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Barrett J. Rollins, MD, PhD


  • Van Allen EM, Wagle N, Stojanov P, Perrin DL, Cibulskis K, Marlow S, Jane-Valbuena J, Friedrich DC, Kryukov G, Carter SL, McKenna A, Sivachenko A, Rosenberg M, Kiezun A, Voet D, Lawrence M, Lichtenstein LT, Gentry JG, Huang FW, Fostel J, Farlow D, Barbie D, Gandhi L, Lander ES, Gray SW, Joffe S, Janne P, Garber J, MacConaill L, Lindeman N, Rollins B, Kantoff P, Fisher SA, Gabriel S, Getz G, Garraway LA.Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.Nat Med. 2014 Jun;20(6):682-8.
  • Gray SW, Hicks-Courant K, Cronin A, Rollins BJ, Weeks JC.Physicians' attitudes about multiplex tumor genomic testing.J Clin Oncol. 2014 May 1;32(13):1317-23.
  • Nelson DS, Quispel W, Badalian-Very G, van Halteren AG, van den Bos C, BovÊe JV, Tian SY, Van Hummelen P, Ducar M, Macconaill LE, Egeler RM, Rollins BJ.Somatic activating ARAF mutations in Langerhans cell histiocytosis.Blood. 2014 Mar 20.
  • Bates SV, Lakshmanan A, Green AL, Terry J, Badalian-Very G, Rollins BJ, Fleck P, Aslam M, Degar BA.BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate.AJP Rep. 2013 Oct;3(2):63-6.
  • Liu Y, Quang P, Braggio E, Ngo H, Badalian-Very G, Flores L, Zhang Y, Sacco A, Maiso P, Azab AK, Azab F, Carrasco R, Rollins BJ, Roccaro AM, Ghobrial IM.Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma.PLoS ONE. 2013;8(6):e66982.
  • Badalian-Very G, Vergilio JA, Fleming M, Rollins BJ.Pathogenesis of Langerhans Cell Histiocytosis.Annu Rev Pathol. 2012 Aug 6.
  • Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ.Recurrent BRAF mutations in Langerhans cell histiocytosis.Blood. 2010 Sep 16;116(11):1919-23.
  • Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CL.The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.J Immunol. 2010 Jun 1;184(11):6114-23.
  • Degar BA, Rollins BJ.Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?.Dis Model Mech.;2(9-10):436-9.
  • Rollins BJ.Where the confusion began: cloning the first chemokine receptors.J Immunol. 2009 Sep 1;183(5):2893-4.
  • Azab AK,Azab F,Blotta S,Pitsillides CM,Thompson B,Runnels JM,Roccaro AM,Ngo HT,Melhem MR,Sacco A,Jia X,Anderson KC,Lin CP,Rollins BJ,Ghobrial IM.Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in multiple myeloma.Blood. 2009 Jul 16;114(3):619-29.
  • Roccaro AM,Sacco A,Thompson B,Leleu X,Azab AK,Azab F,Runnels J,Jia X,Ngo HT,Melhem MR,Lin CP,Ribatti D,Rollins BJ,Witzig TE,Anderson KC,Ghobrial IM.microRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.Blood. 2009 Jun 25;113(26):6669-80.
  • Azab AK,Runnels JM,Pitsillides C,Moreau AS,Azab F,Leleu X,Jia X,Wright R,Ospina B,Carlson AL,Alt C,Burwick N,Roccaro AM,Ngo HT,Farag M,Melhem MR,Sacco A,Munshi NC,Hideshima T,Rollins BJ,Anderson KC,Kung AL,Lin CP,Ghobrial IM.CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.Blood. 2009 Apr 30;113(18):4341-51.
  • Roccaro AM,Sacco A,Chen C,Runnels J,Leleu X,Azab F,Azab AK,Jia X,Ngo HT,Melhem MR,Burwick N,Varticovski L,Novina CD,Rollins BJ,Anderson KC,Ghobrial IM.microRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia.Blood. 2009 Apr 30;113(18):4391-402.
  • Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC.Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.Am J Hematol. 2008 Feb;83(2):116-21.
  • Martin AP, Canasto-Chibuque C, Shang L, Rollins BJ, Lira SA.The chemokine decoy receptor M3 blocks CC chemokine ligand 2 and CXC chemokine ligand 13 function in vivo.J Immunol. 2006 Nov 15;177(10):7296-302.
  • Rollins BJ.Inflammatory chemokines in cancer growth and progression.Eur J Cancer. 2006 Apr;42(6):760-7. Review.
  • Rollins BJ.Release the hounds! A chemokine elicits monocytes from bone marrow.Nat Immunol. 2006 Mar;7(3):230-2.
  • Ferreira AM, Rollins BJ, Faunce DE, Burns AL, Zhu X, Dipietro LA.The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: evidence for a complex network in acute inflammation.Cytokine. 2005 Apr 21;30(2):64-71.
  • Waeckel L, Mallat Z, Potteaux S, Combadičre C, Clergue M, Duriez M, Bao L, Gerard C, Rollins BJ, Tedgui A, Levy BI, Silvestre JS.Impairment in postischemic neovascularization in mice lacking the CXC chemokine receptor 3.Circ Res. 2005 Mar 18;96(5):576-82.
  • Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ.Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.Respir Res. 2004;5(1):12.
  • Ren S, Rollins BJ.Cyclin C/cdk3 promotes Rb-dependent G0 exit.Cell. 2004 Apr 16;117(2):239-51.
  • Conti I, Dube C, Rollins BJ.Chemokine-based pathogenetic mechanisms in cancer.Novartis Found Symp. 2004;256:29-41; discussion 41-52,.
  • Lee I, Wang L, Wells AD, Ye Q, Han R, Dorf ME, Kuziel WA, Rollins BJ, Chen L, Hancock WW.Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.J Immunol. 2003 Dec 15;171(12):6929-35.
  • Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK.An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.Nat Med. 2003 Nov;9(11):1390-7.
  • Panoskaltsis-Mortari A, Hermanson JR, Taras E, Wangensteen OD, Charo IF, Rollins BJ, Blazar BR.Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells.Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L284-92.
  • Kleine-Lowinski K, Rheinwald JG, Fichorova RN, Anderson DJ, Basile J, Münger K, Daly CM, Rösl F, Rollins BJ.Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells.Int J Cancer. 2003 Nov 10;107(3):407-15.
  • DePaolo RW, Rollins BJ, Kuziel W, Karpus WJ.CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.J Immunol. 2003 Oct 1;171(7):3560-7.
  • Soejima K, Fang W, Rollins BJ.DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.Oncogene. 2003 Jul 24;22(30):4723-33.
  • Daly C, Rollins BJ.Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies.Microcirculation. 2003 Jun;10(3-4):247-57.
  • Fleming MD, Pinkus JL, Alexander SW, Tam C, Loda M, Sallan SE, Nichols KE, Carpentieri DF, Pinkus GS, Rollins BJ.Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis.Blood. 2003 Apr 1;101(7):2473-5.
  • Kijima T, Maulik G, Ma PC, Tibaldi EV, Turner RE, Rollins B, Sattler M, Johnson BE, Salgia R.Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.Cancer Res. 2002 Nov 1;62(21):6304-11.
  • Tuaillon N, Shen de F, Berger RB, Lu B, Rollins BJ, Chan CC.MCP-1 expression in endotoxin-induced uveitis.Invest Ophthalmol Vis Sci. 2002 May;43(5):1493-8.
  • Soejima K, Rollins BJ.A functional IFN-gamma-inducible protein-10/CXCL10-specific receptor expressed by epithelial and endothelial cells that is neither CXCR3 nor glycosaminoglycan.J Immunol. 2001 Dec 1;167(11):6576-82.
  • Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ, Zweerink H, Rot A, von Andrian UH.Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues.J Exp Med. 2001 Nov 5;194(9):1361-73.
  • Shapiro GI, Supko JG, Patterson A, Lynch C, Lucca J, Zacarola PF, Muzikansky A, Wright JJ, Lynch TJ, Rollins BJ.A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.Clin Cancer Res. 2001 Jun;7(6):1590-9.
  • Gerard C, Rollins BJ.Chemokines and disease.Nat Immunol. 2001 Feb;2(2):108-15.
  • Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM.Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis.J Exp Med. 2001 Mar 19;193(6):713-26.
  • Grewal I, Gu L, Tseng S, Rollins BJ.Targeted expression of chemokines in vivo.Methods Mol Biol. 2000;138:243-51.
  • Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ.Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1.Nature. 2000 Mar 23;404(6776):407-11.
  • Gu L, Tseng SC, Rollins BJ.Monocyte chemoattractant protein-1.Chem Immunol. 1999;72:7-29.
  • Shapiro GI, Koestner DA, Matranga CB, Rollins BJ.Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.Clin Cancer Res. 1999 Oct;5(10):2925-38.
  • Salgia R, Li JL, Ewaniuk DS, Wang YB, Sattler M, Chen WC, Richards W, Pisick E, Shapiro GI, Rollins BJ, Chen LB, Griffin JD, Sugarbaker DJ.Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.Oncogene. 1999 Jan 7;18(1):67-77.
  • Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ.Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice.J Exp Med. 1998 Feb 16;187(4):601-8.
  • Shapiro GI, Edwards CD, Ewen ME, Rollins BJ.p16INK4A participates in a G1 arrest checkpoint in response to DNA damage.Mol Cell Biol. 1998 Jan;18(1):378-87.
  • Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J.The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell. 1996 Jun 28;85(7):1135-48.
  • Shapiro GI, Park JE, Edwards CD, Mao L, Merlo A, Sidransky D, Ewen ME, Rollins BJ.Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.Cancer Res. 1995 Dec 15;55(24):6200-9.
  • Manome Y, Wen PY, Hershowitz A, Tanaka T, Rollins BJ, Kufe DW, Fine HA.Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors.Cancer Immunol Immunother. 1995 Oct;41(4):227-35.
  • Luo Y, Laning J, Hayashi M, Hancock PR, Rollins B, Dorf ME.Serologic analysis of the mouse beta chemokine JE/monocyte chemoattractant protein-1.J Immunol. 1994 Oct 15;153(8):3708-16.
  • Yaeger PC, Stiles CD, Rollins BJ.Human keratinocyte growth-promoting activity on the surface of fibroblasts.J Cell Physiol. 1991 Oct;149(1):110-6.
  • Rollins BJ, Morton CC, Ledbetter DH, Eddy RL, Shows TB.Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus.Genomics. 1991 Jun;10(2):489-92.
  • Rollins BJ, Morrison ED, Stiles CD.Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.Proc Natl Acad Sci U S A. 1988 Jun;85(11):3738-42.
  • Jones SD, Hall DJ, Rollins BJ, Stiles CD.Platelet-derived growth factor generates at least two distinct intracellular signals that modulate gene expression.Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:531-6.
  • Rollins BJ, Morrison ED, Stiles CD.A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor.Science. 1987 Nov 27;238(4831):1269-71.