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David M. Knipe, PhD


  • Knipe DM, Corey L, Cohen JI, Deal CD.Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines".Vaccine. 2014 Mar 20;32(14):1561-2.
  • Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC.A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.Cell. 2014 Feb 13;156(4):705-16.
  • Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, Henn M, Knipe DM.Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.Virology. 2014 Feb;450-451:140-5.
  • Oh HS, Bryant KF, Nieland TJ, Mazumder A, Bagul M, Bathe M, Root DE, Knipe DM.A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.MBio. 2014;5(1):e01086-13.
  • Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM.Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4492-501.
  • Sen J, Liu X, Roller R, Knipe DM.Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination.Virology. 2013 May 10;439(2):65-73.
  • Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N.Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Nat Immunol. 2013 Feb;14(2):179-85.
  • Cliffe AR, Coen DM, Knipe DM.Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.MBio. 2013;4(1).
  • Orzalli MH, Deluca NA, Knipe DM.Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3008-17.
  • Bryant KF, Colgrove RC, Knipe DM.Cellular SNF2H Chromatin-Remodeling Factor Promotes Herpes Simplex Virus 1 Immediate-Early Gene Expression and Replication.MBio. 2011;2(1).
  • van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA.Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.J Virol. 2010 Oct;84(20):10802-11.
  • Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM.Numerous Conserved and Divergent MicroRNAs Expressed by Herpes Simplex Viruses 1 and 2.J Virol. 2010 May;84(9):4659-72.
  • Reszka N, Zhou C, Song B, Sodroski JG, Knipe DM.Simian TRIM5alpha proteins reduce replication of herpes simplex virus.Virology. 2010 Mar 15;398(2):243-50.
  • Hancock MH, Cliffe AR, Knipe DM, Smiley JR.Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.J Virol. 2010 Feb;84(3):1366-75.
  • Johnson KE, Knipe DM.Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.Virology. 2010 Jan 5;396(1):21-9.
  • Hoshino Y, Pesnicak L, Dowdell KC, Burbelo PD, Knipe DM, Straus SE, Cohen JI.Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs.J Infect Dis. 2009 Oct 1;200(7):1088-95.
  • Cliffe AR, Garber DA, Knipe DM.Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.J Virol. 2009 Aug;83(16):8182-90.
  • Liu X,Broberg E,Watanabe D,Dudek T,Deluca N,Knipe DM.Genetic engineering of a modified herpes simplex virus 1 vaccine vector.Vaccine. 2009 May 11;27(21):2760-7.
  • Brockman MA,Knipe DM.Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection.Vaccine. 2008 Dec 30;26 Suppl 8:I94-9. Review.
  • Taylor TJ,Knipe DM.The use of green fluorescent fusion proteins to monitor herpes simplex virus replication.Methods Mol Biol. 2009;515:239-48.
  • Hamirally S,Kamil JP,Ndassa-Colday YM,Lin AJ,Jahng WJ,Baek MC,Noton S,Silva LA,Simpson-Holley M,Knipe DM,Golan DE,Marto JA,Coen DM.Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.PLoS Pathog. 2009 Jan;5(1):e1000275.
  • Cliffe AR,Knipe DM.Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.J Virol. 2008 Dec;82(24):12030-8.
  • Liu X,Fitzgerald K,Kurt-Jones E,Finberg R,Knipe DM.Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11335-9.
  • Hoshino Y,Pesnicak L,Dowdell KC,Lacayo J,Dudek T,Knipe DM,Straus SE,Cohen JI.Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs.Vaccine. 2008 Jul 29;26(32):4034-40.
  • Silva L,Cliffe A,Chang L,Knipe DM.Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation.PLoS Pathog. 2008 May;4(5):e1000071.
  • Dodson AW, Taylor TJ, Knipe DM, Coen DM.Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.Virology. 2007 Sep 30;366(2):340-8.
  • Petit CM, Chouljenko VN, Iyer A, Colgrove R, Farzan M, Knipe DM, Kousoulas KG.Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion.Virology. 2007 Apr 10;360(2):264-74.
  • Melroe GT, Silva L, Schaffer PA, Knipe DM.Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.Virology. 2007 Apr 10;360(2):305-21.
  • Watanabe D, Brockman MA, Ndung'u T, Mathews L, Lucas WT, Murphy CG, Felber BK, Pavlakis GN, Deluca NA, Knipe DM.Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.Virology. 2007 Jan 20;357(2):186-98.
  • Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC.Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.Virology. 2007 Jan 20;357(2):199-214.
  • Brockman MA, Verschoor A, Zhu J, Carroll MC, Knipe DM.Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.J Virol. 2006 Jul;80(14):7111-7.
  • Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J.An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.Nature. 2006 Jan 5;439(7072):89-94.
  • Wakimoto H, Johnson PR, Knipe DM, Chiocca EA.Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells.Gene Ther. 2003 Jun;10(11):983-90.
  • de Bruyn Kops A, Uprichard SL, Chen M, Knipe DM.Comparison of the intranuclear distributions of herpes simplex virus proteins involved in various viral functions.Virology. 1998 Dec 5;252(1):162-78.
  • Hann LE, Cook WJ, Uprichard SL, Knipe DM, Coen DM.The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.J Virol. 1998 Oct;72(10):7709-14.
  • Morrison LA, Da Costa XJ, Knipe DM.Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge.Virology. 1998 Mar 30;243(1):178-87.
  • Kramer MF, Chen SH, Knipe DM, Coen DM.Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.J Virol. 1998 Feb;72(2):1177-85.
  • Morrison LA, Knipe DM.Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1.Virology. 1997 Dec 22;239(2):315-26.
  • Garber DA, Schaffer PA, Knipe DM.A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.J Virol. 1997 Aug;71(8):5885-93.
  • Da Costa XJ, Bourne N, Stanberry LR, Knipe DM.Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.Virology. 1997 May 26;232(1):1-12.
  • Brehm MA, Bonneau RH, Knipe DM, Tevethia SS.Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.J Virol. 1997 May;71(5):3534-44.
  • Uprichard SL, Knipe DM.Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites.Virology. 1997 Mar 3;229(1):113-25.
  • Chen YM, Knipe DM.A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription.Virology. 1996 Jul 15;221(2):281-90.
  • Kanangat S, Babu JS, Knipe DM, Rouse BT.HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: selective upregulation of IL-6 gene expression.Virology. 1996 May 1;219(1):295-300.
  • Uprichard SL, Knipe DM.Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.J Virol. 1996 Mar;70(3):1969-80.
  • Liptak LM, Uprichard SL, Knipe DM.Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures.J Virol. 1996 Mar;70(3):1759-67.
  • Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO.Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.J Comp Neurol. 1994 Jan 1;339(1):3-11.