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Lee Zou, PhD


  • Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ.Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.Mol Cell. 2014 Mar 20;53(6):993-1004.
  • Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L.PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.Mol Cell. 2014 Jan 23;53(2):235-46.
  • Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T.Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.Carcinogenesis. 2013 Nov;34(11):2486-97.
  • Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H.EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.Cancer Res. 2013 Oct 15;73(20):6254-63.
  • Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.Cell Rep. 2013 May 30;3(5):1651-62.
  • Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H.Detection of impaired homologous recombination repair in NSCLC cells and tissues.J Thorac Oncol. 2013 Mar;8(3):279-86.
  • Zou L.Four pillars of the S-phase checkpoint.Genes Dev. 2013 Feb 1;27(3):227-33.
  • Liu S, Ho CK, Ouyang J, Zou L.Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2175-80.
  • Liu S, Song N, Zou L.The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1.Cell Cycle. 2012 Jul 15;11(14):2711-6.
  • Centore RC, Yazinski SA, Tse A, Zou L.Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.Mol Cell. 2012 Jun 8;46(5):625-35.
  • Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L.TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.Nature. 2011 Mar 24;471(7339):532-6.
  • Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K.Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination.Mol Cell. 2011 Mar 4;41(5):515-28.
  • Flynn RL, Zou L.ATR: a master conductor of cellular responses to DNA replication stress.Trends Biochem Sci. 2010 Oct 12.
  • Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Mol Cell. 2010 Oct 8;40(1):22-33.
  • Zou L.DNA repair: A protein giant in its entirety.Nature. 2010 Oct 7;467(7316):667-8.
  • Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD.The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.Mol Cell. 2010 Jul 30;39(2):259-68.
  • Flynn RL, Zou L.Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians.Crit Rev Biochem Mol Biol. 2010 Aug;45(4):266-75. Review.
  • Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J.A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.Cell. 2010 Apr 2;141(1):69-80.
  • Zou L.Checkpoint Mec-tivation comes in many flavors.Mol Cell. 2009 Dec 11;36(5):734-5.
  • Zhang J, Song YH, Brannigan BW, Wahrer DC, Schiripo TA, Harris PL, Haserlat SM, Ulkus LE, Shannon KM, Garber JE, Freedman ML, Henderson BE, Zou L, Sgroi DC, Haber DA, Bell DW.Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.Mol Cancer Res. 2009 Sep;7(9):1510-6.
  • Shiotani B,Zou L.Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.Mol Cell. 2009 Mar 13;33(5):547-58.
  • Yang XH,Zou L.Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination.Cell Cycle. 2009 Jan 15;8(2):191-4. Review.
  • Shiotani B,Zou L.ATR signaling at a glance.J Cell Sci. 2009 Feb 1;122(Pt 3):301-4.
  • Yang XH, Shiotani B, Classon M, Zou L.Chk1 and Claspin potentiate PCNA ubiquitination.Genes Dev. 2008 May 1;22(9):1147-52.
  • Yang XH, Zou L.Launching a ubiquitination cascade at DNA breaks.Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20645-6.
  • Zou L.Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response.Genes Dev. 2007 Apr 15;21(8):879-85.
  • Yang XH, Zou L.Checkpoint and coordinated cellular responses to DNA damage.Results Probl Cell Differ. 2006;42:65-92. Review.
  • Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L.Rad17 phosphorylation is required for claspin recruitment and chk1 activation in response to replication stress.Mol Cell. 2006 Aug 4;23(3):331-41.
  • Yang XH, Zou L.Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage.Methods Enzymol. 2006;409:118-31.
  • Namiki Y, Zou L.ATRIP associates with replication protein A-coated ssDNA through multiple interactions.Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):580-5.