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Marisa R. Nucci, MD


  • Parra-Herran CE, Yuan L, Nucci MR, Quade BJ.Targeted development of specific biomarkers of endometrial stromal cell differentiation using bioinformatics: the IFITM1 model.Mod Pathol. 2014 Apr;27(4):569-79.
  • Serrano C, Nucci MR, Tirumani SH, Raut CP, George S.Hormone dependency in metastatic low-grade leiomyosarcoma following uterine smooth muscle tumour of uncertain malignant potential.BMJ Case Rep. 2014;2014.
  • George S, Feng Y, Manola J, Nucci MR, Butrynski JE, Morgan JA, Ramaiya N, Quek R, Penson RT, Wagner AJ, Harmon D, Demetri GD, Krasner C.Phase 2 trial of aromatase inhibition with letrozole in patients with uterine leiomyosarcomas expressing estrogen and/or progesterone receptors.Cancer. 2014 Mar 1;120(5):738-43.
  • Oduyebo T, Rauh-Hain AJ, Meserve EE, Seidman MA, Hinchcliff E, George S, Quade B, Nucci MR, Del Carmen MG, Muto MG.The value of re-exploration in patients with inadvertently morcellated uterine sarcoma.Gynecol Oncol. 2014 Feb;132(2):360-5.
  • Ahmed Q, Hussein Y, Hayek K, Bandyopadhyay S, Semaan A, Abdul-Karim F, Al-Wahab Z, Munkarah AR, Elshaikh MA, Alosh B, Nucci MR, Van de Vijver KK, Morris RT, Oliva E, Ali-Fehmi R.Is the two-tier ovarian serous carcinoma grading system potentially useful in stratifying uterine serous carcinoma? A large multi-institutional analysis.Gynecol Oncol. 2014 Feb;132(2):372-6.
  • Winham WM, Lin D, Stone PJ, Nucci MR, Quick CM.Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC): a clinicopathologic comparison of 154 cases with clinical follow-up.Int J Gynecol Pathol. 2014 Mar;33(2):120-6.
  • Schoolmeester JK, Howitt BE, Hirsch MS, Dal Cin P, Quade BJ, Nucci MR.Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: clinicopathologic and immunohistochemical characterization of 16 cases.Am J Surg Pathol. 2014 Feb;38(2):176-88.
  • Previs RA, Edwards JM, Secord AA, Nucci MR, Bentley RC, Hall AH.Cystic fibrosis involving the cervix, mimicking a well-differentiated adenocarcinoma: a case report.Int J Gynecol Pathol. 2014 Jan;33(1):100-4.
  • Lee CH, Hoang LN, Yip S, Reyes C, Marino-Enriquez A, Eilers G, Tao D, Chiang S, Fletcher JA, Soslow RA, Nucci MR, Oliva E.Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement.Mod Pathol. 2013 Nov 1.
  • Hoang LN, McConechy MK, Köbel M, Han G, Rouzbahman M, Davidson B, Irving J, Ali RH, Leung S, McAlpine JN, Oliva E, Nucci MR, Soslow RA, Huntsman DG, Gilks CB, Lee CH.Histotype-genotype correlation in 36 high-grade endometrial carcinomas.Am J Surg Pathol. 2013 Sep;37(9):1421-32.
  • Abdel-Mesih A, Daya D, Onuma K, Sur M, Tang S, Akhtar-Danesh N, Boutross-Tadross O, Ceballos KM, Chapman W, Colgan T, Deb P, Nucci MR, Oliva E, Lytwyn A.Interobserver agreement for assessing invasion in stage 1A vulvar squamous cell carcinoma.Am J Surg Pathol. 2013 Sep;37(9):1336-41.
  • Herfs M, Parra-Herran C, Howitt BE, Laury AR, Nucci MR, Feldman S, Jimenez CA, McKeon FD, Xian W, Crum CP.Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.Am J Surg Pathol. 2013 Sep;37(9):1311-8.
  • Ning G, Bijron JG, Yuan J, Hirsch MS, McKeon FD, Nucci MR, Crum CP, Xian W.Differential expression of p-ERM, a marker of cell polarity, in benign and neoplastic oviductal epithelium.Int J Gynecol Pathol. 2013 Jul;32(4):345-52.
  • Howitt BE, Herfs M, Brister K, Oliva E, Longtine J, Hecht JL, Nucci MR.Intestinal-type Endocervical Adenocarcinoma In Situ: An Immunophenotypically Distinct Subset of AIS Affecting Older Women.Am J Surg Pathol. 2013 May;37(5):625-33.
  • Lim D, Alvarez T, Nucci MR, Gilks B, Longacre T, Soslow RA, Oliva E.Interobserver variability in the interpretation of tumor cell necrosis in uterine leiomyosarcoma.Am J Surg Pathol. 2013 May;37(5):650-8.
  • Semaan A, Mert I, Munkarah AR, Bandyopadhyay S, Mahdi HS, Winer IS, Nucci MR, Hussein Y, Quershi F, Hayek K, Tabassum F, Alosh B, Schultz DS, Cote ML, Vijver KK, Morris RT, Oliva E, Ali-Fehmi R.Clinical and pathologic characteristics of serous carcinoma confined to the endometrium: a multi-institutional study.Int J Gynecol Pathol. 2013 Mar;32(2):181-7.
  • Parra-Herran C, Herfs M, Doria M, Crum CP, Nucci MR.Giant condyloma of the cervix: an uncommon entity associated with low-risk human papilloma virus infection.Am J Surg Pathol. 2013 Feb;37(2):300-4.
  • Howitt BE, Nucci MR, Drapkin R, Crum CP, Hirsch MS.Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity.Am J Surg Pathol. 2013 Jan;37(1):89-97.
  • Ravegnini G, Mariño-Enriquez A, Slater J, Eilers G, Wang Y, Zhu M, Nucci MR, George S, Angelini S, Raut CP, Fletcher JA.MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.Mod Pathol. 2012 Dec 7.
  • Seidman MA, Oduyebo T, Muto MG, Crum CP, Nucci MR, Quade BJ.Peritoneal dissemination complicating morcellation of uterine mesenchymal neoplasms.PLoS ONE. 2012;7(11):e50058.
  • Isphording A, Ali RH, Irving J, Goytain A, Nelnyk N, Hoang LN, Gilks CB, Huntsman DG, Nielsen TO, Nucci MR, Lee CH.YWHAE-FAM22 endometrial stromal sarcoma: diagnosis by reverse transcription-polymerase chain reaction in formalin-fixed, paraffin embedded tumor.Hum Pathol. 2012 Nov 15.
  • Herfs M, Vargas SO, Yamamoto Y, Howitt BE, Nucci MR, Hornick JL, McKeon FD, Xian W, Crum CP.A novel blueprint for "top down" differentiation defines the cervical squamocolumnar junction during development, reproductive life and neoplasia.J Pathol. 2012 Sep 24.
  • Lee CH, Ali RH, Rouzbahman M, Marino-Enriquez A, Zhu M, Guo X, Brunner AL, Chiang S, Leung S, Nelnyk N, Huntsman DG, Blake Gilks C, Nielsen TO, Dal Cin P, van de Rijn M, Oliva E, Fletcher JA, Nucci MR.Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement.Am J Surg Pathol. 2012 Oct;36(10):1562-70.
  • Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W, Crum CP.A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10516-21.
  • Quick CM, May T, Horowitz NS, Nucci MR.Low-grade, low-stage endometrioid endometrial adenocarcinoma: a clinicopathologic analysis of 324 cases focusing on frequency and pattern of myoinvasion.Int J Gynecol Pathol. 2012 Jul;31(4):337-43.
  • Huang EC, Mutter GL, Crum CP, Nucci MR.Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium.Mod Pathol. 2010 Nov;23(11):1486-91.
  • Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, Mckeon FD, Hirsch MS, Wa X, Crum CP.High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression.Mod Pathol. 2010 Oct;23(10):1316-24.
  • Chen E, Fletcher CD, Nucci MR.Meningothelial proliferations in mature cystic teratoma of the ovary: evidence for the common presence of cranially derived tissues paralleling anterior embryonic plate development. An analysis of 25 consecutive cases.Am J Surg Pathol. 2010 Jul;34(7):1014-8.
  • Carlson JW, Jarboe EA, Kindelberger D, Nucci MR, Hirsch MS, Crum CP.Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implications.Int J Gynecol Pathol. 2010 Jul;29(4):310-4.
  • Medeiros F, Araujo AR, Erickson-Johnson MR, Kashyap PC, Dal Cin P, Nucci M, Wang X, Bell DA, Oliveira AM.HMGA1 and HMGA2 rearrangements in mass-forming endometriosis.Genes Chromosomes Cancer. 2010 Jul;49(7):630-4.
  • Raut CP, Nucci MR, Wang Q, Manola J, Bertagnolli MM, Demetri GD, Morgan JA, Muto MG, Fletcher CD, George S.Predictive value of FIGO and AJCC staging systems in patients with uterine leiomyosarcoma.Eur J Cancer. 2009 Nov;45(16):2818-24.
  • Semmel DR,Folkins AK,Hirsch MS,Nucci MR,Crum CP.Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbria.Mod Pathol. 2009 Aug;22(8):985-8.
  • Jarboe EA,Miron A,Carlson JW,Hirsch MS,Kindelberger D,Mutter GL,Crum CP,Nucci MR.Coexisting Intraepithelial Serous Carcinomas of the Endometrium and Fallopian Tube: Frequency and Potential Significance.Int J Gynecol Pathol. 2009 Jul;28(4):308-15.
  • Chang MC,Vargas SO,Hornick JL,Hirsch MS,Crum CP,Nucci MR.Embryonic Stem Cell Transcription Factors and D2-40 (Podoplanin) as Diagnostic Immunohistochemical Markers in Ovarian Germ Cell Tumors.Int J Gynecol Pathol. 2009 Jul;28(4):347-55.
  • Lacey JV Jr,Mutter GL,Nucci MR,Ronnett BM,Ioffe OB,Rush BB,Glass AG,Richesson DA,Chatterjee N,Langholz B,Sherman ME.Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies.Cancer. 2008 Oct 15;113(8):2073-81.
  • Bossuyt V,Medeiros F,Drapkin R,Folkins AK,Crum CP,Nucci MR.Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma.Int J Gynecol Pathol. 2008 Jul;27(3):390-7.
  • Lomo L,Nucci MR,Lee KR,Lin MC,Hirsch MS,Crum CP,Mutter GL.Histologic and immunohistochemical decision-making in endometrial adenocarcinoma.Mod Pathol. 2008 Aug;21(8):937-42.
  • Lomo L, Nucci MR, Lee KR, Lin MC, Hirsch MS, Crum CP, Mutter GL.Histologic and immunohistochemical decision-making in endometrial adenocarcinoma.Mod Pathol.;21:937-42.
  • Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zembowicz A, Mihm MC, McKee PH, Brenn T.Atypical genital nevi. A clinicopathologic analysis of 56 cases.Am J Surg Pathol. 2008 Jan;32(1):51-7.
  • Jarboe E, Folkins A, Nucci MR, Kindelberger D, Drapkin R, Miron A, Lee Y, Crum CP.Serous carcinogenesis in the fallopian tube: a descriptive classification.Int J Gynecol Pathol. 2008 Jan;27(1):1-9.
  • Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J.Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20001-6.
  • Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS.Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis.Histopathology. 2007 Sep;51(3):305-12.
  • McCluggage WG, Sumathi VP, Nucci MR, Hirsch M, Dal Cin P, Wells M, Flanagan AM, Fisher C.Ewing family of tumours involving the vulva and vagina: report of a series of four cases.J Clin Pathol. 2007 Jun;60(6):674-80. Review.
  • Nucci MR, Drapkin R, Cin PD, Fletcher CD, Fletcher JA.Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications.Am J Surg Pathol. 2007 May;31(5):737-743.
  • Nucci MR, Harburger D, Koontz J, Cin PD, Sklar J.Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms.Am J Surg Pathol. 2007 Jan;31(1):65-70.
  • Nucci MR, Crum CP.Redefining early cervical neoplasia: recent progress.Adv Anat Pathol. 2007 Jan;14(1):1-10. Review.
  • Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP.A candidate precursor to serous carcinoma that originates in the distal fallopian tube.J Pathol. 2007 Jan;211(1):26-35.
  • Varnholt H, Otis CN, Nucci MR, Johari VP.Fallopian tube prolapse mimicking aggressive angiomyxoma.Int J Gynecol Pathol. 2005 Jul;24(3):292-4.
  • Fisher RA, Nucci MR, Thaker HM, Weremowicz S, Genest DR, Castrillon DH.Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case.Mod Pathol. 2004 Sep;17(9):1155-60.
  • Nucci MR, Young RH.Arias-Stella reaction of the endocervix: a report of 18 cases with emphasis on its varied histology and differential diagnosis.Am J Surg Pathol. 2004 May;28(5):608-12.
  • Crum CP, Hornstein MD, Nucci MR, Mutter GL.Hertig and beyond: a systematic and practical approach to the endometrial biopsy.Adv Anat Pathol. 2003 Nov;10(6):301-18.
  • Nucci MR, Castrillon DH, Bai H, Quade BJ, Ince TA, Genest DR, Lee KR, Mutter GL, Crum CP.Biomarkers in diagnostic obstetric and gynecologic pathology: a review.Adv Anat Pathol. 2003 Mar;10(2):55-68.
  • Nascimento AF, Hirsch MS, Cviko A, Quade BJ, Nucci MR.The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosis.Mod Pathol. 2003 Jan;16(1):22-7.
  • Lee KR, Nucci MR.Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type: a clinicopathologic analysis of four cases of an uncommon variant associated with endometriosis.Int J Gynecol Pathol. 2003 Jan;22(1):42-51.
  • Nucci MR.Symposium part III: tumor-like glandular lesions of the uterine cervix.Int J Gynecol Pathol. 2002 Oct;21(4):347-59.
  • Castrillon DH, Lee KR, Nucci MR.Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study.Int J Gynecol Pathol. 2002 Jan;21(1):4-10.
  • Lee KR, Castrillon DH, Nucci MR.Pathologic findings in eight cases of ovarian serous borderline tumors, three with foci of serous carcinoma, that preceded death or morbidity from invasive carcinoma.Int J Gynecol Pathol. 2001 Oct;20(4):329-34.
  • Nucci MR, Weremowicz S, Neskey DM, Sornberger K, Tallini G, Morton CC, Quade BJ.Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva.Genes Chromosomes Cancer. 2001 Oct;32(2):172-6.
  • Nucci MR, O'Connell JT, Huettner PC, Cviko A, Sun D, Quade BJ.h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors.Am J Surg Pathol. 2001 Apr;25(4):455-63.
  • Nucci MR, Ferry JA, Young RH.Ectopic prostatic tissue in the uterine cervix: a report of four cases and review of ectopic prostatic tissue.Am J Surg Pathol. 2000 Sep;24(9):1224-30.
  • Nucci MR, Young RH, Fletcher CD.Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma.Am J Surg Pathol. 2000 Feb;24(2):231-40.
  • Nucci MR, Fletcher CD.Vulvovaginal soft tissue tumours: update and review.Histopathology. 2000 Feb;36(2):97-108.
  • Nucci MR, Prasad CJ, Crum CP, Mutter GL.Mucinous endometrial epithelial proliferations: a morphologic spectrum of changes with diverse clinical significance.Mod Pathol. 1999 Dec;12(12):1137-42.
  • Nucci MR, Clement PB, Young RH.Lobular endocervical glandular hyperplasia, not otherwise specified: a clinicopathologic analysis of thirteen cases of a distinctive pseudoneoplastic lesion and comparison with fourteen cases of adenoma malignum.Am J Surg Pathol. 1999 Aug;23(8):886-91.
  • Nucci MR, Krausz T, Lifschitz-Mercer B, Chan JK, Fletcher CD.Angiosarcoma of the ovary: clinicopathologic and immunohistochemical analysis of four cases with a broad morphologic spectrum.Am J Surg Pathol. 1998 May;22(5):620-30.
  • Nucci MR, Fletcher CD.Liposarcoma (atypical lipomatous tumors) of the vulva: a clinicopathologic study of six cases.Int J Gynecol Pathol. 1998 Jan;17(1):17-23.
  • Nucci MR, Granter SR, Fletcher CD.Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma.Am J Surg Pathol. 1997 Jun;21(6):636-44.
  • Granter SR, Nucci MR, Fletcher CD.Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases.Histopathology. 1997 Jan;30(1):3-10.
  • Nucci MR, Genest DR, Tate JE, Sparks CK, Crum CP.Pseudobowenoid change of the vulva: a histologic variant of untreated condylata acuminatum.Mod Pathol. 1996 Apr;9(4):375-9.