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Annick D. Van den Abbeele, M.D.

Associate Professor of Radiology, Department of Radiology, Harvard Medical School

Chief, Radiology, Dana-Farber Cancer Institute

Director, DFCI/BWH Nuclear Medicine Oncology Program, Radiology, Brigham And Women's Hospital

Founding Director, Center for Biomedical Imaging in Oncology (CBIO), Radiology, Dana-Farber Cancer Institute

Contact Info

Annick Van den Abbeele
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Mailstop: DL 145B
Phone: 617-632-2595
Fax: 617-582-8574
abbeele@dfci.harvard.edu

Assistant

James Ryan
Administrative Assistant
Radiology
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Phone: 617-632-2595
Fax: 617-582-8574
james_ryan@dfci.harvard.edu

DF/HCC Program Affiliation

Sarcoma
Lymphoma and Myeloma
Lung Cancer
Cancer Imaging

DF/HCC Associations

Co-Director, Tumor Imaging Metrics

Research Abstract

Molecular imaging; positron emission tomography (PET); evaluation of new drugs for treatment of cancer; imaging as a biomarker of response

Publications

  • Shankar LK, Hoffman JM, Bacharach S, Graham MM, Karp J, Lammertsma AA, Larson S, Mankoff DA, Siegel BA, Van den Abbeele A, Yap J, Sullivan D,.Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in Natio
    16741317
  • Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joen
    12181401
  • Friedberg J, Jacobsen E, Neuberg D, Kutok J, Munoz O, Boussiotis V, Reynolds H, Fisher D, Szot A, Van Den Abbeele A, Freedman A.Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept.Leuk Lymphoma 2008 May;49(5):90
    18464109
  • Hodi FS, Friedlander P, Corless CL, Heinrich MC, Mac Rae S, Kruse A, Jagannathan J, Van den Abbeele AD, Velazquez EF, Demetri GD, Fisher DE.Major response to imatinib mesylate in KIT-mutated melanoma.J Clin Oncol 2008 Apr 20;26(12):2046-51.
    18421059
  • Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris GJ, Bullitt E, Van den Abbeele AD, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Kirsch DG, Crawford A, Hochberg F, Winer EP.Phase II trial of lapatinib for brain metastases in patients
    18421051
  • Raje N, Woo SB, Hande K, Yap JT, Richardson PG, Vallet S, Treister N, Hideshima T, Sheehy N, Chhetri S, Connell B, Xie W, Tai YT, Szot-Barnes A, Tian M, Schlossman RL, Weller E, Munshi NC, Van Den Abbeele AD, Anderson KC.Clinical, radiographic, and bioche
    18413829
  • Masciari S, Van den Abbeele AD, Diller LR, Rastarhuyeva I, Yap J, Schneider K, Digianni L, Li FP, Fraumeni JF Jr, Syngal S, Garber JE.F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome.JAMA 2008 Mar 1
    18349092
  • Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F, Desai J, George S, Morgan JA, Harris DM, Ismail NS, Chen JH, Schoen FJ, Van den Abbeele AD, Demetri GD, Force T, Chen MH.Cardiotoxicity associated with t
    18083403
  • Holdsworth CH, Badawi RD, Manola JB, Kijewski MF, Israel DA, Demetri GD, Van den Abbeele AD.CT and PET: early prognostic indicators of response to imatinib mesylate in patients with gastrointestinal stromal tumor.AJR Am J Roentgenol 2007 Dec;189(6):W324-3
    18029844
  • El Fakhri G, Santos PA, Badawi RD, Holdsworth CH, Van Den Abbeele AD, Kijewski MF.Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET.J Nucl Med 2007 Dec;48(12):1951-1960.
    18006613
  • Herbst RS, Davies AM, Natale RB, Dang TP, Schiller JH, Garland LL, Miller VA, Mendelson D, Van den Abbeele AD, Melenevsky Y, de Vries DJ, Eberhard DA, Lyons B, Lutzker SG, Johnson BE.Efficacy and safety of single-agent pertuzumab, a human epidermal recept
    17947484
  • Desai J, Shankar S, Heinrich MC, Fletcher JA, Fletcher CD, Manola J, Morgan JA, Corless CL, George S, Tuncali K, Silverman SG, Van den Abbeele AD, van Sonnenberg E, Demetri GD.Clonal evolution of resistance to imatinib in patients with metastatic gastroin
    17875769
  • Demetri GD, Benjamin RS, Blanke CD, Blay JY, Casali P, Choi H, Corless CL, Debiec-Rychter M, DeMatteo RP, Ettinger DS, Fisher GA, Fletcher CD, Gronchi A, Hohenberger P, Hughes M, Joensuu H, Judson I, Le Cesne A, Maki RG, Morse M, Pappo AS, Pisters PW, Rau
    17624289
  • Burrell SC, Van den Abbeele AD.2-Deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography of the head and neck: an atlas of normal uptake and variants.Mol Imaging Biol 2005 May-Jun;7(3):244-56.
    15912429
  • Shankar S, vanSonnenberg E, Desai J, Dipiro PJ, Van Den Abbeele A, Demetri GD.Gastrointestinal stromal tumor: new nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate.Radiology 2005 Jun;235(3):892-8.
    15833985
  • Ng AK, Bernardo MV, Silver B, Van Den Abbeele A, Stevenson MA, Fisher DC, Mauch PM.Mid- and post-ABVD gallium scanning predicts for recurrence in early-stage Hodgkin's disease.Int J Radiat Oncol Biol Phys 2005 Jan 1;61(1):175-84.
    15629609
  • McCollum AD, Burrell SC, Haddad RI, Norris CM, Tishler RB, Case MA, Posner MR, Van den Abbeele AD.Positron emission tomography with 18F-fluorodeoxyglucose to predict pathologic response after induction chemotherapy and definitive chemoradiotherapy in head
    15390197
  • Heymach JV, Desai J, Manola J, Davis DW, McConkey DJ, Harmon D, Ryan DP, Goss G, Quigley T, Van den Abbeele AD, Silverman SG, Connors S, Folkman J, Fletcher CD, Demetri GD.Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft ti
    15355900
  • Friedberg JW, Fischman A, Neuberg D, Kim H, Takvorian T, Ng AK, Mauch PM, Canellos GP, van den Abbeele AD.FDG-PET is superior to gallium scintigraphy in staging and more sensitive in the follow-up of patients with de novo Hodgkin lymphoma: a blinded compa
    15061202
  • Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA.Kinase mutations and imatinib
    14645423
  • Van den Abbeele AD, Badawi RD.Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs).Eur J Cancer 2002 Sep;38 Suppl 5:S60-5.
    12528774
  • Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA.A potential murine model for flap-related investigations.Plast Reconstr Surg 2001 May;107(6):1504-8.
    11335827
  • Jacobson AF, Shapiro CL, Van den Abbeele AD, Kaplan WD.Prognostic significance of the number of bone scan abnormalities at the time of initial bone metastatic recurrence in breast carcinoma.Cancer 2001 Jan 1;91(1):17-24.
    11148555
  • Frank DA, Meuse J, Hirsch D, Ibrahim JG, van den Abbeele AD.The treatment and outcome of cancer patients with thromboses on central venous catheters.J Thromb Thrombolysis 2000 Dec;10(3):271-5.
    11122548
  • Frohlich DE, Chen JL, Neuberg D, Kehoe KM, Van den Abbeele AD.When is hilar uptake of 67Ga-citrate indicative of residual disease after CHOP chemotherapy?.J Nucl Med 2000 Feb;41(2):269-74.
    10688110
  • Friedberg JW, Van den Abbeele AD, Kehoe K, Singer S, Fletcher CD, Demetri GD.Uptake of radiolabeled somatostatin analog is detectable in patients with metastatic foci of sarcoma.Cancer 1999 Oct 15;86(8):1621-7.
    10526294
  • Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK.Return of lymphatic function after flap transfer for acute lymphedema.Ann Surg 1999 Mar;229(3):421-7.
    10077056
  • Wu C, Vasconcelles M, DePiro P, Van den Abbeele A, Rakusin A, Bechard K, Skarin A.Primary cardiac angiosarcoma presenting as a malignant pericardial effusion.J Clin Oncol 1998 Dec;16(12):3913-5.
    9850037
  • Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJ.5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats.J Nucl Med 1998 Jul;39(7):1148-54.
    9669385
  • Bartold SP, Donohoe KJ, Fletcher JW, Haynie TP, Henkin RE, Silberstein EB, Royal HD, Van den Abbeele A.Procedure guideline for gallium scintigraphy in the evaluation of malignant disease. Society of Nuclear Medicine.J Nucl Med 1997 Jun;38(6):990-4.
    9189158
  • Slavin SA, Upton J, Kaplan WD, Van den Abbeele AD.An investigation of lymphatic function following free-tissue transfer.Plast Reconstr Surg 1997 Mar;99(3):730-41; discussion 742-3.
    9047193
  • Kassis AI, Tumeh SS, Wen PY, Baranowska-Kortylewicz J, Van den Abbeele AD, Zimmerman RE, Carvalho PA, Garada BM, DeSisto WC, Bailey NO, Castronovo FP, Mariani G, Black PM, Adelstein SJ.Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patie
    8676198
  • Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AI.Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer.J Nucl Med 1996 Feb;37(2):315-20.
    8667069
  • Gangopadhyay A, Saravis CA, van den Abbeele AD, Kassis AI.pI-dependent isolation of antibody isoforms by semipreparative isoelectric focusing.Q J Nucl Med 1995 Jun;39(2):129-33.
    8574807
  • Mariani G, Collecchi P, Giuliani L, Baranowska-Kortylewicz J, Di Luca L, Meucci G, Viacava P, Van den Abbeele AD, Salvadori PA, Di Sacco S.Tumor targeting potential and metabolism of 5-[125I]iodo-2'-deoxyuridine injected intratumorally in patients with br
    8279758
  • Mariani G, Cei A, Collecchi P, Baranowska-Kortylewicz J, Van den Abbeele AD, Di Luca L, Di Stefano R, Viacava P, Ferdeghini EM, Di Sacco S.Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in
    8315499
  • Khawli LA, van den Abbeele AD, Kassis AI.N-(m-[125I]iodophenyl)maleimide: an agent for high yield radiolabeling of antibodies.Int J Rad Appl Instrum B 1992 Apr;19(3):289-95.
    1629018
  • Baranowska-Kortylewicz J, Makrigiorgos GM, Van den Abbeele AD, Berman RM, Adelstein SJ, Kassis AI.5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model.Int J Radiat Oncol Biol Phys 1991 Nov;21(6):1541-51.
    1938564
  • Janicek MJ, Van den Abbeele AD, DeSisto WC, Kassis AI, Holman BL, Tumeh SS, Hollenberg NK.Embolization of platelets after endothelial injury to the aorta in rabbits. Assessment with 111indium-labeled platelets and angiography.Invest Radiol 1991 Jul;26(7):
    1885272
  • Mariani G, Ito S, Nayak RC, Baranowska-Kortylewicz J, Venkateshan CN, Van den Abbeele AD, Eisenbarth GS, Adelstein SJ, Kassis AI.Capping and internalization of a monoclonal antibody-surface antigen complex: a possible mode of interaction of monoclonal ant
    1932178
  • Van den Abbeele AD, Aaronson RA, Daher S, Taube RA, Adelstein SJ, Kassis AI.Antigen-binding site protection during radiolabeling leads to a higher immunoreactive fraction.J Nucl Med 1991 Jan;32(1):116-22.
    1988614
  • Adelstein SJ, Kassis AI, Baranowska-Kortylewicz J, van den Abbeele AD, Mariani G, Ito S.Potential for tumor therapy with iodine-125 labeled immunoglobulins.Int J Rad Appl Instrum B 1991;18(1):43-4.
    2010304
  • Tumeh SS, Carvalho PA, van den Abbeele AD, Maguire JH, Rauh DA, Neptune M, Kassis AI.Detection of focal infection by 111In-human polyclonal IgG.J Nucl Biol Med 1991 Jan-Mar;35(1):4-9.
    1932174
  • Janicek MJ, Van den Abbeele AD, Hollenberg NK, Kassis AI, Holman BL, Tumeh SS.Platelet activation and aggregation after endothelial injury. Assessment with indium-111-labeled platelets and angiography.Invest Radiol 1990 Sep;25(9):988-93.
    2211057
  • Kassis AI, Van den Abbeele AD, Wen PY, Baranowska-Kortylewicz J, Aaronson RA, DeSisto WC, Lampson LA, Black PM, Adelstein SJ.Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnosti
    2379179
  • Makrigiorgos GM, Ito S, Baranowska-Kortylewicz J, Vinter DW, Iqbal A, Van den Abbeele AD, Adelstein SJ, Kassis AI.Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications.J Nucl Med 1990 Aug
    2384804
  • van den Abbeele AD, Aaronson RA, Taube RA, Adelstein SJ, Kassis AI.Preadsorption of radiolabeled monoclonal antibodies to liver and spleen tissues leads to higher tumor-to-normal-tissue ratios.J Nucl Med Allied Sci 1990 Apr-Jun;34(2):94-102.
    2246677
  • Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG.Uptake of the cation hexakis(2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro.Cancer Res 1990 Apr 1;50(7):2198-202.
    2317808
  • Kinsey BM, Van den Abbeele AD, Adelstein SJ, Kassis AI.Absence of preferential uptake of [125I]iododihydrorhodamine 123 by four human tumor xenografts.Cancer Res 1989 Nov 1;49(21):5986-8.
    2676153
  • Muto MG, Lepisto EM, Van den Abbeele AD, Knapp RC, Kassis AI.Influence of human antimurine antibody on CA 125 levels in patients with ovarian cancer undergoing radioimmunotherapy or immunoscintigraphy with murine monoclonal antibody OC 125.Am J Obstet Gyn
    2686446
  • Van den Abbeele AD, Aaronson RA, Adelstein SJ, Kassis AI.Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior?.J Nucl Med Allied Sci 1988 Oct-Dec;32(4):260-7.
    3230413
  • Layne WW, Kassis AI, Van den Abbeele A, Kinsey BM, Adelstein SJ.HPLC analysis of the dissociation and recombination of rabbit immunoglobulin G.J Immunol Methods 1987 Feb 11;96(2):195-9.
    3805740
  • Engelhardt B, Sandberg K, Bratton D, Van den Abbeele A, Grogaard J, Hellerqvist C, Sundell H.The role of granulocytes in the pulmonary response to group B streptococcal toxin in young lambs.Pediatr Res 1987 Feb;21(2):159-65.
    3822595
  • Van den Abbeele AD, Treves ST, Lebowitz RL, Bauer S, Davis RT, Retik A, Colodny A.Vesicoureteral reflux in asymptomatic siblings of patients with known reflux: radionuclide cystography.Pediatrics 1987 Jan;79(1):147-53.
    3025806
  • Grogaard J, Van den Abbeele A, Sundell H.Effect of alcohol on apnea reflexes in young lambs.J Appl Physiol 1985 Aug;59(2):420-5.
    4030595