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Randall W. King, MD, PhD

Publications

  • Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW.Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Nature. 2014 Aug 24.
    25156254
  • Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y.The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.Mol Cell Biol. 2013 Nov;33(21):4166-80.
    23979597
  • Lee BH, Finley D, King RW.A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14.Curr Protoc Chem Biol. 2012 Dec 1;4(4):311-30.
    23788557
  • Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M.A non-genetic route to aneuploidy in human cancers.Nat Cell Biol. 2011 Mar;13(3):324-30.
    21336303
  • Sigoillot FD, King RW.Vigilance and validation: Keys to success in RNAi screening.ACS Chem Biol. 2011 Jan 21;6(1):47-60.
    21142076
  • Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW.Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.Cancer Cell. 2010 Oct 19;18(4):382-95.
    20951947
  • Lee MJ, Lee BH, Hanna J, King RW, Finley D.Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.Mol Cell Proteomics. 2010 Sep 8.
    20823120
  • Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D.Enhancement of proteasome activity by a small-molecule inhibitor of USP14.Nature. 2010 Sep 9;467(7312):179-84.
    20829789
  • Normand G, King RW.Understanding cytokinesis failure.Adv Exp Med Biol. 2010;676:27-55. Review.
    20687468
  • Biswas D, Ranganathan B, King R, Siddiqui N.How we do it: 'tonsillectomy mat', scored rubber sheet to fix the Draffin's rods.European Archives Of Oto Rhino Laryngology : Official Journal Of The European Federation Of Oto Rhino Laryngological Societies (Eufos) : Affiliated With The German Society For Oto Rhino Laryngology Head And Neck Surgery. 2010 Jan;267(1):149-50.
    19834726
  • Pasick J, Berhane Y, Kehler H, Hisanaga T, Handel K, Robinson J, Ojkic D, Kibenge F, Fortin M, King R, Hamel A, Spiro D, Parmley J, Soos C, Jenkins E, Breault A, Caswell D, Davies C, Rodrigue J, McAloney K, Leighton F.Survey of influenza A viruses circulating in wild birds in Canada 2005 to 2007.Avian Dis. 2010 Mar;54(1 Suppl):440-5.
    20521675
  • Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, Zurita AJ, King L.Innovations and challenges in renal cancer: summary statement from the Third Cambridge Conference.Cancer. 2009 May 15;115(10 Suppl):2247-51.
    19402064
  • King RW.When 2+2=5: the origins and fates of aneuploid and tetraploid cells.Biochim Biophys Acta. 2008 Sep;1786(1):4-14. Review.
    18703117
  • Peng M, Falk MJ, Haase VH, King R, Polyak E, Selak M, Yudkoff M, Hancock WW, Meade R, Saiki R, Lunceford AL, Clarke CF, L Gasser D.Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease.PLoS Genet. 2008 Apr;4(4):e1000061.
    18437205
  • Abbasi NR, Yancovitz M, Gutkowicz-Krusin D, Panageas KS, Mihm MC, Googe P, King R, Prieto V, Osman I, Friedman RJ, Rigel DS, Kopf AW, Polsky D.Utility of lesion diameter in the clinical diagnosis of cutaneous melanoma.Arch Dermatol. 2008 Apr;144(4):469-74.
    18427040
  • Friedman RJ, Gutkowicz-Krusin D, Farber MJ, Warycha M, Schneider-Kels L, Papastathis N, Mihm MC Jr, Googe P, King R, Prieto VG, Kopf AW, Polsky D, Rabinovitz H, Oliviero M, Cognetta A, Rigel DS, Marghoob A, Rivers J, Johr R, Grant-Kels JM, Tsao H.The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas.Arch Dermatol. 2008 Apr;144(4):476-82.
    18427041
  • Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS.A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.Cell. 2007 Nov 30;131(5):966-79.
    18045538
  • Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D.Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.Nat Struct Mol Biol. 2007 Dec;14(12):1180-8.
    18026118
  • Bentley AM, Normand G, Hoyt J, King RW.Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis.Mol Biol Cell. 2007 Dec;18(12):4847-58.
    17881737
  • Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP.Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.Nat Cell Biol. 2006 Jul;8(7):700-10.
    16799550
  • Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI.Small molecules that delay S phase suppress a zebrafish bmyb mutant.Nat Chem Biol. 2005 Dec;1(7):366-70.
    16372403
  • Hoyt J, King RW.Adenoviral expression of reporter proteins for high-throughput cell-based screening.Methods Mol Biol. 2005;310:187-95.
    16353377
  • Salic A, King RW.Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts.Methods Enzymol. 2005;399:567-85.
    16338382
  • Shi Q, King RW.Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.Nature. 2005 Oct 13;437(7061):1038-42.
    16222248
  • Lorang J, King RW.Cytological profiling: providing more haystacks for chemists' needles.Genome Biol. 2005;6(8):228.
    16086858
  • Hathaway NA, King RW.Dissecting cell biology with chemical scalpels.Curr Opin Cell Biol. 2005 Feb;17(1):12-9.
    15661514
  • Tochtrop GP, King RW.Target identification strategies in chemical genetics.Comb Chem High Throughput Screen. 2004 Nov;7(7):677-88.
    15578930
  • Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW.Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.Science. 2004 Oct 1;306(5693):117-20.
    15459393
  • Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT.Small molecule regulators of protein arginine methyltransferases.J Biol Chem. 2004 Jun 4;279(23):23892-9.
    15056663
  • King RW.Roughing up Smoothened: chemical modulators of hedgehog signaling.J Biol. 2002 Nov 6;1(2):8.
    12437769
  • Walling LA, Peters NR, Horn EJ, King RW.New technologies for chemical genetics.J Cell Biochem Suppl. 2001;Suppl 37:7-12.
    11842422
  • Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA.A one-bead, one-stock solution approach to chemical genetics: part 2.Chem Biol. 2001 Dec;8(12):1183-95.
    11755397
  • Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL.Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis.Chem Biol. 2000 Apr;7(4):275-86.
    10780927
  • King RW.Chemistry or biology: which comes first after the genome is sequenced?.Chem Biol. 1999 Dec;6(12):R327-33.
    10631509
  • Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ.Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.Science. 1999 Oct 29;286(5441):971-4.
    10542155
  • Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW.Identification of a cullin homology region in a subunit of the anaphase-promoting complex.Science. 1998 Feb 20;279(5354):1219-22.
    9469815
  • King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW.Expression cloning in the test tube.Science. 1997 Aug 15;277(5328):973-4.
    9281074
  • Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW.Systematic identification of mitotic phosphoproteins.Curr Biol. 1997 May 1;7(5):338-48.
    9115395
  • Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW.Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development.Methods Enzymol. 1997;283:83-99.
    9251013
  • King RW, Deshaies RJ, Peters JM, Kirschner MW.How proteolysis drives the cell cycle.Science. 1996 Dec 6;274(5293):1652-9.
    8939846
  • Peters JM, King RW, Hg C, Kirschner MW.Identification of BIME as a subunit of the anaphase-promoting complex.Science. 1996 Nov 15;274(5290):1199-201.
    8895470
  • King RW, Glotzer M, Kirschner MW.Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.Mol Biol Cell. 1996 Sep;7(9):1343-57.
    8885231
  • Yu H, King RW, Peters JM, Kirschner MW.Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation.Curr Biol. 1996 Apr 1;6(4):455-66.
    8723350
  • King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW.A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.Cell. 1995 Apr 21;81(2):279-88.
    7736580
  • King RW, Jackson PK, Kirschner MW.Mitosis in transition.Cell. 1994 Nov 18;79(4):563-71.
    7954823
  • Holloway SL, Glotzer M, King RW, Murray AW.Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.Cell. 1993 Jul 2;73(7):1393-402.
    8391932