Elliott D. Kieff, M.D. Ph.D.

Publications

• Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E.Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; Only the NTD interaction is essential for lymphoblastoid cell growth.Virolo
  21440926
• Kang MS, Lee EK, Soni V, Lewis TA, Koehler AN, Srinivasan V, Kieff E.Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.J Virol. 2011 Mar;85(6):2859-68.
  21209116
• Maruo S, Zhao B, Johannsen E, Kieff E, Zou J, Takada K.Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1919-24.
  21245331
• Zhao B, Mar JC, Maruo S, Lee S, Gewurz BE, Johannsen E, Holton K, Rubio R, Takada K, Quackenbush J, Kieff E.Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines.Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):337-42.
  21173222
• Boehm D, Gewurz BE, Kieff E, Cahir-McFarland E.Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419.Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18103-
  20923877
• Lee S, Sakakibara S, Maruo S, Zhao B, Calderwood MA, Holthaus AM, Lai CY, Takada K, Kieff E, Johannsen E.Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1.J Virol. 2009 Dec;8
  19776126
• Maruo S,Wu Y,Ito T,Kanda T,Kieff ED,Takada K.Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth.Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4419-24.
  19237563
• Choy E,Yelensky R,Bonakdar S,Plenge RM,Saxena R,De Jager PL,Shaw SY,Wolfish CS,Slavik JM,Cotsapas C,Rivas M,Dermitzakis ET,Cahir-McFarland E,Kieff E,Hafler D,Daly MJ,Altshuler D.Genetic analysis of human traits in vitro: drug response and gene expression
  19043577
• Kang MS, Soni V, Bronson R, Kieff E.Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.J Virol. 2008 Apr;82(8):4180-3.
  18256159
• Xing L, Kieff E.Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.J Virol. 2007 Sep;81(18):9967-75.
  17626073
• Calderwood MA, Venkatesan K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, Vidal M, Kieff E, Johannsen E.Epstein-Barr virus and virus human protein interaction maps.Proc Natl Acad Sci U S A. 2007 May 1;104(18):7
  17446270
• Peng CW, Zhao B, Chen HC, Chou ML, Lai CY, Lin SZ, Hsu HY, Kieff E.Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2.Blood. 2007 Jun 15;109(12):5447-54.
  17341665
• Portal D, Rosendorff A, Kieff E.Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19278-83.
  17159145
• Chen A, Zhao B, Kieff E, Aster JC, Wang F.EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines.J Virol. 2006 Oct;80(20):10139-50.
  17005691
• Soni V, Yasui T, Cahir-McFarland E, Kieff E.LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB.J Virol. 2006 Nov;80(21):10787-93.
  16928765
• Hatzivassiliou EG, Kieff E, Mosialos G.Constitutive CD40 signaling phenocopies the transforming function of the Epstein-Barr virus oncoprotein LMP1 in vitro.Leuk Res. 2007 Mar;31(3):315-20.
  16919331
• Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G.NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5308-13.
  16567619
• Yuan J, Cahir-McFarland E, Zhao B, Kieff E.Virus and cell RNAs expressed during Epstein-Barr virus replication.J Virol. 2006 Mar;80(5):2548-65.
  16474161
• Zhao B, Maruo S, Cooper A, R Chase M, Johannsen E, Kieff E, Cahir-McFarland E.RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines.Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1900-5.
  16446431
• Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E.Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical.J Virol. 2005 Aug;79(16):10171-9.
  16051810
• Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E.Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice.Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):820-5.
  15640350
• Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E.Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.J Virol. 2004 Apr;78(8
  15047827
• Yasui T, Luftig M, Soni V, Kieff E.Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):278-83.
  14695890
• Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E.Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK{alpha}-dependent noncanonical NF-{kappa}B activation.Proc Natl Acad Sci U S A. 2004
  14691250
• Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E.Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.Proc
  14673102
• Maruo S, Johannsen E, Illanes D, Cooper A, Kieff E.Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth.J Virol. 2003 Oct;77(19):10437-47.
  12970429
• Cooper A, Johannsen E, Maruo S, Cahir-McFarland E, Illanes D, Davidson D, Kieff E.EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth.J Virol. 2003 Jan;77(2):999-1010.
  12502816
• Carter KL, Cahir-McFarland E, Kieff E.Epstein-barr virus-induced changes in B-lymphocyte gene expression.J Virol. 2002 Oct;76(20):10427-36.
  12239319
• Yang J, Aittomäki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O.Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.EMBO J. 2002 Sep 16;21(18):4950-8.
  12234934
• Han I, Xue Y, Harada S, Orstavik S, Skalhegg B, Kieff E.Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins.Mol Cell Biol. 2002 Apr;22(7):2136-46.
  11884601
• Cahir-McFarland E, Kieff E.NF-kappaB inhibition in EBV-transformed lymphoblastoid cell lines.Recent Results Cancer Res. 2002;159:44-8.
  11785843
• Higuchi M, Kieff E, Izumi KM.The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines.J Virol. 2002 Jan;76(1):455-9.
  11739714
• Lin J, Johannsen E, Robertson E, Kieff E.Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2.J Virol. 2002 Jan;76(1):232-42.
  11739688
• Kang MS, Hung SC, Kieff E.Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15233-8.
  11734622
• Higuchi M, Izumi KM, Kieff E.Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors.Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4675-80.
  11296297
• Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E.Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.J Biol Chem. 2001 May 4;276(18):14602-6.
  11278268
• Hung SC, Kang MS, Kieff E.Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.Proc Natl Acad Sci U S A. 2001 Feb 13;98(
  11172042
• Han I, Harada S, Weaver D, Xue Y, Lane W, Orstavik S, Skalhegg B, Kieff E.EBNA-LP associates with cellular proteins including DNA-PK and HA95.J Virol. 2001 Mar;75(5):2475-81.
  11160753
• Harada S, Yalamanchili R, Kieff E.Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association.J Virol. 2001 Mar;75(5):2482-7.
  11160754
• Cahir-McFarland ED, Davidson DM, Schauer SL, Duong J, Kieff E.NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells.Proc Natl Acad Sci U S A. 2000 May 23;97(11):6055-60.
  10811897
• Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS.Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95.Biol Cell. 2000 Jan;92(1):27-37.
  10761695
• Callahan J, Aster J, Sklar J, Kieff E, Robertson ES.Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.Leukemia. 2000 Jan;14(1):84-92.
  10637481
• Wang L, Grossman SR, Kieff E.Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):430-5.
  10618435
• Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED.The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce
  10409763
• Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU.Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.J Virol. 1999 May;73(5):3913-9.
  10196286
• Harada S, Yalamanchili R, Kieff E.Residues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation.J Virol. 1998 Dec;72(12):9948-54.
  9811732
• Devergne O, Cahir McFarland ED, Mosialos G, Izumi KM, Ware CF, Kieff E.Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression.J Virol. 1998 Oct;72(10):7900-8.
  9733827
• Sylla BS, Hung SC, Davidson DM, Hatzivassiliou E, Malinin NL, Wallach D, Gilmore TD, Kieff E, Mosialos G.Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes t
  9707608
• Hatzivassiliou E, Miller WE, Raab-Traub N, Kieff E, Mosialos G.A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expr
  9570524
• Izumi KM, Kieff ED.The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.Proc Natl Acad Sci U S A.
  9356494
• Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH.The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.J Virol. 1997 Sep;71(9):6560-7.
  9261377
• Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J.Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcriptio
  9111040
• VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF.Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kap
  9122217
• Izumi KM, Kaye KM, Kieff ED.The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1447-52.
  9037073
• Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G.Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.Mol Cell Biol. 1996 Dec
  8943365
• Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K, Aizawa S, Watanabe T, Mosialos G, Kieff E, Yamamoto T, Inoue J.Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-t
  8910514
• Robertson ES, Ooka T, Kieff ED.Epstein-Barr virus vectors for gene delivery to B lymphocytes.Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11334-40.
  8876136
• Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G.Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.Pro
  8855313
• Johannsen E, Miller CL, Grossman SR, Kieff E.EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytes.J Virol. 1996 Jun;70(6):4179-83.
  8648764
• Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E.Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.Am J Pathol. 1996 Feb;148(2):593-600.
  8579121
• Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS.Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.Biochem Biophys Res Commun. 1995 Dec 14;217(2):466-74.
  7503723
• Kaye KM, Izumi KM, Mosialos G, Kieff E.The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.J Virol. 1995 Feb;69(2)
  7815530
• Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman SR.Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.J Virol. 1995 Jan;69(1):253-62.
  7983717