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Harvey Cantor, MD


  • Leavenworth JW, Verbinnen B, Wang Q, Shen E, Cantor H.
    Intracellular osteopontin regulates homeostasis and function of natural killer cells.
    Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):494-9.
  • Kim HJ, Cantor H.
    CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful.
    Cancer Immunol Res. 2014 Feb;2(2):91-8.
  • Alvarez Arias DA, Kim HJ, Zhou P, Holderried TA, Wang X, Dranoff G, Cantor H.
    Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity.
    Cancer Immunol Res. 2014 Mar;2(3):207-16.
  • Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.
    In vivo discovery of immunotherapy targets in the tumour microenvironment.
    Nature. 2014 Feb 6;506(7486):52-7.
  • Holderried TA, Lang PA, Kim HJ, Cantor H.
    Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection.
    Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21089-94.
  • Kreslavsky T, Kim HJ, Koralov SB, Ghitza D, Buch T, Cantor H, Rajewsky K, von Boehmer H.
    Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.
    J Exp Med. 2013 Sep 23;210(10):1911-8.
  • Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H.
    Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells.
    J Clin Invest. 2013 Mar 1;123(3):1382-9.
  • Kim HJ, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H.
    CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice.
    Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2010-5.
  • Kim HJ, Verbinnen B, Tang X, Lu L, Cantor H.
    Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance.
    Nature. 2010 Sep 16;467(7313):328-32.
  • Mitsdoerffer M, Lee Y, J├Ąger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK.
    Proinflammatory T helper type 17 cells are effective B-cell helpers.
    Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14292-7.
  • Varthaman A, Khallou-Laschet J, Clement M, Fornasa G, Kim HJ, Gaston AT, Dussiot M, Caligiuri G, Herbelin A, Kaveri S, Cantor H, Nicoletti A.
    Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells.
    J Immunol. 2010 Jun 15;184(12):6585-91.
  • Arias DA, McCarty N, Lu L, Maldonado RA, Shinohara ML, Cantor H.
    Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.
    Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2556-61.
  • Leavenworth JW, Schellack C, Kim HJ, Lu L, Spee P, Cantor H.
    Analysis of the cellular mechanism underlying inhibition of EAE after treatment with anti-NKG2A F(ab')2.
    Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2562-7.
  • Egli D, Sandler VM, Shinohara ML, Cantor H, Eggan K.
    Reprogramming after chromosome transfer into mouse blastomeres.
    Curr Biol. 2009 Aug 25;19(16):1403-9.
  • Cornejo MG,Kharas MG,Werneck MB,Le Bras S,Moore SA,Ball B,Beylot-Barry M,Rodig SJ,Aster JC,Lee BH,Cantor H,Merlio JP,Gilliland DG,Mercher T.
    Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.
    Blood. 2009 Mar 19;113(12):2746-54.
  • Lu L,Cantor H.
    Generation and regulation of CD8(+) regulatory T cells.
    Cell Mol Immunol. 2008 Dec;5(6):401-6. Review.
  • Cantor H,Shinohara ML.
    Regulation of T-helper-cell lineage development by osteopontin: the inside story.
    Nat Rev Immunol. 2009 Feb;9(2):137-41.
  • Lu L,Kim HJ,Werneck MB,Cantor H.
    Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.
    Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19420-5.
  • Shinohara ML,Kim JH,Garcia VA,Cantor H.
    Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
    Immunity. 2008 Jul;29(1):68-78.
  • Werneck MB,Lugo-Villarino G,Hwang ES,Cantor H,Glimcher LH.
    T-bet plays a key role in NK-mediated control of melanoma metastatic disease.
    J Immunol. 2008 Jun 15;180(12):8004-10.
  • Shinohara ML,Kim HJ,Kim JH,Garcia VA,Cantor H.
    Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells.
    Proc Natl Acad Sci U S A. 2008 May 20;105(20):7235-9.
  • Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H.
    Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. .
  • Colmenero P, Zhang AL, Qian T, Lu L, Cantor H, Soderstrom K, Engleman EG.
    Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.
    J Immunol. 2007 Oct 1;179(7):4608-15.
  • Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H.
    Regulation of Activated CD4(+) T Cells by NK Cells via the Qa-1-NKG2A Inhibitory Pathway.
    Immunity. 2007 May;26(5):593-604.
  • Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, Cantor H.
    Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
    Nat Immunol. 2006 May;7(5):498-506.
  • Shinohara ML, Jansson M, Hwang ES, Werneck MB, Glimcher LH, Cantor H.
    T-bet-dependent expression of osteopontin contributes to T cell polarization.
    Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101-6.
  • Paust S, Cantor H.
    Regulatory T cells and autoimmune disease.
    Immunol Rev. 2005 Apr;204:195-207.
  • Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG.
    The role of innate immunity in autoimmunity.
    J Exp Med. 2004 Dec 20;200(12):1527-31.
  • McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H.
    Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes.
    Nat Immunol. 2005 Jan;6(1):65-72.
  • Sarantopoulos S, Lu L, Cantor H.
    Qa-1 restriction of CD8+ suppressor T cells.
    J Clin Invest. 2004 Nov;114(9):1218-21.
  • Paust S, Lu L, McCarty N, Cantor H.
    Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.
    Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10398-403.
  • McCarty N, Shinohara ML, Lu L, Cantor H.
    Detailed analysis of gene expression during development of T cell lineages in the thymus.
    Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9339-44.
  • Hu D, Ikizawa K, Lu L, Sanchirico ME, Shinohara ML, Cantor H.
    Analysis of regulatory CD8 T cells in Qa-1-deficient mice.
    Nat Immunol. 2004 May;5(5):516-23.
  • Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H.
    Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes.
    J Clin Invest. 2004 Apr;113(8):1218-24.
  • Cantor H.
    Reviving suppression?.
    Nat Immunol. 2004 Apr;5(4):347-9.
  • Kissler S, Lu L, Cantor H.
    Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice.
    Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):210-4.
  • Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H.
    T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.
    J Exp Med. 2002 Jul 1;196(1):87-95.
  • Trimble LA, Prince KA, Pestano GA, Daley J, Cantor H.
    Fas-dependent elimination of nonselected CD8 cells and lpr disease.
    J Immunol. 2002 May 15;168(10):4960-7.
  • Huster KM, Panoutsakopoulou V, Prince K, Sanchirico ME, Cantor H.
    T cell-dependent and -independent pathways to tissue destruction following herpes simplex virus-1 infection.
    Eur J Immunol. 2002 May;32(5):1414-9.
  • Weber GF, Bronson RT, Ilagan J, Cantor H, Schmits R, Mak TW.
    Absence of the CD44 gene prevents sarcoma metastasis.
    Cancer Res. 2002 Apr 15;62(8):2281-6.
  • Jansson M, Panoutsakopoulou V, Baker J, Klein L, Cantor H.
    Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice.
    J Immunol. 2002 Mar 1;168(5):2096-9.
  • Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H.
    Analysis of the relationship between viral infection and autoimmune disease.
    Immunity. 2001 Jul;15(1):137-47.
  • Pestano GA, Zhou Y, Trimble LA, Daley J, Weber GF, Cantor H.
    Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death.
    Science. 1999 May 14;284(5417):1187-91.
  • Noble A, Pestano GA, Cantor H.
    Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells.
    J Immunol. 1998 Jan 15;160(2):559-65.
  • Zhao ZS, Granucci F, Yeh L, Schaffer PA, Cantor H.
    Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.
    Science. 1998 Feb 27;279(5355):1344-7.
  • Yang XF, Weber GF, Cantor H.
    A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells.
    Immunity. 1997 Nov;7(5):629-39.
  • Weber GF, Ashkar S, Glimcher MJ, Cantor H.
    Receptor-ligand interaction between CD44 and osteopontin (Eta-1).
    Science. 1996 Jan 26;271(5248):509-12.
  • Avery AC, Zhao ZS, Rodriguez A, Bikoff EK, Soheilian M, Foster CS, Cantor H.
    Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide.
    Nature. 1995 Aug 3;376(6539):431-4.
  • Weber GF, Abromson-Leeman S, Cantor H.
    A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death.
    Immunity. 1995 Apr;2(4):363-72.
  • Weber GF, Cantor H.
    Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen.
    J Immunol. 1994 May 1;152(9):4433-43.
  • Crump AL, Grusby MJ, Glimcher LH, Cantor H.
    Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
    Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10739-43.
  • Liu H, Lampe MA, Iregui MV, Cantor H.
    Clonal unresponsiveness results from an interaction between staphylococcal enterotoxin B and T cells expressing unexpected V beta elements.
    Int Immunol. 1992 Aug;4(8):851-9.
  • Lampe MA, Patarca R, Iregui MV, Cantor H.
    Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease.
    J Immunol. 1991 Nov 1;147(9):2902-6.
  • Liu H, Lampe MA, Iregui MV, Cantor H.
    Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.
    Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8705-9.
  • Patarca R, Wei FY, Iregui MV, Cantor H.
    Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen.
    Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2736-9.
  • Patarca R, Wei FY, Singh P, Morasso MI, Cantor H.
    Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease.
    J Exp Med. 1990 Oct 1;172(4):1177-83.
  • Singh RP, Patarca R, Schwartz J, Singh P, Cantor H.
    Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.
    J Exp Med. 1990 Jun 1;171(6):1931-42.