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Amy J. Wagers, PhD

Publications

  • Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.Science. 2014 May 9;344(6184):630-4.
    24797482
  • Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ.Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle.Stem Cell Reports. 2014 Jan 14;2(1):92-106.
    24678452
  • Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D.Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.Cancer. 2014 Apr 1;120(7):1068-75.
    24382691
  • Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ.Myogenic Tumors in Nevoid Basal Cell Carcinoma Syndrome.J. Pediatr. Hematol. Oncol. 2014 Feb 10.
    24517962
  • Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.Cell. 2014 Jan 30;156(3):440-55.
    24485453
  • Kikuchi K, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C.Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.PLoS Genet. 2014 Jan;10(1):e1004107.
    24453992
  • Gazit R, Garrison BS, Rao TN, Shay T, Costello J, Ericson J, Kim F, Collins JJ, Regev A, Wagers AJ, Rossi DJ, .Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells.Stem Cell Reports. 2013;1(3):266-80.
    24319662
  • Teo AK, Wagers AJ, Kulkarni RN.New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism.Cell Metab. 2013 Dec 3;18(6):775-91.
    24035588
  • Aslam MI, Hettmer S, Abraham J, Latocha D, Soundararajan A, Huang ET, Goros MW, Michalek JE, Wang S, Mansoor A, Druker BJ, Wagers AJ, Tyner JW, Keller C.Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar Rhabdomyosarcoma.Mol Cancer Res. 2013 Nov;11(11):1303-13.
    23928059
  • Xu C, Tabebordbar M, Iovino S, Ciarlo C, Liu J, Castiglioni A, Price E, Liu M, Barton ER, Kahn CR, Wagers AJ, Zon LI.A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species.Cell. 2013 Nov 7;155(4):909-21.
    24209627
  • Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E.Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.Cell Stem Cell. 2013 Sep 5;13(3):285-99.
    23850243
  • Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ.Mutations in Hedgehog pathway genes in fetal rhabdomyomas.J Pathol. 2013 Sep;231(1):44-52.
    23780909
  • Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, Dibiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI.A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.Development. 2013 Apr 24.
    23615277
  • Nabors LK, Wang LD, Wagers AJ, Kansas GS.Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow.Exp Hematol. 2013 Mar 14.
    23499761
  • Liu J, Hettmer S, Milsom MD, Hofmann I, Hua F, Miller C, Bronson RT, Wagers AJ.Induction of histiocytic sarcoma in mouse skeletal muscle.PLoS ONE. 2012;7(8):e44044.
    22952867
  • Young AP, Wagers AJ.Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors.J Cell Sci. 2010 Aug 1;123(Pt 15):2632-9.
    20605921
  • Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K.Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.Nat Biotechnol. 2010 Aug;28(8):848-55.
    20644536
  • Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL.Patients beware: commercialized stem cell treatments on the web.Cell Stem Cell. 2010 Jul 2;7(1):43-9.
    20621049
  • Schemionek M, Elling C, Steidl U, Baumer N, Hamilton A, Spieker T, Gothert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Muller-Tidow C, Koschmieder S.BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells.Blood. 2010 Apr 22;115(16):3185-95.
    20053753
  • Hettmer S, Wagers AJ.Muscling in: Uncovering the origins of rhabdomyosarcoma.Nat Med. 2010 Feb;16(2):171-3.
    20134473
  • Mayack SR, Shadrach JL, Kim FS, Wagers AJ.Systemic signals regulate ageing and rejuvenation of blood stem cell niches.Nature. 2010 Jan 28;463(7280):495-500.
    20110993
  • Forsberg EC, Passegué E, Prohaska SS, Wagers AJ, Koeva M, Stuart JM, Weissman IL.Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.PLoS ONE. 2010;5(1):e8785.
    20098702
  • Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG.Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.Blood. 2009 Dec 24;114(27):5415-25.
    19797526
  • Breault DT,Min IM,Carlone DL,Farilla LG,Ambruzs DM,Henderson DE,Algra S,Montgomery RK,Wagers AJ,Hole N.Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells.Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10420-5.
    18650388
  • Mayack SR, Wagers AJ.Osteolineage niche cells initiate hematopoietic stem cell mobilization.Blood. 2008 Aug 1;112(3):519-31.
    18456874
  • Min IM, Pietramaggiori G, Kim FS, Passegue E, Stevenson KE, Wagers AJ.The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.Cell Stem Cell. 2008 Apr 10;2(4):380-91.
    18397757
  • Laird DJ, von Andrian UH, Wagers AJ.Stem cell trafficking in tissue development, growth, and disease.Cell. 2008 Feb 22;132(4):612-30. Review.
    18295579
  • Jakubzick C, Tacke F, Ginhoux F, Wagers AJ, van Rooijen N, Mack M, Merad M, Randolph GJ.Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations.J Immunol. 2008 Mar 1;180(5):3019-27.
    18292524
  • Massberg S, Schaerli P, Knezevic-Maramica I, Kollnberger M, Tubo N, Moseman EA, Huff IV, Junt T, Wagers AJ, Mazo IB, von Andrian UH.Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.Cell. 2007 Nov 30;131(5):994-1008.
    18045540
  • Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ.Ovulated oocytes in adult mice derive from non-circulating germ cells.Nature. 2006 Jun 29;441(7097):1109-14.
    16799565
  • Sherwood RI, Wagers AJ.Harnessing the potential of myogenic satellite cells.Trends Mol Med. 2006 May;12(5):189-92.
    16595190
  • Passegu E, Wagers AJ.Regulating quiescence: new insights into hematopoietic stem cell biology.Dev Cell. 2006 Apr;10(4):415-7.
    16580989
  • Wagers AJ, Weissman IL.Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells.Stem Cells. 2006 Apr;24(4):1087-94.
    16373693
  • Sherwood RI, Christensen JL, Weissman IL, Wagers AJ.Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells.Stem Cells. 2004;22(7):1292-304.
    15579647
  • Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC.Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.Nature. 2004 Apr 8;428(6983):668-73.
    15034594
  • Christensen JL, Wright DE, Wagers AJ, Weissman IL.Circulation and chemotaxis of fetal hematopoietic stem cells.PLoS Biol. 2004 Mar;2(3):E75.
    15024423
  • Wagers AJ, Weissman IL.Plasticity of adult stem cells.Cell. 2004 Mar 5;116(5):639-48.
    15006347
  • Cao YA, Wagers AJ, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH.Shifting foci of hematopoiesis during reconstitution from single stem cells.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):221-6.
    14688412
  • Kondo M, Wagers AJ, Manz MG, Prohaska SS, Scherer DC, Beilhack GF, Shizuru JA, Weissman IL.Biology of hematopoietic stem cells and progenitors: implications for clinical application.Annu Rev Immunol. 2003;21:759-806.
    12615892
  • Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG.Langerhans cells renew in the skin throughout life under steady-state conditions.Nat Immunol. 2002 Dec;3(12):1135-41.
    12415265
  • Wagers AJ, Sherwood RI, Christensen JL, Weissman IL.Little evidence for developmental plasticity of adult hematopoietic stem cells.Science. 2002 Sep 27;297(5590):2256-9.
    12215650
  • Wagers AJ, Christensen JL, Weissman IL.Cell fate determination from stem cells.Gene Ther. 2002 May;9(10):606-12.
    12032706
  • Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL.Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.J Exp Med. 2002 May 6;195(9):1145-54.
    11994419
  • Wagers AJ, Allsopp RC, Weissman IL.Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor.Exp Hematol. 2002 Feb;30(2):176-85.
    11823053
  • Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL.Physiological migration of hematopoietic stem and progenitor cells.Science. 2001 Nov 30;294(5548):1933-6.
    11729320
  • Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL.Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle.Blood. 2001 Apr 15;97(8):2278-85.
    11290588
  • Wagers AJ, Kansas GS.Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.J Immunol. 2000 Nov 1;165(9):5011-6.
    11046029
  • Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH.Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.J Immunol. 1999 Mar 15;162(6):3193-201.
    10092770
  • Wagers AJ, Waters CM, Stoolman LM, Kansas GS.Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression.J Exp Med. 1998 Dec 21;188(12):2225-31.
    9858509
  • Wagers AJ, Stoolman LM, Craig R, Knibbs RN, Kansas GS.An sLex-deficient variant of HL60 cells exhibits high levels of adhesion to vascular selectins: further evidence that HECA-452 and CSLEX1 monoclonal antibody epitopes are not essential for high avidity binding to vascular selectins.J Immunol. 1998 May 15;160(10):5122-9.
    9590264
  • Wagers AJ, Stoolman LM, Kannagi R, Craig R, Kansas GS.Expression of leukocyte fucosyltransferases regulates binding to E-selectin: relationship to previously implicated carbohydrate epitopes.J Immunol. 1997 Aug 15;159(4):1917-29.
    9257857
  • Snapp KR, Wagers AJ, Craig R, Stoolman LM, Kansas GS.P-selectin glycoprotein ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines.Blood. 1997 Feb 1;89(3):896-901.
    9028320
  • Wagers AJ, Lowe JB, Kansas GS.An important role for the alpha 1,3 fucosyltransferase, FucT-VII, in leukocyte adhesion to E-selectin.Blood. 1996 Sep 15;88(6):2125-32.
    8822932