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Hanno R. Hock, MD, PhD


  • Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.J Exp Med. 2014 Apr 7.
  • Shi LZ, Kalupahana NS, Turnis ME, Neale G, Hock H, Vignali DA, Chi H.Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3198-205.
  • Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H.The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.Cell Stem Cell. 2012 Sep 7;11(3):319-32.
  • Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H.Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.J Biol Chem. 2010 Sep 3;285(36):27767-75.
  • Hock H.Some hematopoietic stem cells are more equal than others.J Exp Med. 2010 Jun 7;207(6):1127-30. Review.
  • Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D.Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.Arthritis Rheum. 2010 Mar;62(3):753-64.
  • Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K.Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.Nat Genet. 2009 Sep;41(9):968-76.
  • Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H.TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia.Cell Stem Cell. 2009 Jul 2;5(1):43-53.
  • Foudi A,Hochedlinger K,Van Buren D,Schindler JW,Jaenisch R,Carey V,Hock H.Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.Nat Biotechnol. 2009 Jan;27(1):84-90.
  • Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH.ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.Cancer Cell. 2007 Dec;12(6):542-58.
  • Hock H, Orkin SH.Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells.Curr Opin Hematol. 2006 Jan;13(1):1-6.
  • Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH.Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.Nature. 2004 Oct 21;431(7011):1002-7.
  • Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH.Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.Genes Dev. 2004 Oct 1;18(19):2336-41.
  • Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH.Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.Immunity. 2003 Jan;18(1):109-20.