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Stephen C. Harrison, PhD


  • Kirchhausen T, Owen D, Harrison SC.Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.Cold Spring Harb Perspect Biol. 2014 May;6(5):a016725.
  • Hinshaw SM, Harrison SC.An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation.Cell Rep. 2013 Oct 17;5(1):29-36.
  • Corbett KD, Harrison SC.Molecular architecture of the yeast monopolin complex.Cell Rep. 2012 Jun 28;1(6):583-9.
  • Böcking T, Aguet F, Harrison SC, Kirchhausen T.Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.Nat Struct Mol Biol. 2011 Mar;18(3):295-301.
  • Schmidt AG, Yang PL, Harrison SC.Peptide Inhibitors of Flavivirus Entry Derived from the E-protein Stem.J Virol. 2010 Dec;84(24):12549-54.
  • Harrison SC, Brugge JS.Mechanistic biology in the next quarter century.Mol Biol Cell. 2010 Nov 15;21(22):3799-800.
  • Yu A, Xing Y, Harrison SC, Kirchhausen T.Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.Structure. 2010 Oct 13;18(10):1311-20.
  • Guan R, Han D, Harrison SC, Kirchhausen T.Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.Structure. 2010 Sep 8;18(9):1191-8.
  • Harrison SC.Virology. Looking inside adenovirus.Science. 2010 Aug 27;329(5995):1026-7.
  • Harrison SC, Kirchhausen T.Structural biology: Conservation in vesicle coats.Nature. 2010 Aug 26;466(7310):1048-9.
  • Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC.The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.Cell. 2010 Aug 20;142(4):556-67.
  • Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang F.CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.Dev Cell. 2010 Aug 17;19(2):245-58.
  • Floyd DL, Harrison SC, van Oijen AM.Analysis of kinetic intermediates in single-particle dwell-time distributions.Biophys J. 2010 Jul 21;99(2):360-6.
  • Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC.Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.EMBO J. 2010 Feb 3;29(3):655-65.
  • Hite RK, Gonen T, Harrison SC, Walz T.Interactions of lipids with aquaporin-0 and other membrane proteins.Pflugers Arch. 2008 Jul;456(4):651-61.
  • Ivanovic T, Agosto MA, Zhang L, Chandran K, Harrison SC, Nibert ML.Peptides released from reovirus outer capsid form membrane pores that recruit virus particles.EMBO J. 2008 Apr 23;27(8):1289-98.
  • Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N.Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1867-72.
  • Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA.XMAP215 is a processive microtubule polymerase.Cell. 2008 Jan 11;132(1):79-88.
  • Harrison SC.Three-dimensional intricacies in protein-DNA recognition and transcriptional control.Nat Struct Mol Biol. 2007 Dec;14(12):1118-9.
  • Harrison SC.Comments on the NIGMS PSI.Structure. 2007 Nov;15(11):1344-6.
  • Bellizzi JJ 3rd, Sorger PK, Harrison SC.Crystal structure of the yeast inner kinetochore subunit Cep3p.Structure. 2007 Nov;15(11):1422-30.
  • Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D.Structure and function of an essential component of the outer membrane protein assembly machine.Science. 2007 Aug 17;317(5840):961-4.
  • Li F, Li W, Farzan M, Harrison SC.Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.Science. 2005 Sep 16;309(5742):1864-8.
  • Lei M, Robinson MA, Harrison SC.The active conformation of the PAK1 kinase domain.Structure. 2005 May;13(5):769-78.
  • Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ.Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51.
  • Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC.Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.Cell. 2000 Aug 4;102(3):387-97.
  • Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC.Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16.Mol Cell. 2000 Mar;5(3):557-67.
  • Ferrer M, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Wiley DC, Harrison SC.Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements.Nat Struct Biol. 1999 Oct;6(10):953-60.
  • Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM.Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.Mol Cell. 1999 Jun;3(6):761-70.
  • Ferrer M, Harrison SC.Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries.J Virol. 1999 Jul;73(7):5795-802.
  • Bauer PH, Cui C, Liu R, Stehle T, Harrison SC, DeCaprio JA, Benjamin TL.Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse.J Virol. 1999 Jul;73(7):5826-32.
  • Xu W, Doshi A, Lei M, Eck MJ, Harrison SC.Crystal structures of c-Src reveal features of its autoinhibitory mechanism.Mol Cell. 1999 May;3(5):629-38.
  • Jacobs MD, Harrison SC.Structure of an IkappaBalpha/NF-kappaB complex.Cell. 1998 Dec 11;95(6):749-58.
  • Huang H, Chopra R, Verdine GL, Harrison SC.Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.Science. 1998 Nov 27;282(5394):1669-75.
  • ter Haar E, Musacchio A, Harrison SC, Kirchhausen T.Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.Cell. 1998 Nov 13;95(4):563-73.
  • Huse M, Eck MJ, Harrison SC.A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck.J Biol Chem. 1998 Jul 24;273(30):18729-33.
  • Berger JM, Fass D, Wang JC, Harrison SC.Structural similarities between topoisomerases that cleave one or both DNA strands.Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7876-81.
  • Ferrer M, Godbout KL, Sullivan BJ, Austen DA, Sanderson CT, Kelley KC, Osburne MS, Harrison SC, van Schravendijk MR.Construction and characterization of a radio-iodinatable mutant of recombinant human CD4.J Immunol Methods. 1997 Dec 29;210(2):215-25.
  • Chen L, Glover JN, Hogan PG, Rao A, Harrison SC.Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.Nature. 1998 Mar 5;392(6671):42-8.
  • Stehle T, Harrison SC.High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding.EMBO J. 1997 Aug 15;16(16):5139-48.
  • Weissenhorn W, Dessen A, Harrison SC, Skehel JJ, Wiley DC.Atomic structure of the ectodomain from HIV-1 gp41.Nature. 1997 May 22;387(6631):426-30.
  • Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH.Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.Nature. 1997 May 15;387(6630):312-5.
  • Musacchio A, Cantley LC, Harrison SC.Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14373-8.
  • Harrison SC.Peptide-surface association: the case of PDZ and PTB domains.Cell. 1996 Aug 9;86(3):341-3.
  • Fass D, Harrison SC, Kim PS.Retrovirus envelope domain at 1.7 angstrom resolution.Nat Struct Biol. 1996 May;3(5):465-9.
  • Stehle T, Yan Y, Benjamin TL, Harrison SC.Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment.Nature. 1994 May 12;369(6476):160-3.