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Susumu Kobayashi, MD, PhD

Publications

  • Kobayashi S, Canepa HM, Bailey AS, Nakayama S, Yamaguchi N, Goldstein MA, Huberman MS, Costa DB.Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors.J Thorac Oncol. 2013 Jan;8(1):45-51.
    23242437
  • Ackerman A, Goldstein MA, Kobayashi S, Costa DB.EGFR delE709_T710insD: a rare but potentially EGFR inhibitor responsive mutation in non-small-cell lung cancer.J Thorac Oncol. 2012 Oct;7(10):e19-20.
    22982663
  • Yasuda H, de Figueiredo-Pontes LL, Kobayashi S, Costa DB.Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer.J Thorac Oncol. 2012 Jul;7(7):1086-90.
    22617245
  • Costa DB, Kobayashi S, Pandya SS, Yeo WL, Shen Z, Tan W, Wilner KD.CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib.J Clin Oncol. 2011 Mar 21.
    21422405
  • Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T.Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells.Biol Pharm Bull. 2011;34(2):243-8.
    21415535
  • Ushigome T, Kawahara H, Kobayashi T, Kobayashi S, Kashiwagi H, Yanaga K.Where should the specimen be excised for the chemosensitivity of colorectal cancer to 5-fluorouracil?.Hepatogastroenterology.;57(102-103):1090-4.
    21410037
  • Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K.Laparoscopy-assisted lateral pelvic lymph node dissection for advanced rectal cancer.Hepatogastroenterology.;57(102-103):1136-8.
    21410045
  • Zhang Z, Stiegler AL, Boggon TJ, Kobayashi S, Halmos B.EGFR-mutated lung cancer: a paradigm of molecular oncology.Oncotarget. 2010 Nov;1(7):497-514.
    21165163
  • Noaki R, Kawahara H, Watanabe K, Ushigome T, Kobayashi S, Yanaga K.Serum p53 antibody is a useful tumor marker of early colorectal cancer.Int Surg.;95(4):287-92.
    21309408
  • Li-Wan-Po A, Farndon PA, Kobayashi S, Mitsudomi T, Potter VA.The Pharmacogenetic Rescue of Side-Lined Anticancer Drugs to the Front-Line: Gefitinib as a Case Example (February).The Annals Of Pharmacotherapy. 2011 Feb 8.
    21304034
  • Usuba T, Misawa T, Toyama Y, Ishida Y, Ishii Y, Yanagisawa S, Kobayashi S, Yanaga K.Is modified Devine exclusion necessary for gastrojejunostomy in patients with unresectable pancreatobiliary cancer?.Surg Today. 2011 Jan;41(1):97-100.
    21191698
  • Akiba T, Marushima H, Kawahara H, Takagi M, Hirano J, Odaka M, Nakanishi K, Takeyama H, Kobayashi S, Morikawa T.Video-assisted thoracic surgery for patients with lung cancer and interstitial pneumonia.Ann Thorac Cardiovasc Surg. 2010 Aug;16(4):236-41.
    21057439
  • Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K.Retrograde single stapling technique for laparoscopic ultralow anterior resection.Digestive Surgery. 2010;27(4):261-4.
    20668381
  • Costa DB, Kobayashi S, Yeo WL, Hamada A.Serum concentrations of Erlotinib at a dose of 25 mg daily.J Thorac Oncol. 2010 Aug;5(8):1311-2.
    20661096
  • Akiba T, Marushima H, Odaka M, Harada J, Kobayashi S, Morikawa T.Pulmonary vein analysis using three-dimensional computed tomography angiography for thoracic surgery.Gen Thorac Cardiovasc Surg. 2010 Jul;58(7):331-5.
    20628848
  • Yeo WL, Riely GJ, Yeap BY, Lau MW, Warner JL, Bodio K, Huberman MS, Kris MG, Tenen DG, Pao W, Kobayashi S, Costa DB.Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations.J Thorac Oncol. 2010 Jul;5(7):1048-53.
    20512075
  • O'Brien KB, Alberich-Jord√† M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S.CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.Development. 2010 Jul;137(13):2147-56.
    20530543
  • Will B, Siddiqi T, Alberich Jord√† M, Shimamura T, Luptakova K, Staber PB, Costa DB, Steidl U, Tenen DG, Kobayashi S.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Blood. 2010 Apr 8;115(14):2901-9.
    20160166
  • Zhang Z, Kobayashi S, Borczuk AC, Leidner RS, Laframboise T, Levine AD, Halmos B.Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK-signaling in lung cancer cells.Carcinogenesis. 2010 Apr;31(4):577-86.
    20097731
  • Kawahara H, Kobayashi T, Watanabe K, Kobayashi S, Kashiwagi H, Yanaga K.Where is the best surgical incision for laparoscopic anterior resection?.Hepatogastroenterology.;56(96):1629-32.
    20214206
  • Akiba T, Marushima H, Hiramatsu M, Matsudaira H, Nakanishi K, Takeyama H, Kobayashi S, Morikawa T.Video-assisted thoracoscopic surgery for non-small cell lung cancer in patients on hemodialysis.Ann Thorac Cardiovasc Surg. 2010 Aug;16(1):40-4. Review.
    20190709
  • Kinoshita S,Hirano A,Kobayashi S,Komine K,Kyoda S,Takeyama H,Uchida K,Morikawa T,Nagase J,Sakamoto G.Metachronous secondary primary occult breast cancer initially presenting with metastases to the contralateral axillary lymph nodes: report of a case.Breast Cancer. 2010;17(1):71-4.
    19259764
  • Akiba T, Marushima H, Harada J, Kobayashi S, Morikawa T.Importance of preoperative imaging with 64-row three-dimensional multidetector computed tomography for safer video-assisted thoracic surgery in lung cancer.Surg Today. 2009;39(10):844-7.
    19784721
  • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ.Clinical Features and Outcome of Patients With Non-Small-Cell Lung Cancer Who Harbor EML4-ALK.J Clin Oncol. 2009 Sep 10;27(26):4247-53.
    19667264
  • Nguyen KS, Kobayashi S, Costa DB.Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.Clin Lung Cancer. 2009 Jul;10(4):281-9. Review.
    19632948
  • Akiba T,Marushima H,Masubuchi M,Kobayashi S,Morikawa T.Small symptomatic pericardial diverticula treated by video-assisted thoracic surgical resection.Ann Thorac Cardiovasc Surg. 2009 Apr;15(2):123-5. Review.
    19471228
  • Akiba T,Ishiyama M,Marushima H,Nojima K,Kobayashi S,Morikawa T.Temporary claviculectomy approach for plexiform neurofibroma of the first intercostal nerve.Surg Today. 2009;39(6):544-7.
    19468815
  • Naumov GN,Nilsson MB,Cascone T,Briggs A,Straume O,Akslen LA,Lifshits E,Byers LA,Xu L,Wu HK,Janne P,Kobayashi S,Halmos B,Tenen D,Tang XM,Engelman J,Yeap B,Folkman J,Johnson BE,Heymach JV.Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance.Clin Cancer Res. 2009 May 15;15(10):3484-94.
    19447865
  • Kobayashi T,Kawahara H,Koido S,Kobayashi S,Kashiwagi H,Yanaga K.Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer.Hepatogastroenterology. 2008 Nov-Dec;55(88):2045-8.
    19260474
  • Costa DB,Kobayashi S.Gefitinib plus docetaxel in non-small-cell lung cancer.Lancet. 2009 Feb 14;373(9663):541; author reply 542.
    19217979
  • Kitajima K,Kobayashi S,Shiba H,Uwagawa T,Ishida Y,Aiba K,Kawakami M,Yanaga K.Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene.Int J Clin Oncol. 2008 Dec;13(6):545-51.
    19093184
  • Costa DB,Nguyen KS,Cho BC,Sequist LV,Jackman DM,Riely GJ,Yeap BY,Halmos B,Kim JH,Janne PA,Huberman MS,Pao W,Tenen DG,Kobayashi S.Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib.Clin Cancer Res. 2008 Nov 1;14(21):7060-7.
    18981003
  • Akiba T,Marushima H,Takagi M,Odaka M,Harada J,Kobayashi S,Morikawa T.Preoperative evaluation of a tracheal bronchus by three-dimensional 64-row multidetector-row computed tomography (MDCT) bronchography and angiography: report of a case.Surg Today. 2008;38(9):841-3.
    18751951
  • Akiba T,Marushima H,Harada J,Kobayashi S,Morikawa T.Anomalous pulmonary vein detected using three-dimensional computed tomography in a patient with lung cancer undergoing thoracoscopic lobectomy.Gen Thorac Cardiovasc Surg. 2008 Aug;56(8):413-6.
    18696208
  • Kinoshita S,Hirano A,Komine K,Kobayashi S,Kyoda S,Takeyama H,Uchida K,Morikawa T,Nagase J,Sakamoto G.Primary small-cell neuroendocrine carcinoma of the breast: report of a case.Surg Today. 2008;38(8):734-8. Review.
    18668318
  • Shimamura T,Li D,Ji H,Haringsma HJ,Liniker E,Borgman CL,Lowell AM,Minami Y,McNamara K,Perera SA,Zaghlul S,Thomas RK,Greulich H,Kobayashi S,Chirieac LR,Padera RF,Kubo S,Takahashi M,Tenen DG,Meyerson M,Wong KK,Shapiro GI.Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.Cancer Res. 2008 Jul 15;68(14):5827-38.
    18632637
  • Saitoh T, Kuramochi K, Imai T, Takata KI, Takehara M, Kobayashi S, Sakaguchi K, Sugawara F.Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.Bioorg Med Chem. 2008 May 15;16(10):5815-25.
    18396405
  • Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S.Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.Bioorg Med Chem. 2008 May 1;16(9):5039-49.
    18375133
  • Kobayashi S, Hara M, Yano M, Tateyama H, Shibamoto Y.Dendriform pulmonary ossification in a patient with a past history of giant cell tumor in femur.J Thorac Imaging. 2008 Feb;23(1):47-9.
    18347521
  • Costa DB, Schumer ST, Tenen DG, Kobayashi S.Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations.J Clin Oncol. 2008 Mar 1;26(7):1182-4; author reply 1184-6.
    18309959
  • Costa DB, Kobayashi S.Response of intracranial metastases to epidermal growth factor receptor tyrosine kinase inhibitors: it may all depend on EGFR mutations.J Clin Oncol. 2008 Feb 1;26(4):686.
    18235134
  • Costa DB, Kobayashi S, Schumer ST.Erlotinib-associated alopecia in a lung cancer patient.J Thorac Oncol. 2007 Dec;2(12):1136-8.
    18090591
  • Aoki S, Morohashi K, Sunoki T, Kuramochi K, Kobayashi S, Sugawara F.Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin.Bioconjug Chem. 2007 Nov-Dec;18(6):1981-6.
    17979224
  • Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B.Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies.Cancer Res. 2007 Nov 1;67(21):10417-27.
    17974985
  • Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S.BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations.PLoS Med. 2007 Oct;4(10):1669-79; discussion 1680.
    17973572
  • Koido S, Hara E, Homma S, Mitsunaga M, Takahara A, Nagasaki E, Kawahara H, Watanabe M, Toyama Y, Yanagisawa S, Kobayashi S, Yanaga K, Fujise K, Gong J, Tajiri H.Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells.J Immunol. 2007 Oct 1;179(7):4874-83.
    17878387
  • Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trumper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG.A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.J Clin Invest. 2007 Sep;117(9):2611-20.
    17694175
  • Costa DB, Kobayashi S, Tenen DG, Huberman MS.Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers.Lung Cancer. 2007 Oct;58(1):95-103.
    17610986
  • Kobayashi S, Shimamura T, Monti S, Steidl U, Hetherington CJ, Lowell AM, Golub T, Meyerson M, Tenen DG, Shapiro GI, Halmos B.Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.Cancer Res. 2006 Dec 1;66(23):11389-98.
    17145885
  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jšnne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK.The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.Cancer Cell. 2006 Jun;9(6):485-95.
    16730237
  • Kobayashi S, Ji H, Yuza Y, Meyerson M, Wong KK, Tenen DG, Halmos B.An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.Cancer Res. 2005 Aug 15;65(16):7096-101.
    16103058
  • Kobayashi S, Boggon TJ, Dayaram T, Jšnne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B.EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.N Engl J Med. 2005 Feb 24;352(8):786-92.
    15728811