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Andrew J. Wagner, MD, PhD


  • Choy E, Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD.
    Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma.
    Cancer. 2015 Apr 15;121(8):1223-30.
  • Eilers G, Czaplinski JT, Mayeda M, Bahri N, Tao D, Zhu M, Hornick JL, Lindeman NI, Sicinska E, Wagner AJ, Fletcher JA, Marino-Enriquez A.
    CDKN2A/p16 loss implicates CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans.
    Mol Cancer Ther. 2015 Apr 7.
  • Goldberg J, Fisher DE, Demetri GD, Neuberg D, Allsop S, Fonseca C, Nakazaki Y, Nemer D, Raut CP, George S, Morgan JA, Wagner AJ, Freeman GJ, Ritz J, Lezcano C, Mihm MC, Canning C, Hodi FS, Dranoff G.
    Biologic Activity of Autologous, Granulocyte-Macrophage Colony Stimulating Factor Secreting Alveolar Soft Parts Sarcoma and Clear Cell Sarcoma Vaccines.
    Clin Cancer Res. 2015 Mar 24.
  • Wagner AJ, Messersmith WA, Shaik MN, Li S, Zheng X, McLachlan KR, Cesari R, Courtney R, Levin WJ, El-Khoueiry AB.
    A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors.
    Clin Cancer Res. 2015 Mar 1;21(5):1044-51.
  • Sioletic S, Czaplinski J, Hu L, Fletcher JA, Fletcher CD, Wagner AJ, Loda M, Demetri GD, Sicinska ET, Snyder EL.
    c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.
    J Pathol. 2014 May 22.
  • Wagner AJ.
    Patient-derived sarcoma xenografts for individual-patient selection of chemotherapy-ready for prime time?.
    Cancer. 2014 Apr 4.
  • George S, Feng Y, Manola J, Nucci MR, Butrynski JE, Morgan JA, Ramaiya N, Quek R, Penson RT, Wagner AJ, Harmon D, Demetri GD, Krasner C.
    Phase 2 trial of aromatase inhibition with letrozole in patients with uterine leiomyosarcomas expressing estrogen and/or progesterone receptors.
    Cancer. 2014 Mar 1;120(5):738-43.
  • Tirumani SH, Shinagare AB, Hargreaves J, Jagannathan JP, Hornick JL, Wagner AJ, Ramaiya NH.
    Imaging features of primary and metastatic malignant perivascular epithelioid cell tumors.
    AJR Am J Roentgenol. 2014 Feb;202(2):252-8.
  • Wagner AJ, Chugh R, Rosen LS, Morgan JA, George S, Gordon M, Dunbar J, Normant E, Grayzel D, Demetri GD.
    A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas.
    Clin Cancer Res. 2013 Nov 1;19(21):6020-9.
  • Mason EF, Sadow PM, Wagner AJ, Remillard SP, Flood TA, Belanger EC, Hornick JL, Barletta JA.
    Identification of succinate dehydrogenase-deficient bladder paragangliomas.
    Am J Surg Pathol. 2013 Oct;37(10):1612-8.
  • Zhang YX, van Oosterwijk JG, Sicinska E, Moss S, Remillard SP, van Wezel T, Bühnemann C, Hassan AB, Demetri GD, Bovée JV, Wagner AJ.
    Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.
    Clin Cancer Res. 2013 Jul 15;19(14):3796-807.
  • Pishvaian MJ, Marshall JL, Wagner AJ, Hwang JJ, Malik S, Cotarla I, Deeken JF, He AR, Daniel H, Halim AB, Zahir H, Copigneaux C, Liu K, Beckman RA, Demetri GD.
    A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies.
    Cancer. 2012 Nov 1;118(21):5403-13.
  • Wagner AJ, Remillard SP, Zhang YX, Doyle LA, George S, Hornick JL.
    Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors.
    Mod Pathol. 2012 Sep 7.
  • George S, Wang Q, Heinrich MC, Corless CL, Zhu M, Butrynski JE, Morgan JA, Wagner AJ, Choy E, Tap WD, Yap JT, Van den Abbeele AD, Manola JB, Solomon SM, Fletcher JA, von Mehren M, Demetri GD.
    Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial.
    J Clin Oncol. 2012 Jul 1;30(19):2401-7.
  • Wagner AJ, Goldberg JM, Dubois SG, Choy E, Rosen L, Pappo A, Geller J, Judson I, Hogg D, Senzer N, Davis IJ, Chai F, Waghorne C, Schwartz B, Demetri GD.
    Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: Results of a multicenter phase 2 trial.
    Cancer. 2012 May 17.
  • Rege TA, Wagner AJ, Corless CL, Heinrich MC, Hornick JL.
    "Pediatric-type" Gastrointestinal Stromal Tumors in Adults: Distinctive Histology Predicts Genotype and Clinical Behavior.
    Am J Surg Pathol. 2011 Apr;35(4):495-504.
  • Quek R, Wang Q, Morgan JA, Shapiro GI, Butrynski JE, Ramaiya N, Huftalen T, Jederlinic N, Manola J, Wagner AJ, Demetri GD, George S.
    Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors.
    Clin Cancer Res. 2011 Feb 15;17(4):871-9.
  • Thomas DM, Wagner AJ.
    Specific targets in sarcoma and developmental therapeutics.
    J Natl Compr Canc Netw. 2010 Jun;8(6):677-86.
  • Wagner AJ, Malinowska-Kolodziej I, Morgan JA, Qin W, Fletcher CD, Vena N, Ligon AH, Antonescu CR, Ramaiya NH, Demetri GD, Kwiatkowski DJ, Maki RG.
    Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.
    J Clin Oncol. 2010 Feb 10;28(5):835-40.
  • Raut CP, Wang Q, Manola J, Morgan JA, George S, Wagner AJ, Butrynski JE, Fletcher CD, Demetri GD, Bertagnolli MM.
    Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate.
    Ann Surg Oncol. 2010 Feb;17(2):407-15.
  • Davis IJ, McFadden AW, Zhang Y, Coxon A, Burgess TL, Wagner AJ, Fisher DE.
    Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma.
    Cancer Res. 2010 Jan 15;70(2):639-45.
  • Martin JE, Wagner AJ, Murphy GF, Pinkus GS, Wang LC.
    Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma.
    J Clin Oncol. 2009 Nov 1;27(31):e168-71.
  • Mühlenberg T, Zhang Y, Wagner AJ, Grabellus F, Bradner J, Taeger G, Lang H, Taguchi T, Schuler M, Fletcher JA, Bauer S.
    Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
    Cancer Res. 2009 Sep 1;69(17):6941-50.
  • Dei Tos AP, Wagner AJ, Modena P, Comandone A, Leyvraz S.
    Epithelioid soft tissue tumors.
    Semin Oncol. 2009 Aug;36(4):347-57. Review.
  • George S,Merriam P,Maki RG,Van den Abbeele AD,Yap JT,Akhurst T,Harmon DC,Bhuchar G,O'Mara MM,D'Adamo DR,Morgan J,Schwartz GK,Wagner AJ,Butrynski JE,Demetri GD,Keohan ML.
    Multicenter Phase II Trial of Sunitinib in the Treatment of Nongastrointestinal Stromal Tumor Sarcomas.
    J Clin Oncol. 2009 Jul 1;27(19):3154-60.
  • Bivalacqua TJ, Schaeffer EM, Alphs H, Mettee L, Wagner AA, Su LM, Pavlovich CP.
    Intraperitoneal Effects of Extraperitoneal Laparoscopic Radical Prostatectomy.
    Urology. 2008 Aug;72(2):273-7.
  • Wagner AJ, Stumbaugh A, Tigue Z, Edmondson J, Paquet A, Farmer D, Hawgood S.
    Genetic Analysis of Congenital Cystic Adenomatoid Malformation Reveals a Novel Pulmonary Gene: Fatty Acid Binding Protein-7 (Brain type).
    Pediatr Res. 2008 Jul;64(1):11-6.
  • Wagner AA, Link RE, Trock BJ, Sullivan W, Pavlovich CP.
    Comparison of open and laparoscopic radical prostatectomy outcomes from a surgeon's early experience.
    Urology. 2007 Oct;70(4):667-71.
  • Johnson AJ, Wagner AJ, Cheney CM, Smith LL, Lucas DM, Guster SK, Grever MR, Lin TS, Byrd JC.
    Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia.
    British Journal of Haematology. 2007 Dec;139(5):837-44.
  • Ito H, Hornick JL, Bertagnolli MM, George S, Morgan JA, Baldini EH, Wagner AJ, Demetri GD, Raut CP.
    Leiomyosarcoma of the inferior vena cava: survival after aggressive management.
    Ann Surg Oncol. 2007 Dec;14(12):3534-41.
  • Clifton MS, Pelayo JC, Cortes RA, Grethel EJ, Wagner AJ, Lee H, Harrison MR, Farmer DL, Nobuhara KK.
    Surgical treatment of childhood recurrent pancreatitis.
    J Pediatr Surg. 2007 Jul;42(7):1203-7.
  • Kokontis JM, Wagner AJ, O'Leary M, Liao S, Hay N.
    A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.
    Oncogene. 2001 Feb 8;20(6):659-68.
  • Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N.
    Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis.
    Mol Cell Biol. 2000 Aug;20(16):6008-18.
  • Kennedy SG, Wagner AJ, Conzen SD, Jordn J, Bellacosa A, Tsichlis PN, Hay N.
    The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
    Genes Dev. 1997 Mar 15;11(6):701-13.
  • Eves EM, Boise LH, Thompson CB, Wagner AJ, Hay N, Rosner MR.
    Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
    J Neurochem. 1996 Nov;67(5):1908-20.
  • Uhlmann EJ, D'Sa-Eipper C, Subramanian T, Wagner AJ, Hay N, Chinnadurai G.
    Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation.
    Cancer Res. 1996 Jun 1;56(11):2506-9.
  • Wagner AJ, Kokontis JM, Hay N.
    Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
    Genes Dev. 1994 Dec 1;8(23):2817-30.
  • Wagner AJ, Meyers C, Laimins LA, Hay N.
    c-Myc induces the expression and activity of ornithine decarboxylase.
    Cell Growth Differ. 1993 Nov;4(11):879-83.
  • Wagner AJ, Small MB, Hay N.
    Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.
    Mol Cell Biol. 1993 Apr;13(4):2432-40.
  • Amin C, Wagner AJ, Hay N.
    Sequence-specific transcriptional activation by Myc and repression by Max.
    Mol Cell Biol. 1993 Jan;13(1):383-90.
  • Wagner AJ, Le Beau MM, Diaz MO, Hay N.
    Expression, regulation, and chromosomal localization of the Max gene.
    Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3111-5.