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Hongbo R. Luo, PhD

Publications

  • Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L.Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.Blood. 2013 Feb 21;121(8):1413-21.
    23287862
  • Jo H, Mondal S, Tan D, Nagata E, Takizawa S, Sharma AK, Hou Q, Shanmugasundaram K, Prasad A, Tung JK, Tejeda AO, Man H, Rigby AC, Luo HR.Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
    22689977
  • Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR.Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Proc Natl Acad Sci U S A. 2011 Apr 4.
    21464312
  • Hattori H, Subramanian KK, Sakai J, Luo HR.Reactive oxygen species as signaling molecules in neutrophil chemotaxis.Commun Integr Biol. 2010 May;3(3):278-81.
    20714413
  • Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD.Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.J Leukoc Biol. 2010 Aug;88(2):313-9.
    20413728
  • Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR.Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.Leukemia. 2010 May;24(5):1077-80.
    20220776
  • Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR.Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.PLoS ONE. 2010;5(4):e10318.
    20428237
  • Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P.Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.J Immunol. 2010 May 1;184(9):5325-32.
    20363972
  • Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR.Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3546-51.
    20142487
  • Xu Y, Loison F, Luo HR.Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2950-5.
    20133633
  • Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR.Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.J Immunol. 2009 Jul 15;183(2):1032-43.
    19561112
  • Sarraj B,Massberg S,Li Y,Kasorn A,Subramanian K,Loison F,Silberstein LE,von Andrian U,Luo HR.Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.J Immunol. 2009 Jun 1;182(11):7190-200.
    19454716
  • Li Y,Jia Y,Pichavant M,Loison F,Sarraj B,Kasorn A,You J,Robson BE,Umetsu DT,Mizgerd JP,Ye K,Luo HR.Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.Blood. 2009 May 14;113(20):4930-41.
    19286998
  • Jia Y,Schurmans S,Luo HR.Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate.Cell Cycle. 2008 Sep 15;7(18):2803-8.
    18769148
  • Jo H, Jia Y, Subramanian KK, Hattori H, Luo HR.Cancer Cell-Derived Clusterin Modulates the PI3K-Akt Pathway through Attenuation of IGF-1 during Serum Deprivation.Mol Cell Biol. 2008 Jul;28(13):4285-99.
    18458059
  • Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K.Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.Mol Cell. 2008 Mar 28;29(6):665-78.
    18374643
  • Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR.Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4739-44.
    18339802
  • Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE.SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.Immunity. 2007 Nov;27(5):811-23.
    18031698
  • Luo HR, Loison F.Constitutive neutrophil apoptosis: mechanisms and regulation.Am J Hematol. 2008 Apr;83(4):288-95. Review.
    17924549
  • Jia Y, Subramanian KK, Erneux C, Pouillon V, Hattori H, Jo H, You J, Zhu D, Schurmans S, Luo HR.Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.Immunity. 2007 Sep;27(3):453-67.
    17825589
  • Marechal Y, Pesesse X, Jia Y, Pouillon V, Perez-Morga D, Daniel J, Izui S, Cullen PJ, Leo O, Luo HR, Erneux C, Schurmans S.Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13978-83.
    17709751
  • Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE, Luo HR.RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.Blood. 2007 Jul 15;110(2):640-50.
    17420285
  • Luo HR, Hattori H, Hossain MA, Hester L, Huang Y, Lee-Kwon W, Donowitz M, Nagata E, Snyder SH.Akt as a mediator of cell death.Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11712-7.
    14504398
  • Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH.Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.Cell. 2003 Sep 5;114(5):559-72.
    13678580
  • Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SH.Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.Biochemistry. 2002 Feb 26;41(8):2509-15.
    11851397
  • Luo HR, Saiardi A, Nagata E, Ye K, Yu H, Jung TS, Luo X, Jain S, Sawa A, Snyder SH.GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.Neuron. 2001 Aug 16;31(3):439-51.
    11516400