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Thomas M. Roberts, PhD

Publications

  • Schmit F, Utermark T, Zhang S, Wang Q, Von T, Roberts TM, Zhao JJ.PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.Proc Natl Acad Sci U S A. 2014 Apr 15.
    24737887
  • Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ.Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.J Clin Invest. 2014 Apr 1;124(4):1794-809.
    24569456
  • Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P.An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).Cancer Discovery. 2013 Sep;3(9):1030-43.
    23842682
  • Jia S, Gao X, Lee SH, Maira SM, Wu X, Stack EC, Signoretti S, Loda M, Zhao JJ, Roberts TM.Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention.Cancer Discovery. 2013 Jan;3(1):44-51.
    23258246
  • Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M, Roberts TM, Sellers WR, Hofmann F, Maira SM.K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.PLoS ONE. 2012;7(8):e44146.
    22952903
  • Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ.Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Nature. 2012 Aug 2;488(7409):106-10.
    22820256
  • Utermark T, Rao T, Cheng H, Wang Q, Lee SH, Wang ZC, Iglehart JD, Roberts TM, Muller WJ, Zhao JJ.The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Genes Dev. 2012 Jul 15;26(14):1573-86.
    22802530
  • Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J.Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.Cancer Discovery. 2012 May;2(5):425-33.
    22588880
  • Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM.Transgenic expression of polyoma virus middle T antigen in the mouse prostate gives rise to carcinoma.J Virol. 2011 Mar 16.
    21411524
  • Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Nature. 2010 Dec 16;468(7326):968-72.
    21107320
  • Ilić N, Roberts TM.Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer.Curr Top Microbiol Immunol. 2011;347:55-77.
    20517719
  • Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y.Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.Nature. 2010 Jul 22;466(7305):503-7.
    20622853
  • Lee SH, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LC, Roberts TM.A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11002-7.
    20534477
  • Liu P, Cheng H, Roberts TM, Zhao JJ.Targeting the phosphoinositide 3-kinase pathway in cancer.Nat Rev Drug Discov. 2009 Aug;8(8):627-44. Review.
    19644473
  • Yi K,Wang X,Emmett MR,Marshall AG,Stewart M,Roberts TM.Dephosphorylation of MSP Fiber Protein 3 (MFP3) by PP2A during Cell Body Retraction in the MSP-based Amoeboid Motility of Ascaris Sperm.Mol Biol Cell. 2009 Jul;20(14):3200-8.
    19458186
  • Jia S,Roberts TM,Zhao JJ.Should individual PI3 kinase isoforms be targeted in cancer?.Curr Opin Cell Biol. 2009 Apr;21(2):199-208. Review.
    19200708
  • Schaffhausen BS,Roberts TM.Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Virology. 2009 Feb 20;384(2):304-16. Review.
    19022468
  • Hein J,Boichuk S,Wu J,Cheng Y,Freire R,Jat PS,Roberts TM,Gjoerup OV.Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.J Virol. 2009 Jan;83(1):117-27.
    18922873
  • Imamura S,Uchiyama J,Koshimizu E,Hanai J,Raftopoulou C,Murphey RD,Bayliss PE,Imai Y,Burns CE,Masutomi K,Gagos S,Zon LI,Roberts TM,Kishi S.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.PLoS ONE. 2008;3(10):e3364.
    18846223
  • Kishi S,Bayliss PE,Uchiyama J,Koshimizu E,Qi J,Nanjappa P,Imamura S,Islam A,Neuberg D,Amsterdam A,Roberts TM.The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.PLoS Genet. 2008;4(8):e1000152.
    18704191
  • Jia S,Liu Z,Zhang S,Liu P,Zhang L,Lee SH,Zhang J,Signoretti S,Loda M,Roberts TM,Zhao JJ.Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.Nature. 2008 Aug 7;454(7205):776-9.
    18594509
  • Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B.Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19011-6.
    18006659
  • Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.A histone H3 lysine 27 demethylase regulates animal posterior development.Nature. 2007 Oct 11;449(7163):689-94.
    17851529
  • Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.Integrative genomic approaches identify IKBKE as a breast cancer oncogene.Cell. 2007 Jun 15;129(6):1065-79.
    17574021
  • Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ.The p110{alpha} isoform of PI3K is essential for polyoma middle T antigen mediated transformation.J Virol. 2007 Jul;81(13):7069-76.
    17442716
  • Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM.Surveillance mechanism linking Bub1 loss to the p53 pathway.Proc Natl Acad Sci U S A. 2007 May 15;104(20):8334-9.
    17488820
  • Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y.The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.Cell. 2007 Mar 23;128(6):1077-88.
    17320160
  • Zhao JJ, Roberts TM.PI3 kinases in cancer: from oncogene artifact to leading cancer target.Sci STKE. 2006 Dec 12;2006(365):pe52.
    17164467
  • Zhao JJ, Cheng H, Jia S, Wang L, Gjoerup OV, Mikami A, Roberts TM.The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300.
    17060635
  • Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM.PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.J Biol Chem. 2006 Aug 11;281(32):23003-12.
    16717086
  • Liu Z, Roberts TM.Human tumor mutants in the p110alpha subunit of PI3K.Cell Cycle. 2006 Apr;5(7):675-7. Review.
    16627990
  • Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J.Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.Nat Chem Biol. 2006 May;2(5):265-73.
    16565716
  • Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM.The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18443-8.
    16339315
  • Qa'dan M, Christensen KA, Zhang L, Roberts TM, Collier RJ.Membrane insertion by anthrax protective antigen in cultured cells.Mol Cell Biol. 2005 Jul;25(13):5492-8.
    15964805
  • Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.A genetic screen for candidate tumor suppressors identifies REST.Cell. 2005 Jun 17;121(6):837-48.
    15960972
  • Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Cancer Res. 2004 Dec 15;64(24):8867-75.
    15604246
  • Zhao JJ, Roberts TM, Hahn WC.Functional genetics and experimental models of human cancer.Trends Mol Med. 2004 Jul;10(7):344-50.
    15242683
  • Zhang L, Gjoerup O, Roberts TM.The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling.Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10296-301.
    15240878
  • Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA.A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.Cancer Cell. 2003 Dec;4(6):463-76.
    14706338
  • Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC.Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.Cancer Cell. 2003 May;3(5):483-95.
    12781366
  • Chan J, Bayliss PE, Wood JM, Roberts TM.Dissection of angiogenic signaling in zebrafish using a chemical genetic approach.Cancer Cell. 2002 Apr;1(3):257-67.
    12086862
  • Kim HA, Ratner N, Roberts TM, Stiles CD.Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.J Neurosci. 2001 Feb 15;21(4):1110-6.
    11160381
  • Laham LE, Mukhopadhyay N, Roberts TM.The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity.Oncogene. 2000 Aug 17;19(35):3961-70.
    10962552
  • Auger KR, Wang J, Narsimhan RP, Holcombe T, Roberts TM.Constitutive cellular expression of PI 3-kinase is distinct from transient expression.Biochem Biophys Res Commun. 2000 Jun 16;272(3):822-9.
    10860837
  • Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM.A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1.Neuron. 2000 May;26(2):405-16.
    10839359
  • Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y.Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3336-41.
    10716718
  • Gjoerup O, Chao H, DeCaprio JA, Roberts TM.pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression.J Virol. 2000 Jan;74(2):864-74.
    10623749
  • Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H.Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.J Biol Chem. 1999 Nov 5;274(45):32274-8.
    10542266
  • Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM.Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.Mol Cell Biol. 1999 Jul;19(7):4819-24.
    10373531
  • Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR.Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5.
    10051603
  • King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM.DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.Mol Cell Biol. 1999 Mar;19(3):2330-7.
    10022919
  • Liu W, Su W, Roberts TM.Discovery of estrogen-responsive genes using an improved method which combines subtractive hybridization and PCR.Nucleic Acids Res. 1998 Aug 1;26(15):3616-8.
    9671829
  • Oliveira ML, Roberts TM, Druker BJ, Armelin MC.Mapping of polyomavirus middle T domain that is responsible for AP-1 activation.Oncogene. 1998 Jun 11;16(23):2975-82.
    9662329
  • Brownell HL, Lydon NB, Schaefer E, Roberts TM, Raptis L.Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives.DNA Cell Biol. 1998 Mar;17(3):265-74.
    9539106
  • Batt DB, Roberts TM.Cell density modulates protein-tyrosine phosphorylation.J Biol Chem. 1998 Feb 6;273(6):3408-14.
    9452462
  • Culler X, Rose P, Thathamangalam U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL, Roberts TM, Schaffhausen BS.Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins.J Virol. 1998 Jan;72(1):558-63.
    9420259
  • Sheng Q, Denis D, Ratnofsky M, Roberts TM, DeCaprio JA, Schaffhausen B.The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.J Virol. 1997 Dec;71(12):9410-6.
    9371601
  • Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA.Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.Mol Cell Biol. 1997 Sep;17(9):4979-90.
    9271376
  • Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK.Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.Science. 1997 Jun 20;276(5320):1848-50.
    9188528
  • Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA, Roberts TM, Schaffhausen BS, DeCaprio JA.DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.Genes Dev. 1997 May 1;11(9):1098-110.
    9159391
  • Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM, Stiles CD.A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.Neuron. 1997 Apr;18(4):553-62.
    9136765
  • Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD, Dearolf CR.Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.Mol Cell Biol. 1997 Mar;17(3):1562-71.
    9032284
  • Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, Haber DA, Licht JD, Sugrue SP, Roberts T, Rangnekar VM, Shi Y.A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.Mol Cell Biol. 1996 Dec;16(12):6945-56.
    8943350
  • Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM.The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11681-6.
    8876196
  • Auger KR, Songyang Z, Lo SH, Roberts TM, Chen LB.Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes.J Biol Chem. 1996 Sep 20;271(38):23452-7.
    8798552
  • Nam HJ, Haser WG, Roberts TM, Frederick CA.Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.Structure. 1996 Sep 15;4(9):1105-14.
    8805596
  • Jung JU, Lang SM, Jun T, Roberts TM, Veillette A, Desrosiers RC.Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri.J Virol. 1995 Dec;69(12):7814-22.
    7494293
  • Jung JU, Lang SM, Friedrich U, Jun T, Roberts TM, Desrosiers RC, Biesinger B.Identification of Lck-binding elements in tip of herpesvirus saimiri.J Biol Chem. 1995 Sep 1;270(35):20660-7.
    7544793