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Donald W. Kufe, MD

Publications

  • Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D.Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.Oncogene.:2179-2188.
  • Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D.MUC1-C oncoprotein induces tamoxifen resistance in human breast cancer cells.Mol Cancer Res. 2013 Mar 28.
    23538857
  • Uchida Y, Raina D, Kharbanda S, Kufe D.Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells.Cancer Biol Ther. 2012 Oct 31;14(2).
    23114713
  • Vasir B, Zarwan C, Ahmad R, Crawford KD, Rajabi H, Matsuoka K, Rosenblatt J, Wu Z, Mills H, Kufe D, Avigan D.Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC).J Immunother. 2012 Sep;35(7):555-69.
    22892452
  • Jin C, Rajabi H, Pitroda S, Li A, Kharbanda A, Weichselbaum R, Kufe D.Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells.PLoS ONE. 2012;7(7):e39432.
    22792175
  • Luptakova K, Rosenblatt J, Glotzbecker B, Mills H, Stroopinsky D, Kufe T, Vasir B, Arnason J, Tzachanis D, Zwicker JI, Joyce RM, Levine JD, Anderson KC, Kufe D, Avigan D.Lenalidomide enhances anti-myeloma cellular immunity.Cancer Immunol Immunother. 2012 Jun 24.
    22733396
  • Ahmad R, Alam M, Rajabi H, Kufe D.The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function.J Biol Chem. 2012 Jun 15;287(25):20866-75.
    22544745
  • Hong DS, Kurzrock R, Supko JG, He X, Naing A, Wheler J, Lawrence D, Eder JP, Meyer CJ, Ferguson DA, Mier J, Konopleva M, Konoplev S, Andreeff M, Kufe D, Lazarus H, Shapiro GI, Dezube BJ.A phase i first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.Clin Cancer Res. 2012 Jun 15;18(12):3396-406.
    22634319
  • Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D.Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.Oncogene. 2012 Jun 11.
    22689062
  • Avigan D, Rosenblatt J, Kufe D.Dendritic/tumor fusion cells as cancer vaccines.Semin Oncol. 2012 Jun;39(3):287-95. Review.
    22595051
  • Kufe DW.MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches.Oncogene. 2012 May 14.
    22580612
  • Rajabi H, Ahmad R, Jin C, Joshi MD, Guha M, Alam M, Kharbanda S, Kufe D.MUC1-C oncoprotein confers androgen-independent growth of human prostate cancer cells.Prostate. 2012 Apr 2.
    22473899
  • Raina D, Ahmad R, Rajabi H, Panchamoorthy G, Kharbanda S, Kufe D.Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells.Int J Oncol. 2012 May;40(5):1643-9.
    22200620
  • Yin L, Kosugi M, Kufe D.Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH.Blood. 2012 Jan 19;119(3):810-6.
    22117045
  • Panchamoorthy G, Rehan H, Kharbanda A, Ahmad R, Kufe D.A monoclonal antibody against the oncogenic mucin 1 cytoplasmic domain.Hybridoma (Larchmt). 2011 Dec;30(6):531-5.
    22149278
  • Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D.MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.PLoS ONE. 2011;6(11):e28234.
    22140559
  • Mine N, Yamamoto S, Saito N, Yamazaki S, Suda C, Ishigaki M, Kufe DW, Von Hoff DD, Kawabe T.CBP501-Calmodulin Binding Contributes to Sensitizing Tumor Cells to Cisplatin and Bleomycin.Mol Cancer Ther. 2011 Oct;10(10):1929-38.
    21831962
  • Yin L, Kufe D.MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism.Genes Cancer. 2011 Jan;2(1):56-64.
    21643558
  • Sakakibara K, Saito N, Sato T, Suzuki A, Hasegawa Y, Friedman JM, Kufe DW, Vonhoff DD, Iwami T, Kawabe T.CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity.Blood. 2011 Oct 6;118(14):3922-31.
    21841164
  • Rajabi H, Joshi MD, Jin C, Ahmad R, Kufe D.Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells.Prostate. 2011 Sep;71(12):1299-308.
    21308711
  • Rosenblatt J, Glotzbecker B, Mills H, Vasir B, Tzachanis D, Levine JD, Joyce RM, Wellenstein K, Keefe W, Schickler M, Rotem-Yehudar R, Kufe D, Avigan D.PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine.J Immunother. 2011 Jun;34(5):409-18.
    21577144
  • Zhou Y, Rajabi H, Kufe D.Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.Mol Pharmacol. 2011 May;79(5):886-93.
    21346142
  • Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, Kufe D.MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells.Blood. 2011 Mar 21.
    21422470
  • Raina D, Kosugi M, Ahmad R, Panchamoorthy G, Rajabi H, Alam M, Shimamura T, Shapiro GI, Supko JG, Kharbanda S, Kufe DW.DEPENDENCE ON THE MUC1-C ONCOPROTEIN IN NON-SMALL CELL LUNG CANCER CELLS WITH EGFR AND K-RAS MUTATIONS.Mol Cancer Ther. 2011 Mar 18.
    21421804
  • Ahmad R, Rajabi H, Kosugi M, Joshi MD, Alam M, Vasir B, Kawano T, Kharbanda S, Kufe D.MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop.Sci Signal. 2011;4(160):ra9.
    21325207
  • Shapiro GI, Tibes R, Gordon MS, Wong BY, Eder JP, Borad MJ, Mendelson DS, Vogelzang NJ, Bastos BR, Weiss GJ, Fernandez C, Sutherland W, Sato H, Pierceall WE, Weaver D, Slough S, Wasserman E, Kufe DW, Von Hoff DD, Kawabe T, Sharma S.Phase I Studies of CBP501,a G2 Checkpoint Abrogator, as Monotherapy and in Combination with Cisplatin in Patients with Advanced Solid Tumors.Clin Cancer Res. 2011 Jan 10.
    21220472
  • Yin L, Ahmad R, Kosugi M, Kufe T, Vasir B, Avigan D, Kharbanda S, Kufe D.Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function.Mol Pharmacol. 2010 Aug;78(2):166-74.
    20444960
  • Kufe DW.Mucins in cancer: function, prognosis and therapy.Nat Rev Cancer. 2009 Dec;9(12):874-85. Review.
    19935676
  • Joshi MD, Ahmad R, Yin L, Raina D, Rajabi H, Bubley G, Kharbanda S, Kufe D.MUC1 oncoprotein is a druggable target in human prostate cancer cells.Mol Cancer Ther. 2009 Nov;8(11):3056-65.
    19887552
  • Kufe DW.Functional targeting of the MUC1 oncogene in human cancers.Cancer Biol Ther. 2009 Jul;8(13):1197-203. Review.
    19556858
  • Ahmad R, Raina D, Joshi MD, Kawano T, Ren J, Kharbanda S, Kufe D.MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.Cancer Res. 2009 Sep 1;69(17):7013-21.
    19706766
  • Raina D, Ahmad R, Joshi MD, Yin L, Wu Z, Kawano T, Vasir B, Avigan D, Kharbanda S, Kufe D.Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.Cancer Res. 2009 Jun 15;69(12):5133-41.
    19491255