• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Kun Ping Lu, MD, PhD


  • Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP.Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer.Cancer Res. 2014 May 1.
  • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.Nature. 2014 Apr 24;508(7497):541-5.
  • Jalouli M, Déry MA, Lafleur VN, Lamalice L, Zhou XZ, Lu KP, Richard DE.The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity.Cell Signal. 2014 Apr 12.
  • De S, Greenwood AI, Rogals MJ, Kovrigin EL, Lu KP, Nicholson LK.Complete Thermodynamic and Kinetic Characterization of the Isomer-Specific Interaction between Pin1-WW Domain and the Amyloid Precursor Protein Cytoplasmic Tail Phosphorylated at Thr668.Biochemistry. 2012 Oct 16.
  • Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP.Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.Mol Cell Biol. 2012 Aug;32(15):2966-78.
  • Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP.Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.Mol Cell. 2012 Jun 29;46(6):771-83.
  • Luo T, Yu J, Nguyen J, Wang CR, Bristow RG, Jaffray DA, Zhou XZ, Lu KP, Lu QB.Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers.Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10175-80.
  • Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP.The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.J Clin Invest. 2011 Mar 23.
  • Soohoo CY, Shi R, Lee TH, Huang P, Lu KP, Zhou XZ.Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.J Biol Chem. 2011 Feb 4;286(5):3894-906.
  • Driver JA, Lu KP.Pin1: A New Genetic Link between Alzheimer's Disease, Cancer and Aging.Current Aging Science. 2010 Dec;3(3):158-65.
  • Fan G,Fan Y,Gupta N,Matsuura I,Liu F,Zhou XZ,Lu KP,Gelinas C.Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.Cancer Res. 2009 Jun 1;69(11):4589-97.
  • Ryo A,Wulf G,Lee TH,Lu KP.Pinning down HER2-ER crosstalk in SMRT regulation.Trends Biochem Sci. 2009 Apr;34(4):162-5.
  • Lam PB,Burga LN,Wu BP,Hofstatter EW,Lu KP,Wulf GM.Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.Mol Cancer. 2008;7:91.
  • Cole AR, Soutar MP, Rembutsu M, Van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C.Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.J Biol Chem. 2008 Jun 27;283(26):18227-37.
  • Lu HF, Chen YS, Yang JS, Chen JC, Lu KW, Chiu TH, Liu KC, Yeh CC, Chen GW, Lin HJ, Chung JG.Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells.In Vivo. 2008 Mar-Apr;22(2):215-21.
  • Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, Broaddus RR, Walker CL.Loss of tuberous sclerosis complex-2 function and activation of Mammalian target of rapamycin signaling in endometrial carcinoma.Clin Cancer Res. 2008 May 1;14(9):2543-50.
  • Liao WL, Tsai HC, Wang HF, Chang J, Lu KM, Wu HL, Lee YC, Tsai TF, Takahashi H, Wagner M, Ghyselinck NB, Chambon P, Liu FC.Modular patterning of structure and function of the striatum by retinoid receptor signaling.Proc Natl Acad Sci U S A. 2008 May 6;105(18):6765-70.
  • Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP.Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.J Clin Invest. 2008 May 1;118(5):1877-1889.
  • Dehart WK, Gilliam AC, Lu KQ, Brell J.A rare case of melanoma recurring as subcutaneous metastatic melanoma with overlying ecchymoses.Arch Dermatol. 2008 Apr;144(4):561-2.
  • Wildemann D, Hernandez Alvarez B, Stoller G, Zhou XZ, Lu KP, Erdmann F, Ferrari D, Fischer G.An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors.Biol Chem. 2007 Oct;388(10):1103-11.
  • Lu KP, Finn G, Lee TH, Nicholson LK.Prolyl cis-trans isomerization as a molecular timer.Nat Chem Biol. 2007 Oct;3(10):619-29. Review.
  • Li QM, Tep C, Yune TY, Zhou XZ, Uchida T, Lu KP, Yoon SO.Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury.J Neurosci. 2007 Aug 1;27(31):8395-404.
  • Balastik M, Lim J, Pastorino L, Lu KP.Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?.Biochim Biophys Acta. 2007 Apr;1772(4):422-9. Review.
  • Nicholson LK, Lu KP.Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.Mol Cell. 2007 Feb 23;25(4):483-5.
  • Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G.Targeting carcinogenesis: a role for the prolyl isomerase Pin1?.Mol Carcinog. 2006 Jun;45(6):397-402. Review.
  • Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.Nature. 2006 Mar 23;440(7083):528-34.
  • Wulf G, Garg P, Liou YC, Iglehart D, Lu KP.Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.EMBO J. 2004 Aug 18;23(16):3397-407.
  • Lu KP.Pinning down cell signaling, cancer and Alzheimer's disease.Trends Biochem Sci. 2004 Apr;29(4):200-9.
  • Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP.Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.Nature. 2003 Jul 31;424(6948):556-61.
  • Zhou XZ, Lu KP.The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.Cell. 2001 Nov 2;107(3):347-59.
  • Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP.The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.Nature. 1999 Jun 24;399(6738):784-8.
  • Lu PJ, Zhou XZ, Shen M, Lu KP.Function of WW domains as phosphoserine- or phosphothreonine-binding modules.Science. 1999 Feb 26;283(5406):1325-8.