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Elliott D. Kieff, MD, PhD

Publications

  • Lee EK, Kim SY, Noh KW, Joo EH, Zhao B, Kieff E, Kang MS.Small molecule inhibition of Epstein-Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genome.Antiviral Res. 2014 Apr;104:73-83.
    24486954
  • Kim JE, Kim SY, Lim SY, Kieff E, Song YJ.Role of Ca2+/calmodulin-dependent kinase II-IRAK1 interaction in LMP1-induced NF-κB activation.Mol Cell Biol. 2014 Feb;34(3):325-34.
    24248603
  • Jiang S, Willox B, Zhou H, Holthaus AM, Wang A, Shi TT, Maruo S, Kharchenko PV, Johannsen EC, Kieff E, Zhao B.Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A.Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):421-6.
    24344258
  • Chen YL, Liu CD, Cheng CP, Zhao B, Hsu HJ, Shen CL, Chiu SJ, Kieff E, Peng CW.Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription.Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):243-8.
    24344309
  • Portal D, Zhou H, Zhao B, Kharchenko PV, Lowry E, Wong L, Quackenbush J, Holloway D, Jiang S, Lu Y, Kieff E.Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2.Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18537-42.
    24167291
  • Liu CD, Cheng CP, Fang JS, Chen LC, Zhao B, Kieff E, Peng CW.Modulation of Epstein-Barr virus nuclear antigen 2-dependent transcription by protein arginine methyltransferase 5.Biochem Biophys Res Commun. 2013 Jan 18;430(3):1097-102.
    23261437
  • Liu CD, Chen YL, Min YL, Zhao B, Cheng CP, Kang MS, Chiu SJ, Kieff E, Peng CW.The nuclear chaperone nucleophosmin escorts an Epstein-Barr Virus nuclear antigen to establish transcriptional cascades for latent infection in human B cells.PLoS Pathog. 2012;8(12):e1003084.
    23271972
  • Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H.Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21022-7.
    23223530
  • Kim SY, Song KA, Kieff E, Kang MS.Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerization.Biochem Biophys Res Commun. 2012 Jul 27;424(2):251-6.
    22735264
  • Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M.Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.Nature. 2012 Jul 26;487(7408):491-5.
    22810586
  • Gulbahce N, Yan H, Dricot A, Padi M, Byrdsong D, Franchi R, Lee DS, Rozenblatt-Rosen O, Mar JC, Calderwood MA, Baldwin A, Zhao B, Santhanam B, Braun P, Simonis N, Huh KW, Hellner K, Grace M, Chen A, Rubio R, Marto JA, Christakis NA, Kieff E, Roth FP, Roecklein-Canfield J, Decaprio JA, Cusick ME, Quackenbush J, Hill DE, Münger K, Vidal M, Barabási AL.Viral perturbations of host networks reflect disease etiology.PLoS Comput. Biol. 2012;8(6):e1002531.
    22761553
  • Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E.Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; Only the NTD interaction is essential for lymphoblastoid cell growth.Virology. 2011 Mar 25.
    21440926
  • Kang MS, Lee EK, Soni V, Lewis TA, Koehler AN, Srinivasan V, Kieff E.Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.J Virol. 2011 Mar;85(6):2859-68.
    21209116
  • Maruo S, Zhao B, Johannsen E, Kieff E, Zou J, Takada K.Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1919-24.
    21245331
  • Zhao B, Mar JC, Maruo S, Lee S, Gewurz BE, Johannsen E, Holton K, Rubio R, Takada K, Quackenbush J, Kieff E.Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines.Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):337-42.
    21173222
  • Boehm D, Gewurz BE, Kieff E, Cahir-McFarland E.Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419.Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18103-8.
    20923877
  • Lee S, Sakakibara S, Maruo S, Zhao B, Calderwood MA, Holthaus AM, Lai CY, Takada K, Kieff E, Johannsen E.Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1.J Virol. 2009 Dec;83(23):12368-77.
    19776126
  • Maruo S,Wu Y,Ito T,Kanda T,Kieff ED,Takada K.Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth.Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4419-24.
    19237563
  • Choy E,Yelensky R,Bonakdar S,Plenge RM,Saxena R,De Jager PL,Shaw SY,Wolfish CS,Slavik JM,Cotsapas C,Rivas M,Dermitzakis ET,Cahir-McFarland E,Kieff E,Hafler D,Daly MJ,Altshuler D.Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.PLoS Genet. 2008 Nov;4(11):e1000287.
    19043577
  • Kang MS, Soni V, Bronson R, Kieff E.Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.J Virol. 2008 Apr;82(8):4180-3.
    18256159
  • Xing L, Kieff E.Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.J Virol. 2007 Sep;81(18):9967-75.
    17626073
  • Calderwood MA, Venkatesan K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, Vidal M, Kieff E, Johannsen E.Epstein-Barr virus and virus human protein interaction maps.Proc Natl Acad Sci U S A. 2007 May 1;104(18):7606-11.
    17446270
  • Peng CW, Zhao B, Chen HC, Chou ML, Lai CY, Lin SZ, Hsu HY, Kieff E.Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2.Blood. 2007 Jun 15;109(12):5447-54.
    17341665
  • Portal D, Rosendorff A, Kieff E.Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19278-83.
    17159145
  • Chen A, Zhao B, Kieff E, Aster JC, Wang F.EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines.J Virol. 2006 Oct;80(20):10139-50.
    17005691
  • Soni V, Yasui T, Cahir-McFarland E, Kieff E.LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB.J Virol. 2006 Nov;80(21):10787-93.
    16928765
  • Hatzivassiliou EG, Kieff E, Mosialos G.Constitutive CD40 signaling phenocopies the transforming function of the Epstein-Barr virus oncoprotein LMP1 in vitro.Leuk Res. 2007 Mar;31(3):315-20.
    16919331
  • Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G.NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5308-13.
    16567619
  • Yuan J, Cahir-McFarland E, Zhao B, Kieff E.Virus and cell RNAs expressed during Epstein-Barr virus replication.J Virol. 2006 Mar;80(5):2548-65.
    16474161
  • Zhao B, Maruo S, Cooper A, R Chase M, Johannsen E, Kieff E, Cahir-McFarland E.RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines.Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1900-5.
    16446431
  • Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E.Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical.J Virol. 2005 Aug;79(16):10171-9.
    16051810
  • Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E.Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice.Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):820-5.
    15640350
  • Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E.Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.J Virol. 2004 Apr;78(8):4108-19.
    15047827
  • Yasui T, Luftig M, Soni V, Kieff E.Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):278-83.
    14695890
  • Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E.Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK{alpha}-dependent noncanonical NF-{kappa}B activation.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):141-146.
    14691250
  • Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E.Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15595-600.
    14673102
  • Maruo S, Johannsen E, Illanes D, Cooper A, Kieff E.Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth.J Virol. 2003 Oct;77(19):10437-47.
    12970429
  • Cooper A, Johannsen E, Maruo S, Cahir-McFarland E, Illanes D, Davidson D, Kieff E.EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth.J Virol. 2003 Jan;77(2):999-1010.
    12502816
  • Carter KL, Cahir-McFarland E, Kieff E.Epstein-barr virus-induced changes in B-lymphocyte gene expression.J Virol. 2002 Oct;76(20):10427-36.
    12239319
  • Yang J, Aittomki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O.Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.EMBO J. 2002 Sep 16;21(18):4950-8.
    12234934
  • Han I, Xue Y, Harada S, Orstavik S, Skalhegg B, Kieff E.Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins.Mol Cell Biol. 2002 Apr;22(7):2136-46.
    11884601
  • Cahir-McFarland E, Kieff E.NF-kappaB inhibition in EBV-transformed lymphoblastoid cell lines.Recent Results Cancer Res. 2002;159:44-8.
    11785843
  • Lin J, Johannsen E, Robertson E, Kieff E.Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2.J Virol. 2002 Jan;76(1):232-42.
    11739688
  • Higuchi M, Kieff E, Izumi KM.The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines.J Virol. 2002 Jan;76(1):455-9.
    11739714
  • Kang MS, Hung SC, Kieff E.Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15233-8.
    11734622
  • Higuchi M, Izumi KM, Kieff E.Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors.Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4675-80.
    11296297
  • Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E.Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.J Biol Chem. 2001 May 4;276(18):14602-6.
    11278268
  • Hung SC, Kang MS, Kieff E.Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1865-70.
    11172042
  • Han I, Harada S, Weaver D, Xue Y, Lane W, Orstavik S, Skalhegg B, Kieff E.EBNA-LP associates with cellular proteins including DNA-PK and HA95.J Virol. 2001 Mar;75(5):2475-81.
    11160753
  • Harada S, Yalamanchili R, Kieff E.Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association.J Virol. 2001 Mar;75(5):2482-7.
    11160754
  • Cahir-McFarland ED, Davidson DM, Schauer SL, Duong J, Kieff E.NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells.Proc Natl Acad Sci U S A. 2000 May 23;97(11):6055-60.
    10811897
  • Orstavik S, Eide T, Collas P, Han IO, Taskn K, Kieff E, Jahnsen T, Sklhegg BS.Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95.Biol Cell. 2000 Jan;92(1):27-37.
    10761695
  • Callahan J, Aster J, Sklar J, Kieff E, Robertson ES.Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.Leukemia. 2000 Jan;14(1):84-92.
    10637481
  • Wang L, Grossman SR, Kieff E.Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):430-5.
    10618435
  • Izumi KM, Cahir McFarland ED, Ting AT, Riley EA, Seed B, Kieff ED.The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.Mol Cell Biol. 1999 Aug;19(8):5759-67.
    10409763
  • Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU.Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.J Virol. 1999 May;73(5):3913-9.
    10196286
  • Harada S, Yalamanchili R, Kieff E.Residues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation.J Virol. 1998 Dec;72(12):9948-54.
    9811732
  • Devergne O, Cahir McFarland ED, Mosialos G, Izumi KM, Ware CF, Kieff E.Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression.J Virol. 1998 Oct;72(10):7900-8.
    9733827
  • Sylla BS, Hung SC, Davidson DM, Hatzivassiliou E, Malinin NL, Wallach D, Gilmore TD, Kieff E, Mosialos G.Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10106-11.
    9707608
  • Hatzivassiliou E, Miller WE, Raab-Traub N, Kieff E, Mosialos G.A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protein ki.J Immunol. 1998 Feb 1;160(3):1116-21.
    9570524
  • Izumi KM, Kieff ED.The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12592-7.
    9356494
  • Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH.The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.J Virol. 1997 Sep;71(9):6560-7.
    9261377
  • Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J.Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.J Biol Chem. 1997 Apr 25;272(17):11336-43.
    9111040
  • VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF.Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2460-5.
    9122217
  • Izumi KM, Kaye KM, Kieff ED.The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1447-52.
    9037073
  • Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G.Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.Mol Cell Biol. 1996 Dec;16(12):7098-108.
    8943365
  • Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K, Aizawa S, Watanabe T, Mosialos G, Kieff E, Yamamoto T, Inoue J.Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.J Biol Chem. 1996 Nov 15;271(46):28745-8.
    8910514
  • Robertson ES, Ooka T, Kieff ED.Epstein-Barr virus vectors for gene delivery to B lymphocytes.Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11334-40.
    8876136
  • Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G.Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11085-90.
    8855313
  • Johannsen E, Miller CL, Grossman SR, Kieff E.EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytes.J Virol. 1996 Jun;70(6):4179-83.
    8648764
  • Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E.Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.Am J Pathol. 1996 Feb;148(2):593-600.
    8579121
  • Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS.Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.Biochem Biophys Res Commun. 1995 Dec 14;217(2):466-74.
    7503723
  • Kaye KM, Izumi KM, Mosialos G, Kieff E.The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.J Virol. 1995 Feb;69(2):675-83.
    7815530
  • Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman SR.Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.J Virol. 1995 Jan;69(1):253-62.
    7983717