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Tom Kirchhausen, PhD


  • Carmo-Fonseca M, Kirchhausen T.The timing of pre-mRNA splicing visualized in real-time.Nucleus. 2014 Jan 30;5(1).
  • Piccinotti S, Kirchhausen T, Whelan SP.Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.J Virol. 2013 Nov;87(21):11637-47.
  • Martin RM, Rino J, Carvalho C, Kirchhausen T, Carmo-Fonseca M.Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity.Cell Rep. 2013 Sep 26;4(6):1144-55.
  • Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC.Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.Immunity. 2013 Jun 27;38(6):1164-75.
  • Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV.Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.J Cell Biol. 2013 Apr 29;201(3):449-65.
  • Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.Regulation of ligand-independent Notch signal through intracellular trafficking.Commun Integr Biol. 2012 Jul 1;5(4):374-6.
  • Böcking T, Aguet F, Harrison SC, Kirchhausen T.Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.Nat Struct Mol Biol. 2011 Mar;18(3):295-301.
  • Yu A, Xing Y, Harrison SC, Kirchhausen T.Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.Structure. 2010 Oct 13;18(10):1311-20.
  • Guan R, Han D, Harrison SC, Kirchhausen T.Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.Structure. 2010 Sep 8;18(9):1191-8.
  • Harrison SC, Kirchhausen T.Structural biology: Conservation in vesicle coats.Nature. 2010 Aug 26;466(7310):1048-9.
  • Utskarpen A, Massol R, van Deurs B, Lauvrak SU, Kirchhausen T, Sandvig K.Shiga toxin increases formation of clathrin-coated pits through Syk kinase.PLoS ONE. 2010;5(7):e10944.
  • Boucrot E, Saffarian S, Zhang R, Kirchhausen T.Roles of AP-2 in clathrin-mediated endocytosis.PLoS ONE. 2010;5(5):e10597.
  • Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B.Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.Nat Cell Biol. 2010 Apr;12(4):330-40.
  • Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J.Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.Blood. 2010 Feb 25;115(8):1582-93.
  • Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC.Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.EMBO J. 2010 Feb 3;29(3):655-65.
  • Saffarian S, Cocucci E, Kirchhausen T.Distinct dynamics of endocytic clathrin-coated pits and coated plaques.PLoS Biol. 2009 Sep;7(9):e1000191.
  • Cureton DK,Massol RH,Saffarian S,Kirchhausen TL,Whelan SP.Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.PLoS Pathog. 2009 Apr;5(4):e1000394.
  • Kirchhausen T, Macia E, Pelish HE.Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.Methods Enzymol. 2008;438:77-93.
  • Boucrot E, Kirchhausen T.Mammalian Cells Change Volume during Mitosis.PLoS ONE. 2008;3(1):e1477.
  • Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M.Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.Biochemistry. 2008 Jan 8;47(1):460-72.
  • Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerda J, Finlay BB, Kirchhausen T, Cossart P.Invasive and adherent bacterial pathogens co-Opt host clathrin for infection.Cell Host Microbe. 2007 Nov 15;2(5):340-51.
  • Saffarian S, Kirchhausen T.Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane.Biophys J. 2008 Mar 15;94(6):2333-42.
  • Rapoport I, Boll W, Yu A, Bocking T, Kirchhausen T.A motif in the clathrin heavy chain required for the hsc70/auxilin uncoating reaction.Mol Biol Cell. 2008 Jan;19(1):405-13.
  • Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW.An ACAP1-containing clathrin coat complex for endocytic recycling.J Cell Biol. 2007 Jul 30;178(3):453-64.
  • Kirchhausen T.Making COPII coats.Cell. 2007 Jun 29;129(7):1251-2. Review.
  • Jiang S, Zhou X, Kirchhausen T, Wong ST.Tracking molecular particles in live cells using fuzzy rule-based system.Cytometry A. 2007 Aug;71(8):576-84.
  • Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL.PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.Mol Biol Cell. 2007 Jul;18(7):2646-55.
  • Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.Dev Cell. 2007 Jan;12(1):129-41.
  • Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A.The transcription factor NFAT3 mediates neuronal survival.J Biol Chem. 2005 Jan 28;280(4):2818-25.
  • Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T.Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating.Nature. 2004 Dec 2;432(7017):649-53.
  • Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T.Endocytosis by random initiation and stabilization of clathrin-coated pits.Cell. 2004 Sep 3;118(5):591-605.
  • Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW.The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.Cell. 1999 Apr 16;97(2):221-31.
  • ter Haar E, Musacchio A, Harrison SC, Kirchhausen T.Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.Cell. 1998 Nov 13;95(4):563-73.
  • Tong X, Boll W, Kirchhausen T, Howley PM.Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.J Virol. 1998 Jan;72(1):476-82.