• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Matthew P. Frosch, MD, PhD


  • Snuderl M, Wirth D, Sheth SA, Bourne SK, Kwon CS, Ancukiewicz M, Curry WT, Frosch MP, Yaroslavsky AN.Dye-Enhanced Multimodal Confocal Imaging as a Novel Approach to Intraoperative Diagnosis of Brain Tumors.Brain Pathol. 2012 Aug 6.
  • di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK.Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.Cancer Res. 2011 Jan 1;71(1):19-28.
  • Nelson PT, Kukull WA, Frosch MP.Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations.J Neuropathol Exp Neurol. 2010 May;69(5):449-54.
  • Cahill DP, Barker FG, Davis KR, Kalva SP, Sahai I, Frosch MP.Case records of the Massachusetts General Hospital. Case 10-2010. A 37-year-old woman with weakness and a mass in the brain.N Engl J Med. 2010 Apr 8;362(14):1326-33.
  • Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM.CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.Hum Mol Genet. 2010 May 1;19(9):1756-65.
  • Pless ML, Chen YB, Copen WA, Frosch MP.Case records of the Massachusetts General Hospital. Case 9-2010. A 37-year-old woman with paresthesias and ataxia.N Engl J Med. 2010 Mar 25;362(12):1129-38.
  • Gerstner ER, Frosch MP, Batchelor TT.Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab.J Clin Oncol. 2010 Feb 20;28(6):e91-3.
  • Chu-Shore CJ, Frosch MP, Grant PE, Thiele EA.Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings.Epilepsia. 2009 Dec;50(12):2648-51.
  • Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A.No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration.Dement Geriatr Cogn Disord. 2009;28(5):471-5.
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W.Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.Arch Pathol Lab Med. 2009 Dec;133(12):1949-53.
  • Brass SD,Smith EE,Arboleda-Velasquez JF,Copen WA,Frosch MP.Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members.N Engl J Med. 2009 Apr 16;360(16):1656-65.
  • Major P,Rakowski S,Simon MV,Cheng ML,Eskandar E,Baron J,Leeman BA,Frosch MP,Thiele EA.Are cortical tubers epileptogenic? Evidence from electrocorticography.Epilepsia. 2009 Jan;50(1):147-54.
  • Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD.Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations.Brain Pathol. 2009 Jan;19(1):39-47.
  • Nakagawa K,Sheikh SI,Snuderl M,Frosch MP,Greenberg SM.A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis.J Neurol Sci. 2008 Sep 15;272(1-2):186-90.
  • Eichler FS,Ren JQ,Cossoy M,Rietsch AM,Nagpal S,Moser AB,Frosch MP,Ransohoff RM.Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?.Ann Neurol. 2008 Jun;63(6):729-42.
  • Sabatine MS, Poh KK, Mega JL, Shepard JA, Stone JR, Frosch MP.Case records of the Massachusetts General Hospital. Case 36-2007. A 31-year-old woman with rash, fever, and hypotension.N Engl J Med. 2007 Nov 22;357(21):2167-78.
  • Cole AJ, Henson JW, Roehrl MH, Frosch MP.Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental status.N Engl J Med. 2007 Aug 9;357(6):589-600.
  • Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, Frosch MP, Standaert DG.Effects of gender on nigral gene expression and parkinson disease.Neurobiol Dis. 2007 Jun;26(3):606-14.
  • Duffy KR, Murphy KM, Frosch MP, Livingstone MS.Cytochrome Oxidase and Neurofilament Reactivity in Monocularly Deprived Human Primary Visual Cortex.Cereb Cortex. 2007 Jun;17(6):1283-91.
  • Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM.Course of cerebral amyloid angiopathy-related inflammation.Neurology. 2007 Apr 24;68(17):1411-6.
  • Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC.Plasma Abeta levels do not reflect brain Abeta levels.J Neuropathol Exp Neurol. 2007 Apr;66(4):264-71.
  • Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH.Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.Arch Neurol. 2007 Mar;64(3):431-4.
  • Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP.Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.J Neurosci. 2007 Feb 21;27(8):1973-80.
  • Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP.Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.Neurobiol Dis. 2006 Dec;24(3):516-24.
  • Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT.No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.Acta Neuropathol. 2006 Oct;112(4):439-49.
  • Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH.Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.Brain Res. 2006 Sep 21;1111(1):222-6.
  • Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT.Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.J Neuropathol Exp Neurol. 2006 May;65(5):508-15.
  • Costello DJ, Simon MV, Eskandar EN, Frosch MP, Henninger HL, Chiappa KH, Cole AJ.Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus.Arch Neurol. 2006 Jun;63(6):895-901.
  • Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM.The cerebral beta-amyloid angiopathies: hereditary and sporadic.Brain Pathol. 2006 Jan;16(1):30-9. Review.
  • Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch MP, Growdon JH, McLean PJ, Hyman BT.Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.Acta Neuropathol. 2006 Feb;111(2):101-8.
  • Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ.Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.J Neurosci. 2006 Jan 11;26(2):365-71.
  • Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG.Alpha-synuclein and chaperones in dementia with Lewy bodies.J Neuropathol Exp Neurol. 2005 Dec;64(12):1058-66.
  • Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, Macdonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopoulos G, Gullans SR.A compendium of gene expression in normal human tissues.Physiol Genomics. 2001 Dec 21;7(2):97-104.
  • Berezovska O, McLean P, Knowles R, Frosh M, Lu FM, Lux SE, Hyman BT.Notch1 inhibits neurite outgrowth in postmitotic primary neurons.Neuroscience. 1999;93(2):433-9.
  • Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT.The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.Brain Res Mol Brain Res. 1999 Jun 8;69(2):273-80.
  • Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH.Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.J Neurosci. 1999 Jun 1;19(11):4229-37.
  • Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, Mayadas TN.Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury.Stroke. 1999 Jan;30(1):134-9.
  • Simon DK, Rodriguez ML, Frosch MP, Quackenbush EJ, Feske SK, Natowicz MR.A unique familial leukodystrophy with adult onset dementia and abnormal glycolipid storage: a new lysosomal disease?.J Neurol Neurosurg Psychiatry. 1998 Aug;65(2):251-4.
  • Logigian EL, Shefner JM, Frosch MP, Kloman AS, Raynor EM, Adelman LS, Hollander D.Nonvasculitic, steroid-responsive mononeuritis multiplex.Neurology. 1993 May;43(5):879-83.
  • Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ.Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.Am J Pathol. 1993 Jan;142(1):17-24.
  • Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ.Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex.Neurobiol Aging. 1992 Sep-Oct;13(5):561-7.
  • Frosch MP, Lipton SA, Dichter MA.Desensitization of GABA-activated currents and channels in cultured cortical neurons.J Neurosci. 1992 Aug;12(8):3042-53.
  • Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ.Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.Am J Pathol. 1992 Jul;141(1):249-59.
  • Frosch MP, Dichter MA.Non-uniform distribution of GABA activated chloride channels in cultured cortical neurons.Neurosci Lett. 1992 Apr 13;138(1):59-62.
  • Sasahara M, Fries JW, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthron DT, Ross R, Collins T.PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model.Cell. 1991 Jan 11;64(1):217-27.
  • Tauck DL, Frosch MP, Lipton SA.Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture.Neuroscience. 1988 Oct;27(1):193-203.
  • Madison RD, Macklis JD, Frosch MP.Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption.Brain Res. 1988 Mar 29;445(1):101-10.
  • Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E.Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture.Science. 1988 Mar 11;239(4845):1293-6.
  • Aizenman E, Frosch MP, Lipton SA.Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.J Physiol. 1988 Feb;396:75-91.
  • Verkman AS, Frosch MP.Temperature-jump studies of merocyanine 540 relaxation kinetics in lipid bilayer membranes.Biochemistry. 1985 Dec 3;24(25):7117-22.
  • Frosch MP, Dichter MA.Physiology and pharmacology of olfactory bulb neurons in dissociated cell culture.Brain Res. 1984 Jan 9;290(2):321-32.