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Ellis L. Reinherz, MD

Publications

  • Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G.Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2182-90.
    24782546
  • Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL.Constitutively oxidized CxxC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.J Biol Chem. 2014 May 21.
    24849600
  • Zhang GL, Riemer AB, Keskin DB, Chitkushev L, Reinherz EL, Brusic V.HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.Database (Oxford). 2014;2014:bau031.
    24705205
  • Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL.Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):379-84.
    24344262
  • Li XL, Teng MK, Reinherz EL, Wang JH.Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment.Frontiers In Immunology. 2013;4:383.
    24319443
  • Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL.Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology.Frontiers In Immunology. 2013;4:392.
    24312099
  • Olsen LR, Kudahl UJ, Simon C, Sun J, Schönbach C, Reinherz EL, Zhang GL, Brusic V.BlockLogo: visualization of peptide and sequence motif conservation.J Immunol Methods. 2013 Dec 31;400-401:37-44.
    24001880
  • Kang YJ, Zeng W, Song W, Reinhold B, Choi J, Brusic V, Yamashita T, Munshi A, Li C, Minvielle S, Anderson KC, Munshi N, Reinherz EL, Sasada T.Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOβ as a novel target for multiple myeloma.British Journal of Haematology. 2013 Nov;163(3):343-51.
    24032635
  • Wang JH, Reinherz EL.Revisiting the putative TCR Cα dimerization model through structural analysis.Frontiers In Immunology. 2013;4:16.
    23386853
  • Wang JH, Reinherz EL.The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Immunol Rev. 2012 Nov;250(1):102-19.
    23046125
  • Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH.Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.BMC Genomics. 2012 Aug 6;13(1):378.
    22866951
  • Riemer AB, Keskin DB, Reinherz EL.Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-γ - a method for qRT-PCR reference gene determination.Exp Dermatol. 2012 Aug;21(8):625-9.
    22775998
  • Reinherz EL.Pharmacology: A false sense of non-self.Nature. 2012 Jun 28;486(7404):479-81.
    22739311
  • Anderson KS, Zeng W, Sasada T, Choi J, Riemer AB, Su M, Drakoulakos D, Kang YJ, Brusic V, Wu C, Reinherz EL.Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B: cells and dendritic cells.Cancer Immunol Immunother. 2011 Mar 13.
    21400024
  • Zhang Z, Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T.Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.Biomaterials. 2011 May;32(14):3666-78.
    21345488
  • Zhang GL, Deluca DS, Keskin DB, Chitkushev L, Zlateva T, Lund O, Reinherz EL, Brusic V.MULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.J Immunol Methods. 2010 Dec 2.
    21130094
  • Reinhold B, Keskin DB, Reinherz EL.Molecular Detection of Targeted Major Histocompatibility Complex I-Bound Peptides Using a Probabilistic Measure and Nanospray MS(3) on a Hybrid Quadrupole-Linear Ion Trap.Anal Chem. 2010 Oct 8.
    20932029
  • Riemer AB, Keskin DB, Zhang G, Handley M, Anderson KS, Brusic V, Reinhold B, Reinherz EL.A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.J Biol Chem. 2010 Sep 17;285(38):29608-22.
    20615877
  • Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL.Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.J Immunol. 2010 Sep 1;185(5):2951-9.
    20660709
  • Zhang W, Choi J, Zeng W, Rogers SA, Alyea EP, Rheinwald JG, Canning CM, Brusic V, Sasada T, Reinherz EL, Ritz J, Soiffer RJ, Wu CJ.Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion.Clin Cancer Res. 2010 May 15;16(10):2729-39.
    20460482
  • Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, Lang MJ, Wagner G, Reinherz EL.The alphabeta T cell receptor is an anisotropic mechanosensor.J Biol Chem. 2009 Nov 6;284(45):31028-37.
    19755427
  • Waite AL, Schaner P, Richards N, Balci-Peynircioglu B, Masters SL, Brydges SD, Fox M, Hong A, Yilmaz E, Kastner DL, Reinherz EL, Gumucio DL.Pyrin Modulates the Intracellular Distribution of PSTPIP1.PLoS ONE. 2009;4(7):e6147.
    19584923
  • Song L,Sun ZY,Coleman KE,Zwick MB,Gach JS,Wang JH,Reinherz EL,Wagner G,Kim M.Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface.Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9057-62.
    19458040
  • Grandpre LE,Duke-Cohan JS,Ewald BA,Devoy C,Barouch DH,Letvin NL,Reinherz EL,Baden LR,Dolin R,Seaman MS.Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys.Vaccine. 2009 Mar 4;27(10):1549-56.
    19168105
  • Duke-Cohan JS,Wollenick K,Witten EA,Seaman MS,Baden LR,Dolin R,Reinherz EL.The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays.Vaccine. 2009 Feb 18;27(8):1154-65.
    19146908
  • Lin HH,Zhang GL,Tongchusak S,Reinherz EL,Brusic V.Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research.BMC Bioinformatics. 2008;9 Suppl 12:S22.
    19091022
  • Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL.PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.Immunity. 2008 Dec;29(6):888-98.
    19027330
  • Takeuchi K,Yang H,Ng E,Park SY,Sun ZY,Reinherz EL,Wagner G.Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.J Mol Biol. 2008 Jul 18;380(4):704-16.
    18555270
  • Garcia-Boronat M,Diez-Rivero CM,Reinherz EL,Reche PA.PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery.Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W35-41.
    18442995
  • Lin HH, Ray S, Tongchusak S, Reinherz EL, Brusic V.Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research.BMC Immunol. 2008;9:8.
    18366636
  • Wang JH, Mallis RJ, Reinherz EL.Immunodominant-peptide recognition: beta testing TCRalphabeta.Immunity. 2008 Feb;28(2):139-41.
    18275824
  • Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL.HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.Immunity. 2008 Jan;28(1):52-63.
    18191596
  • Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL.CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications.J Mol Biol. 2007 Sep 14;372(2):535-48.
    17658550
  • Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK.Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.J Immunol. 2007 Aug 1;179(3):1681-92.
    17641034
  • Aldaz-Carroll L, Xiao Y, Whitbeck JC, Ponce de Leon M, Lou H, Kim M, Yu J, Reinherz EL, Isaacs SN, Eisenberg RJ, Cohen GH.Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.J Virol. 2007 Aug;81(15):8131-9.
    17522205
  • Brusic V, Marina O, Wu CJ, Reinherz EL.Proteome informatics for cancer research: From molecules to clinic.Proteomics. 2007 Mar 16;7(6):976-991. Review.
    17370257
  • Kim M, Qiao Z, Yu J, Montefiori D, Reinherz EL.Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state.Vaccine. 2007 Jun 28;25(27):5102-14.
    17055621
  • Touma M, Chang HC, Sasada T, Handley M, Clayton LK, Reinherz EL.The TCR C beta FG loop regulates alpha beta T cell development.J Immunol. 2006 Jun 1;176(11):6812-23.
    16709841
  • Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabduza D, Reinherz EL.Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.Med Immunol. 2006 May 4;5(1):1.
    16674822
  • Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH.Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.Immunity. 2005 Dec;23(6):661-71.
    16356863
  • Attinger A, Devine L, Wang-Zhu Y, Martin D, Wang JH, Reinherz EL, Kronenberg M, Cheroutre H, Kavathas P.Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.J Immunol. 2005 Mar 15;174(6):3501-7.
    15749886
  • Sasada T, Touma M, Chang HC, Clayton LK, Wang JH, Reinherz EL.Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.J Exp Med. 2002 Jun 3;195(11):1419-31.
    12045240
  • Crawford K, Gabuzda D, Pantazopoulos V, Xu J, Clement C, Reinherz E, Alper CA.Circulating CD2+ monocytes are dendritic cells.J Immunol. 1999 Dec 1;163(11):5920-8.
    10570278
  • Kern P, Hussey RE, Spoerl R, Reinherz EL, Chang HC.Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers.J Biol Chem. 1999 Sep 17;274(38):27237-43.
    10480942
  • Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZY, Wagner G, Reinherz EL.Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.Cell. 1999 Jun 11;97(6):791-803.
    10380930
  • Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL.Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.EMBO J. 1998 Jan 2;17(1):10-26.
    9427737
  • Liu J, Tse AG, Chang HC, Liu J, Wang J, Hussey RE, Chishti Y, Rheinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL.Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment.J Biol Chem. 1996 Dec 27;271(52):33639-46.
    8969233
  • Koyasu S, Hussey RE, Clayton LK, Lerner A, Pedersen R, Delany-Heiken P, Chau F, Reinherz EL.Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.EMBO J. 1994 Feb 15;13(4):784-97.
    8112294
  • Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, Reinherz EL.Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion.Cell. 1988 Aug 12;54(4):561-75.
    2969774
  • Richardson NE, Brown NR, Hussey RE, Vaid A, Matthews TJ, Bolognesi DP, Reinherz EL.Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.Proc Natl Acad Sci U S A. 1988 Aug;85(16):6102-6.
    3261864
  • Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL.A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.Nature. 1988 Jan 7;331(6151):78-81.
    2829023
  • Royer HD, Acuto O, Fabbi M, Tizard R, Ramachandran K, Smart JE, Reinherz EL.Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.Cell. 1984 Dec;39(2 Pt 1):261-6.
    6333925
  • Fabbi M, Acuto O, Smart JE, Reinherz EL.Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin.Nature. 1984 Nov 15-21;312(5991):269-71.
    6504140
  • Weiss MJ, Daley JF, Hodgdon JC, Reinherz EL.Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.Proc Natl Acad Sci U S A. 1984 Nov;81(21):6836-40.
    6093124
  • Royer HD, Bensussan A, Acuto O, Reinherz EL.Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex.J Exp Med. 1984 Sep 1;160(3):947-52.
    6432935
  • Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL.An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.Cell. 1984 Apr;36(4):897-906.
    6231105
  • Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL.Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.Science. 1983 Dec 16;222(4629):1239-42.
    6606228
  • Acuto O, Hussey RE, Fitzgerald KA, Protentis JP, Meuer SC, Schlossman SF, Reinherz EL.The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors.Cell. 1983 Oct;34(3):717-26.
    6605197
  • Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL.Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor.Nature. 1983 Jun 30;303(5920):808-10.
    6191218
  • Meuer SC, Hussey RE, Hodgdon JC, Hercend T, Schlossman SF, Reinherz EL.Surface structures involved in target recognition by human cytotoxic T lymphocytes.Science. 1982 Oct 29;218(4571):471-3.
    6981845
  • Meuer SC, Schlossman SF, Reinherz EL.Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.Proc Natl Acad Sci U S A. 1982 Jul;79(14):4395-9.
    6981813
  • Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF.Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92.
    6966400
  • Reinherz EL, Kung PC, Goldstein G, Schlossman SF.Separation of functional subsets of human T cells by a monoclonal antibody.Proc Natl Acad Sci U S A. 1979 Aug;76(8):4061-5.
    315070