DF/HCC Program Affiliation

Leukemia
Cancer Immunology

DF/HCC Associations

Director, Cell Manipulation
Member, Center Scientific Council
Associate Director, Core Facilities, Executive Committee

Research Abstract

Hematopoietic stem cell transplantation provides effective therapy for patients with a variety of hematologic malignancies, but this continues to be a very intensive and potentially dangerous treatment approach. With recent improvements in supportive care, the most common causes of treatment failure are disease relapse and infectious complications associated with immune deficiency following transplant. To address these 2 issues, my laboratory research is focused on the characterization of immune reconstitution following allogeneic hematopoietic stem cell transplantation. It is now well established that reconstitution of donor hematopoiesis not only replaces the recipients own immune system but also results in the development of immunity against patient tumor cells. This development of anti-tumor immunity is very effective and plays an important role in the prevention of relapse following stem cell transplantation. Both laboratory projects and clinical trials are attempting to define the immunologic mechanisms as well as the target antigens of this response. With better understanding of the mechanisms and target specificity of the graft-versus-leukemia (GVL) response, it will be possible to distinguish GVL from graft-versus-host disease (GVHD) and to develop new methods for selectively enhancing GVL.

Publications

• Mullally A, Ritz J.Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation.Blood 2007 Feb 15;109(4):1355-62.
  17008540
• Wu CJ, Ritz J.Induction of tumor immunity following allogeneic stem cell transplantation.Adv Immunol 2006;90:133-73.
  16730263
• Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J.IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT dependent mechanism and induces the expansio
  16645171
• Zorn E, Kim HT, Lee SJ, Floyd BH, Litsa D, Arumugarajah S, Bellucci R, Alyea EP, Antin JH, Soiffer RJ, Ritz J.Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.Blood 2005 Oct 15;106(8):2903-11.
  15972448
• Wu CJ, Biernacki M, Kutok JL, Rogers S, Chen L, Yang XF, Soiffer RJ, Ritz J.Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells.Clin Cancer Res 2005 Jun 15;11(12):4504-11.
  15958636
• Bellucci R, Alyea EP, Chiaretti S, Wu CJ, Zorn E, Weller E, Wu B, Canning C, Schlossman R, Munshi NC, Anderson KC, Ritz J.Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane re
  15692072
• Miklos DB, Kim HT, Miller KH, Guo L, Zorn E, Lee SJ, Hochberg EP, Wu CJ, Alyea EP, Cutler C, Ho V, Soiffer RJ, Antin JH, Ritz J.Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remiss
  15613541
• Zorn E, Miklos DB, Floyd BH, Mattes-Ritz A, Guo L, Soiffer RJ, Antin JH, Ritz J.Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response after Allogeneic Stem Cell Transplantation.J Exp Med 2004 Apr 19;199(8):1133-42.
  15096539
• Bellucci R, Wu CJ, Chiaretti S, Weller E, Davies FE, Alyea EP, Dranoff G, Anderson KC, Munshi NC, Ritz J.Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens.Blood 2004 Jan 1
  14563636
• Miklos DB, Kim HT, Zorn E, Hochberg EP, Guo L, Mattes-Ritz A, Viatte S, Soiffer RJ, Antin JH, Ritz J.Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors.Blood 2004 Ja
  14512314
• Orsini E, Bellucci R, Alyea EP, Schlossman R, Canning C, McLaughlin S, Ghia P, Anderson KC, Ritz J.Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusion.Cancer Res 2003 May 15;63(10):2561-8.
  12750280
• Hochberg EP, Miklos DB, Neuberg D, Eichner DA, McLaughlin SF, Mattes-Ritz A, Alyea EP, Antin JH, Soiffer RJ, Ritz J.A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transp
  12393452
• Bellucci R, Alyea EP, Weller E, Chillemi A, Hochberg E, Wu CJ, Canning C, Schlossman R, Soiffer RJ, Anderson KC, Ritz J.Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma.Blood 2002 J
  12036895
• Hochberg EP, Chillemi AC, Wu CJ, Neuberg D, Canning C, Hartman K, Alyea EP, Soiffer RJ, Kalams SA, Ritz J.Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults.Blood 2001 Aug 15;98(4):1116-21.
  11493459
• Wu CJ, Yang XF, McLaughlin S, Neuberg D, Canning C, Stein B, Alyea EP, Soiffer RJ, Dranoff G, Ritz J.Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia.J Clin Invest 2000 Sep;106(5):705-14.
  10974024
• Frericks BB, Ritz JP, Albrecht T, Valdeig S, Schenk A, Wolf KJ, Lehmann K.Influence of Intrahepatic Vessels on Volume and Shape of Percutaneous Thermal Ablation Zones: In Vivo Evaluation in a Porcine Model.Invest Radiol 2008 Apr;43(4):211-218.
  18340244
• Jinushi M, Vanneman M, Munshi NC, Tai YT, Prabhala RH, Ritz J, Neuberg D, Anderson KC, Carrasco DR, Dranoff G.MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.Proc Natl Acad Sci U S A 2008
  18202175
• Armand P, Kim HT, Cutler CS, Ho VT, Koreth J, Ritz J, Alyea EP, Antin JH, Soiffer RJ.A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation.Biol Blood Marrow Transplant 2008 Jan;14(
  18158958
• Moser L, Ritz JP, Hinkelbein W, Hocht S.Adjuvant and neoadjuvant chemoradiation or radiotherapy in rectal cancer--a review focusing on open questions.Int J Colorectal Dis 2008 Mar;23(3):227-36.
  18064471
• Sarantopoulos S, Stevenson KE, Kim HT, Bhuiya NS, Cutler CS, Soiffer RJ, Antin JH, Ritz J.High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.Clin Cancer Res 2007 Oct 15;13(20):6107-14.
  17947475
• Wu CJ, Gladwin M, Tisdale J, Hsieh M, Law T, Biernacki M, Rogers S, Wang X, Walters M, Zahrieh D, Antin JH, Ritz J, Krishnamurti L.Mixed haematopoietic chimerism for sickle cell disease prevents intravascular haemolysis.Br J Haematol 2007 Nov;139(3):504-7
  17910640
• Ritz JP, Lehmann KS, Mols A, Frericks B, Knappe V, Buhr HJ, Holmer C.Laser-induced thermotherapy for lung tissue--evaluation of two different internally cooled application systems for clinical use.Lasers Med Sci 2008 Apr;23(2):195-202.
  17599236
• Armand P, Kim HT, Deangelo DJ, Ho VT, Cutler CS, Stone RM, Ritz J, Alyea EP, Antin JH, Soiffer RJ.Impact of Cytogenetics on Outcome of De Novo and Therapy-Related AML and MDS after Allogeneic Transplantation.Biol Blood Marrow Transplant 2007 Jun;13(6):655
  17531775
• Chiaretti S, Tavolaro S, Ghia EM, Ariola C, Matteucci C, Elia L, Maggio R, Messina M, Ricciardi MR, Vitale A, Ritz J, Mecucci C, Guarini A, Foà R.Characterization of ABL1 expression in adult T-cell acute lymphoblastic leukemia by oligonucleotide array ana
  17488685
• Brown JR, Kim HT, Li S, Stephans K, Fisher DC, Cutler C, Ho V, Lee SJ, Milford EL, Ritz J, Antin JH, Soiffer RJ, Gribben JG, Alyea EP.Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced
  17084369
• Bellucci R, Oertelt S, Gallagher M, Li S, Zorn E, Weller E, Porcheray F, Alyea EP, Soiffer RJ, Munshi NC, Gershwin ME, Ritz J.Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic ste
  17068145
• Alyea EP, Kim HT, Ho V, Cutler C, DeAngelo DJ, Stone R, Ritz J, Antin JH, Soiffer RJ.Impact of conditioning regimen intensity on outcome of allogeneic hematopoietic cell transplantation for advanced acute myelogenous leukemia and myelodysplastic syndrome.
  17067911
• Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L.SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Blood 2006 Jun 8.
  16763212
• Cutler C, Miklos D, Kim HT, Treister N, Woo SB, Bienfang D, Klickstein LB, Levin J, Miller K, Reynolds C, Macdonell R, Pasek M, Lee SJ, Ho V, Soiffer R, Antin JH, Ritz J, Alyea E.Rituximab for steroid-refractory chronic graft-versus-host disease.Blood 200
  16551963
• Chiaretti S, Li X, Gentleman R, Vitale A, Wang KS, Mandelli F, Foà R, Ritz J.Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation.Clin Can
  16243790
• Gribben JG, Zahrieh D, Stephans K, Bartlett-Pandite L, Alyea EP, Fisher DC, Freedman AS, Mauch P, Schlossman R, Sequist LV, Soiffer RJ, Marshall B, Neuberg D, Ritz J, Nadler LM.Autologous and allogeneic stem cell transplantations for poor-risk chronic lym
  16131571
• Chiaretti S, Ritz J, Foa R.Genomic analysis in lymphoid leukemias.Rev Clin Exp Hematol 2005 Jun;9(1):E3.
  16027105
• Tadesse MG, Ibrahim JG, Gentleman R, Chiaretti S, Ritz J, Foa R.Bayesian error-in-variable survival model for the analysis of GeneChip arrays.Biometrics 2005 Jun;61(2):488-97.
  16011696
• Robertson MJ, Schacterle RS, Mackin GA, Wilson SN, Bloomingdale KL, Ritz J, Komaroff AL.Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression.Clin Exp Immunol 2005 Aug;141(2):326-32.
  15996197
• Torelli GF, Guarini A, Porzia A, Chiaretti S, Tatarelli C, Diverio D, Maggio R, Vitale A, Ritz J, Foa R.FLT3 inhibition in t(4;11)+ adult acute lymphoid leukaemia.Br J Haematol 2005 Jul;130(1):43-50.
  15982343
• Alyea EP, Kim HT, Ho VT, Cutler C, Gribben J, DeAngelo DJ, Lee SJ, Windawi S, Ritz J, Stone RM, Antin JH, Soiffer RJ.Comparative outcome of non-myeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients greater than fifty y
  15459007
• DeAngelo DJ, Hochberg EP, Alyea EP, Longtine J, Lee S, Galinsky I, Parekkedon B, Ritz J, Antin JH, Stone RM, Soiffer RJ.Extended follow-up of patients treated with imatinib mesylate (gleevec) for chronic myelogenous leukemia relapse after allogeneic trans
  15297408
• Ho VT, Zahrieh D, Hochberg E, Micale E, Levin J, Reynolds C, Steckel S, Cutler C, Fisher DC, Lee SJ, Alyea EP, Ritz J, Soiffer RJ, Antin JH.Safety and Efficacy of Denileukin Diftitox in Patients with Steroid Refractory Acute Graft-versus-Host Disease afte
  15113758
• Zubair AC, Zahrieh D, Daley H, Schott D, Gribben JG, Alyea EP, Schlossman R, Freedman A, Antin JH, Soiffer RJ, Neuberg D, Ritz J.Engraftment of autologous and allogeneic marrow HPCs after myeloablative therapy.Transfusion 2004 Feb;44(2):253-61.
  14962317
• Yan Y, Phan L, Yang F, Talpaz M, Yang Y, Xiong Z, Ng B, Timchenko NA, Wu CJ, Ritz J, Wang H, Yang XF.A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L.J Immunol 2004 Jan 1;172(1):651-60.
  14688378
• Chiaretti S, Li X, Gentleman R, Vitale A, Vignetti M, Mandelli F, Ritz J, Foa R.Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival.Blood 2004 Apr 1;103
  14684422
• Alyea E, Weller E, Schlossman R, Canning C, Mauch P, Ng A, Fisher D, Gribben J, Freeman A, Parikh B, Richardson P, Soiffer R, Ritz J, Anderson KC.Outcome after autologous and allogeneic stem cell transplantation for patients with multiple myeloma: impact
  14647268
• Wu CJ, Hochberg EP, Rogers SA, Kutok JL, Biernacki M, Nascimento AF, Marks P, Bridges K, Ritz J.Molecular assessment of erythroid lineage chimerism following nonmyeloablative allogeneic stem cell transplantation.Exp Hematol 2003 Oct;31(10):924-33.
  14550808
• Zubair A, Zahrieh D, Daley H, Schott D, Gribben JG, Freedman A, Ritz J.Early neutrophil engraftment following autologous BMT provides a functional predictor of long-term hematopoietic reconstitution.Transfusion 2003 May;43(5):614-21.
  12702183
• Wu CJ, Neuberg D, Chillemi A, McLaughlin S, Hochberg EP, Galinsky I, DeAngelo D, Soiffer RJ, Alyea EP, Capdeville R, Stone RM, Ritz J.Quantitative monitoring of BCR/ABL transcript during STI-571 therapy.Leuk Lymphoma 2002 Dec;43(12):2281-9.
  12613514
• Soiffer RJ, Alyea EP, Hochberg E, Wu C, Canning C, Parikh B, Zahrieh D, Webb I, Antin J, Ritz J.Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion.Biol Blood Marrow Transplant
  12463482
• Yang XF, Wu CJ, Chen L, Alyea EP, Canning C, Kantoff P, Soiffer RJ, Dranoff G, Ritz J.CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells.Cancer Res 2002 Oct 1;62(19):5517-22.
  12359762
• Zorn E, Wang KS, Hochberg EP, Canning C, Alyea EP, Soiffer RJ, Ritz J.Infusion of CD4+ donor lymphocytes induces the expansion of CD8+ donor T cells with cytolytic activity directed against recipient hematopoietic cells.Clin Cancer Res 2002 Jul;8(7):2052-
  12114403
• Friedberg JW, Neuberg D, Gribben JG, Fisher DC, Canning C, Koval M, Poor CM, Green LM, Daley J, Soiffer R, Ritz J, Freedman AS.Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non-Hodgkin's lymp
  12060117
• Testa U, Torelli GF, Riccioni R, Muta AO, Militi S, Annino L, Mariani G, Guarini A, Chiaretti S, Ritz J, Mandelli F, Peschle C, Foa R.Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor recept
  12036900
• Hodi FS, Schmollinger JC, Soiffer RJ, Salgia R, Lynch T, Ritz J, Alyea EP, Yang J, Neuberg D, Mihm M, Dranoff G.ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.Proc Natl Acad Sci U S A 2002 May 14;99(10):6919-24.
  11983866
• Alyea E, Neuberg D, Mauch P, Marcus K, Freedman A, Webb I, Anderson K, Schlossman R, Fisher D, Gribben J, Ritz J, Soiffer R.Effect of total body irradiation dose escalation on outcome following T-cell-depleted allogeneic bone marrow transplantation.Biol B
  11939603
• Zaki MH, Wysocka M, Everetts SE, Wang KS, French LE, Ritz J, Rook AH.Synergistic enhancement of cell-mediated immunity by interleukin-12 plus interleukin-2: basis for therapy of cutaneous T cell lymphoma.J Invest Dermatol 2002 Feb;118(2):366-71.
  11841558
• Alyea E, Weller E, Schlossman R, Canning C, Webb I, Doss D, Mauch P, Marcus K, Fisher D, Freeman A, Parikh B, Gribben J, Soiffer R, Ritz J, Anderson K.T-cell--depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patient
  11493435
• Yang XF, Wu CJ, McLaughlin S, Chillemi A, Wang KS, Canning C, Alyea EP, Kantoff P, Soiffer RJ, Dranoff G, Ritz J.CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia.Proc N
  11416219
• Wang KS, Zorn E, Ritz J.Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation.Blood 2001 Jun 15;97(12):3860-6.
  11389027
• Zorn E, Orsini E, Wu CJ, Stein B, Chillemi A, Canning C, Alyea EP, Soiffer RJ, Ritz J.A CD4+ T cell clone selected from a CML patient after donor lymphocyte infusion recognizes BCR-ABL breakpoint peptides but not tumor cells.Transplantation 2001 Apr 27;71
  11374415
• Soiffer RJ, Weller E, Alyea EP, Mauch P, Webb IL, Fisher DC, Freedman AS, Schlossman RL, Gribben J, Lee S, Anderson KC, Marcus K, Stone RM, Antin JH, Ritz J.CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in pa
  11181681
• Mahajan S, Gollob JA, Ritz J, Frank DA.CD2 stimulation leads to the delayed and prolonged activation of STAT1 in T cells but not NK cells.Exp Hematol 2001 Feb;29(2):209-20.
  11166460
• Orsini E, Alyea EP, Chillemi A, Schlossman R, McLaughlin S, Canning C, Soiffer RJ, Anderson KC, Ritz J.Conversion to full donor chimerism following donor lymphocyte infusion is associated with disease response in patients with multiple myeloma.Biol Blood
  10917573
• Wang KS, Frank DA, Ritz J.Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4.Blood 2000 May 15;95(10):3183-90.
  10807786
• Orsini E, Alyea EP, Schlossman R, Canning C, Soiffer RJ, Chillemi A, Neuberg D, Anderson KC, Ritz J.Changes in T cell receptor repertoire associated with graft-versus-tumor effect and graft-versus-host disease in patients with relapsed multiple myeloma af
  10734296
• Wu CJ, Chillemi A, Alyea EP, Orsini E, Neuberg D, Soiffer RJ, Ritz J.Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism.Blood 2000 Jan 1;95(1):352-9
  10607724
• Freedman AS, Neuberg D, Mauch P, Soiffer RJ, Anderson KC, Fisher DC, Schlossman R, Alyea EP, Takvorian T, Jallow H, Kuhlman C, Ritz J, Nadler LM, Gribben JG.Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular
  10552941
• Friedberg JW, Neuberg D, Stone RM, Alyea E, Jallow H, LaCasce A, Mauch PM, Gribben JG, Ritz J, Nadler LM, Soiffer RJ, Freedman AS.Outcome in patients with myelodysplastic syndrome after autologous bone marrow transplantation for non-Hodgkin's lymphoma.J C
  10506609
• Friedberg JW, Neuberg D, Gribben JG, Mauch P, Anderson KC, Soiffer RJ, Takvorian T, Fisher DC, Schlossman R, Jallow H, Kuhlman C, Ritz J, Freedman AS.Autologous bone marrow transplantation after histologic transformation of indolent B cell malignancies.Bi
  10465106
• Borrego F, Robertson MJ, Ritz J, Peña J, Solana R.CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor.Immunology 1999 May;97(1):159-65.
  10447727
• Frank DA, Mahajan S, Ritz J.Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.Nat Med 1999 Apr;5(4):444-7.
  10202937
• Gollob JA, Schnipper CP, Murphy EA, Ritz J, Frank DA.The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.J Immunol 1999 Apr 15;162(8):4472-81.
  10201984
• Sehn LH, Alyea EP, Weller E, Canning C, Lee S, Ritz J, Antin JH, Soiffer RJ.Comparative outcomes of T-cell-depleted and non-T-cell-depleted allogeneic bone marrow transplantation for chronic myelogenous leukemia: impact of donor lymphocyte infusion.J Clin
  10080600
• Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C.PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.Hum Mol Gene
  9931326
• Robertson MJ, Cameron C, Atkins MB, Gordon MS, Lotze MT, Sherman ML, Ritz J.Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer.Clin Cancer Res 1999 Jan;5(1):9-16.
  9918197
• Wang KS, Ritz J, Frank DA.IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells.J Immunol 1999 Jan 1;162(1):299-304.
  9886399
• Soiffer RJ, Murray C, Shapiro C, Collins H, Chartier S, Lazo S, Ritz J.Expansion and manipulation of natural killer cells in patients with metastatic cancer by low-dose continuous infusion and intermittent bolus administration of interleukin 2.Clin Cancer
  9816195
• Atkins MB, Robertson MJ, Gordon M, Lotze MT, DeCoste M, DuBois JS, Ritz J, Sandler AB, Edington HD, Garzone PD, Mier JW, Canning CM, Battiato L, Tahara H, Sherman ML.Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advan
  9815699
• Soiffer RJ, Chapman PB, Murray C, Williams L, Unger P, Collins H, Houghton AN, Ritz J.Administration of R24 monoclonal antibody and low-dose interleukin 2 for malignant melanoma.Clin Cancer Res 1997 Jan;3(1):17-24.
  9815532
• Lee SJ, Weller E, Alyea EP, Ritz J, Soiffer RJ.Efficacy and costs of granulocyte colony-stimulating factor in allogeneic T-cell depleted bone marrow transplantation.Blood 1998 Oct 15;92(8):2725-9.
  9763556
• Delabesse E, Bernard M, Meyer V, Smit L, Pulford K, Cayuela JM, Ritz J, Bourquelot P, Strominger JL, Valensi F, Macintyre EA.TAL1 expression does not occur in the majority of T-ALL blasts.Br J Haematol 1998 Jul;102(2):449-57.
  9695959
• Gollob JA, Schnipper CP, Orsini E, Murphy E, Daley JF, Lazo SB, Frank DA, Neuberg D, Ritz J.Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12.J Clin Invest 1998 Aug 1;102(3):561-75.
  9691093
• Soiffer RJ, Freedman AS, Neuberg D, Fisher DC, Alyea EP, Gribben J, Schlossman RL, Bartlett-Pandite L, Kuhlman C, Murray C, Freeman A, Mauch P, Anderson KC, Nadler LM, Ritz J.CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin's ly
  9674848
• Alyea EP, Soiffer RJ, Canning C, Neuberg D, Schlossman R, Pickett C, Collins H, Wang Y, Anderson KC, Ritz J.Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant.Blood 1998 May
  9573003
• Gollob JA, Murphy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA.Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1.Blood 1998 Feb 15;91(4):1341-54.
  9454765
• Voss SD, Daley J, Ritz J, Robertson MJ.Participation of the CD94 receptor complex in costimulation of human natural killer cells.J Immunol 1998 Feb 15;160(4):1618-26.
  9469418
• Webb IJ, Soiffer RJ, Andersen JW, Cohen CA, Freeman A, Sugrue M, Ritz J, Anderson KC.In vivo adsorption of isohemagglutinins with fresh frozen plasma in major ABO-incompatible bone marrow transplantation.Biol Blood Marrow Transplant 1997 Nov;3(5):267-72.
  9450922
• Frank DA, Mahajan S, Ritz J.B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.J Clin Invest 1997 Dec 15;100(12):3140-8
  9399961
• Freedman A, Neuberg D, Mauch P, Gribben J, Soiffer R, Anderson K, Robertson M, Fisher DC, Schlossman R, Kroon M, Rhuda C, Kuhlman C, Ritz J, Nadler L.Cyclophosphamide, doxorubicin, vincristine, prednisone dose intensification with granulocyte colony-stimu
  9389719
• Weisdorf DJ, Billett AL, Hannan P, Ritz J, Sallan SE, Steinbuch M, Ramsay NK.Autologous versus unrelated donor allogeneic marrow transplantation for acute lymphoblastic leukemia.Blood 1997 Oct 15;90(8):2962-8.
  9376576
• Ida H, Robertson MJ, Voss S, Ritz J, Anderson P.CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells.J Immunol 1997 Sep 1;159(5):2154-60.
  9278302
• Claret EJ, Alyea EP, Orsini E, Pickett CC, Collins H, Wang Y, Neuberg D, Soiffer RJ, Ritz J.Characterization of T cell repertoire in patients with graft-versus-leukemia after donor lymphocyte infusion.J Clin Invest 1997 Aug 15;100(4):855-66.
  9259585
• Soiffer RJ, Fairclough D, Robertson M, Alyea E, Anderson K, Freedman A, Bartlett-Pandite L, Fisher D, Schlossman RL, Stone R, Murray C, Freeman A, Marcus K, Mauch P, Nadler L, Ritz J.CD6-depleted allogeneic bone marrow transplantation for acute leukemia i
  9108425
• Soiffer RJ, Mauch P, Fairclough D, Alyea E, Anderson K, Fisher D, Freedman A, Bartlett-Pandite L, Robertson M, Schlossman R, Gollob J, Marcus K, Murray C, Kuhlman C, Freeman A, Nadler L, Ritz J.CD6+ T cell depleted allogeneic bone marrow transplantation f
  9209736
• Gollob JA, Kawasaki H, Ritz J.Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression.Eur J Immunol 1997 Mar;27(3):647-52.
  9079804
• Lynch TJ, Lambert JM, Coral F, Shefner J, Wen P, Blattler WA, Collinson AR, Ariniello PD, Braman G, Cook S, Esseltine D, Elias A, Skarin A, Ritz J.Immunotoxin therapy of small-cell lung cancer: a phase I study of N901-blocked ricin.J Clin Oncol 1997 Feb;1
  9053498
• Vance EA, Soiffer RJ, McDonald GB, Myerson D, Fingeroth J, Ritz J.Prevention of transmission of hepatitis C virus in bone marrow transplantation by treating the donor with alpha-interferon.Transplantation 1996 Nov 15;62(9):1358-60.
  8932286
• Gollob JA, Ritz J.CD2-CD58 interaction and the control of T-cell interleukin-12 responsiveness. Adhesion molecules link innate and acquired immunity.Ann N Y Acad Sci 1996 Oct 31;795:71-81.
  8958918
• Freedman AS, Gribben JG, Neuberg D, Mauch P, Soiffer RJ, Anderson KC, Pandite L, Robertson MJ, Kroon M, Ritz J, Nadler LM.High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission.Blood 1996 O
  8839876
• Pignata C, Sanghera JS, Soiffer RJ, Chartier S, Eder M, Pelech SL, Ritz J.Defective activation of mitogen-activated protein kinase after allogeneic bone marrow transplantation.Blood 1996 Sep 15;88(6):2334-41.
  8822956
• Gollob JA, Li J, Kawasaki H, Daley JF, Groves C, Reinherz EL, Ritz J.Molecular interaction between CD58 and CD2 counter-receptors mediates the ability of monocytes to augment T cell activation by IL-12.J Immunol 1996 Sep 1;157(5):1886-93.
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• Boussiotis VA, Pardo NA, Collins H, Houghton A, Ritz J, Nadler LM, Soiffer RJ.R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy.Eur J Immunol 1996 Sep;26(9):2149-54.
  8814260
• Nguyen PL, Harris NL, Ritz J, Robertson MJ.Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease.Am J Pathol 1996 Mar;148(3):847-53.
  8774139
• Gollob JA, Li J, Reinherz EL, Ritz J.CD2 regulates responsiveness of activated T cells to interleukin 12.J Exp Med 1995 Sep 1;182(3):721-31.
  7544396
• Frank DA, Robertson MJ, Bonni A, Ritz J, Greenberg ME.Interleukin 2 signaling involves the phosphorylation of Stat proteins.Proc Natl Acad Sci U S A 1995 Aug 15;92(17):7779-83.
  7544001
• Robertson MJ, Manley TJ, Pichert G, Cameron C, Cochran KJ, Levine H, Ritz J.Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells.Leuk Lymphoma 1995 Mar;17(1-2):51-61.
  7539660
• Soiffer RJ, Murray C, Ritz J, Phillips N, Jacobsohn D, Chartier S, Ambrosino DM.Recombinant interleukin-2 infusions and decreased IgG2 subclass concentrations.Blood 1995 Feb 15;85(4):925-8.
  7849314
• Kameoka J, Sato T, Torimoto Y, Sugita K, Soiffer RJ, Schlossman SF, Ritz J, Morimoto C.Differential CD26-mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation.Blood 1995 Feb 15;85(4):1132-7.
  7849301
• Soiffer RJ, Alyea EP, Ritz J.Immunomodulatory effects of donor lymphocyte infusions following allogeneic bone marrow transplantation.J Clin Apheresis 1995;10(3):139-43.
  8582896
• Roy DC, Perreault C, Bélanger R, Gyger M, Le Houillier C, Blättler WA, Lambert JM, Ritz J.Elimination of B-lineage leukemia and lymphoma cells from bone marrow grafts using anti-B4-blocked-ricin immunotoxin.J Clin Immunol 1995 Jan;15(1):51-7.
  7539011
• Lew MA, Kehoe K, Ritz J, Antman KH, Nadler L, Kalish LA, Finberg R.Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomized, controlled trial.J Clin Oncol 1995 Jan;13(1):
  7799026
• Pichert G, Alyea EP, Soiffer RJ, Roy DC, Ritz J.Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia.Blood 1994 Oct 1;84(7):2109-14.
  7919323
• Sugita K, Nojima Y, Tachibana K, Soiffer RJ, Murray C, Schlossman SF, Ritz J, Morimoto C.Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantation.J
  7518837
• Soiffer RJ, Murray C, Gonin R, Ritz J.Effect of low-dose interleukin-2 on disease relapse after T-cell-depleted allogeneic bone marrow transplantation.Blood 1994 Aug 1;84(3):964-71.
  8043878
• Nakarai T, Robertson MJ, Streuli M, Wu Z, Ciardelli TL, Smith KA, Ritz J.Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells.J Exp Med 1994 Jul 1;180(1):241-51.
  8006584
• Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA.CD antigens 1993.Blood 1994 Feb 15;83(4):879-80.
  8111060
• Ritz J.Tumor immunity: will new keys unlock the door?.J Clin Oncol 1994 Feb;12(2):237-8.
  8113831
• Epstein C, Lynch T, Shefner J, Wen P, Maxted D, Braman V, Ariniello P, Coral F, Ritz J.Use of the immunotoxin N901-blocked ricin in patients with small-cell lung cancer.Int J Cancer Suppl 1994;8:57-9.
  7515030
• Robertson MJ, Roy DC, Stone RM, Ritz J.Use of CD33 monoclonal antibodies in bone marrow transplantation for acute myeloid leukemia.Prog Clin Biol Res 1994;389:47-63.
  7700916
• Robertson MJ, Ritz J.Prognostic significance of the surface antigens expressed by leukemic cells.Leuk Lymphoma 1994;13 Suppl 1:15-22.
  8075574
• Soiffer RJ, Robertson MJ, Murray C, Cochran K, Ritz J.Interleukin-12 augments cytolytic activity of peripheral blood lymphocytes from patients with hematologic and solid malignancies.Blood 1993 Nov 1;82(9):2790-6.
  8106018
• Sugita K, Robertson MJ, Torimoto Y, Ritz J, Schlossman SF, Morimoto C.Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells.J Immunol 1992 Aug 15;149(4):1199-203.
  1354231
• Robertson MJ, Soiffer RJ, Wolf SF, Manley TJ, Donahue C, Young D, Herrmann SH, Ritz J.Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.J
  1346796
• Grossbard ML, Freedman AS, Ritz J, Coral F, Goldmacher VS, Eliseo L, Spector N, Dear K, Lambert JM, Blättler WA.Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion.Blood 1992 Feb 1;79(3):576-85.
  1370636
• Soiffer RJ, Murray C, Cochran K, Cameron C, Wang E, Schow PW, Daley JF, Ritz J.Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation.Blood 1
  1730094
• Tycko B, Ritz J, Sallan S, Sklar J.Changing antigen receptor gene rearrangements in a case of early pre-B cell leukemia: evidence for a tumor progenitor cell with stem cell features and implications for monitoring residual disease.Blood 1992 Jan 15;79(2):
  1309670
• Baume DM, Robertson MJ, Levine H, Manley TJ, Schow PW, Ritz J.Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells.Eur J Immunol 1992 Jan;22(1):1-6.
  1370410
• Delage R, Soiffer RJ, Dear K, Ritz J.Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia.Blood 1991 Nov 15;78(10):2759-67.
  1824268
• Robertson MJ, Ritz J.Biology and clinical relevance of human natural killer cells.Blood 1990 Dec 15;76(12):2421-38.
  2265240
• Robertson MJ, Caligiuri MA, Manley TJ, Levine H, Ritz J.Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis.J Immunol 1990 Nov 15;145(10):3194-201.
  1700001
• Jochelson M, Tarbell NJ, Freedman AS, Rabinowe SN, Takvorian T, Soiffer R, Anderson K, Ritz J, Nadler LM.Acute and chronic pulmonary complications following autologous bone marrow transplantation in non-Hodgkin's lymphoma.Bone Marrow Transplant 1990 Nov;6
  2291994
• Soiffer RJ, Bosserman L, Murray C, Cochran K, Daley J, Ritz J.Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation.Blood 1990 May 15;75(10):2076-84.
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• Caligiuri MA, Zmuidzinas A, Manley TJ, Levine H, Smith KA, Ritz J.Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.J Exp Med 1990 M
  1692080
• Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF.Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.Proc Natl Acad Sci U S A 1990 Mar;87(6):2274-8.
  2138330
• Roy DC, Tantravahi R, Murray C, Dear K, Gorgone B, Anderson KC, Freedman AS, Nadler LM, Ritz J.Natural history of mixed chimerism after bone marrow transplantation with CD6-depleted allogeneic marrow: a stable equilibrium.Blood 1990 Jan 1;75(1):296-304.
  1967216
• Anderson P, Caligiuri M, Ritz J, Schlossman SF.CD3-negative natural killer cells express zeta TCR as part of a novel molecular complex.Nature 1989 Sep 14;341(6238):159-62.
  2528695
• Schmidt RE, Michon JM, Woronicz J, Schlossman SF, Reinherz EL, Ritz J.Enhancement of natural killer function through activation of the T11 E rosette receptor.J Clin Invest 1987 Jan;79(1):305-8.
  3098784
• Schmidt RE, Murray C, Daley JF, Schlossman SF, Ritz J.A subset of natural killer cells in peripheral blood displays a mature T cell phenotype.J Exp Med 1986 Jul 1;164(1):351-6.
  3088199
• Hercend T, Takvorian T, Nowill A, Tantravahi R, Moingeon P, Anderson KC, Murray C, Bohuon C, Ythier A, Ritz J.Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation.Blood 1986 Mar;67(3):722-8.
  3081066
• Schmidt RE, MacDermott RP, Bartley G, Bertovich M, Amato DA, Austen KF, Schlossman SF, Stevens RL, Ritz J.Specific release of proteoglycans from human natural killer cells during target lysis.Nature 1985 Nov 21-27;318(6043):289-91.
  4069203
• Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL.Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.Nature 1985 Oct 3-9;317(6036):428-30.
  2864636
• Ritz J, Campen TJ, Schmidt RE, Royer HD, Hercend T, Hussey RE, Reinherz EL.Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.Science 1985 Jun 28;228(4707):1540-3.
  2409597
• Hercend T, Griffin JD, Bensussan A, Schmidt RE, Edson MA, Brennan A, Murray C, Daley JF, Schlossman SF, Ritz J.Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2,
  3884668
• Hercend T, Reinherz EL, Meuer S, Schlossman SF, Ritz J.Phenotypic and functional heterogeneity of human cloned natural killer cell lines.Nature 1983 Jan 13;301(5896):158-60.
  6823293