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Shyamala Maheswaran, PhD
Publications
- Yu M, Stott S, Toner M, Maheswaran S, Haber DA.Circulating tumor cells: approaches to isolation and characterization.J Cell Biol. 2011 Feb 7;192(3):373-82.
21300848 - Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA.Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.Scien
21233348 - Yang C, Hayashida T, Forster N, Li C, Shen D, Maheswaran S, Chen L, Anderson KS, Ellisen LW, Sgroi D, Schmidt EV.The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in
21127199 - Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, Rothenberg SM, Shah AM, Smas ME, Korir GK, Floyd FP, Gilman AJ, Lord JB, Winokur D, Springer S, Irimia D, Nagrath S, Sequist LV, Lee RJ, Isselbacher KJ, Maheswaran S, Haber DA, Toner M.Isolation
20930119 - Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S.Isolation and characteri
20424012 - Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J.A chromatin-mediated reversible drug-tolerant state in cancer cell subpopu
20371346 - Maheswaran S, Haber DA.Circulating tumor cells: a window into cancer biology and metastasis.Curr Opin Genet Dev. 2010 Feb;20(1):96-9. Review.
20071161 - Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco MM, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran S.HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.Proc Natl
20080567 - Yu M, Smolen GA, Zhang J, Wittner B, Schott BJ, Brachtel E, Ramaswamy S, Maheswaran S, Haber DA.A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.Genes Dev. 2009 Aug 1;23(15):1737-42.
19651985 - McDermott U,Ames RY,Iafrate AJ,Maheswaran S,Stubbs H,Greninger P,McCutcheon K,Milano R,Tam A,Lee DY,Lucien L,Brannigan BW,Ulkus LE,Ma XJ,Erlander MG,Haber DA,Sharma SV,Settleman J.Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha acti
19366796 - Maheswaran S,Sequist LV,Nagrath S,Ulkus L,Brannigan B,Collura CV,Inserra E,Diederichs S,Iafrate AJ,Bell DW,Digumarthy S,Muzikansky A,Irimia D,Settleman J,Tompkins RG,Lynch TJ,Toner M,Haber DA.Detection of mutations in EGFR in circulating lung-cancer cells
18596266 - McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J.Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to an
18451166 - Godin-Heymann N, Ulkus L, Brannigan BW, McDermott U, Lamb J, Maheswaran S, Settleman J, Haber DA.The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.Mol Cancer Ther. 2008 Apr;7(4):8
18413800 - Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M.Isolation of rare circulating tumour cells in cancer patients by microchip technology.Nature.
18097410 - McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA, S
18077425 - Gupta V, Yeo G, Kawakubo H, Rangnekar V, Ramaswamy P, Hayashida T, MacLaughlin DT, Donahoe PK, Maheswaran S.Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mec
17363596 - Tran TT, Segev DL, Gupta V, Kawakubo H, Yeo G, Donahoe PK, Maheswaran S.Mullerian Inhibiting Substance regulates androgen-induced gene expression and growth in prostate cancer cells through a NFkB-dependent Smad-independent mechanism.Mol Endocrinol. 2006
16740653 - Kawakubo H, Brachtel E, Hayashida T, Yeo G, Kish J, Muzikansky A, Walden PD, Maheswaran S.Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein.Cancer Res.
16849553 - Gupta V, Carey J, Kawakubo H, Muzikansky A, Green J, Donahoe PK, MacLaughlin DT, Maheswaran S.Mullerian Inhibiting Substance suppresses tumor grown in the C3(1)T antigen transgenic mouse mammary carcinoma model.Proc Natl Acad Sci U S A. 2005 MAR 01;102(9)
- Gupta V, Carey JL, Kawakubo H, Muzikansky A, Green JE, Donahoe PK, MacLaughlin DT, Maheswaran S.Mullerian inhibiting substance suppresses tumor growth in the C3(1)T antigen transgenic mouse mammary carcinoma model.Proc Natl Acad Sci U S A. 2005 Mar 1;102(
15728372 - Kawakubo H, Carey JL, Brachtel E, Gupta V, Green JE, Walden PD, Maheswaran S.Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.Oncogene. 2004 Oct 28;23(50):8310-9.
15378000 - Gupta V, Harkin DP, Kawakubo H, Maheswaran S.Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents.Curr Cancer Drug Targets. 2004 Mar;4(2):165-82.
15032667 - Carey JL, Sasur LM, Kawakubo H, Gupta V, Christian B, Bailey PM, Maheswaran S.Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth.Mol Endocrinol. 2004 Mar;18(3):696-707.
14684851 - Barbie TU, Barbie DA, MacLaughlin DT, Maheswaran S, Donahoe PK.Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15601-6.
14671316 - Hoshiya Y, Gupta V, Segev DL, Hoshiya M, Carey JL, Sasur LM, Tran TT, Ha TU, Maheswaran S.Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells.Mol Cell Endocrinol. 2003 Dec 15;211(1-2):43-9.
14656475 - Donahoe PK, Clarke T, Teixeira J, Maheswaran S, MacLaughlin DT.Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications.Mol Cell Endocrinol. 2003 Dec 15;211(1-2):37-42.
14656474 - Hoshiya Y, Gupta V, Kawakubo H, Brachtel E, Carey JL, Sasur L, Scott A, Donahoe PK, Maheswaran S.Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells.J Biol Chem. 2003 Dec 19;278(51):51703-1
14532292 - Segev DL, Hoshiya Y, Hoshiya M, Tran TT, Carey JL, Stephen AE, MacLaughlin DT, Donahoe PK, Maheswaran S.Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo.Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):239-44.
11773638 - Mullan PB, Quinn JE, Gilmore PM, McWilliams S, Andrews H, Gervin C, McCabe N, McKenna S, White P, Song YH, Maheswaran S, Liu E, Haber DA, Johnston PG, Harkin DP.BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.Oncogen
11593420 - Teixeira J, Maheswaran S, Donahoe PK.Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications.Endocr Rev. 2001 Oct;22(5):657-74.
11588147 - Segev DL, Hoshiya Y, Stephen AE, Hoshiya M, Tran TT, MacLaughlin DT, Donahoe PK, Maheswaran S.Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo.J Biol Chem. 2001 Jul 20;276(29):26799-806.
11356848 - Ha TU, Segev DL, Barbie D, Masiakos PT, Tran TT, Dombkowski D, Glander M, Clarke TR, Lorenzo HK, Donahoe PK, Maheswaran S.Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism.J Biol Chem. 2000 Nov 24;275(47):3710
10958795 - Segev DL, Ha TU, Tran TT, Kenneally M, Harkin P, Jung M, MacLaughlin DT, Donahoe PK, Maheswaran S.Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathway.J Biol Chem. 2000 Sep 15;275(37):28371-9.
10874041 - Masiakos PT, MacLaughlin DT, Maheswaran S, Teixeira J, Fuller AF, Shah PC, Kehas DJ, Kenneally MK, Dombkowski DM, Ha TU, Preffer FI, Donahoe PK.Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (M
10589763 - Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA.Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.Cell. 1999 May 28;97(5):575-86.
10367887 - Maheswaran S, Englert C, Zheng G, Lee SB, Wong J, Harkin DP, Bean J, Ezzell R, Garvin AJ, McCluskey RT, DeCaprio JA, Haber DA.Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.Ge
9553041 - Maheswaran S, Englert C, Lee SB, Ezzel RM, Settleman J, Haber DA.E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.Oncogene. 1998 Apr 23;16(16):2041-50.
9572485 - Lee SB, Kolquist KA, Nichols K, Englert C, Maheswaran S, Ladanyi M, Gerald WL, Haber DA.The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour.Nat Genet. 1997 Nov;17(3):309-13.
9354795 - Englert C, Maheswaran S, Garvin AJ, Kreidberg J, Haber DA.Induction of p21 by the Wilms' tumor suppressor gene WT1.Cancer Res. 1997 Apr 15;57(8):1429-34.
9108440 - Haber DA, Englert C, Maheswaran S.Functional properties of WT1.Med Pediatr Oncol. 1996 Nov;27(5):453-5.
8827073 - Englert C, Vidal M, Maheswaran S, Ge Y, Ezzell RM, Isselbacher KJ, Haber DA.Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):11960-4.
8618823 - Englert C, Hou X, Maheswaran S, Bennett P, Ngwu C, Re GG, Garvin AJ, Rosner MR, Haber DA.WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.EMBO J. 1995 Oct 2;14(19):4662-75.
7588596 - Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA.The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.Genes Dev. 1995 Sep 1;9(17):2143-56.
7657166 - Maheswaran S, Lee H, Sonenshein GE.Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein.Mol Cell Biol. 1994 Feb;14(2):1147-52.
8289795 - Haber DA, Park S, Maheswaran S, Englert C, Re GG, Hazen-Martin DJ, Sens DA, Garvin AJ.WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.Science. 1993 Dec 24;262(5142):2057-9.
8266105 - Park S, Schalling M, Bernard A, Maheswaran S, Shipley GC, Roberts D, Fletcher J, Shipman R, Rheinwald J, Demetri G.The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.Nat Genet. 1993 Aug;4(4):415-2
8401592 - Maheswaran S, Park S, Bernard A, Morris JF, Rauscher FJ, Hill DE, Haber DA.Physical and functional interaction between WT1 and p53 proteins.Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5100-4.
8389468 - Maheswaran S, McCormack JE, Sonenshein GE.Changes in phosphorylation of myc oncogene and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line.Oncogene. 1991 Nov;6(11):1965-71.
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