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John P. Manis, MD


  • Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS.Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.J Exp Med. 2014 Apr 21.
  • Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA.BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.Mol Cell Biol. 2013 Feb;33(4):845-57.
  • Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE.Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.J Immunol. 2013 Feb 1;190(3):1094-102.
  • Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8.
  • Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.PLoS ONE. 2010;5(11):e13992.
  • Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA.AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.Mol Cell. 2010 Sep 24;39(6):873-85.
  • Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5.
  • Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.J Exp Med. 2010 Feb 15;207(2):417-27.
  • Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA.BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.Mol Cell. 2009 Oct 9;36(1):110-20.
  • Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA.BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.Mol Cell..
  • Cheng HL,Vuong BQ,Basu U,Franklin A,Schwer B,Astarita J,Phan RT,Datta A,Manis J,Alt FW,Chaudhuri J.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2717-22.
  • Wang JH,Alt FW,Gostissa M,Datta A,Murphy M,Alimzhanov MB,Coakley KM,Rajewsky K,Manis JP,Yan CT.Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.J Exp Med. 2008 Dec 22;205(13):3079-90.
  • Jolly CJ, Cook AJ, Manis JP.Fixing DNA breaks during class switch recombination.J Exp Med. 2008 Mar 17;205(3):509-13. Review.
  • Takeyama K, Monti S, Manis JP, Cin PD, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.Oncogene. 2008 Jan 10;27(3):318-22.
  • Manis JP.Knock out, knock in, knock down--genetically manipulated mice and the Nobel Prize.N Engl J Med. 2007 Dec 13;357(24):2426-9.
  • Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE.SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.Immunity. 2007 Nov;27(5):811-23.
  • Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL.S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.Immunity. 2007 Nov;27(5):711-22.
  • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.IgH class switching and translocations use a robust non-classical end-joining pathway.Nature. 2007 Sep 27;449(7161):478-82.
  • Franco S, Alt FW, Manis JP.Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.DNA Repair (Amst). 2006 Sep 8;5(9-10):1030-41. Review.
  • Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3310-5.
  • Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.Mol Cell. 2006 Jan 20;21(2):201-14.