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Raju Kucherlapati, PhD

Publications

  • Kucherlapati R, Leinwand LA.Frank Ruddle (1929-2013).Am J Hum Genet. 2013 Jun 6;92(6):839-40.
    24242788
  • Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM.The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration.PLoS ONE. 2013;8(10):e77787.
    24204966
  • Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L, .The somatic genomic landscape of glioblastoma.Cell. 2013 Oct 10;155(2):462-77.
    24120142
  • Kucherlapati MH, Esfahani S, Habibollahi P, Wang J, Still ER, Bronson RT, Mahmood U, Kucherlapati RS.Genotype directed therapy in murine mismatch repair deficient tumors.PLoS ONE. 2013;8(7):e68817.
    23935891
  • Kucherlapati R.Francis H. Ruddle (1929-2013): a pioneer in human gene mapping.Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9619-20.
    23716665
  • Yang L, Luquette LJ, Gehlenborg N, Xi R, Haseley PS, Hsieh CH, Zhang C, Ren X, Protopopov A, Chin L, Kucherlapati R, Lee C, Park PJ.Diverse mechanisms of somatic structural variations in human cancer genomes.Cell. 2013 May 9;153(4):919-29.
    23663786
  • , Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA.Integrated genomic characterization of endometrial carcinoma.Nature. 2013 May 2;497(7447):67-73.
    23636398
  • Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P.Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.Dev Biol. 2013 Apr 3.
    23562608
  • Kikinis Z, Makris N, Finn CT, Bouix S, Lucia D, Coleman MJ, Tworog-Dube E, Kikinis R, Kucherlapati R, Shenton ME, Kubicki M.Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome.Brain Imaging And Behavior. 2013 Apr 24.
    23612843
  • Smpokou P, Tworog-Dube E, Kucherlapati RS, Roberts AE.Medical complications, clinical findings, and educational outcomes in adults with Noonan syndrome.Am J Med Genet A. 2012 Dec;158A(12):3106-11.
    23165751
  • Hammerman PS, Hayes DN, Wilkerson MD, Schultz N, Bose R, Chu A, Collisson EA, Cope L, Creighton CJ, Getz G, Herman JG, Johnson BE, Kucherlapati R, Ladanyi M, Maher CA, Robertson G, Sander C, Shen R, Sinha R, Sivachenko A, Thomas RK, Travis WD, Tsao MS, Weinstein JN, Wigle DA, Baylin SB, Govindan R, Meyerson M.Comprehensive genomic characterization of squamous cell lung cancers.Nature. 2012 Sep 27;489(7417):519-25.
    22960745
  • Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC.Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.PLoS ONE. 2012;7(9):e44273.
    22970194
  • Sheth RA, Kunin A, Stangenberg L, Sinnamon M, Hung KE, Kucherlapati R, Mahmood U.In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.Molecular Imaging.;11(5):417-25.
    22954186
  • Larman TC, DePalma SR, Hadjipanayis AG, , Protopopov A, Zhang J, Gabriel SB, Chin L, Seidman CE, Kucherlapati R, Seidman JG.Spectrum of somatic mitochondrial mutations in five cancers.Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14087-91.
    22891333
  • Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ, Lohr JG, Harris CC, Ding L, Wilson RK, Wheeler DA, Gibbs RA, Kucherlapati R, Lee C, Kharchenko PV, Park PJ, .Landscape of somatic retrotransposition in human cancers.Science. 2012 Aug 24;337(6097):967-71.
    22745252
  • Ladd JJ, Busald T, Johnson MM, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati R, Feng Z, Prentice RL, Hanash SM.Increased Plasma Levels of the APC-Interacting Protein MAPRE1, LRG1, and IGFBP2 Preceding a Diagnosis of Colorectal Cancer in Women.Cancer Prev Res (Phila Pa). 2012 Mar 13.
    22277732
  • Kucherlapati R.Genetically modified mouse models for biomarker discovery and preclinical drug testing.Clin Cancer Res. 2012 Feb 1;18(3):625-30.
    22298895
  • Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA.The Creating an Optimal Warfarin Nomogram (CROWN) Study.Thromb Haemost. 2012 Jan;107(1):59-68.
    22116191
  • Kucherlapati R.Introduction for: frontiers of personalized cancer medicine.Cancer J.;17(6):403-4.
    22157283
  • Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP.Impaired lymphatic contraction associated with immunosuppression.Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18784-9.
    22065738
  • Xi R, Hadjipanayis AG, Luquette LJ, Kim TM, Lee E, Zhang J, Johnson MD, Muzny DM, Wheeler DA, Gibbs RA, Kucherlapati R, Park PJ.Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1128-36.
    22065754
  • Hiramoto T, Kang G, Suzuki G, Satoh Y, Kucherlapati R, Watanabe Y, Hiroi N.Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model.Hum Mol Genet. 2011 Sep 20.
    21908517
  • Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM.Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.Cancer Cell. 2011 Sep 13;20(3):289-99.
    21907921
  • McIlhatton MA, Tyler J, Kerepesi LA, Bocker Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati RS, Kopelovich L, Fishel R.Aspirin and Low Dose Nitric Oxide-Donating Aspirin Increase Life Span in a Lynch Syndrome Mouse Model.Cancer Prev Res (Phila Pa). 2011 Mar 24.
    21436383
  • McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA.A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.Hum Mol Genet. 2011 Jan 15;20(2):211-22.
    20940147
  • Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R.Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.J Clin Invest. 2010 Dec 1;120(12):4353-65.
    21041952
  • Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S.Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia.Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2777-85.
    20833970
  • Kucherlapati R.Personalized medicine for non-small-cell lung cancer.Oncology (Huntingt). 2010 Apr 30;24(5):399-400.
    20480736
  • Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH.In vivo wide-area cellular imaging by side-view endomicroscopy.Nat Methods. 2010 Apr;7(4):303-5.
    20228814
  • Wang Y, Zhang W, Edelmann L, Kolodner RD, Kucherlapati R, Edelmann W.Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5511-5.
    20212136
  • Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W.An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.Gastroenterology. 2010 Mar;138(3):993-1002.e1.
    19931261
  • Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R.Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1565-70.
    20080688
  • Lee I, Pecinova A, Pecina P, Neel BG, Araki T, Kucherlapati R, Roberts AE, Hüttemann M.A suggested role for mitochondria in Noonan syndrome.Biochim Biophys Acta. 2010 Feb;1802(2):275-83.
    19835954
  • Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M.A restricted spectrum of NRAS mutations causes Noonan syndrome.Nat Genet. 2010 Jan;42(1):27-9.
    19966803
  • Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M.Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.Carcinogenesis. 2009 Nov;30(11):1923-6.
    19755659
  • Bell AW,Deutsch EW,Au CE,Kearney RE,Beavis R,Sechi S,Nilsson T,Bergeron JJ,Beardslee TA,Chappell T,Meredith G,Sheffield P,Gray P,Hajivandi M,Pope M,Predki P,Kullolli M,Hincapie M,Hancock WS,Jia W,Song L,Li L,Wei J,Yang B,Wang J,Ying W,Zhang Y,Cai Y,Qian X,He F,Meyer HE,Stephan C,Eisenacher M,Marcus K,Langenfeld E,May C,Carr SA,Ahmad R,Zhu W,Smith JW,Hanash SM,Struthers JJ,Wang H,Zhang Q,An Y,Goldman R,Carlsohn E,van der Post S,Hung KE,Sarracino DA,Parker K,Krastins B,Kucherlapati R,Bourassa S,Poirier GG,Kapp E,Patsiouras H,Moritz R,Simpson R,Houle B,Laboissiere S,Metalnikov P,Nguyen V,Pawson T,Wong CC,Cociorva D,Yates Iii JR,Ellison MJ,Lopez-Campistrous A,Semchuk P,Wang Y,Ping P,Elia G,Dunn MJ,Wynne K,Walker AK,Strahler JR,Andrews PC,Hood BL,Bigbee WL,Conrads TP,Smith D,Borchers CH,Lajoie GA,Bendall SC,Speicher KD,Speicher DW,Fujimoto M,Nakamura K,Paik YK,Cho SY,Kwon MS,Lee HJ,Jeong SK,Chung AS,Miller CA,Grimm R,Williams K,Dorschel C,Falkner JA,Martens L,Vizcaino JA.A HUPO test sample study reveals common problems in mass spectrometry-based proteomics.Nat Methods. 2009 Jun;6(6):423-30.
    19448641
  • Suzuki G, Harper KM, Hiramoto T, Funke B, Lee M, Kang G, Buell M, Geyer MA, Kucherlapati R, Morrow B, Männistö PT, Agatsuma S, Hiroi N.Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.Hum Mol Genet. 2009 Oct 15;18(20):3914-25.
    19617637
  • Herman DS, Hovingh GK, Iartchouk O, Rehm HL, Kucherlapati R, Seidman JG, Seidman CE.Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection.Nat Methods. 2009 Jul;6(7):507-10.
    19543287
  • Vassilopoulos S,Esk C,Hoshino S,Funke BH,Chen CY,Plocik AM,Wright WE,Kucherlapati R,Brodsky FM.A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.Science. 2009 May 29;324(5931):1192-6.
    19478182
  • Narr KL,Szeszko PR,Lencz T,Woods RP,Hamilton LS,Phillips O,Robinson D,Burdick KE,Derosse P,Kucherlapati R,Thompson PM,Toga AW,Malhotra AK,Bilder RM.DTNBP1 is associated with imaging phenotypes in schizophrenia.Hum Brain Mapp. 2009 May 15.
    19449336
  • Wang XP,O'Connell DJ,Lund JJ,Saadi I,Kuraguchi M,Turbe-Doan A,Cavallesco R,Kim H,Park PJ,Harada H,Kucherlapati R,Maas RL.Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood.Development. 2009 Jun;136(11):1939-49.
    19429790
  • Hung KE,Faca V,Song K,Sarracino DA,Richard LG,Krastins B,Forrester S,Porter A,Kunin A,Mahmood U,Haab BB,Hanash SM,Kucherlapati R.Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.Cancer Prev Res (Phila Pa). 2009 Mar;2(3):224-33.
    19240248
  • Kuraguchi M,Ohene-Baah NY,Sonkin D,Bronson RT,Kucherlapati R.Genetic mechanisms in Apc-mediated mammary tumorigenesis.PLoS Genet. 2009 Feb;5(2):e1000367.
    19197353
  • Luong MX,Tam J,Lin Q,Hagendoorn J,Moore KJ,Padera TP,Seed B,Fukumura D,Kucherlapati R,Jain RK.Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.J Cell Physiol. 2009 May;219(2):430-7.
    19170073
  • Montgomery KT,Iartchouck O,Li L,Loomis S,Obourn V,Kucherlapati R.PolyPhred analysis software for mutation detection from fluorescence-based sequence data.Curr Protoc Hum Genet. 2008 Oct;Chapter 7:Unit 7.16.
    18972372
  • Dragileva E,Hendricks A,Teed A,Gillis T,Lopez ET,Friedberg EC,Kucherlapati R,Edelmann W,Lunetta KL,MacDonald ME,Wheeler VC.Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.Neurobiol Dis. 2009 Jan;33(1):37-47.
    18930147
  • Kucherlapati MH,Yang K,Fan K,Kuraguchi M,Sonkin D,Rosulek A,Lipkin M,Bronson RT,Aronow BJ,Kucherlapati R.Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15493-8.
    18832169
  • Yang K,Lamprecht SA,Shinozaki H,Fan K,Yang W,Newmark HL,Kopelovich L,Edelmann W,Jin B,Gravaghi C,Augenlicht L,Kucherlapati R,Lipkin M.Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.J Nutr. 2008 Sep;138(9):1658-63.
    18716166
  • The Cancer Genome Atlas Research Network.Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature.;455(7216):1061-8.
  • Chen PC,Kuraguchi M,Velasquez J,Wang Y,Yang K,Edwards R,Gillen D,Edelmann W,Kucherlapati R,Lipkin SM.Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.PLoS Genet. 2008 Jun;4(6):e1000092.
    18551179
  • Barrera-Oro J,Liu TY,Gorden E,Kucherlapati R,Shao C,Tischfield JA.Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.Mutat Res. 2008 Jul 3;642(1-2):74-9.
    18538799
  • Zhang Q,Menon R,Deutsch EW,Pitteri SJ,Faca VM,Wang H,Newcomb LF,Depinho RA,Bardeesy N,Dinulescu D,Hung KE,Kucherlapati R,Jacks T,Politi K,Aebersold R,Omenn GS,States DJ,Hanash SM.A mouse plasma peptide atlas as a resource for disease proteomics.Genome Biol. 2008;9(6):R93.
    18522751
  • Joshi VA, Kucherlapati R.Genetics and genomics in the practice of medicine.Gastroenterology. 2008 May;134(5):1284-8. Review.
    18471501
  • Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE.Shared genetic causes of cardiac hypertrophy in children and adults.N Engl J Med. 2008 May 1;358(18):1899-908.
    18403758
  • Montgomery KT, Iartchouck O, Li L, Perera A, Yassin Y, Tamburino A, Loomis S, Kucherlapati R.Mutation detection using automated fluorescence-based sequencing.Curr Protoc Hum Genet. 2008 Apr;Chapter 7:Unit7.9.
    18428426
  • Busuttil RA, Lin Q, Stambrook PJ, Kucherlapati R, Vijg J.Mutation frequencies and spectra in DNA polymerase eta-deficient mice.Cancer Res. 2008 Apr 1;68(7):2081-4.
    18381412
  • Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H Jr, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B.Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4247-52.
    18337503
  • Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG.SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients.Genes Chromosomes Cancer. 2007 Dec 6;47(3):253-259.
    18064648
  • Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA.Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.Cancer Res. 2007 Nov 15;67(22):10736-43.
    18006816
  • Joshi VA, Kucherlapati R.Pharmacogenomics of lung cancer: with a view to address EGFR-targeted therapies.Pharmacogenomics. 2007 Sep;8(9):1211-20. Review.
    17924836
  • Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R.Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.Oncogene. 2007 Sep 20;26(43):6297-306.
    17452984
  • Kratz CP, Niemeyer CM, Thomas C, Bauhuber S, Matejas V, Bergstrasser E, Flotho C, Flores NJ, Haas O, Hasle H, van den Heuvel-Eibrink MM, Kucherlapati RS, Lang P, Roberts AE, Stary J, Strahm B, Swanson KD, Trebo M, Zecca M, Neel B, Locatelli F, Loh ML, Zenker M.Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia.Leukemia. 2007 May;21(5):1108-9.
    17315019
  • Sequist LV, Joshi VA, Jnne PA, Muzikansky A, Fidias P, Meyerson M, Haber DA, Kucherlapati R, Johnson BE, Lynch TJ.Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing.Oncologist. 2007 Jan;12(1):90-8.
    17285735
  • Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS.Germline gain-of-function mutations in SOS1 cause Noonan syndrome.Nat Genet. 2007 Jan;39(1):70-4.
    17143285
  • Joshi VA, Kucherlapati R.Lung cancer genetics and pharmacogenomics.Cytogenet Genome Res. 2006;115(3-4):298-302.
    17124413
  • Dumstorf CA, Clark AB, Lin Q, Kissling GE, Yuan T, Kucherlapati R, McGregor WG, Kunkel TA.Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8.
    17114294
  • Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R.Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.PLoS Genet. 2006 Sep 15;2(9):e146.
    17002498
  • Hung KE, Kho AT, Sarracino D, Richard LG, Krastins B, Forrester S, Haab BB, Kohane IS, Kucherlapati R.Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model.J Proteome Res. 2006 Aug;5(8):1866-78.
    16889408
  • Sequist LV, Joshi VA, Jnne PA, Bell DW, Fidias P, Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ.Epidermal growth factor receptor mutation testing in the care of lung cancer patients.Clin Cancer Res. 2006 Jul 15;12(14):4403s-8s. Review.
    16857818
  • Kucherlapati MH, Nguyen AA, Bronson RT, Kucherlapati RS.Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.Cancer Res. 2006 Apr 1;66(7):3576-83.
    16585182
  • Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK.Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.Cancer Res. 2006 Apr 1;66(7):3360-4.
    16585153
  • Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA.The finished DNA sequence of human chromosome 12.Nature. 2006 Mar 16;440(7082):346-51.
    16541075
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  • Yang K, Fan KH, Lamprecht SA, Edelmann W, Kopelovich L, Kucherlapati R, Lipkin M.Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice.Int J Cancer. 2005 Sep 10;116(4):495-9.
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  • Lin DP, Wang Y, Scherer SJ, Clark AB, Yang K, Avdievich E, Jin B, Werling U, Parris T, Kurihara N, Umar A, Kucherlapati R, Lipkin M, Kunkel TA, Edelmann W.An Msh2 point mutation uncouples DNA mismatch repair and apoptosis.Cancer Res. 2004 Jan 15;64(2):517-22.
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  • Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME.Rb and N-ras function together to control differentiation in the mouse.Mol Cell Biol. 2003 Aug;23(15):5256-68.
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    12414650
  • Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM.APC-dependent suppression of colon carcinogenesis by PPARgamma.Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6.
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  • Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, Viani S, Kucherlapati R, Lipkin M, Yang K, Augenlicht L.Colorectal cancer in mice genetically deficient in the mucin Muc2.Science. 2002 Mar 1;295(5560):1726-9.
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    11793011
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    11507085
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    11395749
  • Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R.A high-resolution map of human chromosome 12.Nature. 2001 Feb 15;409(6822):945-6.
    11237017
  • Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R.TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.Cell. 2001 Feb 23;104(4):619-29.
    11239417
  • Puech A, Saint-Jore B, Merscher S, Russell RG, Cherif D, Sirotkin H, Xu H, Factor S, Kucherlapati R, Skoultchi AI.Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5.
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  • Kneitz B, Cohen PE, Avdievich E, Zhu L, Kane MF, Hou H, Kolodner RD, Kucherlapati R, Pollard JW, Edelmann W.MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.Genes Dev. 2000 May 1;14(9):1085-97.
    10809667
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    10802664
  • Wu G, Markowitz GS, Li L, D'Agati VD, Factor SM, Geng L, Tibara S, Tuchman J, Cai Y, Park JH, van Adelsberg J, Hou H, Kucherlapati R, Edelmann W, Somlo S.Cardiac defects and renal failure in mice with targeted mutations in Pkd2.Nat Genet. 2000 Jan;24(1):75-8.
    10615132
  • Cheung VG, Morley M, Aguilar F, Massimi A, Kucherlapati R, Childs G.Making and reading microarrays.Nat Genet. 1999 Jan;21(1 Suppl):15-9.
    9915495
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  • Wu G, D'Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H, Kucherlapati R, Edelmann W, Somlo S.Somatic inactivation of Pkd2 results in polycystic kidney disease.Cell. 1998 Apr 17;93(2):177-88.
    9568711
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  • Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T.K-ras is an essential gene in the mouse with partial functional overlap with N-ras.Genes Dev. 1997 Oct 1;11(19):2468-81.
    9334313
  • Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE.Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.Nat Genet. 1997 Jan;15(1):30-5.
    8988165
  • Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS.GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.Neuron. 1996 Oct;17(4):607-15.
    8893019
  • Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R, Pollard JW, Kolodner RD, Kucherlapati R.Meiotic pachytene arrest in MLH1-deficient mice.Cell. 1996 Jun 28;85(7):1125-34.
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  • Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon SJ, Stenzel TT, Speer M, Pericak-Vance MA, Diamond A, Guttmacher AE, Jackson CE, Attisano L, Kucherlapati R, Porteous ME, Marchuk DA.Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.Nat Genet. 1996 Jun;13(2):189-95.
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  • Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS.Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.Nature. 1985 Sep 19-25;317(6034):230-4.
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  • Roginski RS, Skoultchi AI, Henthorn P, Smithies O, Hsiung N, Kucherlapati R.Coordinate modulation of transfected HSV thymidine kinase and human globin genes.Cell. 1983 Nov;35(1):149-55.
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  • Davies RL, Fuhrer-Krusi S, Kucherlapati RS.Modulation of transfected gene expression mediated by changes in chromatin structure.Cell. 1982 Dec;31(3 Pt 2):521-9.
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  • Kucherlapati R, Shin SI.Genetic control of tumorigenicity in interspecific mammalian cell hybrids.Cell. 1979 Mar;16(3):639-48.
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