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David L. Van Vactor, PhD


  • Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC.A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.Development. 2012 Aug;139(15):2821-31.
  • Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.Conserved genes act as modifiers of invertebrate SMN loss of function defects.PLoS Genet. 2010 Oct;6(10):e1001172.
  • Lowery LA, Lee H, Lu C, Murphy R, Obar RA, Zhai B, Schedl M, Van Vactor D, Zhan Y.Parallel Genetic and Proteomic Screens Identify Msps as a CLASP-Abl Pathway Interactor in Drosophila.Genetics. 2010 Aug;185(4):1311-25.
  • Loya CM, Van Vactor D, Fulga TA.Understanding neuronal connectivity through the post-transcriptional toolkit.Genes Dev. 2010 Apr 1;24(7):625-35. Review.
  • Loya CM, Lu CS, Van Vactor D, Fulga TA.Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.Nat Methods. 2009 Dec;6(12):897-903.
  • Prakash S, McLendon HM, Dubreuil CI, Ghose A, Hwa J, Dennehy KA, Tomalty KM, Clark KL, Van Vactor D, Clandinin TR.Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.Dev Biol. 2009 Dec 1;336(1):10-9.
  • Lowery LA, Van Vactor D.The trip of the tip: understanding the growth cone machinery.Nat Rev Mol Cell Biol. 2009 May;10(5):332-43. Review.
  • Tsai PI, Kao HH, Grabbe C, Lee YT, Ghose A, Lai TT, Peng KP, Van Vactor D, Palmer RH, Chen RH, Yeh SR, Chien CT.Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.Neural Develop. 2008;3:26.
  • Fulga TA, Van Vactor D.Synapses and growth cones on two sides of a highwire.Neuron. 2008 Feb 7;57(3):339-44. Review.
  • Lu CS, Van Vactor D.Synapse specificity: Wnts keep motor axons on target.Curr Biol. 2007 Oct 23;17(20):R895-8. Review.
  • Gates J, Mahaffey JP, Rogers SL, Emerson M, Rogers EM, Sottile SL, Van Vactor D, Gertler FB, Peifer M.Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila.Development. 2007 Jun;134(11):2027-39.
  • Takai Y, Matikainen T, Jurisicova A, Kim MR, Trbovich AM, Fujita E, Nakagawa T, Lemmers B, Flavell RA, Hakem R, Momoi T, Yuan J, Tilly JL, Perez GI.Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells.Apoptosis. 2007 Apr;12(4):791-800.
  • Johnson KG, Tenney AP, Ghose A, Duckworth AM, Higashi ME, Parfitt K, Marcu O, Heslip TR, Marsh JL, Schwarz TL, Flanagan JG, Van Vactor D.The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development.Neuron. 2006 Feb 16;49(4):517-31.
  • Lee H, Engel U, Rusch J, Scherrer S, Sheard K, Van Vactor D.The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.Neuron. 2004 Jun 24;42(6):913-26.
  • Johnson KG, Ghose A, Epstein E, Lincecum J, O'Connor MB, Van Vactor D.Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance.Curr Biol. 2004 Mar 23;14(6):499-504.
  • Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, Van Vactor D.A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.Neuron. 2002 Nov 14;36(4):611-22.
  • Van Vactor D, Flanagan JG.The middle and the end: slit brings guidance and branching together in axon pathway selection.Neuron. 1999 Apr;22(4):649-52.
  • Wills Z, Bateman J, Korey CA, Comer A, Van Vactor D.The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.Neuron. 1999 Feb;22(2):301-12.
  • Van Vactor D, O'Reilly AM, Neel BG.Genetic analysis of protein tyrosine phosphatases.Curr Opin Genet Dev. 1998 Feb;8(1):112-26.
  • Flanagan JG, Van Vactor D.Through the looking glass: axon guidance at the midline choice point.Cell. 1998 Feb 20;92(4):429-32.
  • Kaufmann N, Wills ZP, Van Vactor D.Drosophila Rac1 controls motor axon guidance.Development. 1998 Feb;125(3):453-61.
  • Krueger NX, Van Vactor D, Wan HI, Gelbart WM, Goodman CS, Saito H.The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila.Cell. 1996 Feb 23;84(4):611-22.
  • Hart AC, Harrison SD, Van Vactor DL, Rubin GM, Zipursky SL.The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster.Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5047-51.
  • Van Vactor DL, Cagan RL, Krämer H, Zipursky SL.Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell.Cell. 1991 Dec 20;67(6):1145-55.
  • Hart AC, Krämer H, Van Vactor DL, Paidhungat M, Zipursky SL.Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.Genes Dev. 1990 Nov;4(11):1835-47.