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Daniel P. Silver, MD, PhD


  • Silver DP, Livingston DM.Mechanisms of BRCA1 tumor suppression.Cancer Discovery. 2012 Aug;2(8):679-84.
  • Birkbak NJ, Wang ZC, Kim JY, Eklund AC, Li Q, Tian R, Bowman-Colin C, Li Y, Greene-Colozzi A, Iglehart JD, Tung N, Ryan PD, Garber JE, Silver DP, Szallasi Z, Richardson AL.Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents.Cancer Discovery. 2012 Apr;2(4):366-75.
  • Tung N, Silver DP.Chek2 DNA damage response pathway and inherited breast cancer risk.J Clin Oncol. 2011 Oct 1;29(28):3813-5.
  • Tung N, Miron A, Schnitt SJ, Gautam S, Fetten K, Kaplan J, Yassin Y, Buraimoh A, Kim JY, Szasz AM, Tian R, Wang ZC, Collins LC, Brock J, Krag K, Legare RD, Sgroi D, Ryan PD, Silver D, Garber JE, Richardson AL.Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers.Breast Cancer Res. 2010 Nov 16;12(6):R95.
  • Liu JF, Silver DP.Poly ADP-ribose polymerase inhibitors: science and current clinical development.Curr Opin Oncol. 2010 Nov;22(6):567-72.
  • Anders CK, Winer EP, Ford JM, Dent R, Silver DP, Sledge GW, Carey LA.Poly(ADP-Ribose) polymerase inhibition: "Targeted" therapy for triple-negative breast cancer.Clin Cancer Res. 2010 Oct 1;16(19):4702-10.
  • Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JE.Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.J Clin Oncol. 2010 Mar 1;28(7):1145-53.
  • Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerød A, Russnes HE, Foekens JA, Reis-Filho JS, van 't Veer L, Richardson AL, Børresen-Dale AL, Campbell PJ, Futreal PA, Stratton MR.Complex landscapes of somatic rearrangement in human breast cancer genomes.Nature. 2009 Dec 24;462(7276):1005-10.
  • Zhao JJ, Silver DP.Estrogen Receptor-Negative Breast Cancer: New Insights into Subclassification and Targeting.Clin Cancer Res. 2009 Oct 15;15(20):6309-10.
  • Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.Cell. 2009 Jul 23;138(2):352-65.
  • Iglehart JD, Silver DP.Synthetic lethality--a new direction in cancer-drug development.N Engl J Med. 2009 Jul 9;361(2):189-91.
  • Iglehart JD, and Silver DP.A New Direction in Cancer-Drug Development.NEJM..
  • Matera I, Watkins-Chow DE, Loftus SK, Hou L, Incao A, Silver DL, Rivas C, Elliott EC, Baxter LL, Pavan WJ.A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.Hum Mol Genet. 2008 Jul 15;17(14):2118-31.
  • Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ.The secreted metalloprotease ADAMTS20 is required for melanoblast survival.PLoS Genet. 2008 Feb;4(2):e1000003.
  • Livingston DM, Silver DP.Cancer: crossing over to drug resistance.Nature. 2008 Feb 28;451(7182):1066-7.
  • Zhu W, Saddar S, Seetharam D, Chambliss KL, Longoria C, Silver DL, Yuhanna IS, Shaul PW, Mineo C.The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity.Circ Res. 2008 Feb 29;102(4):480-7.
  • Gopal M, Silver D.Fibromatosis of the appendix and cecum.J Minim Invasive Gynecol. 2007 Nov-Dec;14(6):678.
  • Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM.Further evidence for BRCA1 communication with the inactive X chromosome.Cell. 2007 Mar 9;128(5):991-1002.
  • Ganesan S, Richardson AL, Wang ZC, Iglehart JD, Miron A, Feunteun J, Silver D, Livingston DM.Abnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal-like Breast Cancer.Cold Spring Harb Symp Quant Biol. 2005;70:93-7.
  • Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T.Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.Cancer Cell. 2004 Apr;5(4):375-87.
  • Ganesan S, Silver DP, Drapkin R, Greenberg R, Feunteun J, Livingston DM.Association of BRCA1 with the inactive X chromosome and XIST RNA.Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):123-8.
  • Silver DP.HIN-1 and the nosology of breast cancer.Cancer Biol Ther. 2003 Sep-Oct;2(5):564-5.
  • Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM.BRCA1 supports XIST RNA concentration on the inactive X chromosome.Cell. 2002 Nov 1;111(3):393-405.
  • Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA.p16(INK4a) and p53 deficiency cooperate in tumorigenesis.Cancer Res. 2002 May 15;62(10):2761-5.
  • Silver DP, Livingston DM.Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity.Mol Cell. 2001 Jul;8(1):233-43.
  • Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R.Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.Mol Cell. 1998 Sep;2(3):317-28.