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James G. Rheinwald, PhD


  • Degen M, Barron P, Natarajan E, Widlund HR, Rheinwald JG.RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma.PLoS ONE. 2013;8(10):e78979.
  • Pinto AP, Degen M, Barron P, Crum CP, Rheinwald JG.Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia.Mod Pathol. 2013 Nov;26(11):1498-507.
  • Wei W, Barron PD, Rheinwald JG.Modulation of TGF-β-inducible hypermotility by EGF and other factors in human prostate epithelial cells and keratinocytes.In Vitro Cell Dev Biol Anim. 2010 Dec;46(10):841-55.
  • Zhang W, Choi J, Zeng W, Rogers SA, Alyea EP, Rheinwald JG, Canning CM, Brusic V, Sasada T, Reinherz EL, Ritz J, Soiffer RJ, Wu CJ.Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion.Clin Cancer Res. 2010 May 15;16(10):2729-39.
  • Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K.Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.Nature. 2009 Aug 27;460(7259):1145-8.
  • Dabelsteen S,Hercule P,Barron P,Rice M,Dorsainville G,Rheinwald JG.Epithelial Cells Derived from Human Embryonic Stem Cells Display P16(INK4A) Senescence, Hypermotility, and Differentiation Properties Shared by Many P63(+) Somatic Cell Types.Stem Cells. 2009 Mar 19;27(6):1388-1399.
  • Natarajan E, Omobono JD, Guo Z, Hopkinson S, Lazar AJ, Brenn T, Jones JC, Rheinwald JG.A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.Am J Pathol. 2006 Jun;168(6):1821-37.
  • Iuchi S, Dabelsteen S, Easley K, Rheinwald JG, Green H.Immortalized keratinocyte lines derived from human embryonic stem cells.Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1792-7.
  • Gordon GJ, Rockwell GN, Jensen RV, Rheinwald JG, Glickman JN, Aronson JP, Pottorf BJ, Nitz MD, Richards WG, Sugarbaker DJ, Bueno R.Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.Am J Pathol. 2005 Jun;166(6):1827-40.
  • Kim M, Yang H, Kim SK, Reche PA, Tirabassi RS, Hussey RE, Chishti Y, Rheinwald JG, Morehead TJ, Zech T, Damon IK, Welsh RM, Reinherz EL.Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies.J Biol Chem. 2004 Jun 11;279(24):25838-48.
  • Rheinwald JG.Becoming a scientist: what I learned from Gunny.Biochem Biophys Res Commun. 2003 Dec 5;312(1):61-4.
  • Kleine-Lowinski K, Rheinwald JG, Fichorova RN, Anderson DJ, Basile J, Mnger K, Daly CM, Rsl F, Rollins BJ.Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells.Int J Cancer. 2003 Nov 10;107(3):407-15.
  • Natarajan E, Saeb M, Crum CP, Woo SB, McKee PH, Rheinwald JG.Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.Am J Pathol. 2003 Aug;163(2):477-91.
  • Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catrical C, O'Toole KM.A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Mol Cell Biol. 2002 Jul;22(14):5157-72.
  • Verselis SJ, Rheinwald JG, Fraumeni JF, Li FP.Novel p53 splice site mutations in three families with Li-Fraumeni syndrome.Oncogene. 2000 Aug 31;19(37):4230-5.
  • Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG.Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Mol Cell Biol. 2000 Feb;20(4):1436-47.
  • Schn M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG.Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture.J Cell Sci. 1999 Jun;112 ( Pt 12):1925-36.
  • Murphy JE, Rheinwald JG.Intraperitoneal injection of genetically modified, human mesothelial cells for systemic gene therapy.Hum Gene Ther. 1997 Nov 1;8(16):1867-79.
  • Fichorova RN, Rheinwald JG, Anderson DJ.Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins.Biol Reprod. 1997 Oct;57(4):847-55.
  • Schrager HM, Rheinwald JG, Wessels MR.Hyaluronic acid capsule and the role of streptococcal entry into keratinocytes in invasive skin infection.J Clin Invest. 1996 Nov 1;98(9):1954-8.
  • Schn M, Rheinwald JG.A limited role for retinoic acid and retinoic acid receptors RAR alpha and RAR beta in regulating keratin 19 expression and keratinization in oral and epidermal keratinocytes.J Invest Dermatol. 1996 Sep;107(3):428-38.
  • Lindberg K, Brown ME, Chaves HV, Kenyon KR, Rheinwald JG.In vitro propagation of human ocular surface epithelial cells for transplantation.Invest Ophthalmol Vis Sci. 1993 Aug;34(9):2672-9.
  • Park S, Schalling M, Bernard A, Maheswaran S, Shipley GC, Roberts D, Fletcher J, Shipman R, Rheinwald J, Demetri G.The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.Nat Genet. 1993 Aug;4(4):415-20.
  • Crowe DL, Hu L, Gudas LJ, Rheinwald JG.Variable expression of retinoic acid receptor (RAR beta) mRNA in human oral and epidermal keratinocytes; relation to keratin 19 expression and keratinization potential.Differentiation. 1991 Dec;48(3):199-208.
  • Hu L, Crowe DL, Rheinwald JG, Chambon P, Gudas LJ.Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines.Cancer Res. 1991 Aug 1;51(15):3972-81.
  • Lindberg K, Rheinwald JG.Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenografts.Differentiation. 1990 Dec;45(3):230-41.
  • Demetri GD, Ernst TJ, Pratt ES, Zenzie BW, Rheinwald JG, Griffin JD.Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.J Clin Invest. 1990 Oct;86(4):1261-9.
  • Henrard DR, Thornley AT, Brown ML, Rheinwald JG.Specific effects of ras oncogene expression on the growth and histogenesis of human epidermal keratinocytes.Oncogene. 1990 Apr;5(4):475-81.
  • Cicila GT, O'Connell TM, Hahn WC, Rheinwald JG.Cloned cDNA sequence for the human mesothelial protein 'mesosecrin' discloses its identity as a plasminogen activator inhibitor (PAI-1) and a recent evolutionary change in transcript processing.J Cell Sci. 1989 Sep;94 ( Pt 1):1-10.
  • Demetri GD, Zenzie BW, Rheinwald JG, Griffin JD.Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro.Blood. 1989 Aug 15;74(3):940-6.
  • Rollins BJ, O'Connell TM, Bennett G, Burton LE, Stiles CD, Rheinwald JG.Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta.J Cell Physiol. 1989 Jun;139(3):455-62.
  • Lindberg K, Rheinwald JG.Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium.Am J Pathol. 1989 Jan;134(1):89-98.
  • Tubo RA, Rheinwald JG.Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.Oncogene Res. 1987 Sep-Oct;1(4):407-21.
  • Rheinwald JG, Jorgensen JL, Hahn WC, Terpstra AJ, O'Connell TM, Plummer KK.Mesosecrin: a secreted glycoprotein produced in abundance by human mesothelial, endothelial, and kidney epithelial cells in culture.J Cell Biol. 1987 Feb;104(2):263-75.
  • La Rocca PJ, Rheinwald JG.Anchorage-independent growth of normal human mesothelial cells: a sensitive bioassay for EGF which discloses the absence of this factor in fetal calf serum.In Vitro Cell Dev Biol. 1985 Jan;21(1):67-72.
  • Rheinwald JG, O'Connell TM.Intermediate filament proteins as distinguishing markers of cell type and differentiated state in cultured human urinary tract epithelia.Ann N Y Acad Sci. 1985;455:259-67.
  • Allen-Hoffmann BL, Rheinwald JG.Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture.Proc Natl Acad Sci U S A. 1984 Dec;81(24):7802-6.
  • LaRocca PJ, Rheinwald JG.Coexpression of simple epithelial keratins and vimentin by human mesothelium and mesothelioma in vivo and in culture.Cancer Res. 1984 Jul;44(7):2991-9.
  • Weichselbaum R, Dahlberg W, Little JB, Ervin TJ, Miller D, Hellman S, Rheinwald JG.Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.Br J Cancer. 1984 May;49(5):595-601.
  • Connell ND, Rheinwald JG.Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture.Cell. 1983 Aug;34(1):245-53.
  • Kim KH, Rheinwald JG, Fuchs EV.Tissue specificity of epithelial keratins: differential expression of mRNAs from two multigene families.Mol Cell Biol. 1983 Apr;3(4):495-502.
  • Wu YJ, Parker LM, Binder NE, Beckett MA, Sinard JH, Griffiths CT, Rheinwald JG.The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia.Cell. 1982 Dec;31(3 Pt 2):693-703.
  • Rheinwald JG.Human squamous cell carcinoma in culture: a defect in terminal differentiation and its relation to malignancy.Natl Cancer Inst Monogr. 1982;60:133-8.
  • Didinsky JB, Rheinwald JG.Failure of hydrocortisone or growth factors to influence the senescence of fibroblasts in a new culture system for assessing replicative lifespan.J Cell Physiol. 1981 Oct;109(1):171-9.
  • Wu YJ, Rheinwald JG.A new small (40 kd) keratin filament protein made by some cultured human squamous cell carcinomas.Cell. 1981 Sep;25(3):627-35.
  • Rheinwald JG, Beckett MA.Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas.Cancer Res. 1981 May;41(5):1657-63.
  • Rheinwald JG, Beckett MA.Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes.Cell. 1980 Nov;22(2 Pt 2):629-32.
  • Rheinwald JG, Green H.Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes.Nature. 1977 Feb 3;265(5593):421-4.
  • Rheinwald JG, Green H.Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.Cell. 1975 Nov;6(3):317-30.
  • Rheinwald JG, Green H.Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.Cell. 1975 Nov;6(3):331-43.
  • Rheinwald JG, Green H.Growth of cultured mammalian cells on secondary glucose sources.Cell. 1974 Aug;2(4):287-93.
  • Rheinwald JG, Chakrabarty AM, Gunsalus IC.A transmissible plasmid controlling camphor oxidation in Pseudomonas putida.Proc Natl Acad Sci U S A. 1973 Mar;70(3):885-9.