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Carl Novina, MD, PhD

Publications

  • Joyce CE, Novina CD.miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?.J Clin Oncol. 2013 May 6.
    23650419
  • Horman SR, Janas MM, Litterst C, Wang B, Macrae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP.Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets.Mol Cell. 2013 Apr 16.
    23603119
  • Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD.Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins.RNA. 2012 Nov;18(11):2041-55.
    23019594
  • Li X, Sanda T, Look AT, Novina CD, von Boehmer H.Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.J Exp Med. 2011 Apr 4.
    21464222
  • Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD.MicroRNA Expression Profiling Identifies Activated B Cell Status in Chronic Lymphocytic Leukemia Cells.PLoS ONE. 2011;6(3):e16956.
    21408091
  • Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD.Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma.Mol Cell. 2010 Dec 10;40(5):841-849.
    21109473
  • Wang B, Li S, Qi HH, Chowdhury D, Shi Y, Novina CD.Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.Nat Struct Mol Biol. 2009 Dec;16(12):1259-66.
    19946268
  • Omer AD, Janas MM, Novina CD.The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability.Mol Cell. 2009 Sep 24;35(6):739-40.
    19782024
  • Cosmopoulos K,Pegtel M,Hawkins J,Moffett H,Novina C,Middeldorp J,Thorley-Lawson DA.Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma.J Virol. 2009 Mar;83(5):2357-67.
    19091858
  • Roccaro AM,Sacco A,Chen C,Runnels J,Leleu X,Azab F,Azab AK,Jia X,Ngo HT,Melhem MR,Burwick N,Varticovski L,Novina CD,Rollins BJ,Anderson KC,Ghobrial IM.microRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia.Blood. 2009 Apr 30;113(18):4391-402.
    19074725
  • Wang B, Yanez A, Novina CD.MicroRNA-repressed mRNAs contain 40S but not 60S components.Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5343-8.
    18390669
  • Love TM, Moffett HF, Novina CD.Not miR-ly small RNAs: big potential for microRNAs in therapy.J Allergy Clin Immunol. 2008 Feb;121(2):309-19. Review.
    18269923
  • Novina CD, Chabner BA.RNA-Directed Therapy: The Next Step in the miRNA Revolution.Oncologist. 2008 Jan;13(1):1-3.
    18245006
  • Wang B, Doench JG, Novina CD.Analysis of microRNA effector functions in vitro.Methods. 2007 Oct;43(2):91-104. Review.
    17889795
  • Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A.Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.J Clin Invest. 2007 Jan;117(1):112-21.
    17200714
  • Hakre S, Tussie-Luna MI, Ashworth T, Novina CD, Settleman J, Sharp PA, Roy AL.Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.Mol Cell. 2006 Oct 20;24(2):301-8.
    17052463
  • Wang B, Love TM, Call ME, Doench JG, Novina CD.Recapitulation of short RNA-directed translational gene silencing in vitro.Mol Cell. 2006 May 19;22(4):553-60.
    16713585
  • Oka T, Vasile E, Penman M, Novina CD, Dykxhoorn DM, Ungar D, Hughson FM, Krieger M.Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.J Biol Chem. 2005 Sep 23;280(38):32736-45.
    16051600
  • Chowdhury D, Novina CD.Potential roles for short RNAs in lymphocytes.Immunol Cell Biol. 2005 Jun;83(3):201-10.
    15877596
  • Novina CD, Sharp PA.The RNAi revolution.Nature. 2004 Jul 8;430(6996):161-4.
    15241403
  • Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P.Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.J Virol. 2003 Jul;77(13):7174-81.
    12805416
  • Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD.Lentivirus-delivered stable gene silencing by RNAi in primary cells.RNA. 2003 Apr;9(4):493-501.
    12649500
  • Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA.siRNA-directed inhibition of HIV-1 infection.Nat Med. 2002 Jul;8(7):681-6.
    12042777