Sabina Signoretti, MD

Publications

• Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM.Transgenic expression of polyoma virus middle T antigen in the mouse prostate gives rise to carcinoma.J Virol. 2011 Mar 16.
  21411524
• Flavin R, Finn SP, Choueiri TK, Ingoldsby H, Ring M, Barrett C, Rogers M, Smyth P, O'Regan E, Gaffney E, O'Leary JJ, Loda M, Signoretti S, Sheils O.RET protein expression in papillary renal cell carcinoma.Urol Oncol. 2011 Mar 9.
  21396847
• Bernardi R, Papa A, Egia A, Coltella N, Teruya-Feldstein J, Signoretti S, Pandolfi PP.Pml represses tumour progression through inhibition of mTOR.EMBO Mol Med. 2011 Feb 17.
  21387562
• Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho R
  21289624
• Genega EM, Ghebremichael M, Najarian R, Fu Y, Wang Y, Argani P, Grisanzio C, Signoretti S.Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade.Am J Clin Pathol. 2010 Dec;134(6):873-9.
  21088149
• Yang W, Ahmed M, Elian M, Hady ES, Levchenko TS, Sawant RR, Signoretti S, Collins M, Torchilin VP, Goldberg SN.Do Liposomal Apoptotic Enhancers IncreaseTumor Coagulation and End-Point Survival in Percutaneous Radiofrequency Ablation of Tumors in a Rat Tum
  20858851
• Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA.FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumori
  21075312
• Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, Goldberg SN, Atkins MB, Mier JW.Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling.Mol Cancer Ther. 2010 Oct;9(10):2793-802.
  20699227
• Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG.Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.Circulation. 2010 Sep 7;122(10):1004-16
  20733101
• Choueiri TK, Regan MM, Rosenberg JE, Oh WK, Clement J, Amato AM, McDermott D, Cho DC, Atkins MB, Signoretti S.Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving va
  20230385
• Cho DC, Cohen MB, Panka DJ, Collins M, Ghebremichael M, Atkins MB, Signoretti S, Mier JW.The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma.Clin Cancer Res. 2010 Jul 15;16(14):3628-38.
  20606035
• Bhatt RS, Zhang L, Bullock A, Moreno K, Signoretti S, Atkins M, Sabbadini R, Mier J.Sphingosine-1-phosphate (S1P) as a novel target in renal cancer (RCC).AACR Proceedings 2010..
• Lee SH, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LC, Roberts TM.A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.Proc Natl Acad Sci U S A. 2010 Jun 15;107(
  20534477
• McDermott DF, Ghebremichael M, Signoretti S, Margolin KA, Clark J, Sosman JA, Dutcher JP, French M, Regan MM, Atkins MB.The high-dose aldesleukin (HD IL-2) "Select" Trial in patients with metastatic renal cell carcinoma (mRCC).Journal of Clinica
• Panka DJ, Collins M, Atkins MB, Signoretti S, Mier JW.Enhancement of efficacy of sorafenib and sunitinib with the HDM2 antagonist MI-319 in RCC tumor xenografts.AACR Proceedings..
• Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN.Liposomal Doxorubicin Increases Radiofrequency Ablation-induced Tumor Destruction by Increasing Cellular Oxidative and Ni
  20160000
• Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Lo
  20164920
• Hulick P, Zimmer M, Margulis V, Skates S, Hamel M, Dahl DM, Michaelson DM, Libermann T, Signoretti S, Carney W, Wood C, Iliopoulos O.Blood Levels of Carbonic Anhydrase 9 Correlate with Clear Cell Renal Cell Carcinoma Activity.Clin. Proteomics.;5(1):37-45.
• Wiklund F, Tretli S, Choueiri TK, Signoretti S, Fall K, Adami HO.Risk of bilateral renal cell cancer.J Clin Oncol. 2009 Aug 10;27(23):3737-41.
  19597028
• Bhatt R, Wang X, Zhang L, Bhasin M, Libermann T, O’Neil A, Signoretti S, Atkins M, Mier J, Goldberg SN.Cox-2 inhibition delays resistance to sunitinib in RCC xenograft models.AACR Proceedings 2009..
• Walker SR, Nelson EA, Zou L, Chaudhury M, Signoretti S, Richardson A, Frank DA.Reciprocal effects of STAT5 and STAT3 in breast cancer.Mol Cancer Res. 2009 Jun;7(6):966-76.
  19491198
• Sabbisetti V, Di Napoli A, Seeley A, Amato AM, O'Regan E, Ghebremichael M, Loda M, Signoretti S.p63 promotes cell survival through fatty acid synthase.PLoS ONE. 2009;4(6):e5877.
  19517019
• Schor-Bardach R,Alsop DC,Pedrosa I,Solazzo SA,Wang X,Marquis RP,Atkins MB,Regan M,Signoretti S,Lenkinski RE,Goldberg SN.Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in
  19474376
• Beroukhim R,Brunet JP,Di Napoli A,Mertz KD,Seeley A,Pires MM,Linhart D,Worrell RA,Moch H,Rubin MA,Sellers WR,Meyerson M,Linehan WM,Kaelin WG Jr,Signoretti S.Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated an
  19470766
• Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, Zurita AJ, King L.Innovations and challenges in renal cancer: summary statement from the
  19402064
• Di Napoli A, Signoretti S.Tissue biomarkers in renal cell carcinoma: issues and solutions.Cancer. 2009 May 15;115(10 Suppl):2290-7. Review.
  19402057
• Atkins MB, Choueiri TK, Cho D, Regan M, Signoretti S.Treatment selection for patients with metastatic renal cell carcinoma.Cancer. 2009 May 15;115(10 Suppl):2327-33. Review.
  19402069
• Migita T,Ruiz S,Fornari A,Fiorentino M,Priolo C,Zadra G,Inazuka F,Grisanzio C,Palescandolo E,Shin E,Fiore C,Xie W,Kung AL,Febbo PG,Subramanian A,Mucci L,Ma J,Signoretti S,Stampfer M,Hahn WC,Finn S,Loda M.Fatty acid synthase: a metabolic enzyme and candida
  19318631
• Xie H,Valera VA,Merino MJ,Amato AM,Signoretti S,Linehan WM,Sukhatme VP,Seth P.LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.Mol Cancer Ther. 2009 Mar;8(3):626-35.
  19276158
• Majumder PK,Grisanzio C,O'Connell F,Barry M,Brito JM,Xu Q,Guney I,Berger R,Herman P,Bikoff R,Fedele G,Baek WK,Wang S,Ellwood-Yen K,Wu H,Sawyers CL,Signoretti S,Hahn WC,Loda M,Sellers WR.A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint i
  18691549
• Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.Nature.;454:776-9.
• Jia S,Liu Z,Zhang S,Liu P,Zhang L,Lee SH,Zhang J,Signoretti S,Loda M,Roberts TM,Zhao JJ.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.Nature. 2008 Aug 7;454(7205):776-9.
  18594509
• Libermann TA, Bhasin M, Joseph MG, Signoretti S, Ernstoff MS, McDermott D, Atkins MB.Gene Expression Profiling Signatures Associated with RCC response to IL-2 Therapy.Proceedings of the 23rd ISBTC Meeting, J Immunotherapy ..
• Sabir A,Schor-Bardach R,Wilcox CJ,Rahmanuddin S,Atkins MB,Kruskal JB,Signoretti S,Raptopoulos VD,Goldberg SN.Perfusion MDCT enables early detection of therapeutic response to antiangiogenic therapy.AJR Am J Roentgenol. 2008 Jul;191(1):133-9.
  18562736
• Signoretti S, Bratslavsky G, Waldman FM, Reuter VE, Haaga J, Merino M, Thomas GV, Pins MR, Libermann T, Gillespie J, Tomaszewski JE, Compton CC, Hruszkewycz A, Linehan WM, Atkins MB.Tissue-based research in kidney cancer: current challenges and future dir
  18559586
• Jaeger E, Waldman F, Roydasgupta R, Klatte T, McDermott DF, Signoretti S, Atkins MB, LaRochelle J, Belledegrun AS, Pantuck AJ.Array-based comparative genomic hybridization (CGH) identifies imbalances between interleukin-2 complete and non-responders.Journ
• Regan MM, Brick AJ, Choueiri TK, Clement JM, Kwabi C, Shah K, Amato A, McDermott DF, Atkins MB, Signoretti S.Carbonic anhydrase IX (CA IX) and pathologic features as predictors of outcome in patients (pts) with metastatic renal cell carcinoma (mRCC) recei
• Signoretti S,Regan M,Atkins M.Carbonic anhydrase IX as a predictive biomarker of response to kidney cancer therapy.BJU Int. 2008 Jun;101 Suppl 4:31-5. Review.
  18430120
• Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG Jr.VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.Nat Cell Biol. 2008 Mar;10(3):361-9.
  18297059
• Cho D, Signoretti S, Dabora S, Regan M, Seeley A, Mariotti M, Youmans A, Polivy A, Mandato L, McDermott D, Stanbridge E, Atkins M.Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma.Clin
  17956710
• Grisanzio C, Signoretti S.p63 in prostate biology and pathology.J Cell Biochem. 2008 Apr 1;103(5):1354-68. Review.
  17879953
• Hakime A, Hines-Peralta A, Peddi H, Atkins MB, Sukhatme VP, Signoretti S, Regan M, Goldberg SN.Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice.Radiology. 2007 Aug;244(2):464-70.
  17641366
• Signoretti S, Loda M.Prostate stem cells: From development to cancer.Semin Cancer Biol. 2007 Jun;17(3):219-24. Review.
  16781871
• Sabir A, Schor-Bardach R, Wilcox CJ, Rahmanuddin S, Atkins MB, Kruskal JB, Signoretti S, Regan M, Raptopoulos VD, Goldberg SM.Multislice CT Perfusion Imaging Enables Early Detection of Therapeutic Response to Antiangiogenic Therapy.Radiology. 2007 Mar 01;
• Cho D, Signoretti S, Regan M, Mier JW, Atkins MB.The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer.Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):758s-763s. Review.
  17255306
• Zhan Q, Signoretti S, Whitaker-Menezes D, Friedman TM, Korngold R, Murphy GF.Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype.J Invest Dermatol. 2007 Jan;127(1):106-15.
  17039241
• De Marzo AM, Platz EA, Epstein JI, Ali T, Billis A, Chan TY, Cheng L, Datta M, Egevad L, Ertoy-Baydar D, Farre X, Fine SW, Iczkowski KA, Ittmann M, Knudsen BS, Loda M, Lopez-Beltran A, Magi-Galluzzi C, Mikuz G, Montironi R, Pikarsky E, Pizov G, Rubin MA,
  17001160
• Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M.Androgen-dependent regulation of Her-2/neu in prostate cancer cells.Cancer Res. 2006 Jun 1;66(11):5723-8.
  16740710
• Hines-Peralta A, Sukhatme V, Regan M, Signoretti S, Liu ZJ, Goldberg SN.Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models.Radiology. 2006 Jul;240(1):82-9.
  16720872
• Signoretti S, Loda M.Defining cell lineages in the prostate epithelium.Cell Cycle. 2006 Jan;5(2):138-41.
  16357539
• Signoretti S, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F, Kantoff PW, Sellers WR, Loda M.p63 regulates commitment to the prostate cell lineage.Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11355-60.
  16051706
• Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC.Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide
  16006513
• Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S.Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.Clin Cancer Res. 2005 May 15;11(10):3714-21.
  15897568
• Ahmed M, Liu Z, Lukyanov AN, Signoretti S, Horkan C, Monsky WL, Torchilin VP, Goldberg SN.Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in anima
  15858089
• Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, McDermott D, Quiceno D, Youmans A, O'Neill A, Mier J, Ochoa AC.Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.Cancer Res. 2
  15833831
• Horkan C, Dalal K, Coderre JA, Kiger JL, Dupuy DE, Signoretti S, Halpern EF, Goldberg SN.Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model.Radiology. 2005 Apr;235(1):81-8.
  15731375
• Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Cancer Res. 2004 Dec 15;64(24):8867-
  15604246
• Atkins M, McDermott D, Mier J, Stanbridge E, Youmans A, Regan M., Febbo P Upton M, Lechpammer M, Signoretti S.Carbonic Anhydrase IX (CAIX) expression predicts for renal cell cancer (RCC) patient response and survival to IL-2 therapy.J Clin Oncol.:In Pres
• Murphy M, Carlson JA, Keough MP, Claffey KP, Signoretti S, Loda M.Hypoxia regulation of the cell cycle in malignant melanoma: putative role for the cyclin-dependent kinase inhibitor p27.J Cutan Pathol. 2004 Aug;31(7):477-82.
  15239677
• Graner E, Tang D, Rossi S, Baron A, Migita T, Weinstein LJ, Lechpammer M, Huesken D, Zimmermann J, Signoretti S, Loda M.The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.Cancer Cell. 2004 Mar;5(3):253-61.
  15050917
• Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, Bhattacharya N, Loda M.Intermediate basal cells of the prostate: in vitro and in vivo characterization.Prostate. 2003 May 15;55(3):206-18.
  12692787
• Weinstein MH, Signoretti S, Loda M.Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells.Mod Pathol. 2002 Dec;15(12):1302-8.
  12481011
• Lindeman N, Waltregny D, Signoretti S, Loda M.Gene transcript quantitation by real-time RT-PCR in cells selected by immunohistochemistry-laser capture microdissection.Diagn Mol Pathol. 2002 Dec;11(4):187-92.
  12459634
• Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.Nature. 2002 Sep 12;419(6903):162-7.
  12226664
• Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M, Pagano M.Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.J Clin Invest. 2002 Sep;110(5):633-41.
  12208864
• Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K.Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of
  12037666
• DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M.Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.Cancer Res. 2002 Jan 1;62(1):89-98.
  11782364
• Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA.Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.Mol Cell Biol. 2002 Jan;22(2):635-43.
  11756558