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Stephen C. Harrison, PhD


  • Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan J.
    Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
    Elife. 2015;4.
  • Kirchhausen T, Owen D, Harrison SC.
    Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.
    Cold Spring Harb Perspect Biol. 2014 May;6(5):a016725.
  • Hinshaw SM, Harrison SC.
    An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation.
    Cell Rep. 2013 Oct 17;5(1):29-36.
  • Corbett KD, Harrison SC.
    Molecular architecture of the yeast monopolin complex.
    Cell Rep. 2012 Jun 28;1(6):583-9.
  • Böcking T, Aguet F, Harrison SC, Kirchhausen T.
    Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.
    Nat Struct Mol Biol. 2011 Mar;18(3):295-301.
  • Schmidt AG, Yang PL, Harrison SC.
    Peptide Inhibitors of Flavivirus Entry Derived from the E-protein Stem.
    J Virol. 2010 Dec;84(24):12549-54.
  • Harrison SC, Brugge JS.
    Mechanistic biology in the next quarter century.
    Mol Biol Cell. 2010 Nov 15;21(22):3799-800.
  • Yu A, Xing Y, Harrison SC, Kirchhausen T.
    Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.
    Structure. 2010 Oct 13;18(10):1311-20.
  • Guan R, Han D, Harrison SC, Kirchhausen T.
    Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.
    Structure. 2010 Sep 8;18(9):1191-8.
  • Harrison SC.
    Virology. Looking inside adenovirus.
    Science. 2010 Aug 27;329(5995):1026-7.
  • Harrison SC, Kirchhausen T.
    Structural biology: Conservation in vesicle coats.
    Nature. 2010 Aug 26;466(7310):1048-9.
  • Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC.
    The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.
    Cell. 2010 Aug 20;142(4):556-67.
  • Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang F.
    CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.
    Dev Cell. 2010 Aug 17;19(2):245-58.
  • Floyd DL, Harrison SC, van Oijen AM.
    Analysis of kinetic intermediates in single-particle dwell-time distributions.
    Biophys J. 2010 Jul 21;99(2):360-6.
  • Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC.
    Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
    EMBO J. 2010 Feb 3;29(3):655-65.
  • Hite RK, Gonen T, Harrison SC, Walz T.
    Interactions of lipids with aquaporin-0 and other membrane proteins.
    Pflugers Arch. 2008 Jul;456(4):651-61.
  • Ivanovic T, Agosto MA, Zhang L, Chandran K, Harrison SC, Nibert ML.
    Peptides released from reovirus outer capsid form membrane pores that recruit virus particles.
    EMBO J. 2008 Apr 23;27(8):1289-98.
  • Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N.
    Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.
    Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1867-72.
  • Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA.
    XMAP215 is a processive microtubule polymerase.
    Cell. 2008 Jan 11;132(1):79-88.
  • Harrison SC.
    Three-dimensional intricacies in protein-DNA recognition and transcriptional control.
    Nat Struct Mol Biol. 2007 Dec;14(12):1118-9.
  • Bellizzi JJ 3rd, Sorger PK, Harrison SC.
    Crystal structure of the yeast inner kinetochore subunit Cep3p.
    Structure. 2007 Nov;15(11):1422-30.
  • Harrison SC.
    Comments on the NIGMS PSI.
    Structure. 2007 Nov;15(11):1344-6.
  • Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D.
    Structure and function of an essential component of the outer membrane protein assembly machine.
    Science. 2007 Aug 17;317(5840):961-4.
  • Li F, Li W, Farzan M, Harrison SC.
    Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.
    Science. 2005 Sep 16;309(5742):1864-8.
  • Lei M, Robinson MA, Harrison SC.
    The active conformation of the PAK1 kinase domain.
    Structure. 2005 May;13(5):769-78.
  • Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ.
    Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.
    Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51.
  • Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC.
    Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
    Cell. 2000 Aug 4;102(3):387-97.
  • Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC.
    Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16.
    Mol Cell. 2000 Mar;5(3):557-67.
  • Ferrer M, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Wiley DC, Harrison SC.
    Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements.
    Nat Struct Biol. 1999 Oct;6(10):953-60.
  • Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM.
    Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.
    Mol Cell. 1999 Jun;3(6):761-70.
  • Bauer PH, Cui C, Liu R, Stehle T, Harrison SC, DeCaprio JA, Benjamin TL.
    Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse.
    J Virol. 1999 Jul;73(7):5826-32.
  • Ferrer M, Harrison SC.
    Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries.
    J Virol. 1999 Jul;73(7):5795-802.
  • Xu W, Doshi A, Lei M, Eck MJ, Harrison SC.
    Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
    Mol Cell. 1999 May;3(5):629-38.
  • Jacobs MD, Harrison SC.
    Structure of an IkappaBalpha/NF-kappaB complex.
    Cell. 1998 Dec 11;95(6):749-58.
  • Huang H, Chopra R, Verdine GL, Harrison SC.
    Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
    Science. 1998 Nov 27;282(5394):1669-75.
  • ter Haar E, Musacchio A, Harrison SC, Kirchhausen T.
    Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.
    Cell. 1998 Nov 13;95(4):563-73.
  • Huse M, Eck MJ, Harrison SC.
    A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck.
    J Biol Chem. 1998 Jul 24;273(30):18729-33.
  • Berger JM, Fass D, Wang JC, Harrison SC.
    Structural similarities between topoisomerases that cleave one or both DNA strands.
    Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7876-81.
  • Ferrer M, Godbout KL, Sullivan BJ, Austen DA, Sanderson CT, Kelley KC, Osburne MS, Harrison SC, van Schravendijk MR.
    Construction and characterization of a radio-iodinatable mutant of recombinant human CD4.
    J Immunol Methods. 1997 Dec 29;210(2):215-25.
  • Chen L, Glover JN, Hogan PG, Rao A, Harrison SC.
    Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
    Nature. 1998 Mar 5;392(6671):42-8.
  • Stehle T, Harrison SC.
    High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding.
    EMBO J. 1997 Aug 15;16(16):5139-48.
  • Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC.
    Atomic structure of the ectodomain from HIV-1 gp41.
    Nature. 1997 May 22;387(6631):426-30.
  • Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH.
    Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.
    Nature. 1997 May 15;387(6630):312-5.
  • Musacchio A, Cantley LC, Harrison SC.
    Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14373-8.
  • Harrison SC.
    Peptide-surface association: the case of PDZ and PTB domains.
    Cell. 1996 Aug 9;86(3):341-3.
  • Fass D, Harrison SC, Kim PS.
    Retrovirus envelope domain at 1.7 angstrom resolution.
    Nat Struct Biol. 1996 May;3(5):465-9.
  • Stehle T, Yan Y, Benjamin TL, Harrison SC.
    Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment.
    Nature. 1994 May 12;369(6476):160-3.