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Robert Fuhlbrigge, MD, PhD


  • Vander Lugt B, Tubo NJ, Nizza ST, Boes M, Malissen B, Fuhlbrigge RC, Kupper TS, Campbell JJ.CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.J Immunol. 2013 Sep 15;191(6):3119-27.
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Aug(8):1248-53.
  • Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA.Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells.Mol Cancer Ther. 2012 Nov;11(11):2451-61.
  • Li SC, Torok KS, Pope E, Dedeoglu F, Hong S, Jacobe HT, Egla Rabinovich C, Laxer RM, Higgins GC, Lasky A, Baszis K, Becker M, Campillo S, Cartwright V, Cidon M, Inman CJ, Jerath R, O'Neil KM, Vora S, Zeft A, Wallace CA, Ilowite NT, Fuhlbrigge RC.Development of consensus treatment plans for juvenile localized scleroderma.Arthritis Care & Research. 2012 Apr 13.
  • Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS.Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity.Nature. 2012 Mar 8;483(7388):227-31.
  • Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC.Disruption of TNF-α/TNFR1 Function in Resident Skin Cells Impairs Host Immune Response against Cutaneous Vaccinia Virus Infection.J Invest Dermatol. 2012 Feb 9.
  • Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R.Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells.Blood. 2011 Aug 18;118(7):1774-83.
  • Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS.Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16252-6.
  • Yamanaka KI, Fuhlbrigge RC, Mizutani H, Kupper TS.Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma.Arch Dermatol Res. 2010 Aug;302(6):453-9.
  • Ozen S, Fuhlbrigge RC.Update in paediatric vasculitis.Best Pract Res Clin Rheumatol. 2009 Oct;23(5):679-88. Review.
  • Clark RA, Fuhlbrigge RC.Immunology and skin disease 2009: frontiers in cutaneous immunology.J Invest Dermatol. 2009 Aug;129(8):1849-51.
  • Sackstein R,Fuhlbrigge R.Western Blot Analysis of Adhesive Interactions under Fluid Shear Conditions: The Blot Rolling Assay.Methods Mol Biol. 2009;536:343-54.
  • Bianchi T,Pincus LB,Wurbel MA,Rich BE,Kupper TS,Fuhlbrigge RC,Boes M.Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.J Immunol. 2009 Apr 15;182(8):4665-74.
  • Tian T,Liu L,Freyschmidt EJ,Murphy GF,Kupper TS,Fuhlbrigge RC.Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus.J Invest Dermatol. 2009 Jan;129(1):70-8.
  • Ota S, Cron RQ, Schanberg LE, O'Neil K, Mellins ED, Fuhlbrigge RC, Feldman BM.Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus.Pediatr Rheumatol Online J. 2008;6:5.
  • Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9.
  • Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS.Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.J Allergy Clin Immunol. 2008 Jan;121(1):148-157.e3.
  • Clark RA, Fuhlbrigge RC.Meeting report of immunology and skin disease: new perspectives.J Invest Dermatol. 2007 Aug;127(8):1838-41.
  • Fuhlbrigge RC, Weishaupt C.Adhesion molecules in cutaneous immunity.Semin Immunopathol. 2007 Apr;29(1):45-57. Review.
  • Weishaupt C, Munoz KN, Buzney E, Kupper TS, Fuhlbrigge RC.T-cell distribution and adhesion receptor expression in metastatic melanoma.Clin Cancer Res. 2007 May 1;13(9):2549-56.
  • Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW.The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.J Invest Dermatol. 2007 Aug;127(8):1964-72.
  • Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS.The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.J Immunol. 2006 Oct 1;177(7):4488-94.
  • Liu L, Fuhlbrigge RC, Karibian K, Tian T, Kupper TS.Dynamic programming of CD8+ T cell trafficking after live viral immunization.Immunity. 2006 Sep;25(3):511-20.
  • Sackstein R, Fuhlbrigge R.The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions.Methods Mol Biol. 2006;341:217-26. Review.
  • Fuhlbrigge RC, King SL, Sackstein R, Kupper TS.CD43 is a ligand for E-selectin on CLA+ human T cells.Blood. 2006 Feb 15;107(4):1421-6.
  • Gallego MD, de la Fuente MA, Anton IM, Snapper S, Fuhlbrigge R, Geha RS.WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha.Int Immunol. 2006 Feb;18(2):221-32.
  • Liu L, Xu Z, Fuhlbrigge RC, Pea-Cruz V, Lieberman J, Kupper TS.Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.J Virol. 2005 Jun;79(12):7363-70.
  • Kupper TS, Fuhlbrigge RC.Immune surveillance in the skin: mechanisms and clinical consequences.Nat Rev Immunol. 2004 Mar;4(3):211-22.
  • Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC.E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.J Immunol. 2004 Feb 1;172(3):1575-81.
  • Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS.Increased CCR4 expression in cutaneous T cell lymphoma.J Invest Dermatol. 2002 Dec;119(6):1405-10.
  • Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R.Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots.J Immunol. 2002 Jun 1;168(11):5645-51.
  • Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S.Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1.Blood. 2002 Feb 1;99(3):946-56.
  • Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R.CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.J Cell Biol. 2001 Jun 11;153(6):1277-86.
  • Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R.A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13841-6.