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Thomas S. Deisboeck, MD


  • Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS.Simulating cancer growth with multiscale agent-based modeling.Semin Cancer Biol. 2014 May 2.
  • Wang Z, Deisboeck TS.Mathematical modeling in cancer drug discovery.Drug Discov Today. 2014 Feb;19(2):145-50.
  • Sfakianakis S, Sakkalis V, Marias K, Stamatakos G, McKeever S, Deisboeck TS, Graf N.An architecture for integrating cancer model repositories.Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6628-31.
  • Wang Z, Sagotsky J, Taylor T, Shironoshita P, Deisboeck TS.Accelerating cancer systems biology research through Semantic Web technology.Wiley Interdisciplinary Reviews. Systems Biology And Medicine.;5(2):135-51.
  • Wang Z, Bordas V, Sagotsky J, Deisboeck TS.Identifying therapeutic targets in a combined EGFR-TGF{beta}R signalling cascade using a multiscale agent-based cancer model.Mathematical Medicine And Biology : A Journal Of The Ima. 2010 Dec 8.
  • Chen LL, Ulmer S, Deisboeck TS.An agent-based model identifies MRI regions of probable tumor invasion in a patient with glioblastoma.Phys Med Biol. 2010 Jan 21;55(2):329-38.
  • Castorina P, Carcò D, Guiot C, Deisboeck TS.Tumor growth instability and its implications for chemotherapy.Cancer Res. 2009 Nov 1;69(21):8507-15.
  • Wang Z, Birch CM, Sagotsky J, Deisboeck TS.Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model.Bioinformatics. 2009 Sep 15;25(18):2389-96.
  • Deisboeck TS.Personalizing medicine: a systems biology perspective.Mol Syst Biol. 2009;5:249.
  • Yoon J,Deisboeck TS.Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis.PLoS ONE. 2009;4(2):e4560.
  • Deisboeck TS,Couzin ID.Collective behavior in cancer cell populations.Bioessays. 2009 Feb;31(2):190-7.
  • Deisboeck TS,Wang Z.A new concept for cancer therapy: out-competing the aggressor.Cancer Cell Int. 2008;8:19.
  • Chen LL,Zhang L,Yoon J,Deisboeck TS.Cancer cell motility: optimizing spatial search strategies.Biosystems. 2009 Mar;95(3):234-42.
  • Deisboeck TS,Zhang L,Yoon J,Costa J.In silico cancer modeling: is it ready for prime time?.Nat Clin Pract Oncol. 2009 Jan;6(1):34-42. Review.
  • Zhang L,Wang Z,Sagotsky JA,Deisboeck TS.Multiscale agent-based cancer modeling.J Math Biol. 2009 Apr;58(4-5):545-59.
  • Deisboeck TS.Cancer: A profit-driven biosystem?.Med Hypotheses. 2008 Aug;71(2):186-9.
  • Sole RV,Rodriguez-Caso C,Deisboeck TS,Saldana J.Cancer stem cells as the engine of unstable tumor progression.J Theor Biol. 2008 Aug 21;253(4):629-37.
  • Wang Z, Birch CM, Deisboeck TS.Cross-scale sensitivity analysis of a non-small cell lung cancer model: Linking molecular signaling properties to cellular behavior.Biosystems. 2008 Jun;92(3):249-58.
  • Deisboeck TS, Guiot C.Surgical impact on brain tumor invasion: A physical perspective.Ann Surg Innov Res. 2008;2:1.
  • Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS.Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study.BMC Med Imaging. 2008;8:3.
  • Guiot C, Pugno N, Delsanto PP, Deisboeck TS.Physical aspects of cancer invasion.Phys Biol. 2007 Dec;4(4):P1-6.
  • Wang Z, Zhang L, Sagotsky J, Deisboeck TS.Simulating non-small cell lung cancer with a multiscale agent-based model.Theor Biol Med Model. 2007;4:50.
  • Castorina P, Deisboeck TS, Gabriele P, Guiot C.Growth laws in cancer: implications for radiotherapy.Radiat Res. 2007 Sep;168(3):349-56.
  • Zhang L, Athale CA, Deisboeck TS.Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer.J Theor Biol. 2007 Jan 7;244(1):96-107.
  • Guiot C, Delsanto PP, Carpinteri A, Pugno N, Mansury Y, Deisboeck TS.The dynamic evolution of the power exponent in a universal growth model of tumors.J Theor Biol. 2006 Jun 7;240(3):459-63.
  • Athale CA, Deisboeck TS.The effects of EGF-receptor density on multiscale tumor growth patterns.J Theor Biol. 2006 Feb 21;238(4):771-9.
  • Athale C, Mansury Y, Deisboeck TS.Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors.J Theor Biol. 2005 Apr 21;233(4):469-81.
  • Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS.Does tumor growth follow a "universal law"?.J Theor Biol. 2003 Nov 21;225(2):147-51.