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Charles Willard Mortimer Roberts, MD, PhD

Publications

  • Kim KH, Roberts CW.Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.Cancer Genet. 2014 Apr 13.
    24853101
  • Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW.ARID1B is a specific vulnerability in ARID1A-mutant cancers.Nat Med. 2014 Mar;20(3):251-4.
    24562383
  • Hoffman GR, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, Bagdasarian L, Huber J, Lindeman A, Chen D, Romero R, Ramadan N, Phadke T, Haas K, Jaskelioff M, Wilson BG, Meyer MJ, Saenz-Vash V, Zhai H, Myer VE, Porter JA, Keen N, McLaughlin ME, Mickanin C, Roberts CW, Stegmeier F, Jagani Z.Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3128-33.
    24520176
  • Wilson BG, Helming KC, Wang X, Kim Y, Vazquez F, Jagani Z, Hahn WC, Roberts CW.Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.Mol Cell Biol. 2014 Mar;34(6):1136-44.
    24421395
  • Wang X, Roberts CW.CARMA: CARM1 methylation of SWI/SNF in breast cancer.Cancer Cell. 2014 Jan 13;25(1):3-4.
    24434203
  • Wang X, Haswell JR, Roberts CW.Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.Clin Cancer Res. 2014 Jan 1;20(1):21-7.
    24122795
  • Lu P, Roberts CW.The SWI/SNF tumor suppressor complex: Regulation of promoter nucleosomes and beyond.Nucleus.;4(5):374-8.
    24145903
  • Wöhrle S, Weiss A, Ito M, Kauffmann A, Murakami M, Jagani Z, Thuery A, Bauer-Probst B, Reimann F, Stamm C, Pornon A, Romanet V, Guagnano V, Brümmendorf T, Sellers WR, Hofmann F, Roberts CW, Graus Porta D.Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors.PLoS ONE. 2013;8(10):e77652.
    24204904
  • Lee RS, Roberts CW.Linking the SWI/SNF complex to prostate cancer.Nat Genet. 2013 Nov;45(11):1268-9.
    24165726
  • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CW, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G.Mutational heterogeneity in cancer and the search for new cancer-associated genes.Nature. 2013 Jul 11;499(7457):214-8.
    23770567
  • Kim KH, Roberts CW.CHD7 in charge of neurogenesis.Cell Stem Cell. 2013 Jul 3;13(1):1-2.
    23827700
  • Tolstorukov MY, Sansam CG, Lu P, Koellhoffer EC, Helming KC, Alver BH, Tillman EJ, Evans JA, Wilson BG, Park PJ, Roberts CW.Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters.Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10165-70.
    23723349
  • Kieran MW, Roberts CW, Chi SN, Ligon KL, Rich BE, Macconaill LE, Garraway LA, Biegel JA.Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.Pediatr Blood Cancer. 2012 Dec 15;59(7):1155-7.
    22997201
  • Lee RS, Stewart C, Carter SL, Ambrogio L, Cibulskis K, Sougnez C, Lawrence MS, Auclair D, Mora J, Golub TR, Biegel JA, Getz G, Roberts CW.A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.J Clin Invest. 2012 Aug 1;122(8):2983-8.
    22797305
  • McKenna ES, Tamayo P, Cho YJ, Tillman EJ, Mora-Blanco EL, Sansam CG, Koellhoffer EC, Pomeroy SL, Roberts CW.Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.Cell Cycle. 2012 May 15;11(10):1956-65.
    22544318
  • Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M.Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Nat Med. 2010 Dec;16(12):1429-33.
    21076395
  • Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW.Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.Cancer Cell. 2010 Oct 19;18(4):316-28.
    20951942
  • DelBove J, Kuwahara Y, Mora-Blanco EL, Godfrey V, Funkhouser WK, Fletcher CD, Van Dyke T, Roberts CW, Weissman BE.Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice.Mol Carcinog. 2009 Dec;48(12):1139-48.
    19676100
  • Wang X, Sansam CG, Thom CS, Metzger D, Evans JA, Nguyen PT, Roberts CW.Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.Cancer Res. 2009 Oct 15;69(20):8094-101.
    19789351
  • Bourgo RJ,Siddiqui H,Fox S,Solomon D,Sansam CG,Yaniv M,Muchardt C,Metzger D,Chambon P,Roberts CW,Knudsen ES.SWI/SNF-Deficiency Results in Aberrant Chromatin Organization, Mitotic Failure, and Diminished Proliferative Capacity.Mol Biol Cell. 2009 Jul;20(14):3192-9.
    19458193
  • Roberts CW,Biegel JA.The role of SMARCB1/INI1 in development of rhabdoid tumor.Cancer Biol Ther. 2009 Mar;8(5):412-6. Review.
    19305156
  • McKenna ES,Roberts CW.Epigenetics and cancer without genomic instability.Cell Cycle. 2009 Jan 1;8(1):23-6. Review.
    19098432
  • McKenna ES,Sansam CG,Cho YJ,Greulich H,Evans JA,Thom CS,Moreau LA,Biegel JA,Pomeroy SL,Roberts CW.Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.Mol Cell Biol. 2008 Oct;28(20):6223-33.
    18710953
  • Chai J, Lu X, Godfrey V, Fletcher C, Roberts CW, Van Dyke T, Weissman BE.Tumor-specific cooperation of retinoblastoma protein family and Snf5 inactivation.Cancer Res. 2007 Apr 1;67(7):3002-9.
    17409406
  • Tamayo P, Scanfeld D, Ebert BL, Gillette MA, Roberts CW, Mesirov JP.Metagene projection for cross-platform, cross-species characterization of global transcriptional states.Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5959-64.
    17389406
  • Roberts CW.Genetic causes of familial risk in rhabdoid tumors.Pediatr Blood Cancer. 2006 Sep;47(3):235-7.
    16304667
  • Sansam CG, Roberts CW.Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.Cell Cycle. 2006 Mar;5(6):621-4. Review.
    16582616
  • Isakoff MS, Sansam CG, Tamayo P, Subramanian A, Evans JA, Fillmore CM, Wang X, Biegel JA, Pomeroy SL, Mesirov JP, Roberts CW.Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17745-50.
    16301525
  • Roberts CW, Orkin SH.The SWI/SNF complex--chromatin and cancer.Nat Rev Cancer. 2004 Feb;4(2):133-42.
    14964309
  • Roberts CW, Leroux MM, Fleming MD, Orkin SH.Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.Cancer Cell. 2002 Nov;2(5):415-25.
    12450796
  • Biegel JA, Kalpana G, Knudsen ES, Packer RJ, Roberts CW, Thiele CJ, Weissman B, Smith M.The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.Cancer Res. 2002 Jan 1;62(1):323-8.
    11782395
  • Roberts CW, Galusha SA, McMenamin ME, Fletcher CD, Orkin SH.Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800.
    11095756
  • Roberts CW, Shutter JR, Korsmeyer SJ.Hox11 controls the genesis of the spleen.Nature. 1994 Apr 21;368(6473):747-9.
    7908720