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Andrea L. Richardson, MD, PhD

Publications

  • Seo JH, Li Q, Fatima A, Eklund A, Szallasi Z, Polyak K, Richardson AL, Freedman ML.Deconvoluting complex tissues for expression quantitative trait locus-based analyses.Philos Trans R Soc Lond B Biol Sci. 2013;368(1620):20120363.
    23650637
  • Rath MG, Masciari S, Gelman R, Miron A, Miron P, Foley K, Richardson AL, Krop IE, Verselis SJ, Dillon DA, Garber JE.Prevalence of germline TP53 mutations in HER2+ breast cancer patients.Breast Cancer Res Treat. 2013 Apr 12.
    23580068
  • Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X.SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer.J Biol Chem. 2013 Mar 1;288(9):6478-87.
    23306204
  • Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.A metabolic prosurvival role for PML in breast cancer.J Clin Invest. 2012 Sep 4;122(9):3088-100.
    22886304
  • Kuznetsov HS, Marsh T, Markens BA, Castaño Z, Greene-Colozzi A, Hay SA, Brown VE, Richardson AL, Signoretti S, Battinelli EM, McAllister SS.Identification of Luminal Breast Cancers that Establish a Tumor Supportive Macroenvironment Defined by Pro-Angiogenic Platelets and Bone Marrow Derived Cells.Cancer Discovery. 2012 Aug 15.
    22896036
  • Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M.Sequence analysis of mutations and translocations across breast cancer subtypes.Nature. 2012 Jun 21;486(7403):405-9.
    22722202
  • Richardson AL, Iglehart JD.BEAMing up personalized medicine: mutation detection in blood.Clin Cancer Res. 2012 Jun 15;18(12):3209-11.
    22550168
  • Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M.A non-genetic route to aneuploidy in human cancers.Nat Cell Biol. 2011 Mar;13(3):324-30.
    21336303
  • Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Rakha EA, Richardson AL, Schmitt FC, Tan PH, Tse GM, Weigelt B, Ellis IO, Reis-Filho JS.Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists.Mod Pathol. 2011 Feb;24(2):157-67.
    21076464
  • Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, Tan IB, Richardson AL, Szallasi Z, Swanton C.Paradoxical relationship between chromosomal instability and survival outcome in cancer.Cancer Res. 2011 Jan 26.
    21270108
  • Li Q, Eklund AC, Juul N, Haibe-Kains B, Workman CT, Richardson AL, Szallasi Z, Swanton C.Minimising immunohistochemical false negative ER classification using a complementary 23 gene expression signature of ER status.PLoS ONE. 2010;5(12):e15031.
    21152022
  • Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA, Orimo A.Autocrine TGF-{beta} and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20009-14.
    21041659
  • Pomerantz MM, Shrestha Y, Flavin RJ, Regan MM, Penney KL, Mucci LA, Stampfer MJ, Hunter DJ, Chanock SJ, Schafer EJ, Chan JA, Tabernero J, Baselga J, Richardson AL, Loda M, Oh WK, Kantoff PW, Hahn WC, Freedman ML.Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis.PLoS Genet. 2010;6(11):e1001204.
    21085629
  • Tung N, Miron A, Schnitt SJ, Gautam S, Fetten K, Kaplan J, Yassin Y, Buraimoh A, Kim JY, Szasz AM, Tian R, Wang ZC, Collins LC, Brock J, Krag K, Legare RD, Sgroi D, Ryan PD, Silver D, Garber JE, Richardson AL.Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers.Breast Cancer Res. 2010 Nov 16;12(6):R95.
    21080930
  • Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Richardson AL, Schnitt SJ, Schmitt FC, Tan PH, Tse GM, Badve S, Ellis IO.Breast cancer prognostic classification in the molecular era: the role of histological grade.Breast Cancer Res. 2010;12(4):207.
    20804570
  • Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.PTK6 regulates IGF-1-induced anchorage-independent survival.PLoS ONE. 2010;5(7):e11729.
    20668531
  • Wagoner MP, Gunsalus KT, Schoenike B, Richardson AL, Friedl A, Roopra A.The transcription factor REST is lost in aggressive breast cancer.PLoS Genet. 2010;6(6):e1000979.
    20548947
  • Ray PS, Wang J, Qu Y, Sim MS, Shamonki J, Bagaria SP, Ye X, Liu B, Elashoff D, Hoon DS, Walter MA, Martens JW, Richardson AL, Giuliano AE, Cui X.FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer.Cancer Res. 2010 May 15;70(10):3870-6.
    20406990
  • Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A, Salmena L, Sampieri K, Haveman WJ, Brogi E, Richardson AL, Zhang J, Pandolfi PP.Subtle variations in Pten dose determine cancer susceptibility.Nat Genet. 2010 May;42(5):454-8.
    20400965
  • International Cancer Genome Consortium.International network of cancer genome projects.Nature. 2010 Apr 15;464(7291):993-998.
    20393554
  • Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JE.Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.J Clin Oncol. 2010 Mar 1;28(7):1145-53.
    20100965
  • Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Li Y, Desmedt C, Sotiriou C, Szallasi Z, Iglehart JD, Richardson AL, Wang ZC.Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer.Nat Med. 2010 Feb;16(2):214-8.
    20098429
  • Collins LC,Martyniak AJ,Kandel MJ,Stadler ZK,Masciari S,Miron A,Richardson AL,Schnitt SJ,Garber JE.Basal Cytokeratin and Epidermal Growth Factor Receptor Expression Are Not Predictive of BRCA1 Mutation Status in Women With Triple-negative Breast Cancers.Am J Surg Pathol. 2009 Jul;33(7):1093-7.
    19390427
  • Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerød A, Russnes HE, Foekens JA, Reis-Filho JS, van 't Veer L, Richardson AL, Børresen-Dale AL, Campbell PJ, Futreal PA, Stratton MR.Complex landscapes of somatic rearrangement in human breast cancer genomes.Nature. 2009 Dec 24;462(7276):1005-10.
    20033038
  • Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A.Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.Cancer Cell. 2009 Nov 6;16(5):413-24.
    19878873
  • Brock JE, Hornick JL, Richardson AL, Dillon DA, Lester SC.A comparison of estrogen receptor SP1 and 1D5 monoclonal antibodies in routine clinical use reveals similar staining results.Am J Clin Pathol. 2009 Sep;132(3):396-401.
    19687316
  • Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.Cancer Cell. 2009 Aug 4;16(2):115-25.
    19647222
  • Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ.SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.Sci Signal. 2009;2(80):ra35.
    19622832
  • Walker SR, Nelson EA, Zou L, Chaudhury M, Signoretti S, Richardson A, Frank DA.Reciprocal effects of STAT5 and STAT3 in breast cancer.Mol Cancer Res. 2009 Jun;7(6):966-76.
    19491198
  • Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szász AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA.A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.Cell. 2009 Jun 12;137(6):1032-46.
    19524507
  • Bloushtain-Qimron N,Yao J,Snyder EL,Shipitsin M,Campbell LL,Mani SA,Hu M,Chen H,Ustyansky V,Antosiewicz JE,Argani P,Halushka MK,Thomson JA,Pharoah P,Porgador A,Sukumar S,Parsons R,Richardson AL,Stampfer MR,Gelman RS,Nikolskaya T,Nikolsky Y,Polyak K.Cell type-specific DNA methylation patterns in the human breast.Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14076-81.
    18780791
  • Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K.Regulation of in situ to invasive breast carcinoma transition.Cancer Cell. 2008 May;13(5):394-406.
    18455123
  • Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME.CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.Cancer Res. 2008 May 1;68(9):3204-13.
    18451146
  • Lu X, Lu X, Wang ZC, Iglehart JD, Zhang X, Richardson AL.Predicting features of breast cancer with gene expression patterns.Breast Cancer Res Treat. 2008 Mar;108(2):191-201.
    18297396
  • Baird PN, Robman LD, Richardson AJ, Dimitrov PN, Tikellis G, McCarty CA, Guymer RH.Gene-environment interaction in progression of AMD: the CFH gene, smoking and exposure to chronic infection.Hum Mol Genet. 2008 May 1;17(9):1299-305.
    18203751
  • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA.Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.Nature. 2007 Oct 4;449(7162):557-63.
    17914389
  • Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA.Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.Cancer Cell. 2007 Aug;12(2):160-70.
    17692807
  • Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.Integrative genomic approaches identify IKBKE as a breast cancer oncogene.Cell. 2007 Jun 15;129(6):1065-79.
    17574021
  • Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA.Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers.Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10069-74.
    17537911
  • Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K.Molecular definition of breast tumor heterogeneity.Cancer Cell. 2007 Mar;11(3):259-73.
    17349583
  • Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.Cancer Res. 2006 Dec 1;66(23):11502-13.
    17114236
  • Golshan M, Kuten A, William J, Richardson A, Modarressi A, Matulonis U.Metaplastic carcinoma of the breast with neuroglial differentiation.Breast. 2006 Aug;15(4):545-9.
    16253505
  • Ganesan S, Richardson AL, Wang ZC, Iglehart JD, Miron A, Feunteun J, Silver D, Livingston DM.Abnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal-like Breast Cancer.Cold Spring Harb Symp Quant Biol. 2005;70:93-7.
    16869742
  • Wang ZC, Buraimoh A, Iglehart JD, Richardson AL.Genome-Wide Analysis for Loss of Heterozygosity in Primary and Recurrent Phyllodes Tumor and Fibroadenoma of Breast using Single Nucleotide Polymorphism Arrays.Breast Cancer Res Treat. 2006 Jun;97(3):301-9.
    16791486
  • Wang ZC, Buraimoh A, Iglehart JD, Richardson AL.Genome-Wide Analysis for Loss of Heterozygosity in Primary and Recurrent Phyllodes Tumor and Fibroadenoma of Breast using Single Nucleotide Polymorphism Arrays.Breast Cancer Res Treat. 2006 Apr 27.
    16642273
  • Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.X chromosomal abnormalities in basal-like human breast cancer.Cancer Cell. 2006 Feb;9(2):121-32.
    16473279
  • Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H.A role for the scaffolding adapter GAB2 in breast cancer.Nat Med. 2006 Jan;12(1):114-21.
    16369543
  • Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA.Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.Cancer Res. 2005 Jun 15;65(12):5054-62.
    15958548
  • Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K.Molecular characterization of the tumor microenvironment in breast cancer.Cancer Cell. 2004 Jul;6(1):17-32.
    15261139
  • Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA.Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.Cell. 2004 Jun 25;117(7):927-39.
    15210113
  • Kuperwasser C, Chavarria T, Wu M, Magrane G, Gray JW, Carey L, Richardson A, Weinberg RA.Reconstruction of functionally normal and malignant human breast tissues in mice.Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4966-71.
    15051869
  • Wang ZC, Lin M, Wei LJ, Li C, Miron A, Lodeiro G, Harris L, Ramaswamy S, Tanenbaum DM, Meyerson M, Iglehart JD, Richardson A.Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers.Cancer Res. 2004 Jan 1;64(1):64-71.
    14729609
  • Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K.A neural survival factor is a candidate oncogene in breast cancer.Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931-6.
    12953101
  • Hu Y, Hines LM, Weng H, Zuo D, Rivera M, Richardson A, LaBaer J.Analysis of genomic and proteomic data using advanced literature mining.J Proteome Res. 2003 Jul-Aug;2(4):405-12.
    12938930
  • Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K.Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.Cancer Res. 2003 May 1;63(9):2024-7.
    12727813
  • Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K.Molecular markers in ductal carcinoma in situ of the breast.Mol Cancer Res. 2003 Mar;1(5):362-75.
    12651909
  • Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M, Pagano M.Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.J Clin Invest. 2002 Sep;110(5):633-41.
    12208864
  • Seth P, Porter D, Lahti-Domenici J, Geng Y, Richardson A, Polyak K.Cellular and molecular targets of estrogen in normal human breast tissue.Cancer Res. 2002 Aug 15;62(16):4540-4.
    12183401
  • Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P.Expression of cyclins E1 and E2 during mouse development and in neoplasia.Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13138-43.
    11687642