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Leslie E. Silberstein, MD


  • Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L.Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: Mechanism, function, and implication for a potential novel therapeutic target.Exp Hematol. 2014 Apr;42(4):307-316.e8.
  • Silberstein LE, Lin CP.A new image of the hematopoietic stem cell vascular niche.Cell Stem Cell. 2013 Nov 7;13(5):514-6.
  • Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR.Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment.Dev Cell. 2013 May 28;25(4):333-49.
  • Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE.Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment.Nat Cell Biol. 2013 May;15(5):533-43.
  • Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG.Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.Mol Cell. 2013 Mar 7;49(5):934-46.
  • Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG.In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.Blood. 2013 Feb 21;121(8):1255-64.
  • Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE.Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.J Immunol. 2013 Feb 1;190(3):1094-102.
  • Gao H, Wu X, Sun Y, Zhou S, Silberstein LE, Zhu Z.Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.J Biol Chem. 2012 Aug 24;287(35):29979-87.
  • Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR.Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Proc Natl Acad Sci U S A. 2011 Apr 4.
  • Nombela-Arrieta C, Ritz J, Silberstein LE.The elusive nature and function of mesenchymal stem cells.Nat Rev Mol Cell Biol. 2011 Feb;12(2):126-31.
  • Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR.Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.Leukemia. 2010 May;24(5):1077-80.
  • Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR.Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.PLoS ONE. 2010;5(4):e10318.
  • Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z.VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor.Cancer Res. 2010 Jan 1;70(1):202-11.
  • Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR.Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.J Immunol. 2009 Jul 15;183(2):1032-43.
  • Sarraj B,Massberg S,Li Y,Kasorn A,Subramanian K,Loison F,Silberstein LE,von Andrian U,Luo HR.Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.J Immunol. 2009 Jun 1;182(11):7190-200.
  • Lu J,Jeong H,Kong N,Yang Y,Carroll J,Luo HR,Silberstein LE,Yupoma,Chai L.Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.PLoS ONE. 2009;4(5):e5577.
  • Le Y,Xu L,Lu J,Fang J,Nardi V,Chai L,Silberstein LE.FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells.Am J Hematol. 2009 May;84(5):273-8.
  • Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR.Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4739-44.
  • Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE.SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.Immunity. 2007 Nov;27(5):811-23.
  • Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.Leukemia. 2007 Aug;21(8):1723-32.
  • Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y.Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10494-9.
  • Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM.In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration.Transfusion. 2007 Mar;47(3):442-51.