Mark W. Kieran, MD, PhD

Publications

• Rajagopal MU, Hathout Y, MacDonald TJ, Kieran MW, Gururangan S, Blaney SM, Phillips P, Packer R, Gordish-Dressman H, Rood BR.Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblast
  21271676
• Chaponis D, Barnes JW, Dellagatta JL, Kesari S, Fast E, Sauvageot C, Panagrahy D, Greene ER, Ramakrishna N, Wen PY, Kung AL, Stiles C, Kieran MW.Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.J.
  21246394
• Prabhu SP, Ng S, Vajapeyam S, Kieran MW, Pollack IF, Geyer R, Haas-Kogan D, Boyett JM, Kun L, Poussaint TY.DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium.Ch
  21052693
• Winkfield KM, Tsai HK, Yao X, Larson E, Neuberg D, Pomeroy SL, Ullrich NJ, Cohen LE, Kieran MW, Scott RM, Goumnerova LC, Marcus KJ.Long-term clinical outcomes following treatment of childhood craniopharyngioma.Pediatr Blood Cancer. 2010 Dec 1.
  21125615
• Geyer JR, Stewart CF, Kocak M, Broniscer A, Phillips P, Douglas JG, Blaney SM, Packer RJ, Gururangan S, Banerjee A, Kieran MW, Kun LE, Gilbertson RJ, Boyett JM.A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain s
  20708924
• Kieran MW, Walker D, Frappaz D, Prados M.Brain Tumors: From Childhood Through Adolescence Into Adulthood.J Clin Oncol. 2010 Nov 10;28(32):4783-9.
  20458039
• Garcia I, Mayol G, Rodriguez E, Sunol M, Gershon TR, Rios J, Cheung NK, Kieran MW, George RE, Perez-Atayde AR, Casala C, Galvan P, de Torres C, Mora J, Lavarino C.Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neurob
  20950435
• Ullrich NJ, Zimmerman M, Smith E, Irons M, Marcus K, Kieran MW.Association of Rapidly Progressive Moyamoya Syndrome With Bevacizumab Treatment for Glioblastoma in a Child With Neurofibromatosis Type 1.J Child Neurol. 2010 Sep 7.
  20823033
• Huttner AJ, Kieran MW, Yao X, Cruz L, Ladner J, Quayle K, Goumnerova LC, Irons MB, Ullrich NJ.Clinicopathologic study of glioblastoma in children with neurofibromatosis type 1.Pediatr Blood Cancer. 2010 Jul 1;54(7):890-6.
  20310005
• Zacharoulis S, Chi S, Kadota R, Kieran M.Biological modification strategies following marrow ablative, high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell rescue (AHSCR) for pediatric brain tumors.Pediatr Blood Cancer. 2010 Apr;54(4):654
  20146216
• Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nol
  20014119
• MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasan
  19924296
• Ayyanar K, Blackman SC, Chordas C, Frazier L, Kieran MW.Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent.J Pediatr Hematol Oncol. 2009 Nov;31(11):861-4.
  19779380
• Turner CD,Chordas CA,Liptak CC,Rey-Casserly C,Delaney BL,Ullrich NJ,Goumnerova LC,Scott RM,Begley HC,Fletcher WJ,Yao X,Chi S,Kieran MW.Medical, psychological, cognitive and educational late-effects in pediatric low-grade glioma survivors treated with surg
  19479971
• Manley P,Li X,Turner C,Chi S,Zimmerman MA,Chordas C,Gordon A,Baker A,Ullrich NJ,Goumnerova L,Marcus K,Hoffman K,Kieran MW.A prospective, blinded analysis of A-PROTEIN (recoverin or CAR protein) levels in pediatric patients with central nervous system tumo
  19422022
• Herrington B,Kieran MW.Small molecule inhibitors in children with malignant gliomas.Pediatr Blood Cancer. 2009 Sep;53(3):312-7. Review.
  19434732
• Panigrahy D, Kaipainen A, Kieran MW, Huang S.PPARs: A Double-Edged Sword in Cancer Therapy?.PPAR Res. 2008;2008:350351.
  19590598
• Samuel DP, Wen PY, Kieran MW.Antiangiogenic (metronomic) chemotherapy for brain tumors: current and future perspectives.Expert Opin Investig Drugs. 2009 Jul;18(7):973-83. Review.
  19548852
• Kieran MW,Supko JG,Wallace D,Fruscio R,Poussaint TY,Phillips P,Pollack I,Packer R,Boyett JM,Blaney S,Banerjee A,Geyer R,Friedman H,Goldman S,Kun LE,Macdonald T.Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor r
  19065567
• Chi SN,Zimmerman MA,Yao X,Cohen KJ,Burger P,Biegel JA,Rorke-Adams LB,Fisher MJ,Janss A,Mazewski C,Goldman S,Manley PE,Bowers DC,Bendel A,Rubin J,Turner CD,Marcus KJ,Goumnerova L,Ullrich NJ,Kieran MW.Intensive multimodality treatment for children with newl
  19064966
• Snuderl M,Chi SN,De Santis SM,Stemmer-Rachamimov AO,Betensky RA,De Girolami U,Kieran MW.Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas.J Neuropathol Exp Neurol. 2008 Sep;67(9):911-20.
  18716553
• Sauvageot CM,Weatherbee JL,Kesari S,Winters SE,Barnes J,Dellagatta J,Ramakrishna NR,Stiles CD,Kung AL,Kieran MW,Wen PY.Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.Neuro-oncol. 2009 Apr;11(2):109-21.
  18682579
• Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY.Phase II study of temozolomide, thalidomide, and celecox
  18403492
• Gilheeney SW, Saad A, Chi S, Turner C, Ullrich NJ, Goumnerova L, Scott RM, Marcus K, Lehman L, De Girolami U, Kieran MW.Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy.J Neurooncol. 2008 Aug;89(1):89-95.
  18415046
• Rauen KA, Hefner E, Carrillo K, Taylor J, Messier L, Aoki Y, Gripp KW, Matsubara Y, Proud VK, Hammond P, Allanson JE, Delrue MA, Axelrad ME, Lin AE, Doyle DA, Kerr B, Carey JC, McCormick F, Silva AJ, Kieran MW, Hinek A, Nguyen TT, Schoyer L.Molecular aspe
  18412122
• Goumnerova L, Drzymalski D, Kieran M, Pomeroy S, Scott RM, Tarbell N.Long-term neurological and neurosurgical outcomes after surgery only in children with low-grade brain tumors.J Neurosurg Pediatrics. 2008 Apr;1(4):A354-5.
  18377286
• Auriti C, Kieran MW, Deb G, Devito R, Pasquini L, Danhaive O.Remission of infantile generalized myofibromatosis after interferon alpha therapy.J Pediatr Hematol Oncol. 2008 Feb;30(2):179-81.
  18376275
• Mundel TM, Yliniemi AM, Maeshima Y, Sugimoto H, Kieran M, Kalluri R.Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6(IV)NC1) inhibits angiogenesis and tumor growth.Int J Cancer. 2008 Apr 15;122(8):1738-44.
  18074349
• MacDonald TJ, Stewart CF, Kocak M, Goldman S, Ellenbogen RG, Phillips P, Lafond D, Poussaint TY, Kieran MW, Boyett JM, Kun LE.Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.J
  18281665
• Xie L, Palmsten K, Macdonald B, Kieran MW, Potenta S, Vong S, Kalluri R.Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.Exp Biol Med (Maywood). 2008 Feb;233(2):155-62.
  18222970
• Ziegler DS, Kung AL, Kieran MW.Anti-apoptosis mechanisms in malignant gliomas.J Clin Oncol. 2008 Jan 20;26(3):493-500. Review.
  18202424
• Panigrahy D, Kaipainen A, Huang S, Butterfield CE, Barnes CM, Fannon M, Laforme AM, Chaponis DM, Folkman J, Kieran MW.PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.Proc Natl Acad Sci U S A. 2008
  18199835
• Ullrich NJ, Raja AI, Irons MB, Kieran MW, Goumnerova L.Brainstem lesions in neurofibromatosis type 1.Neurosurgery. 2007 Oct;61(4):762-6; discussion 766-7.
  17986937
• Gordon LB,McCarten KM,Giobbie-Hurder A,Machan JT,Campbell SE,Berns SD,Kieran MW.Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development.Pediatrics. 2007 Oct;120(4):824-33.
  17908770
• Kieran MW,Gordon L,Kleinman M.New approaches to progeria.Pediatrics. 2007 Oct;120(4):834-41. Review.
  17908771
• Kieran MW, Packer RJ, Onar A, Blaney SM, Phillips P, Pollack IF, Geyer JR, Gururangan S, Banerjee A, Goldman S, Turner CD, Belasco JB, Broniscer A, Zhu Y, Frank E, Kirschmeier P, Statkevich P, Yver A, Boyett JM, Kun LE.Phase I and pharmacokinetic study of
  17634493
• Kesari S, Schiff D, Doherty L, Gigas DC, Batchelor TT, Muzikansky A, O'neill A, Drappatz J, Chen-Plotkin AS, Ramakrishna N, Weiss SE, Levy B, Bradshaw J, Kracher J, Laforme A, Black PM, Folkman J, Kieran M, Wen PY.Phase II study of metronomic chemothe
  17452651
• Ullrich NJ, Robertson R, Kinnamon DD, Scott RM, Kieran MW, Turner CD, Chi SN, Goumnerova L, Proctor M, Tarbell NJ, Marcus KJ, Pomeroy SL.Moyamoya following cranial irradiation for primary brain tumors in children.Neurology. 2007 Mar 20;68(12):932-8.
  17372129
• Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D.PPARalpha Deficiency in Inflammatory Cells Suppresses Tumor Growth.PLoS ONE. 2007;2:e260.
  17327920
• Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM.Phase I trial of imatinib in children with newly di
  17293590
• Sugimoto H, Mundel TM, Kieran MW, Kalluri R.Identification of fibroblast heterogeneity in the tumor microenvironment.Cancer Biol Ther. 2006 Dec;5(12):1640-6.
  17106243
• Turner CD, Chi S, Marcus KJ, MacDonald T, Packer RJ, Poussaint TY, Vajapeyam S, Ullrich N, Goumnerova LC, Scott RM, Briody C, Chordas C, Zimmerman MA, Kieran MW.Phase II study of thalidomide and radiation in children with newly diagnosed brain stem glioma
  17031553
• Sathornsumetee S, Hjelmeland AB, Keir ST, McLendon RE, Batt D, Ramsey T, Yusuff N, Rasheed BK, Kieran MW, Laforme A, Bigner DD, Friedman HS, Rich JN.AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities
  16951188
• Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA.A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated mod
  16645619
• Ullrich NJ, Marcus K, Pomeroy SL, Turner CD, Zimmerman M, Lehmann LE, Scott RM, Goumnerova L, Gillan E, Kieran MW, Chi SN.Transverse Myelitis After Therapy For Primitive Neuroectodermal Tumors.Pediatr Neurol. 2006 Aug;35(2):122-125.
  16876009
• Riedlinger WF, Juraszek AL, Jenkins KJ, Nugent AW, Balasubramanian S, Calicchio ML, Kieran MW, Collins T.Pulmonary vein stenosis: expression of receptor tyrosine kinases by lesional cells.Cardiovasc Pathol.;15(2):91-9.
  16533697
• Waber DP, Pomeroy SL, Chiverton AM, Kieran MW, Scott RM, Goumnerova LC, Rivkin MJ.Everyday cognitive function after craniopharyngioma in childhood.Pediatr Neurol. 2006 Jan;34(1):13-9.
  16376272
• Rich JN, Sathornsumetee S, Keir ST, Kieran MW, Laforme A, Kaipainen A, McLendon RE, Graner MW, Rasheed BK, Wang L, Reardon DA, Ryan AJ, Wheeler C, Dimery I, Bigner DD, Friedman HS.ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth fa
  16299247
• Kieran MW, Turner CD, Rubin JB, Chi SN, Zimmerman MA, Chordas C, Klement G, Laforme A, Gordon A, Thomas A, Neuberg D, Browder T, Folkman J.A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive
  16282886
• Prasad V, Fishman SJ, Mulliken JB, Fox VL, Liang MG, Klement G, Kieran MW, Burrows PE, Waltz DA, Powell J, Dubois J, Levy ML, Perez-Atayde AR, Kozakewich HP.Cutaneovisceral angiomatosis with thrombocytopenia.Pediatr Dev Pathol.;8(4):407-19.
  16034654
• Kieran MW.Anti-angiogenic therapy in pediatric neuro-oncology.J Neurooncol. 2005 Dec;75(3):327-34.
  16195797
• Panigrahy D, Huang S, Kieran MW, Kaipainen A.PPARgamma as a therapeutic target for tumor angiogenesis and metastasis.Cancer Biol Ther. 2005 Jul;4(7):687-93.
  16082179
• Applebaum H, Kieran MW, Cripe TP, Coffin CM, Collins MH, Kaipainen A, Laforme A, Shamberger RC.The rationale for nonsteroidal anti-inflammatory drug therapy for inflammatory myofibroblastic tumors: a Children's Oncology Group study.J Pediatr Surg. 200
  15991185
• Zacharoulis S, Kieran MW.Treatment of low-grade gliomas in children: an update.Expert Rev Neurother. 2004 Nov;4(6):1005-14.
  15853527
• Zimmerman MA, Goumnerova LC, Proctor M, Scott RM, Marcus K, Pomeroy SL, Turner CD, Chi SN, Chordas C, Kieran MW.Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor.J Neurooncol. 2005 Mar;72(1):77-84
  15803379
• Sun Y, Mulkern RV, Schmidt K, Doshi S, Albert MS, Schmidt NO, Ziu M, Black P, Carrol R, Kieran MW.Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model.NMR Biomed. 2004 Oct;17(6):399-404.
  15386627
• Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW.Perfusion MRI of U87 brain tumors in a mouse model.Magn Reson Med. 2004 May;51(5):893-9.
  15122670
• Greene AK, Kieran M, Burrows PE, Mulliken JB, Kasser J, Fishman SJ.Wilms tumor screening is unnecessary in Klippel-Trenaunay syndrome.Pediatrics. 2004 Apr;113(4):e326-9.
  15060262
• Kieran MW.Anti-angiogenic chemotherapy in central nervous system tumors.Cancer Treat Res. 2004;117:337-49.
  15015568
• Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, Sudhakar A, Kalluri R.Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.Canc
  14996710
• Gorlick R, Anderson P, Andrulis I, Arndt C, Beardsley GP, Bernstein M, Bridge J, Cheung NK, Dome JS, Ebb D, Gardner T, Gebhardt M, Grier H, Hansen M, Healey J, Helman L, Hock J, Houghton J, Houghton P, Huvos A, Khanna C, Kieran M, Kleinerman E, Ladanyi M,
  14654523
• Panigrahy D, Shen LQ, Kieran MW, Kaipainen A.Therapeutic potential of thiazolidinediones as anticancer agents.Expert Opin Investig Drugs. 2003 Dec;12(12):1925-37.
  14640937
• Gesundheit B, Klement G, Senger C, Kerbel R, Kieran M, Baruchel S, Becker L.Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood.Med Pediatr Oncol. 2003 Dec;41(6):516-26.
  14595708
• Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA.A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13513-8.
  14595012
• Marcus KJ, Goumnerova L, Billett AL, Lavally B, Scott R, Bishop K, Xu R, Kieran M, Kooy H, Pomeroy SL, Tarbell NJ.Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial.Int J Radiat Oncol Biol Phys. 200
  12965450
• Heath JA, Turner CD, Poussaint TY, Scott RM, Goumnerova L, Kieran MW.Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience.Pediatr Hematol Oncol. 2003 Oct-Nov;20(7):497-504.
  12959854
• Kieran MW, Folkman J, Heymach J.Angiogenesis inhibitors and hypoxia.Nat Med. 2003 Sep;9(9):1104; author reply 1104-5.
  12949515
• McLaughlin ME, Robson CD, Kieran MW, Jacks T, Pomeroy SL, Cameron S.Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation.J Pediatr Hematol Oncol. 2003
  12902920
• Carpentieri SC, Meyer EA, Delaney BL, Victoria ML, Gannon BK, Doyle JM, Kieran MW.Psychosocial and behavioral functioning among pediatric brain tumor survivors.J Neurooncol. 2003 Jul;63(3):279-87.
  12892234
• Carpentieri SC, Waber DP, Pomeroy SL, Scott RM, Goumnerova LC, Kieran MW, Billett AL, Tarbell NJ.Neuropsychological functioning after surgery in children treated for brain tumor.Neurosurgery. 2003 Jun;52(6):1348-56; discussion 1356-.
  12762880
• Marcus KJ, Dutton SC, Barnes P, Coleman CN, Pomeroy SL, Goumnerova L, Billett AL, Kieran M, Tarbell NJ.A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma.Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(
  12654425
• Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R.Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria.J Biol Chem. 2003 Apr 11
  12538598
• Browder T, Folkman J, Hahnfeldt P, Heymach J, Hlatky L, Kieran M, Rogers MS.Antiangiogenic therapy and p53.Science. 2002 Jul 26;297(5581):471; discussion 471.
  12143876
• Carpentieri SC, Waber DP, Scott RM, Goumnerova LC, Kieran MW, Cohen LE, Kim F, Billett AL, Tarbell NJ, Pomeroy SL.Memory deficits among children with craniopharyngiomas.Neurosurgery. 2001 Nov;49(5):1053-7; discussion 1057-8.
  11846897
• Meyer EA, Kieran MW.Psychological adjustment of 'surgery-only' pediatric neuro-oncology patients: a retrospective analysis.Psychooncology. 2002 Jan-Feb;11(1):74-9.
  11835594
• Kieran MW, Billett A.Antiangiogenesis therapy. Current and future agents.Hematol Oncol Clin North Am. 2001 Oct;15(5):835-51, viii.
  11765376
• Zissiadis Y, Dutton S, Kieran M, Goumnerova L, Scott RM, Kooy HM, Tarbell NJ.Stereotactic radiotherapy for pediatric intracranial germ cell tumors.Int J Radiat Oncol Biol Phys. 2001 Sep 1;51(1):108-12.
  11516859
• Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, August GP, Smith SH, Moshang T.Growth hormone replacement therapy in children with medullobla
  11208842
• Kieran MW.Advances in pediatric neuro-oncology.Curr Opin Neurol. 2000 Dec;13(6):627-34.
  11148661
• Sadr IM, Tan PE, Kieran MW, Jenkins KJ.Mechanism of pulmonary vein stenosis in infants with normally connected veins.Am J Cardiol. 2000 Sep 1;86(5):577-9, A10.
  11009286
• Kieran MW, Katz S, Vail B, Zon LI, Mayer BJ.Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase.Oncogene. 1999 Nov 18;18(48):6647-57.
  10597270
• Rubin JB, Kieran MW.Innovative therapies for pediatric brain tumors.Curr Opin Pediatr. 1999 Feb;11(1):39-46.
  10084083
• Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israël A.The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.Cell. 1990 Sep 7;62(5):1007-1
  2203531