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Andrew D. Luster, MD, PhD

Publications

  • Griffith JW, Luster AD.Targeting cells in motion: migrating toward improved therapies.Eur J Immunol. 2013 Apr 12.
    23580465
  • Mehling M, Brinkmann V, Burgener AV, Gubser P, Luster AD, Kappos L, Hess C.Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade.J Allergy Clin Immunol. 2013 Feb 21.
    23434284
  • Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD.Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern.J Immunol. 2013 Feb 1;190(3):970-6.
    23255361
  • Sakai N, Chun J, Duffield JS, Wada T, Luster AD, Tager AM.LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.FASEB J. 2013 Jan 15.
    23322166
  • Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD.CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation.Immunity. 2012 Dec 14;37(6):1091-103.
    23123063
  • Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Groom JR, Luster AD, von Andrian UH.Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes.Cell. 2012 Sep 14;150(6):1249-63.
    22980984
  • Groom JR, Luster AD.CXCR3 in T cell function.Exp Cell Res. 2011 Mar 10;317(5):620-31.
    21376175
  • Groom JR, Luster AD.CXCR3 ligands: redundant, collaborative and antagonistic functions.Immunol Cell Biol. 2011 Feb;89(2):207-15.
    21221121
  • Colvin RA, Luster AD.Movement within and movement beyond: synaptotagmin-mediated vesicle fusion during chemotaxis.Cell Adh Migr.;5(1):56-8.
    20798599
  • Campanella GS, Colvin RA, Luster AD.CXCL10 can inhibit endothelial cell proliferation independently of CXCR3.PLoS ONE. 2010;5(9):e12700.
    20856926
  • Chou RC, Kim ND, Sadik CD, Seung E, Lan Y, Byrne MH, Haribabu B, Iwakura Y, Luster AD.Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.Immunity. 2010 Aug 27;33(2):266-78.
    20727790
  • Means TK, Luster AD.Integrins limit the Toll.Nat Immunol. 2010 Aug;11(8):691-3.
    20644576
  • Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW.Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.J Clin Invest. 2010 Jun 1;120(6):2049-57.
    20484822
  • Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD.Synaptotagmin-mediated vesicle fusion regulates cell migration.Nat Immunol. 2010 Jun;11(6):495-502.
    20473299
  • Thomas SY, Chyung YH, Luster AD.Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma.J Allergy Clin Immunol. 2010 May;125(5):980-4. Review.
    20304475
  • Mikhak Z, Luster AD.The emergence of basophils as antigen-presenting cells in Th2 inflammatory responses.Journal Of Molecular Cell Biology. 2009 Dec;1(2):69-71.
    19776083
  • Brainard DM,Seung E,Frahm N,Cariappa A,Bailey CC,Hart WK,Shin HS,Brooks SF,Knight HL,Eichbaum Q,Yang YG,Sykes M,Walker BD,Freeman GJ,Pillai S,Westmoreland SV,Brander C,Luster AD,Tager AM.Induction of robust cellular and humoral virus-specific adaptive immune responses in HIV-infected humanized BLT mice.J Virol. 2009 Jul;83(14):7305-21.
    19420076
  • Mikhak Z, Farsidjani A, Luster AD.Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation.J Immunol. 2009 Jun 15;182(12):7946-56.
    19494319
  • Campanella GS,Luster AD.Chapter 18. A chemokine-mediated in vivo T-cell recruitment assay.Methods Enzymol. 2009;461:397-412.
    19480929
  • Means TK,Mylonakis E,Tampakakis E,Colvin RA,Seung E,Puckett L,Tai MF,Stewart CR,Pukkila-Worley R,Hickman SE,Moore KJ,Calderwood SB,Hacohen N,Luster AD,El Khoury J.Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.J Exp Med. 2009 Mar 16;206(3):637-53.
    19237602
  • Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ.Differential requirement for CARMA1 in agonist-selected T-cell development.Eur J Immunol. 2009 Jan;39(1):78-84.
    19130560
  • Mikhak Z,Fukui M,Farsidjani A,Medoff BD,Tager AM,Luster AD.Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.J Allergy Clin Immunol. 2009 Jan;123(1):67-73.e3.
    19062085
  • Zenhaeusern G,Gubser P,Eisele P,Gasser O,Steinhuber A,Trampuz A,Handschin C,Luster AD,Hess C.A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.Blood. 2009 Jan 1;113(1):95-9.
    18845792
  • Bromley SK,Mempel TR,Luster AD.Orchestrating the orchestrators: chemokines in control of T cell traffic.Nat Immunol. 2008 Sep;9(9):970-80. Review.
    18711434
  • Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR.CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.J Am Soc Nephrol. 2008 Jun;19(6):1177-89.
    18337479
  • Medoff BD, Thomas SY, Luster AD.T Cell Trafficking in Allergic Asthma: The Ins and Outs.Annu Rev Immunol. 2008 Apr;26:205-232. Review.
    18304002
  • Campanella GS, Medoff BD, Manice LA, Colvin RA, Luster AD.Development of a novel chemokine-mediated in vivo T cell recruitment assay.J Immunol Methods. 2008 Feb 29;331(1-2):127-39.
    18206159
  • Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD.The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.Nat Med. 2008 Jan;14(1):45-54.
    18066075
  • Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW.CXCL10 regulates liver innate immune response against ischemia and reperfusion injury.Hepatology. 2008 Jan;47(1):207-14.
    18041715
  • Okamoto Y, Folco EJ, Minami M, Wara AK, Feinberg MW, Sukhova GK, Colvin RA, Kihara S, Funahashi T, Luster AD, Libby P.Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis.Circ Res. 2008 Feb 1;102(2):218-25.
    17991878
  • Viola A, Luster AD.Chemokines and their receptors: drug targets in immunity and inflammation.Annu Rev Pharmacol Toxicol. 2008;48:171-97. Review.
    17883327
  • Kim N, Luster AD.Regulation of immune cells by eicosanoid receptors.ScientificWorldJournal. 2007;7:1307-28. Review.
    17767352
  • Thomas SY, Banerji A, Medoff BD, Lilly CM, Luster AD.Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway.J Immunol. 2007 Aug 1;179(3):1901-12.
    17641057
  • Mullegger RR, Means TK, Shin JJ, Lee M, Jones KL, Glickstein LJ, Luster AD, Steere AC.Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma.Infect Immun. 2007 Sep;75(9):4621-8.
    17606602
  • Brainard DM, Tager AM, Misdraji J, Frahm N, Lichterfeld M, Draenert R, Brander C, Walker BD, Luster AD.Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.J Virol. 2007 Aug;81(16):8439-50.
    17553894
  • Yuan Q, Bromley SK, Means TK, Jones KJ, Hayashi F, Bhan AK, Luster AD.CCR4-dependent regulatory T cell function in inflammatory bowel disease.J Exp Med. 2007 Jun 11;204(6):1327-34.
    17548518
  • Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM.Chitin induces accumulation in tissue of innate immune cells associated with allergy.Nature. 2007 May 3;447(7140):92-6.
    17450126
  • El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD.Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.Nat Med. 2007 Apr;13(4):432-8.
    17351623
  • Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD.Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity.J Immunol. 2006 Nov 15;177(10):6991-8.
    17082614
  • Ariel A, Fredman G, Sun YP, Kantarci A, Van Dyke TE, Luster AD, Serhan CN.Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression.Nat Immunol. 2006 Nov;7(11):1209-16.
    17013391
  • Yuan Q, Campanella GS, Colvin RA, Hamilos DL, Jones KJ, Mathew A, Means TK, Luster AD.Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells.Eur J Immunol. 2006 Oct;36(10):2700-14.
    16983721
  • Colvin RA, Campanella GS, Manice LA, Luster AD.CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis.Mol Cell Biol. 2006 Aug;26(15):5838-49.
    16847335
  • Khan IA, Thomas SY, Moretto MM, Lee FS, Islam SA, Combe C, Schwartzman JD, Luster AD.CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection.PLoS Pathog. 2006 Jun;2(6):e49.
    16789839
  • Medoff BD, Wain JC, Seung E, Jackobek R, Means TK, Ginns LC, Farber JM, Luster AD.CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function.J Immunol. 2006 Jun 1;176(11):7087-95.
    16709871
  • Mikhak Z, Fleming CM, Medoff BD, Thomas SY, Tager AM, Campanella GS, Luster AD.STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.J Immunol. 2006 Apr 15;176(8):4959-67.
    16585592
  • Kim ND, Chou RC, Seung E, Tager AM, Luster AD.A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis.J Exp Med. 2006 Apr 17;203(4):829-35.
    16567386
  • Islam SA, Thomas SY, Hess C, Medoff BD, Means TK, Brander C, Lilly CM, Tager AM, Luster AD.The Leukotriene B4 Lipid Chemoattractant Receptor BLT1 Defines Antigen-primed T-cells in Humans.Blood. 2006 Jan 15;107(2):444-53.
    16179368
  • Luster AD, Alon R, von Andrian UH.Immune cell migration in inflammation: present and future therapeutic targets.Nat Immunol. 2005 Dec;6(12):1182-90.
    16369557
  • Bromley SK, Thomas SY, Luster AD.Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.Nat Immunol. 2005 Sep;6(9):895-901.
    16116469
  • Medoff BD, Seung E, Wain JC, Means TK, Campanella GS, Islam SA, Thomas SY, Ginns LC, Grabie N, Lichtman AH, Tager AM, Luster AD.BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation.J Exp Med. 2005 Jul 4;202(1):97-110.
    15998790
  • Sipkins DA, Wei X, Wu JW, Runnels JM, Côté D, Means TK, Luster AD, Scadden DT, Lin CP.In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.Nature. 2005 Jun 16;435(7044):969-73.
    15959517
  • Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD.Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.J Clin Invest. 2005 Feb;115(2):407-17.
    15668740