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Dale T. Umetsu, MD, PhD

Publications

  • Albacker LA, Yu S, Bedoret D, Lee WL, Umetsu SE, Monahan S, Freeman GJ, Umetsu DT, Dekruyff RH.TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.Mucosal Immunol. 2013 May;6(3):580-90.
    23149665
  • Recher M, Fried AJ, Massaad MJ, Kim HY, Rizzini M, Frugoni F, Walter JE, Mathew D, Eibel H, Hess C, Giliani S, Umetsu DT, Notarangelo LD, Geha RS.Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia.Clin Immunol. 2013 Feb;146(2):84-9.
    23280491
  • Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, Dekruyff RH, Kuchroo VK.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Eur J Immunol. 2011 Mar 18.
    21469101
  • Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.J Immunol. 2010 Dec 1;185(11):6839-49.
    21037090
  • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.Immunol Rev. 2010 May;235(1):172-89. Review.
    20536563
  • Tachdjian R, Al Khatib S, Schwinglshackl A, Kim HS, Chen A, Blasioli J, Mathias C, Kim HY, Umetsu DT, Oettgen HC, Chatila TA.In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.J Allergy Clin Immunol. 2010 May;125(5):1128-1136.e8.
    20392476
  • Umetsu DT, Dekruyff RH.The regulatory role of natural killer T cells in the airways.Int J Biochem Cell Biol. 2010 Apr;42(4):529-34. Review.
    19897049
  • DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, Casasnovas JM.T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.J Immunol. 2010 Feb 15;184(4):1918-30.
    20083673
  • He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS.Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.J Allergy Clin Immunol. 2009 Oct;124(4):761-70.e1.
    19815118
  • Yi T, Chen Y, Wang L, Du G, Huang D, Zhao D, Johnston H, Young J, Todorov I, Umetsu DT, Chen L, Iwakura Y, Kandeel F, Forman S, Zeng D.Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.Blood. 2009 Oct 1;114(14):3101-12.
    19602708
  • Iweala OI, Smith DW, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR.Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice.J Immunol. 2009 Aug 15;183(4):2252-60.
    19620295
  • Matangkasombut P,Marigowda G,Ervine A,Idris L,Pichavant M,Kim HY,Yasumi T,Wilson SB,DeKruyff RH,Faul JL,Israel E,Akbari O,Umetsu DT.Natural killer T cells in the lungs of patients with asthma.J Allergy Clin Immunol. 2009 May;123(5):1181-5.
    19356791
  • Li Y,Jia Y,Pichavant M,Loison F,Sarraj B,Kasorn A,You J,Robson BE,Umetsu DT,Mizgerd JP,Ye K,Luo HR.Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.Blood. 2009 May 14;113(20):4930-41.
    19286998
  • Kim HY,Pichavant M,Matangkasombut P,Koh YI,Savage PB,DeKruyff RH,Umetsu DT.The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells.J Immunol. 2009 Mar 1;182(5):3252-61.
    19234223
  • Mariat C,Degauque N,Balasubramanian S,Kenny J,DeKruyff RH,Umetsu DT,Kuchroo V,Zheng XX,Strom TB.Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.J Immunol. 2009 Feb 1;182(3):1379-85.
    19155484
  • Stenard F, Nguyen C, Cox K, Kambham N, Umetsu DT, Krams SM, Esquivel CO, Martinez OM.Decreases in circulating CD4(+)CD25(hi)FOXP3(+) cells and increases in intragraft FOXP3(+) cells accompany allograft rejection in pediatric liver allograft recipients.Pediatr Transplant. 2009 Feb;13(1):70-80.
    18331536
  • Koh YI,Kim HY,Meyer EH,Pichavant M,Akbari O,Yasumi T,Savage PB,Dekruyff RH,Umetsu DT.Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.J Immunol. 2008 Oct 1;181(7):4560-9.
    18802058
  • Pichavant M, Goya S, Hamelmann E, Gelfand EW, Umetsu DT.Animal models of airway sensitization.Curr Protoc Immunol. 2007 Nov;Chapter 15:Unit 15.18.
    18432985
  • Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH.ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.J Immunol. 2008 Apr 15;180(8):5448-56.
    18390727
  • Matangkasombut P, Pichavant M, Yasumi T, Hendricks C, Savage PB, Dekruyff RH, Umetsu DT.Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates.J Allergy Clin Immunol. 2008 May;121(5):1287-9.
    18355909
  • Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, DeKruyff RH, Shore SA, Umetsu DT.Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.J Exp Med. 2008 Feb 18;205(2):385-93.
    18250191
  • Kobayashi N, Karisola P, Peņa-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells.Immunity. 2007 Dec;27(6):927-40.
    18082433
  • Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB.Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.J Clin Invest. 2008 Feb;118(2):735-41.
    18079964
  • Akbari O, Faul JL, Umetsu DT.Invariant natural killer T cells in obstructive pulmonary diseases.N Engl J Med. 2007 Jul 12;357(2):193-4; author reply 194-5.
    17625134
  • Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, Saito H, Galli SJ.TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.Blood. 2007 Oct 1;110(7):2565-8.
    17620455
  • Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK.Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.J Exp Med. 2007 Jul 9;204(7):1691-702.
    17606630
  • Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH.TIM-1 induces T cell activation and inhibits the development of peripheral tolerance.Nat Immunol. 2005 May;6(5):447-54.
    15793575
  • Stock P, Akbari O, Berry G, Freeman GJ, Dekruyff RH, Umetsu DT.Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity.Nat Immunol. 2004 Nov;5(11):1149-56.
    15448689
  • McIntire JJ, Umetsu SE, Macaubas C, Hoyte EG, Cinnioglu C, Cavalli-Sforza LL, Barsh GS, Hallmayer JF, Underhill PA, Risch NJ, Freeman GJ, DeKruyff RH, Umetsu DT.Immunology: hepatitis A virus link to atopic disease.Nature. 2003 Oct 9;425(6958):576.
    14534576
  • Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT.Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.Nat Med. 2003 May;9(5):582-8.
    12669034
  • Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT.Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.Nat Med. 2002 Sep;8(9):1024-32.
    12145647