• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Michael Klagsbrun, PhD

Publications

  • Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK.Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.Cell. 2013 Feb 28;152(5):1065-76.
    23452854
  • Shimizu A, Nakayama H, Wang P, K├Ânig C, Akino T, Sandlund J, Coma S, Italiano JE, Mammoto A, Bielenberg DR, Klagsbrun M.Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.J Biol Chem. 2013 Jan 25;288(4):2210-22.
    23195957
  • Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR.Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.Am J Pathol. 2012 Nov;181(5):1573-84.
    23022210
  • Wagner M, Bjerkvig R, Wiig H, Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC.Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.Angiogenesis. 2012 Sep;15(3):481-95.
    22614697
  • Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses MA, Klagsbrun M.Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors.Blood. 2010 Oct 28;116(17):3367-71.
    20453162
  • Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M.A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression.Mol Cancer Res. 2010 Aug;8(8):1063-73.
    20651020
  • Melero-Martin J, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J.Host myeloid cells are necessary for creating bio-engineered human vascular networks in vivo.Tissue Eng Part A. 2010 Aug;16(8):2457-66.
    20218762
  • Klagsbrun M, Shimizu A.Semaphorin 3E, an exception to the rule.J Clin Invest. 2010 Aug 2;120(8):2658-60.
    20664165
  • Coma S, Amin DN, Shimizu A, Lasorella A, Iavarone A, Klagsbrun M.Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.Cancer Res. 2010 May 1;70(9):3823-32.
    20388805
  • Matsuda K, Ohga N, Hida Y, Muraki C, Kurosu T, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.Isolated tumor endothelial cells maintain specific character during long-term culture.Biochem Biophys Res Commun. 2010 Apr 16;394(4):947-54.
    20302845
  • Akino T, Hida K, Hida Y, Tsuchiya K, Freedman D, Muraki C, Ohga N, Matsuda K, Akiyama K, Harabayashi T, Shinohara N, Nonomura K, Klagsbrun M, Shindoh M.Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors.Am J Pathol. 2009 Dec;175(6):2657-67.
    19875502
  • Dudley AC, Klagsbrun M.Tumor endothelial cells join the resistance.Clin Cancer Res. 2009 Aug 1;15(15):4787-9.
    19638456
  • Dudley AC,Klagsbrun M.Tumor endothelial cells have features of adult stem cells.Cell Cycle. 2009 Jan 15;8(2):236-8.
    19158490
  • Dudley AC,Khan ZA,Shih SC,Kang SY,Zwaans BM,Bischoff J,Klagsbrun M.Calcification of multipotent prostate tumor endothelium.Cancer Cell. 2008 Sep 9;14(3):201-11.
    18772110
  • Ghosh K,Thodeti CK,Dudley AC,Mammoto A,Klagsbrun M,Ingber DE.Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro.Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11305-10.
    18685096
  • Amin DN, Bielenberg DR, Lifshits E, Heymach JV, Klagsbrun M.Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.Microvasc Res. 2008 May;76(1):15-22.
    18440031
  • Geretti E, Shimizu A, Klagsbrun M.Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis.Angiogenesis. 2008 Mar;11(1):31-39. Review.
    18283547
  • Klagsbrun M, Moses MA.Obituary: M. Judah Folkman (1933-2008).Nature. 2008 Feb 14;451(7180):781.
    18273010
  • Bielenberg DR, Klagsbrun M.Targeting endothelial and tumor cells with semaphorins.Cancer Metastasis Rev. 2007 Dec;26(3-4):421-31. Review.
    17768598
  • Bahary N, Goishi K, Stuckenholz C, Weber G, Leblanc J, Schafer CA, Berman SS, Klagsbrun M, Zon LI.Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish.Blood. 2007 Nov 15;110(10):3627-36.
    17698971
  • Geretti E, Shimizu A, Kurschat P, Klagsbrun M.Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F.J Biol Chem. 2007 Aug 31;282(35):25698-707.
    17595163
  • Stahl A, Wu X, Wenger A, Klagsbrun M, Kurschat P.Endothelial progenitor cell sprouting in spheroid cultures is resistant to inhibition by osteoblasts: a model for bone replacement grafts.FEBS Lett. 2005 Oct 10;579(24):5338-42.
    16194535
  • Feldner J, Becker T, Goishi K, Schweitzer J, Lee P, Schachner M, Klagsbrun M, Becker CG.Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish.Dev Dyn. 2005 Nov;234(3):535-49.
    16110501
  • Klagsbrun M, Eichmann A.A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis.Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):535-48.
    15979925
  • Wey JS, Gray MJ, Fan F, Belcheva A, McCarty MF, Stoeltzing O, Somcio R, Liu W, Evans DB, Klagsbrun M, Gallick GE, Ellis LM.Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.Br J Cancer. 2005 Jul 25;93(2):233-41.
    15956974
  • Hida K, Klagsbrun M.A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities.Cancer Res. 2005 Apr 1;65(7):2507-10.
    15805239
  • Nishi E, Klagsbrun M.Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways.Growth Factors. 2004 Dec;22(4):253-60.
    15621728
  • Hida K, Hida Y, Amin DN, Flint AF, Panigrahy D, Morton CC, Klagsbrun M.Tumor-associated endothelial cells with cytogenetic abnormalities.Cancer Res. 2004 Nov 15;64(22):8249-55.
    15548691
  • Goishi K, Klagsbrun M.Vascular endothelial growth factor and its receptors in embryonic zebrafish blood vessel development.Curr Top Dev Biol. 2004;62:127-52.
    15522741
  • Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim CC, Klagsbrun M.Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype.J Clin Invest. 2004 Nov;114(9):1260-71.
    15520858
  • Kutcher ME, Klagsbrun M, Mamluk R.VEGF is required for the maintenance of dorsal root ganglia blood vessels but not neurons during development.FASEB J. 2004 Dec;18(15):1952-4.
    15479766
  • Bovenkamp DE, Goishi K, Bahary N, Davidson AJ, Zhou Y, Becker T, Becker CG, Zon LI, Klagsbrun M.Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish.Gene Expr Patterns. 2004 Jul;4(4):361-70.
    15183302
  • Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, Reinmuth N, Bielenberg D, Bucana CD, Klagsbrun M, Ellis LM.Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis.Am J Pathol. 2004 Jun;164(6):2139-51.
    15161648
  • Goishi K, Lee P, Davidson AJ, Nishi E, Zon LI, Klagsbrun M.Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.Mech Dev. 2003 Jul;120(7):811-22.
    12915231
  • Iwamoto R, Yamazaki S, Asakura M, Takashima S, Hasuwa H, Miyado K, Adachi S, Kitakaze M, Hashimoto K, Raab G, Nanba D, Higashiyama S, Hori M, Klagsbrun M, Mekada E.Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6.
    12621152
  • Bates D, Taylor GI, Minichiello J, Farlie P, Cichowitz A, Watson N, Klagsbrun M, Mamluk R, Newgreen DF.Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1.Dev Biol. 2003 Mar 1;255(1):77-98.
    12618135