematologica. 2010 Oct;95(10):1642-50.
    20494928
  • Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP.Comprehensive methylome map of lineage commitment from haematopoietic progenitors.Nature. 2010 Sep 16;467(7313):338-42.
    20720541
  • Hartung O, Huo H, Daley GQ, Schlaeger TM.Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.Curr Protoc Stem Cell Biol. 2010 Aug;Chapter 1:Unit 1C.10.
    20814935
  • Chen L, Wang D, Wu Z, Ma L, Daley GQ.Molecular basis of the first cell fate determination in mouse embryogenesis.Cell Res. 2010 Sep;20(9):982-93.
    20628366
  • Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ.Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.Nat Med. 2010 Aug;16(8):903-8.
    20616797
  • Mauney JR, Ramachandran A, Yu RN, Daley GQ, Adam RM, Estrada CR.All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.PLoS ONE. 2010;5(7):e11513.
    20644631
  • de Jong JL, Davidson AJ, Wang Y, Palis J, Opara P, Pugach E, Daley GQ, Zon LI.Interaction of retinoic acid and scl controls primitive blood development.Blood. 2010 Jul 15;116(2):201-9.
    20410509
  • Loh YH, Hartung O, Li H, Guo C, Sahalie JM, Manos PD, Urbach A, Heffner GC, Grskovic M, Vigneault F, Lensch MW, Park IH, Agarwal S, Church GM, Collins JJ, Irion S, Daley GQ.Reprogramming of T cells from human peripheral blood.Cell Stem Cell. 2010 Jul 2;7(1):15-9.
    20621044
  • Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ.Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.Nat Genet. 2010 Jul;42(7):626-30.
    20512147
  • Kim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, Park IH, Daley GQ, Hwang DY, Kim DW.Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.Stem Cell Rev. 2010 Jun;6(2):270-81.
    20376579
  • Urbach A, Bar-Nur O, Daley GQ, Benvenisty N.Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.Cell Stem Cell. 2010 May 7;6(5):407-11.
    20452313
  • Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, Shimamura A, Daley GQ.Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.Blood. 2010 Apr 29;115(17):3453-62.
    20089964
  • Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ.Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.Nature. 2010 Mar 11;464(7286):292-6.
    20164838
  • Agarwal S, Daley GQ.AID for reprogramming.Cell Res. 2010 Mar;20(3):253-5.
    20190775
  • Viswanathan SR, Daley GQ.Lin28: A microRNA regulator with a macro role.Cell. 2010 Feb 19;140(4):445-9.
    20178735
  • Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS.Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature. 2010 Jan 28;463(7280):501-6.
    20072125
  • Lengerke C, Daley GQ.Autologous blood cell therapies from pluripotent stem cells.Blood Rev. 2010 Jan;24(1):27-37. Review.
    19910091
  • Azam M, Powers JT, Einhorn W, Huang WS, Shakespeare WC, Zhu X, Dalgarno D, Clackson T, Sawyer TK, Daley GQ.AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.Chem Biol Drug Des. 2010 Feb;75(2):223-7.
    20028401
  • Daley GQ.Stem cells: roadmap to the clinic.J Clin Invest. 2010 Jan;120(1):8-10. Review.
    20051631
  • Sullivan GJ, Hay DC, Park IH, Fletcher J, Hannoun Z, Payne CM, Dalgetty D, Black JR, Ross JA, Samuel K, Wang G, Daley GQ, Lee JH, Church GM, Forbes SJ, Iredale JP, Wilmut I.Generation of functional human hepatic endoderm from human induced pluripotent stem cells.Hepatology. 2010 Jan;51(1):329-35.
    19877180
  • Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ, Feinberg AP.Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.Nat Genet. 2009 Dec;41(12):1350-3.
    19881528
  • Lee JH, Park IH, Gao Y, Li JB, Li Z, Daley GQ, Zhang K, Church GM.A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.PLoS Genet. 2009 Nov;5(11):e1000718.
    19911041
  • Chan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, Huo H, Miller JD, Hartung O, Rho J, Ince TA, Daley GQ, Schlaeger TM.Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.Nat Biotechnol. 2009 Nov;27(11):1033-7.
    19826408
  • Lengerke C, Grauer M, Niebuhr NI, Riedt T, Kanz L, Park IH, Daley GQ.Hematopoietic development from human induced pluripotent stem cells.Ann N Y Acad Sci. 2009 Sep;1176:219-27.
    19796250
  • Lengerke C, Daley GQ.Disease models from pluripotent stem cells.Ann N Y Acad Sci. 2009 Sep;1176:191-6.
    19796247
  • Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, Daley GQ.Cross-regulation of the Nanog and Cdx2 promoters.Cell Res. 2009 Sep;19(9):1052-61.
    19564890
  • Huang WS, Zhu X, Wang Y, Azam M, Wen D, Sundaramoorthi R, Thomas RM, Liu S, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT, Broudy MI, Russian K, Daley GQ, Iuliucci J, Dalgarno DC, Clackson T, Sawyer TK, Shakespeare WC.9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.J Med Chem. 2009 Aug 13;52(15):4743-56.
    19572547
  • West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, Sero JE, Zhu H, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ.A role for Lin28 in primordial germ-cell development and germ-cell malignancy.Nature. 2009 Aug 13;460(7257):909-13.
    19578360
  • McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ.Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.Blood. 2009 Jul 9;114(2):268-78.
    19420357
  • Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ.Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.Nature. 2009 Jul 9;460(7252):259-63.
    19516257
  • Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ.microRNA expression during trophectoderm specification.PLoS ONE. 2009;4(7):e6143.
    19582159
  • Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L.Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.Cell Stem Cell. 2009 Jul 2;5(1):97-110.
    19540188
  • Viswanathan SR,Powers JT,Einhorn W,Hoshida Y,Ng TL,Toffanin S,O'Sullivan M,Lu J,Phillips LA,Lockhart VL,Shah SP,Tanwar PS,Mermel CH,Beroukhim R,Azam M,Teixeira J,Meyerson M,Hughes TP,Llovet JM,Radich J,Mullighan CG,Golub TR,Sorensen PH,Daley GQ.Lin28 promotes transformation and is associated with advanced human malignancies.Nat Genet. 2009 Jul;41(7):843-8.
    19483683
  • Baek KH,Zaslavsky A,Lynch RC,Britt C,Okada Y,Siarey RJ,Lensch MW,Park IH,Yoon SS,Minami T,Korenberg JR,Folkman J,Daley GQ,Aird WC,Galdzicki Z,Ryeom S.Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.Nature. 2009 Jun 25;459(7250):1126-30.
    19458618
  • Adamo L,Naveiras O,Wenzel PL,McKinney-Freeman S,Mack PJ,Gracia-Sancho J,Suchy-Dicey A,Yoshimoto M,Lensch MW,Yoder MC,Garcia-Cardena G,Daley GQ.Biomechanical forces promote embryonic haematopoiesis.Nature. 2009 Jun 25;459(7250):1131-5.
    19440194
  • Jeter CR,Badeaux M,Choy G,Chandra D,Patrawala L,Liu C,Calhoun-Davis T,Zaehres H,Daley GQ,Tang DG.Functional evidence that the self-renewal gene NANOG regulates human tumor development.Stem Cells. 2009 May;27(5):993-1005.
    19415763
  • Muller LU,Daley GQ,Williams DA.Upping the ante: recent advances in direct reprogramming.Mol Ther. 2009 Jun;17(6):947-53. Review.
    19337233
  • Ball MP,Li JB,Gao Y,Lee JH,LeProust EM,Park IH,Xie B,Daley GQ,Church GM.Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.Nat Biotechnol. 2009 Apr;27(4):361-8.
    19329998
  • Deng J,Shoemaker R,Xie B,Gore A,LeProust EM,Antosiewicz-Bourget J,Egli D,Maherali N,Park IH,Yu J,Daley GQ,Eggan K,Hochedlinger K,Thomson J,Wang W,Gao Y,Zhang K.Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.Nat Biotechnol. 2009 Apr;27(4):353-60.
    19330000
  • Goessling W,North TE,Loewer S,Lord AM,Lee S,Stoick-Cooper CL,Weidinger G,Puder M,Daley GQ,Moon RT,Zon LI.Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.Cell. 2009 Mar 20;136(6):1136-47.
    19303855
  • Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ.Generation of induced pluripotent stem cells from human blood.Blood. 2009 May 28;113(22):5476-9.
    19299331
  • Daley GQ,Lensch MW,Jaenisch R,Meissner A,Plath K,Yamanaka S.Broader implications of defining standards for the pluripotency of iPSCs.Cell Stem Cell. 2009 Mar 6;4(3):200-1; author reply 202.
    19265657
  • Nardi V,Naveiras O,Azam M,Daley GQ.ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.Blood. 2009 Apr 16;113(16):3813-20.
    19171873
  • Park IH,Daley GQ.Human iPS cell derivation/reprogramming.Curr Protoc Stem Cell Biol. 2009 Jan;Chapter 4:Unit 4A.1.
    19170021
  • Tulpule A,Daley GQ.Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi.Methods Mol Biol. 2009;482:35-42.
    19089348
  • Hyun I,Lindvall O,Ahrlund-Richter L,Cattaneo E,Cavazzana-Calvo M,Cossu G,De Luca M,Fox IJ,Gerstle C,Goldstein RA,Hermeren G,High KA,Kim HO,Lee HP,Levy-Lahad E,Li L,Lo B,Marshak DR,McNab A,Munsie M,Nakauchi H,Rao M,Rooke HM,Valles CS,Srivastava A,Sugarman J,Taylor PL,Veiga A,Wong AL,Zoloth L,Daley GQ.New ISSCR guidelines underscore major principles for responsible translational stem cell research.Cell Stem Cell. 2008 Dec 4;3(6):607-9. Review.
    19041777
  • Ismailoglu I,Yeamans G,Daley GQ,Perlingeiro RC,Kyba M.Mesodermal patterning activity of SCL.Exp Hematol. 2008 Dec;36(12):1593-603.
    18809240
  • Azam M,Seeliger MA,Gray NS,Kuriyan J,Daley GQ.Activation of tyrosine kinases by mutation of the gatekeeper threonine.Nat Struct Mol Biol. 2008 Oct;15(10):1109-18.
    18794843
  • Park IH,Arora N,Huo H,Maherali N,Ahfeldt T,Shimamura A,Lensch MW,Cowan C,Hochedlinger K,Daley GQ.Disease-specific induced pluripotent stem cells.Cell. 2008 Sep 5;134(5):877-86.
    18691744
  • Zhao R,Daley GQ.From fibroblasts to iPS cells: induced pluripotency by defined factors.J Cell Biochem. 2008 Nov 1;105(4):949-55. Review.
    18668528
  • Piskounova E,Viswanathan SR,Janas M,LaPierre RJ,Daley GQ,Sliz P,Gregory RI.Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.J Biol Chem. 2008 Aug 1;283(31):21310-4.
    18550544
  • Lu CW,Yabuuchi A,Chen L,Viswanathan S,Kim K,Daley GQ.Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.Nat Genet. 2008 Jul;40(7):921-6.
    18536715
  • Wang Y,Yabuuchi A,McKinney-Freeman S,Ducharme DM,Ray MK,Chawengsaksophak K,Archer TK,Daley GQ.Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7756-61.
    18511567
  • Lensch MW, Schlaeger TM, Zon LI, Daley GQ.Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera.Cell Stem Cell. 2007 Sep 13;1(3):253-8.
    18371359
  • Kim K, Ng K, Rugg-Gunn PJ, Shieh JH, Kirak O, Jaenisch R, Wakayama T, Moore MA, Pedersen RA, Daley GQ.Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.Cell Stem Cell. 2007 Sep 13;1(3):346-52.
    18371368
  • Lengerke C, Schmitt S, Bowman TV, Jang IH, Maouche-Chretien L, McKinney-Freeman S, Davidson AJ, Hammerschmidt M, Rentzsch F, Green JB, Zon LI, Daley GQ.BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.Cell Stem Cell. 2008 Jan 10;2(1):72-82.
    18371423
  • Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A.Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.J Clin Invest. 2008 Apr;118(4):1511-8.
    18324336
  • Daley GQ, Scadden DT.Prospects for stem cell-based therapy.Cell. 2008 Feb 22;132(4):544-8.
    18295571
  • Viswanathan SR, Daley GQ, Gregory RI.Selective blockade of microRNA processing by Lin28.Science. 2008 Apr 4;320(5872):97-100.
    18292307
  • Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ.Human embryonic stem cell derivation from poor-quality embryos.Nat Biotechnol. 2008 Feb;26(2):212-4.
    18223642
  • McKinney-Freeman SL, Lengerke C, Jang IH, Schmitt S, Wang Y, Philitas M, Shea J, Daley GQ.Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.Blood. 2008 May 15;111(10):4944-53.
    18252864
  • Chan EM, Yates F, Boyer LF, Schlaeger TM, Daley GQ.Enhanced plating efficiency of trypsin-adapted human embryonic stem cells is reversible and independent of trisomy 12/17.Cloning Stem Cells. 2008 Mar;10(1):107-18.
    18241122
  • Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ.Reprogramming of human somatic cells to pluripotency with defined factors.Nature. 2008 Jan 10;451(7175):141-6.
    18157115
  • Daley GQ.Towards the generation of patient-specific pluripotent stem cells for combined gene and cell therapy of hematologic disorders.Hematology Am Soc Hematol Educ Program. 2007;2007:17-22. Review.
    18024604
  • Agarwal S, Lensch MW, Daley GQ.Current prospects for the generation of patient-specific pluripotent cells from adult tissues.Regen Med. 2007 Sep;2(5):743-52.
    17907926
  • Nardi V, Raz T, Cao X, Wu CJ, Stone RM, Cortes J, Deininger MW, Church G, Zhu J, Daley GQ.Quantitative monitoring by polymerase colony assay of known mutations resistant to ABL kinase inhibitors.Oncogene. 2008 Jan 31;27(6):775-82.
    17684485
  • Park IH, Daley GQ.Debugging cellular reprogramming.Nat Cell Biol. 2007 Aug;9(8):871-3.
    17671453
  • Lengerke C, Kim K, Lerou P, Daley GQ.Differentiation potential of histocompatible parthenogenetic embryonic stem cells.Ann N Y Acad Sci. 2007 Jun;1106:209-18.
    17360798
  • Lengerke C, McKinney-Freeman S, Naveiras O, Yates F, Wang Y, Bansal D, Daley GQ.The Cdx-Hox pathway in hematopoietic stem cell formation from embryonic stem cells.Ann N Y Acad Sci. 2007 Jun;1106:197-208.
    17303828
  • Cortes J, Jabbour E, Daley GQ, O'Brien S, Verstovsek S, Ferrajoli A, Koller C, Zhu Y, Statkevich P, Kantarjian H.Phase 1 study of lonafarnib (SCH 66336) and imatinib mesylate in patients with chronic myeloid leukemia who have failed prior single-agent therapy with imatinib.Cancer. 2007 Sep 15;110(6):1295-302.
    17623836
  • North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI.Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.Nature. 2007 Jun 21;447(7147):1007-11.
    17581586
  • Chen Z, Naveiras O, Balduini AA, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA.The May-Hegglin anomaly gene Myh9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.Blood. 2007 Jul 1;110(1):171-9.
    17392504
  • Raz T, Nardi V, Azam M, Cortes J, Daley GQ.Farnesyl transferase inhibitor resistance probed by target mutagenesis.Blood. 2007 Sep 15;110(6):2102-9.
    17536018
  • McKinney-Freeman SL, Daley GQ.Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future.Curr Opin Hematol. 2007 Jul;14(4):343-7. Review.
    17534159
  • Daley GQ.Gametes from embryonic stem cells: a cup half empty or half full?.Science. 2007 Apr 20;316(5823):409-10. Review.
    17446394
  • Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Scholer HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L.Ethics. The ISSCR guidelines for human embryonic stem cell research.Science. 2007 Feb 2;315(5812):603-4.
    17272706
  • Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly MJ, Daley GQ.Histocompatible embryonic stem cells by parthenogenesis.Science. 2007 Jan 26;315(5811):482-6.
    17170255
  • Zaehres H, Daley GQ.Transgene expression and RNA interference in embryonic stem cells.Methods Enzymol. 2006;420:49-64.
    17161693
  • Geijsen N, Daley GQ.Male germ cells.Methods Enzymol. 2006;418:307-14.
    17141043
  • Bansal D, Scholl C, Frhling S, McDowell E, Lee BH, Dhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ.Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16924-9.
    17068127
  • Azam M, Nardi V, Shakespeare WC, Metcalf CA, Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ.Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9244-9.
    16754879
  • Naveiras O, Daley GQ.Stem cells and their niche: a matter of fate.Cell Mol Life Sci. 2006 Apr;63(7-8):760-6. Review.
    16568245
  • Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Sahr KE, Adlam MJ, Kyba M, Daley GQ, Keller G, Baron MH.Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.Blood. 2006 Apr 15;107(8):3122-30.
    16403910
  • Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS.Novel role for PDEF in epithelial cell migration and invasion.Cancer Res. 2005 Dec 15;65(24):11572-80.
    16357167
  • Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ.Embryonic stem cell-derived hematopoietic stem cells.Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19081-6.
    16357205
  • Lensch MW, Daley GQ.Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells.Blood. 2006 Apr 1;107(7):2605-12.
    16332966
  • Lerou PH, Daley GQ.Therapeutic potential of embryonic stem cells.Blood Rev. 2005 Nov;19(6):321-331.
    16275420
  • Lengerke C, Daley GQ.Patterning definitive hematopoietic stem cells from embryonic stem cells.Exp Hematol. 2005 Sep;33(9):971-9.
    16140144
  • Daley GQ.Customized human embryonic stem cells.Nat Biotechnol. 2005 Jul;23(7):826-8.
    16003368
  • Daley GQ, Sandel MJ, Moreno JD.Stem cell research: science, ethics and policy.Med Ethics (Burlingt, Mass). 2005 Winter;12(1):5.
    15856604
  • Zaehres H, Lensch MW, Daheron L, Stewart SA, Itskovitz-Eldor J, Daley GQ.High-efficiency RNA interference in human embryonic stem cells.Stem Cells. 2005 Mar;23(3):299-305.
    15749924
  • Barnes K, McIntosh E, Whetton AD, Daley GQ, Bentley J, Baldwin SA.Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.Oncogene. 2005 May 5;24(20):3257-67.
    15735728
  • Kubo A, Chen V, Kennedy M, Zahradka E, Daley GQ, Keller G.The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation.Blood. 2005 Jun 15;105(12):4590-7.
    15728128
  • Weisberg E, Manley PW, Breitenstein W, Brggen J, Cowan-Jacob SW, Ray A, Huntly B, Fabbro D, Fendrich G, Hall-Meyers E, Kung AL, Mestan J, Daley GQ, Callahan L, Catley L, Cavazza C, Azam M, Mohammed A, Neuberg D, Wright RD, Gilliland DG, Griffin JD.Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.Cancer Cell. 2005 Feb;7(2):129-41.
    15710326
  • Daley GQ.Alchemy in the liver: fact or fusion?.Nat Med. 2004 Jul;10(7):671-2.
    15229507
  • Lensch MW, Daley GQ.Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models.Curr Top Dev Biol. 2004;60:127-96.
    15094298
  • Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P.A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.Oncogene. 2004 Jun 3;23(26):4641-5.
    15064711
  • Prudhomme W, Daley GQ, Zandstra P, Lauffenburger DA.Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2900-5.
    14978270
  • West JA, Daley GQ.Human embryonic stem cells.Bone Marrow Transplant. 2004 Jan;33(1):135.
    14704666
  • Kyba M, Perlingeiro RC, Daley GQ.Development of hematopoietic repopulating cells from embryonic stem cells.Methods Enzymol. 2003;365:114-29.
    14696341
  • Nardi V, Azam M, Daley GQ.Mechanisms and implications of imatinib resistance mutations in BCR-ABL.Curr Opin Hematol. 2004 Jan;11(1):35-43.
    14676625
  • Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ.Derivation of embryonic germ cells and male gametes from embryonic stem cells.Nature. 2004 Jan 8;427(6970):148-54.
    14668819
  • Koh EY, Chen T, Daley GQ.Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation.Oncogene. 2004 Feb 12;23(6):1214-20.
    14647454
  • Daley GQ, Goodell MA, Snyder EY.Realistic prospects for stem cell therapeutics.Hematology Am Soc Hematol Educ Program. 2003:398-418.
    14633792
  • Azam M, Raz T, Nardi V, Opitz SL, Daley GQ.A screen to identify drug resistant variants to target-directed anti-cancer agents.Biol Proced Online. 2003;5:204-210.
    14615817
  • Kyba M, Daley GQ.Hematopoiesis from embryonic stem cells: lessons from and for ontogeny.Exp Hematol. 2003 Nov;31(11):994-1006.
    14585361
  • Larson RA, Daley GQ, Schiffer CA, Porcu P, Pui CH, Marie JP, Steelman LS, Bertrand FE, McCubrey JA.Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.Leukemia. 2003 Dec;17(12):2358-82.
    14562120
  • Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI.cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.Nature. 2003 Sep 18;425(6955):300-6.
    13679919
  • Kyba M, Perlingeiro RC, Hoover RR, Lu CW, Pierce J, Daley GQ.Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5.Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11904-10.
    12930895
  • Daley GQ.Cloning and stem cells--handicapping the political and scientific debates.N Engl J Med. 2003 Jul 17;349(3):211-2.
    12867604
  • Daley GQ.From embryos to embryoid bodies: generating blood from embryonic stem cells.Ann N Y Acad Sci. 2003 May;996:122-31.
    12799290
  • Daley GQ.Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors.Semin Hematol. 2003 Apr;40(2 Suppl 2):11-4.
    12783369
  • Perlingeiro RC, Kyba M, Bodie S, Daley GQ.A role for thrombopoietin in hemangioblast development.Stem Cells. 2003;21(3):272-80.
    12743322
  • Daley GQ.Gleevec resistance: lessons for target-directed drug development.Cell Cycle. 2003 May-Jun;2(3):190-1.
    12734421
  • Daley GQ.Dodging the magic bullet: understanding imatinib resistance.Cancer Biol Ther. 2003 Jan-Feb;2(1):109-10.
    12673130
  • Azam M, Latek RR, Daley GQ.Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.Cell. 2003 Mar 21;112(6):831-43.
    12654249
  • Koh EY, Chen T, Daley GQ.Novel retroviral vectors to facilitate expression screens in mammalian cells.Nucleic Acids Res. 2002 Dec 15;30(24):e142.
    12490733
  • Daley GQ.Prospects for stem cell therapeutics: myths and medicines.Curr Opin Genet Dev. 2002 Oct;12(5):607-13.
    12200167
  • Hoover RR, Mahon FX, Melo JV, Daley GQ.Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.Blood. 2002 Aug 1;100(3):1068-71.
    12130526
  • Kyba M, Perlingeiro RC, Daley GQ.HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.Cell. 2002 Apr 5;109(1):29-37.
    11955444
  • Rideout WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R.Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.Cell. 2002 Apr 5;109(1):17-27.
    11955443
  • Dang SM, Kyba M, Perlingeiro R, Daley GQ, Zandstra PW.Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems.Biotechnol Bioeng. 2002 May 20;78(4):442-53.
    11948451
  • Jena N, Deng M, Sicinska E, Sicinski P, Daley GQ.Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.Cancer Res. 2002 Jan 15;62(2):535-41.
    11809706
  • Perlingeiro RC, Kyba M, Daley GQ.Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential.Development. 2001 Nov;128(22):4597-604.
    11714684
  • Hoover RR, Gerlach MJ, Koh EY, Daley GQ.Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells.Oncogene. 2001 Sep 13;20(41):5826-35.
    11593388
  • Peters DG, Klucher KM, Perlingeiro RC, Dessain SK, Koh EY, Daley GQ.Autocrine and paracrine effects of an ES-cell derived, BCR/ABL-transformed hematopoietic cell line that induces leukemia in mice.Oncogene. 2001 May 10;20(21):2636-46.
    11420675
  • Deng M, Daley GQ.Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.Blood. 2001 Jun 1;97(11):3491-7.
    11369642
  • Reichert A, Heisterkamp N, Daley GQ, Groffen J.Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.Blood. 2001 Mar 1;97(5):1399-403.
    11222386
  • Peters DG, Hoover RR, Gerlach MJ, Koh EY, Zhang H, Choe K, Kirschmeier P, Bishop WR, Daley GQ.Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia.Blood. 2001 Mar 1;97(5):1404-12.
    11222387
  • Jacobs JJ, Keblusek P, Robanus-Maandag E, Kristel P, Lingbeek M, Nederlof PM, van Welsem T, van de Vijver MJ, Koh EY, Daley GQ, van Lohuizen M.Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.Nat Genet. 2000 Nov;26(3):291-9.
    11062467
  • Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA.Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation.Biotechnol Bioeng. 2000 Sep 20;69(6):607-17.
    10918135
  • Berns K, Hijmans EM, Koh E, Daley GQ, Bernards R.A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts.Oncogene. 2000 Jul 6;19(29):3330-4.
    10918589
  • Salgia R, Quackenbush E, Lin J, Souchkova N, Sattler M, Ewaniuk DS, Klucher KM, Daley GQ, Kraeft SK, Sackstein R, Alyea EP, von Andrian UH, Chen LB, Gutierrez-Ramos JC, Pendergast AM, Griffin JD.The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.Blood. 1999 Dec 15;94(12):4233-46.
    10590068
  • Ghaffari S, Wu H, Gerlach M, Han Y, Lodish HF, Daley GQ.BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells.Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13186-90.
    10557295
  • Ghaffari S, Daley GQ, Lodish HF.Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays.Leukemia. 1999 Aug;13(8):1200-6.
    10450747
  • Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES.Characterization of single-nucleotide polymorphisms in coding regions of human genes.Nat Genet. 1999 Jul;22(3):231-8.
    10391209
  • Li S, Ilaria RL, Million RP, Daley GQ, Van Etten RA.The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity.J Exp Med. 1999 May 3;189(9):1399-412.
    10224280
  • Klucher KM, Lopez DV, Daley GQ.Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression.Blood. 1998 May 15;91(10):3927-34.
    9573031
  • Socolovsky M, Lodish HF, Daley GQ.Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors.Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6573-5.
    9618452
  • Murray PJ, Young RA, Daley GQ.Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria.Blood. 1998 Apr 15;91(8):2914-24.
    9531602
  • Klucher KM, Gerlach MJ, Daley GQ.A novel method to isolate cells with conditional gene expression using fluorescence activated cell sorting.Nucleic Acids Res. 1997 Dec 1;25(23):4858-60.
    9365269
  • Daley GQ.Rationalizing autotransplant strategies for chronic myeloid leukemia.Leuk Lymphoma. 1996 May;21(5-6):353-8.
    9172799
  • Daley GQ, Van Etten RA, Jackson PK, Bernards A, Baltimore D.Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.Mol Cell Biol. 1992 Apr;12(4):1864-71.
    1549131
  • Daley GQ, Van Etten RA, Baltimore D.Blast crisis in a murine model of chronic myelogenous leukemia.Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11335-8.
    1763047
  • Scott ML, Van Etten RA, Daley GQ, Baltimore D.v-abl causes hematopoietic disease distinct from that caused by bcr-abl.Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6506-10.
    1862078
  • Varticovski L, Daley GQ, Jackson P, Baltimore D, Cantley LC.Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.Mol Cell Biol. 1991 Feb;11(2):1107-13.
    1846663
  • Daley GQ, Ben-Neriah Y.Implicating the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia.Adv Cancer Res. 1991;57:151-84.
    1950703
  • Daley GQ, Baltimore D.Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.Proc Natl Acad Sci U S A. 1988 Dec;85(23):9312-6.
    3143116
  • Daley GQ, McLaughlin J, Witte ON, Baltimore D.The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts.Science. 1987 Jul 31;237(4814):532-5.
    2440107
  • Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D.The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.Science. 1986 Jul 11;233(4760):212-4.
    3460176