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Marc W. Kirschner, PhD


  • Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.APC(Cdc20) Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction.Dev Cell. 2014 May 27;29(4):377-91.
  • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.Nature. 2014 Apr 24;508(7497):541-5.
  • Gujral TS, Peshkin L, Kirschner MW.Exploiting polypharmacology for drug target deconvolution.Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5048-53.
  • Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S.Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated.J Am Chem Soc. 2014 Apr 2;136(13):4845-8.
  • Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW.Size homeostasis in adherent cells studied by synthetic phase microscopy.Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16687-92.
  • Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W.SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.Cell Rep. 2013 Aug 29;4(4):803-16.
  • Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW.Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2848-53.
  • Wang W, Kirschner MW.Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.Nat Cell Biol. 2013 Jul;15(7):797-806.
  • Gallop JL, Walrant A, Cantley LC, Kirschner MW.Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.Proc Natl Acad Sci U S A. 2013 Apr 15.
  • Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.Nature. 2013 Feb 28;494(7438):480-3.
  • Hernández AR, Klein AM, Kirschner MW.Kinetic responses of β-catenin specify the sites of Wnt control.Science. 2012 Dec 7;338(6112):1337-40.
  • Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP.Accurate Multiplexed Proteomics at the MS2 Level Using the Complement Reporter Ion Cluster.Anal Chem. 2012 Nov 6;84(21):9214-21.
  • Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR.Direct observation of mammalian cell growth and size regulation.Nat Methods. 2012 Sep;9(9):910-2.
  • Li VC, Ballabeni A, Kirschner MW.Gap 1 phase length and mouse embryonic stem cell self-renewal.Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12550-5.
  • Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW.Remodeling of the metabolome during early frog development.PLoS ONE. 2011;6(2):e16881.
  • Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC.Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.Genes Dev. 2010 Nov 15;24(22):2531-42.
  • Merbl Y, Kirschner MW.Protein microarrays for genome-wide posttranslational modification analysis.Wiley Interdisciplinary Reviews. Systems Biology And Medicine. 2010 Sep 23.
  • Lee K, Gallop JL, Rambani K, Kirschner MW.Self-assembly of filopodia-like structures on supported lipid bilayers.Science. 2010 Sep 10;329(5997):1341-5.
  • Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.Genes Dev. 2010 Jul 1;24(13):1434-47.
  • Springer M, Weissman JS, Kirschner MW.A general lack of compensation for gene dosage in yeast.Mol Syst Biol. 2010 May 11;6:368.
  • Godin M, Delgado FF, Son S, Grover WH, Bryan AK, Tzur A, Jorgensen P, Payer K, Grossman AD, Kirschner MW, Manalis SR.Using buoyant mass to measure the growth of single cells.Nat Methods. 2010 May;7(5):387-90.
  • DeLuna A, Springer M, Kirschner MW, Kishony R.Need-based up-regulation of protein levels in response to deletion of their duplicate genes.PLoS Biol. 2010;8(3):e1000347.
  • Deibler RW, Kirschner MW.Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts.Mol Cell. 2010 Mar 26;37(6):753-67.
  • Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW.UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1355-60.
  • Yang W, Di Vizio D, Kirchner M, Steen H, Freeman MR.Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.Mol Cell Proteomics. 2010 Jan;9(1):54-70.
  • Goentoro L, Shoval O, Kirschner MW, Alon U.The incoherent feedforward loop can provide fold-change detection in gene regulation.Mol Cell. 2009 Dec 11;36(5):894-9.
  • Goentoro L, Kirschner MW.Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling.Mol Cell. 2009 Dec 11;36(5):872-84.
  • Lebensohn AM, Kirschner MW.Activation of the WAVE complex by coincident signals controls actin assembly.Mol Cell. 2009 Nov 13;36(3):512-24.
  • Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F.Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.Nature. 2009 Oct 1;461(7264):614-20.
  • Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW.Cell growth and size homeostasis in proliferating animal cells.Science. 2009 Jul 10;325(5937):167-71.
  • Singh S,Springer M,Steen J,Kirschner MW,Steen H.FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides.J Proteome Res. 2009 May;8(5):2201-10.
  • Merbl Y,Kirschner MW.Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2543-8.
  • Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW.Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis.Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6069-74.
  • Mor I, Sklan EH, Podoly E, Pick M, Kirschner M, Yogev L, Bar-Sheshet Itach S, Schreiber L, Geyer B, Mor T, Grisaru D, Soreq H.Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility.J Cell Mol Med. 2008 Mar-Apr;12(2):479-95.
  • Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW.The relationship between evolutionary and physiological variation in hemoglobin.Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16998-7003.
  • Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW.An actin-based wave generator organizes cell motility.PLoS Biol. 2007 Sep;5(9):e221.
  • Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.Nature. 2007 Apr 19;446(7138):876-81.
  • Reddy SK, Rape M, Margansky WA, Kirschner MW.Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation.Nature. 2007 Apr 19;446(7138):921-5.
  • Rape M, Reddy SK, Kirschner MW.The processivity of multiubiquitination by the APC determines the order of substrate degradation.Cell. 2006 Jan 13;124(1):89-103.
  • Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG.Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Nature. 2004 Mar 11;428(6979):194-8.
  • Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.EMBO J. 2003 Jul 15;22(14):3602-12.
  • Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW.A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9.
  • Zou H, McGarry TJ, Bernal T, Kirschner MW.Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.Science. 1999 Jul 16;285(5426):418-22.
  • Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW.The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.Cell. 1999 Apr 16;97(2):221-31.
  • Ma L, Rohatgi R, Kirschner MW.The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42.Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15362-7.
  • Fang G, Yu H, Kirschner MW.Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.Mol Cell. 1998 Aug;2(2):163-71.
  • McGarry TJ, Kirschner MW.Geminin, an inhibitor of DNA replication, is degraded during mitosis.Cell. 1998 Jun 12;93(6):1043-53.
  • Fang G, Yu H, Kirschner MW.The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.Genes Dev. 1998 Jun 15;12(12):1871-83.
  • King RW, Deshaies RJ, Peters JM, Kirschner MW.How proteolysis drives the cell cycle.Science. 1996 Dec 6;274(5293):1652-9.
  • Lustig KD, Kroll KL, Sun EE, Kirschner MW.Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation.Development. 1996 Dec;122(12):4001-12.
  • Peters JM, King RW, Hg C, Kirschner MW.Identification of BIME as a subunit of the anaphase-promoting complex.Science. 1996 Nov 15;274(5290):1199-201.